Karin Fromell

Extracellular vesicle secretome from mesenchymal stromal cells prevents post-ischemic heart failure by targeting cardiac fibrosis

Grinnemo, Karl-Henrik; Braesch-Andersen, Ken; Wedin, Johan; Velica, Anna et al.

Part of Cell Stem Cell, p. 1324-1338, 2026

• DOI for Extracellular vesicle secretome from mesenchymal stromal cells prevents post-ischemic heart failure by targeting cardiac fibrosis
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A new principle to attenuate ischemia-reperfusion injury in kidney transplantation

Biglarnia, Ali-Reza; Teramura, Yuji; Asif, Sana; Dührkop, Claudia et al.

Part of American Journal of Transplantation, p. 263-275, 2026

• DOI for A new principle to attenuate ischemia-reperfusion injury in kidney transplantation
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Native C3 is activated without proteolytic cleavage by transformation to C3(H2O) on phospholipid-scrambled cell membranes

Eikrem, David; Manivel, Vivek Anand; Whittaker, Jacob; Hamad, Osama A. et al.

Part of Frontiers in Immunology, 2025

• DOI for Native C3 is activated without proteolytic cleavage by transformation to C3(H2O) on phospholipid-scrambled cell membranes
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Changes in the pulmonary surfactant in patients with mild to moderate COVID-19

Kokelj, Spela; Larsson, Per; Viklund, Emilia; Koca, Hatice et al.

Part of PLOS ONE, 2025

• DOI for Changes in the pulmonary surfactant in patients with mild to moderate COVID-19
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The blood response to subway-derived iron nanoparticles

Ekdahl, Kristina N.; Monie, Lisa; Juárez-Facio, Ana T.; Olofsson, Ulf et al.

Part of Environmental Toxicology and Pharmacology, 2025

• DOI for The blood response to subway-derived iron nanoparticles
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Extracellular vesicle secretome from mesenchymal stromal cells prevents post-ischemic heart failure by targeting cardiac fibrosis

Grinnemo, Karl-Henrik; Braesch-Andersen, Ken; Wedin, Johan; Velica, Anna et al.

Part of Cell Stem Cell, p. 1324-1338, 2026

• DOI for Extracellular vesicle secretome from mesenchymal stromal cells prevents post-ischemic heart failure by targeting cardiac fibrosis
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A new principle to attenuate ischemia-reperfusion injury in kidney transplantation

Biglarnia, Ali-Reza; Teramura, Yuji; Asif, Sana; Dührkop, Claudia et al.

Part of American Journal of Transplantation, p. 263-275, 2026

• DOI for A new principle to attenuate ischemia-reperfusion injury in kidney transplantation
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Native C3 is activated without proteolytic cleavage by transformation to C3(H2O) on phospholipid-scrambled cell membranes

Eikrem, David; Manivel, Vivek Anand; Whittaker, Jacob; Hamad, Osama A. et al.

Part of Frontiers in Immunology, 2025

• DOI for Native C3 is activated without proteolytic cleavage by transformation to C3(H2O) on phospholipid-scrambled cell membranes
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Changes in the pulmonary surfactant in patients with mild to moderate COVID-19

Kokelj, Spela; Larsson, Per; Viklund, Emilia; Koca, Hatice et al.

Part of PLOS ONE, 2025

• DOI for Changes in the pulmonary surfactant in patients with mild to moderate COVID-19
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The blood response to subway-derived iron nanoparticles

Ekdahl, Kristina N.; Monie, Lisa; Juárez-Facio, Ana T.; Olofsson, Ulf et al.

Part of Environmental Toxicology and Pharmacology, 2025

• DOI for The blood response to subway-derived iron nanoparticles
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Regulation of the innate immune system by fragmented heparin-conjugated lipids on lipid bilayered membranes in vitro

Adler, Anna; Fritsch, Marlene; Fromell, Karin; Leneweit, Gero et al.

Part of Journal of materials chemistry. B, p. 11121-11134, 2023

• DOI for Regulation of the innate immune system by fragmented heparin-conjugated lipids on lipid bilayered membranes in vitro
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Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis

Martin, Myriam; Nilsson, Sara C. C.; Eikrem, David; Fromell, Karin et al.

Part of Frontiers in Immunology, 2023

• DOI for Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis
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Analysis of local extracellular matrix identifies different aetiologies behind bicuspid and tricuspid aortic valve degeneration and suggests therapies

Beusch, Christian M.; Simonson, Oscar; Wedin, Johan O; Sabatier, Pierre et al.

Part of Cellular and Molecular Life Sciences (CMLS), 2023

• DOI for Analysis of local extracellular matrix identifies different aetiologies behind bicuspid and tricuspid aortic valve degeneration and suggests therapies
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How COVID-19 and other pathological conditions and medical treatments activate our intravascular innate immune system

Nilsson, Bo; Eriksson, Oskar; Fromell, Karin; Persson, Barbro et al.

Part of Frontiers in Immunology, 2023

• DOI for How COVID-19 and other pathological conditions and medical treatments activate our intravascular innate immune system
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Activation of the Complement and Coagulation Systems in the Small Airways in Asthma

Kokelj, Spela; Östling, Jörgen; Fromell, Karin; Vanfleteren, Lowie E. G. W. et al.

Part of Respiration, p. 621-631, 2023

• DOI for Activation of the Complement and Coagulation Systems in the Small Airways in Asthma
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The effect of airborne Palladium nanoparticles on human lung cells, endothelium and blood-A combinatory approach using three in vitro models

Fromell, Karin; Johansson, Ulrika; Abadgar, Sophia; Bourzeix, Pauline et al.

Part of Toxicology in Vitro, 2023

• DOI for The effect of airborne Palladium nanoparticles on human lung cells, endothelium and blood-A combinatory approach using three in vitro models
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Angiopoietin-2 Inhibition of Thrombomodulin-Mediated Anticoagulation: A Novel Mechanism That May Contribute to Hypercoagulation in Critically Ill COVID-19 Patients

Hultström, Michael; Fromell, Karin; Larsson, Anders; Persson, Barbro et al.

Part of Biomedicines, 2022

• DOI for Angiopoietin-2 Inhibition of Thrombomodulin-Mediated Anticoagulation: A Novel Mechanism That May Contribute to Hypercoagulation in Critically Ill COVID-19 Patients
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Elevated Angiopoietin-2 inhibits thrombomodulin-mediated anticoagulation in critically ill COVID-19 patients

Hultström, Michael; Fromell, Karin; Larsson, Anders; Quaggin, Susan E et al.

Part of Biomedicines, p. 1333-27, 2022

• DOI for Elevated Angiopoietin-2 inhibits thrombomodulin-mediated anticoagulation in critically ill COVID-19 patients
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A Robust Method to Store Complement C3 With Superior Ability to Maintain the Native Structure and Function of the Protein

Adler, Anna; Manivel, Vivek Anand; Fromell, Karin; Teramura, Yuji et al.

Part of Frontiers in Immunology, 2022

• DOI for A Robust Method to Store Complement C3 With Superior Ability to Maintain the Native Structure and Function of the Protein
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The Outcome of Critically Ill COVID-19 Patients Is Linked to Thromboinflammation Dominated by the Kallikrein/Kinin System

Lipcsey, Miklós; Persson, Barbro; Eriksson, Oskar; Blom, Anna M. et al.

Part of Frontiers in Immunology, 2021

• DOI for The Outcome of Critically Ill COVID-19 Patients Is Linked to Thromboinflammation Dominated by the Kallikrein/Kinin System
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Hemocompatibility of Nanotitania-Nanocellulose Hybrid Materials

Svensson, Fredric G.; Manivel, Vivek Anand; Seisenbaeva, Gulaim A.; Kessler, Vadim G. et al.

Part of Nanomaterials, 2021

• DOI for Hemocompatibility of Nanotitania-Nanocellulose Hybrid Materials
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Smoking induces sex-specific changes in the small airway proteome

Kokelj, Spela; Ostling, Jorgen; Georgi, Benjamin; Fromell, Karin et al.

Part of Respiratory Research, 2021

• DOI for Smoking induces sex-specific changes in the small airway proteome
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Assessment of the Role of C3(H2O) in the Alternative Pathway

Fromell, Karin; Adler, Anna; Åman, Amanda; Manivel, Vivek Anand et al.

Part of Frontiers in Immunology, 2020

• DOI for Assessment of the Role of C3(H2O) in the Alternative Pathway
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Potential of Cell Surface Engineering with Biocompatible Polymers for Biomedical Applications

Teramura, Yuji; Nilsson Ekdahl, Kristina; Fromell, Karin; Nilsson, Bo et al.

Part of Langmuir, p. 12088-12106, 2020

• DOI for Potential of Cell Surface Engineering with Biocompatible Polymers for Biomedical Applications

C1q recognizes antigen-bound IgG in a curvature-dependent manner

Zeuthen, Christina M.; Shahrokhtash, Ali; Fromell, Karin; Nilsson Ekdahl, Kristina et al.

Part of Nano Reseach, p. 1651-1658, 2020

• DOI for C1q recognizes antigen-bound IgG in a curvature-dependent manner

Is generation of C3(H₂O) necessary for activation of the alternative pathway in real life?

Nilsson Ekdahl, Kristina; Mohlin, Camilla; Adler, Anna; Åman, Amanda et al.

Part of Molecular Immunology, p. 353-361, 2019

• DOI for Is generation of C3(H₂O) necessary for activation of the alternative pathway in real life?
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The lectin pathway of complement and the contact/kallikrein system are integrated

Fromell, Karin; Dührkop, Claudia; Kozarcanin, Huda; Johansson, Ulrika et al.

Part of Molecular Immunology, p. 151-152, 2018

• DOI for The lectin pathway of complement and the contact/kallikrein system are integrated

Generation of an alternative pathway convertase by contact-activated C3 is dependent on the conformation of C3

Fromell, Karin; Johansson, Ulrika; Dührkop, Claudia; Adler, Anna et al.

Part of Molecular Immunology, p. 193-193, 2018

• DOI for Generation of an alternative pathway convertase by contact-activated C3 is dependent on the conformation of C3

Contact (kallikrein/kinin) system activation in whole human blood induced by low concentrations of α-Fe2O3 nanoparticles.

Nilsson Ekdahl, Kristina; Davoodpour, Padideh; Ekstrand-Hammarström, Barbro; Fromell, Karin et al.

Part of Nanomedicine, p. 735-744, 2018

• DOI for Contact (kallikrein/kinin) system activation in whole human blood induced by low concentrations of α-Fe2O3 nanoparticles.

Shiga toxin 2a binds antithrombin and heparin, but does not directly activate platelets

Knabl, Ludwig; Berktold, Michael; Hamad, Osama A.; Fromell, Karin et al.

Part of International Journal of Medical Microbiology, p. 969-976, 2018

• DOI for Shiga toxin 2a binds antithrombin and heparin, but does not directly activate platelets

Absence of conformational change in complement factor 3 and factor XII adsorbed to acrylate polymers is related to a high degree of polymer backbone flexibility

Fromell, Karin; Yang, Yi; Nilsson Ekdahl, Kristina; Nilsson, Bo et al.

Part of Biointerphases, 2017

• DOI for Absence of conformational change in complement factor 3 and factor XII adsorbed to acrylate polymers is related to a high degree of polymer backbone flexibility
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Dispersion of TiO₂ nanoparticles improves burn wound healing and tissue regeneration through specific interaction with blood serum proteins

Seisenbaeva, Gulaim A.; Fromell, Karin; Vinogradov, Vasiliy V.; Terekhov, Aleksey N. et al.

Part of Scientific Reports, 2017

• DOI for Dispersion of TiO₂ nanoparticles improves burn wound healing and tissue regeneration through specific interaction with blood serum proteins
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Forms of contact-activated C3 associated with AP convertase formation

Fromell, Karin; Dührkop, Claudia; Johansson, Ulrika; Nilsson Ekdahl, Kristina et al.

Part of Molecular Immunology, p. 141-141, 2017

• DOI for Forms of contact-activated C3 associated with AP convertase formation

Reciprocal relationship between contact and complement system activation on artificial polymers exposed to whole human blood

Huang, Shan; Engberg, Anna E.; Jonsson, Nina; Sandholm, Kerstin et al.

Part of Biomaterials, p. 111-119, 2016

• DOI for Reciprocal relationship between contact and complement system activation on artificial polymers exposed to whole human blood

Heparinization of cell surfaces with short pepetide-conjugated PEG-lipid regulates thromboinflammation in thransplantation of human MSCs and hepatocytes

Asif, Sana; Ekdahl, Kristina N; Fromell, Karin; Gustafson, Elisabet et al.

Part of Acta Biomaterialia, p. 194-205, 2016

• DOI for Heparinization of cell surfaces with short pepetide-conjugated PEG-lipid regulates thromboinflammation in thransplantation of human MSCs and hepatocytes

Dangerous liaisons: complement, coagulation, and kallikrein/kinin cross-talk act as a linchpin in the events leading to thromboinflammation

Nilsson Ekdahl, Kristina; Teramura, Yuji; Hamad, Osama A.; Asif, Sana et al.

Part of Immunological Reviews, p. 245-269, 2016

• DOI for Dangerous liaisons: complement, coagulation, and kallikrein/kinin cross-talk act as a linchpin in the events leading to thromboinflammation

Development and characterization of an innovtive heparin coating to stabilize and protect liposomes against adverse immune reactions

Duehrkop, Claudia; Leneweit, Gero; Heyder, Christoph; Fromell, Karin et al.

Part of Colloids and Surfaces B, p. 576-583, 2016

• DOI for Development and characterization of an innovtive heparin coating to stabilize and protect liposomes against adverse immune reactions

Contact activation of C3 enables tethering between activated platelets and polymorphonuclear leukocytes via CD11b/CD18

Hamad, Osama A.; Mitroulis, Ioannis; Fromell, Karin; Kozarcanin, Huda et al.

Part of Thrombosis and Haemostasis, p. 1207-1217, 2015

• DOI for Contact activation of C3 enables tethering between activated platelets and polymorphonuclear leukocytes via CD11b/CD18

Vascular repair utilising immobilised heparin conjugate for protection against early activation of inflammation and coagulation

Nordling, Sofia; Hong, Jaan; Fromell, Karin; Edin, Fredrik et al.

Part of Thrombosis and Haemostasis, p. 1312-1322, 2015

• DOI for Vascular repair utilising immobilised heparin conjugate for protection against early activation of inflammation and coagulation

Contact activation of C3 enables tethering between activated platelets and polymorphonuclear leukocytes via CD11b/CD18

Hamad, Osama A.; Mitroulis, Ioannis; Fromell, Karin; Kozarcanin, Huda et al.

Part of Molecular Immunology, p. 141-142, 2015

Prediction of inflammatory responses induced by biomaterials in contact with human blood using protein fingerprint from plasma

Engberg, Anna E.; Nilsson, Per H.; Huang, Shan; Fromell, Karin et al.

Part of Biomaterials, p. 55-65, 2015

• DOI for Prediction of inflammatory responses induced by biomaterials in contact with human blood using protein fingerprint from plasma

Contact activation of C3 enables tethering between activated platelets and polymorphonuclear leukocytes via CD11b/CD18

Ekdahl, Kristina N.; Hamad, Osama A.; Mitroulis, Ioannis; Fromell, Karin et al.

Part of Molecular Immunology, p. 242-243, 2014

Designed protein binders in combination with nanocrystalline diamond for use in high-sensitivity biosensors

Fromell, Karin; Forsberg, Pontus; Karlsson, Mikael; Larsson, Karin et al.

Part of Analytical and Bioanalytical Chemistry, p. 1643-1651, 2012

• DOI for Designed protein binders in combination with nanocrystalline diamond for use in high-sensitivity biosensors

Comparison between Chicken and Rabbit Antibody Based Particle Enhanced Cystatin C Reagents for Immunoturbidimetry

Hansson, Lars-Olof; Flodin, Mats; Nilsen, Tom; Caldwell, Karin et al.

Part of Journal of immunoassay & immunochemistry, p. 1-9, 2008

• DOI for Comparison between Chicken and Rabbit Antibody Based Particle Enhanced Cystatin C Reagents for Immunoturbidimetry

Nanoparticle decorated surfaces with potential use in glycosylation analysis

Fromell, Karin; Andersson, Margaretha; Elihn, Karine; Caldwell, Karin

Part of Colloids and Surfaces B: Biointerfaces, 2005

Shifts in polystyrene particle surface charge upon adsorption of the Pluronic F108 surfactant

ter Veen, Rik; Fromell, Karin; Caldwell, Karin

Part of Journal of Colloid and Interface Science, p. 124-128, 2005

Characterization of Surface-Modified Nanoparticles for in Vivo Biointeraction. A Sedimentation Field Flow Fractionation Study

Andersson, Margaretha; Fromell, Karin; Gullberg, Elisabet; Artursson, Per et al.

Part of Analytical Chemistry, p. 5488-5493, 2005

Surface attachment of nanoparticles using oligonucleotides

Andersson, Margaretha; Elihn, K.; Fromell, Karin; Caldwell, Karin

Part of Colloids and Surfaces B: Biointerfaces, p. 165-171, 2004

Therapeutic regulation of complement activation in extracorporeal circuits and intravascular treatments with special reference to the alternative pathway amplification loop

Ekdahl, Kristina N.; Fromell, Karin; Mannes, Marco; Grinnemo, Karl-Henrik et al.

Part of Immunological Reviews, p. 91-103, 2023

• DOI for Therapeutic regulation of complement activation in extracorporeal circuits and intravascular treatments with special reference to the alternative pathway amplification loop
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How the Innate Immune System of the Blood Contributes to Systemic Pathology in COVID-19-Induced ARDS and Provides Potential Targets for Treatment

Nilsson, Bo; Persson, Barbro; Eriksson, Oskar; Fromell, Karin et al.

Part of Frontiers in Immunology, 2022

• DOI for How the Innate Immune System of the Blood Contributes to Systemic Pathology in COVID-19-Induced ARDS and Provides Potential Targets for Treatment
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A human whole-blood model to study the activation of innate immunity system triggered by nanoparticles as a demonstrator for toxicity

N.Ekdahl, Kristina; Fromell, Karin; Mohlin, Camilla; Teramura, Yuji et al.

Part of Science and Technology of Advanced Materials, p. 688-698, 2019

• DOI for A human whole-blood model to study the activation of innate immunity system triggered by nanoparticles as a demonstrator for toxicity
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Auxiliary activation of the complement system and its importance for the pathophysiology of clinical conditions

Huber-Lang, Markus; Nilsson Ekdahl, Kristina; Wiegner, Rebecca; Fromell, Karin et al.

Part of Seminars in Immunopathology, p. 87-102, 2018

• DOI for Auxiliary activation of the complement system and its importance for the pathophysiology of clinical conditions
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The innate immunity response: A key factor in biocompatibility

Ekdahl, Kristina N; Fromell, Karin; Hilborn, Jöns; Nilsson, Bo

Part of Bioresorbable Polymers for Biomedical Applications, p. 85-94, Elsevier, 2017