Fredrik Johansson Swartling

Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models

Schoof, Melanie; Zheng, Tuyu; Sill, Martin; Imle, Roland et al.

Part of Nature Genetics, p. 143-156, 2026

• DOI for Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models
• Download full text (pdf) of Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models

Childhood brain tumors instruct cranial hematopoiesis and immunotolerance

Cooper, Elizabeth; Posner, David A.; Lee, Colin Y. C.; Hu, Linda et al.

Part of Nature Genetics, p. 317-328, 2026

• DOI for Childhood brain tumors instruct cranial hematopoiesis and immunotolerance
• Download full text (pdf) of Childhood brain tumors instruct cranial hematopoiesis and immunotolerance

A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies

Gudenas, Brian L.; Ahmad, Shiekh Tanveer; Englinger, Bernhard; Liu, Anthony P. Y. et al.

Part of Cancer Cell, p. 831-845, 2026

• DOI for A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies
• Download full text (pdf) of A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies

Albacarcin V adds EPLIN as a novel and promising target for the treatment of female cancers and pediatric medulloblastoma

Krahulcova, Lucia; Lindell, Emma; Lu, Xi; Conejeros Monsalve, Jessica Javiera et al.

Part of Biochemical Pharmacology, 2026

• DOI for Albacarcin V adds EPLIN as a novel and promising target for the treatment of female cancers and pediatric medulloblastoma
• Download full text (pdf) of Albacarcin V adds EPLIN as a novel and promising target for the treatment of female cancers and pediatric medulloblastoma

scFFPE-ATAC enables high-throughput single cell chromatin accessibility profiling in formalin-fixed paraffin-embedded samples

Yadav, Ram Prakash; Xing, Pengwei; Zhao, Miao; Hollander, Peter et al.

Part of Nature Communications, 2025

• DOI for scFFPE-ATAC enables high-throughput single cell chromatin accessibility profiling in formalin-fixed paraffin-embedded samples
• Download full text (pdf) of scFFPE-ATAC enables high-throughput single cell chromatin accessibility profiling in formalin-fixed paraffin-embedded samples

Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models

Schoof, Melanie; Zheng, Tuyu; Sill, Martin; Imle, Roland et al.

Part of Nature Genetics, p. 143-156, 2026

• DOI for Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models
• Download full text (pdf) of Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models

Childhood brain tumors instruct cranial hematopoiesis and immunotolerance

Cooper, Elizabeth; Posner, David A.; Lee, Colin Y. C.; Hu, Linda et al.

Part of Nature Genetics, p. 317-328, 2026

• DOI for Childhood brain tumors instruct cranial hematopoiesis and immunotolerance
• Download full text (pdf) of Childhood brain tumors instruct cranial hematopoiesis and immunotolerance

A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies

Gudenas, Brian L.; Ahmad, Shiekh Tanveer; Englinger, Bernhard; Liu, Anthony P. Y. et al.

Part of Cancer Cell, p. 831-845, 2026

• DOI for A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies
• Download full text (pdf) of A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies

Albacarcin V adds EPLIN as a novel and promising target for the treatment of female cancers and pediatric medulloblastoma

Krahulcova, Lucia; Lindell, Emma; Lu, Xi; Conejeros Monsalve, Jessica Javiera et al.

Part of Biochemical Pharmacology, 2026

• DOI for Albacarcin V adds EPLIN as a novel and promising target for the treatment of female cancers and pediatric medulloblastoma
• Download full text (pdf) of Albacarcin V adds EPLIN as a novel and promising target for the treatment of female cancers and pediatric medulloblastoma

scFFPE-ATAC enables high-throughput single cell chromatin accessibility profiling in formalin-fixed paraffin-embedded samples

Yadav, Ram Prakash; Xing, Pengwei; Zhao, Miao; Hollander, Peter et al.

Part of Nature Communications, 2025

• DOI for scFFPE-ATAC enables high-throughput single cell chromatin accessibility profiling in formalin-fixed paraffin-embedded samples
• Download full text (pdf) of scFFPE-ATAC enables high-throughput single cell chromatin accessibility profiling in formalin-fixed paraffin-embedded samples

Rolling Ultrasharp Microneedle Spheres Enable Topical Delivery of Biologics Through the Skin

Iordanidis, Theocharis Nikiforos; Spyrou, Argyris; Roudi, Samantha; Swartling, Fredrik J. et al.

Part of Advanced Healthcare Materials, 2025

• DOI for Rolling Ultrasharp Microneedle Spheres Enable Topical Delivery of Biologics Through the Skin
• Download full text (pdf) of Rolling Ultrasharp Microneedle Spheres Enable Topical Delivery of Biologics Through the Skin

The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma

Ohata, Yae; Ali, Mohamad M.; Tsubakihara, Yutaro; Itoh, Yuka et al.

Part of Cell Death and Differentiation, p. 1915-1929, 2025

• DOI for The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma
• Download full text (pdf) of The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma

Identification of a small molecule targeting EPLIN as a novel strategy for the treatment of pediatric neuroblastoma and medulloblastoma

Lindell, Emma; Guo, Jing; Zhao, Miao; Rameika, Natallia et al.

Part of Cell Death and Disease, 2025

• DOI for Identification of a small molecule targeting EPLIN as a novel strategy for the treatment of pediatric neuroblastoma and medulloblastoma
• Download full text (pdf) of Identification of a small molecule targeting EPLIN as a novel strategy for the treatment of pediatric neuroblastoma and medulloblastoma

Development of an orthotopic medulloblastoma zebrafish model for rapid drug testing

van Bree, Niek; Oppelt, Ann-Sophie; Lindstroem, Susanne; Zhou, Leilei et al.

Part of Neuro-Oncology, p. 779-794, 2025

• DOI for Development of an orthotopic medulloblastoma zebrafish model for rapid drug testing
• Download full text (pdf) of Development of an orthotopic medulloblastoma zebrafish model for rapid drug testing

An Indolin-3-imine Photobase and pH Sensitive Fluorophore

Doloczki, Susanne; Kern, Christoph; Holmberg, Karl O.; Zhao, Miao et al.

Part of ChemPhotoChem, 2023

• DOI for An Indolin-3-imine Photobase and pH Sensitive Fluorophore
• Download full text (pdf) of An Indolin-3-imine Photobase and pH Sensitive Fluorophore

Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells

Lu, Xi; Zhong, Lei; Lindell, Emma; Veanes, Margus et al.

Part of Cell Death and Disease, 2023

• DOI for Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells
• Download full text (pdf) of Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells

Photoinduced ring‐opening and phototoxicity of an indolin‐3‐one derivative

Doloczki, Susanne; Kern, Christoph; Holmberg Olausson, Karl; Swartling, Fredrik J. et al.

Part of Chemistry - A European Journal, 2023

• DOI for Photoinduced ring‐opening and phototoxicity of an indolin‐3‐one derivative
• Download full text (pdf) of Photoinduced ring‐opening and phototoxicity of an indolin‐3‐one derivative

ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors

Mainwaring, Oliver; Weishaupt, Holger; Zhao, Miao; Rosén, Gabriela et al.

Part of Nature Communications, 2023

• DOI for ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors
• Download full text (pdf) of ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors

Novel cancer gene discovery using a forward genetic screen in RCAS-PDGFB-driven gliomas

Weishaupt, Holger; Čančer, Matko; Rosén, Gabriela; Holmberg, Karl O. et al.

Part of Neuro-Oncology, p. 97-107, 2023

• DOI for Novel cancer gene discovery using a forward genetic screen in RCAS-PDGFB-driven gliomas
• Download full text (pdf) of Novel cancer gene discovery using a forward genetic screen in RCAS-PDGFB-driven gliomas

Article Basal cell carcinomas acquire secondary mutations to overcome dormancy and progress from microscopic to macroscopic disease

Trieu, Kenneth G.; Tsai, Shih-Ying; Eberl, Markus; Ju, Virginia et al.

Part of Cell Reports, 2022

• DOI for Article Basal cell carcinomas acquire secondary mutations to overcome dormancy and progress from microscopic to macroscopic disease
• Download full text (pdf) of Article Basal cell carcinomas acquire secondary mutations to overcome dormancy and progress from microscopic to macroscopic disease

Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma

Borgenvik, Anna; Holmberg, Karl O.; Bolin, Sara; Zhao, Miao et al.

Part of Cancer Research, p. 4586-4603, 2022

• DOI for Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma
• Download full text (pdf) of Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma

Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions

Westergren Jakobsson, Amanda; Kundu, Snehangshu; Guo, Jing; Chowdhury, Azazul Islam et al.

Part of Cancers, 2022

• DOI for Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions
• Download full text (pdf) of Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions

Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples

Zhang, Hua; Polavarapu, Vamsi Krishna; Xing, Pengwei; Zhao, Miao et al.

Part of Genome Research, p. 150-161, 2022

• DOI for Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples
• Download full text (pdf) of Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples

Photophysical characterization and fluorescence cell imaging applications of 4-N-substituted benzothiadiazoles

Doloczki, Susanne; Holmberg, Karl O.; Galván, Ignacio Fdez.; Swartling, Fredrik J. et al.

Part of RSC Advances, p. 14544-14550, 2022

• DOI for Photophysical characterization and fluorescence cell imaging applications of 4-N-substituted benzothiadiazoles
• Download full text (pdf) of Photophysical characterization and fluorescence cell imaging applications of 4-N-substituted benzothiadiazoles

FACT-seq: profiling histone modifications in formalin-fixed paraffin-embedded samples with low cell numbers

Zhao, Linxuan; Xing, Pengwei; Polavarapu, Vamsi Krishna; Zhao, Miao et al.

Part of Nucleic Acids Research, 2021

• DOI for FACT-seq: profiling histone modifications in formalin-fixed paraffin-embedded samples with low cell numbers
• Download full text (pdf) of FACT-seq: profiling histone modifications in formalin-fixed paraffin-embedded samples with low cell numbers

SOX9 Defines Distinct Populations of Cells in SHH Medulloblastoma but Is Not Required for Math1-Driven Tumor Formation

Adolphe, Christelle; Millar, Amanda; Kojic, Marija; Barkauskas, Deborah S. et al.

Part of Molecular Cancer Research, p. 1831-1839, 2021

• DOI for SOX9 Defines Distinct Populations of Cells in SHH Medulloblastoma but Is Not Required for Math1-Driven Tumor Formation

The Irradiated Brain Microenvironment Supports Glioma Stemness and Survival via Astrocyte-Derived Transglutaminase 2

Berg, Tracy J.; Marques, Carolina; Pantazopoulou, Vasiliki; Johansson, Elinn et al.

Part of Cancer Research, p. 2101-2115, 2021

• DOI for The Irradiated Brain Microenvironment Supports Glioma Stemness and Survival via Astrocyte-Derived Transglutaminase 2

Indolylbenzothiadiazoles as highly tunable fluorophores for imaging lipid droplet accumulation in astrocytes and glioblastoma cells

Colas, Kilian; Holmberg Olausson, Karl; Chiang, Linus; Doloczki, Susanne et al.

Part of RSC Advances, p. 23960-23967, 2021

• DOI for Indolylbenzothiadiazoles as highly tunable fluorophores for imaging lipid droplet accumulation in astrocytes and glioblastoma cells
• Download full text (pdf) of Indolylbenzothiadiazoles as highly tunable fluorophores for imaging lipid droplet accumulation in astrocytes and glioblastoma cells

Deep immune profiling reveals targetable mechanisms of immune evasion in immune checkpoint inhibitor-refractory glioblastoma

Simonds, Erin F.; Lu, Edbert D.; Badillo, Oscar; Karimi, Shokoufeh et al.

Part of Journal for ImmunoTherapy of Cancer, 2021

• DOI for Deep immune profiling reveals targetable mechanisms of immune evasion in immune checkpoint inhibitor-refractory glioblastoma
• Download full text (pdf) of Deep immune profiling reveals targetable mechanisms of immune evasion in immune checkpoint inhibitor-refractory glioblastoma

A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma

Johansson, Patrik; Krona, Cecilia; Kundu, Soumi; Doroszko, Milena et al.

Part of Cell Reports, 2020

• DOI for A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma
• Download full text (pdf) of A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma

Perturbation-based gene regulatory network inference to unravel oncogenic mechanisms

Morgan, Daniel; Studham, Matthew; Tjarnberg, Andreas; Weishaupt, Holger et al.

Part of Scientific Reports, 2020

• DOI for Perturbation-based gene regulatory network inference to unravel oncogenic mechanisms
• Download full text (pdf) of Perturbation-based gene regulatory network inference to unravel oncogenic mechanisms

Nuclear Receptor Binding Protein 2 Is Downregulated in Medulloblastoma, and Reduces Tumor Cell Survival upon Overexpression

Xiong, Anqi; Roy, Ananya; Spyrou, Argyris; Weishaupt, Holger et al.

Part of Cancers, 2020

• DOI for Nuclear Receptor Binding Protein 2 Is Downregulated in Medulloblastoma, and Reduces Tumor Cell Survival upon Overexpression
• Download full text (pdf) of Nuclear Receptor Binding Protein 2 Is Downregulated in Medulloblastoma, and Reduces Tumor Cell Survival upon Overexpression

Modeling SHH-driven medulloblastoma with patient iPS cell-derived neural stem cells

Susanto, Evelyn; Navarro, Ana Marin; Zhou, Leilei; Sundström, Anders et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 20127-20138, 2020

• DOI for Modeling SHH-driven medulloblastoma with patient iPS cell-derived neural stem cells
• Download full text (pdf) of Modeling SHH-driven medulloblastoma with patient iPS cell-derived neural stem cells

BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells

Cancer, Matko; Drews, Lisa F.; Bengtsson, Johan; Bolin, Sara et al.

Part of Cell Death and Disease, 2019

• DOI for BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells
• Download full text (pdf) of BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells

LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Xie, Yuan; Sundström, Anders; Maturi, Naga P; Tan, E-Jean et al.

Part of Journal of Pathology, p. 228-240, 2019

• DOI for LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Batch-normalization of cerebellar and medulloblastoma gene expression datasets utilizing empirically defined negative control genes

Weishaupt, Holger; Johansson, Patrik; Sundström, Anders; Lubovac-Pilav, Zelmina et al.

Part of Bioinformatics, p. 3357-3364, 2019

• DOI for Batch-normalization of cerebellar and medulloblastoma gene expression datasets utilizing empirically defined negative control genes
• Download full text (pdf) of Batch-normalization of cerebellar and medulloblastoma gene expression datasets utilizing empirically defined negative control genes

Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy

Čančer, Matko; Hutter, Sonja; Holmberg Olausson, Karl; Rosén, Gabriela et al.

Part of Cell Stem Cell, p. 855-870, 2019

• DOI for Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy
• Download full text (pdf) of Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy

Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis

Huang, Miller; Tailor, Jignesh; Zhen, Qiqi; Gillmor, Aaron H. et al.

Part of Cell Stem Cell, p. 433-+, 2019

• DOI for Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis
• Download full text (pdf) of Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis

Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma

Kahn, Suzana A.; Wang, Xin; Nitta, Ryan T.; Gholamin, Sharareh et al.

Part of Nature Communications, 2018

• DOI for Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma
• Download full text (pdf) of Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma

Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma

Bolin, Sara; Borgenvik, Anna; Persson, Camilla U.; Sundström, Anders et al.

Part of Oncogene, p. 2850-2862, 2018

• DOI for Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma
• Download full text (pdf) of Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma

Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity

Wallmann, Tatjana; Zhang, Xing-Mei; Wallerius, Majken; Bolin, Sara et al.

Part of iScience, p. 71-83, 2018

• DOI for Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity
• Download full text (pdf) of Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity

Targeting PRUNE-1 in a GEMM of Metastatic Medulloblastoma: A Potential Route of Inhibition for New Future Therapies

Ferrucci, Veronica; de Antonellis, Pasqualino; Pennino, Francesco Paolo; Asadzadeh, Fatemeh et al.

Part of Neuro-Oncology, p. 139-139, 2018

• DOI for Targeting PRUNE-1 in a GEMM of Metastatic Medulloblastoma: A Potential Route of Inhibition for New Future Therapies

GMYC: A Novel Inducible Transgenic Model of Group 3 Medulloblastoma

Weishaupt, Holger; Mainwaring, Oliver; Hutter, Sonja; Kalushkova, Antonia et al.

Part of Neuro-Oncology, p. 137-137, 2018

• DOI for GMYC: A Novel Inducible Transgenic Model of Group 3 Medulloblastoma

Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1–TGF-β–OTX2–SNAIL via PTEN inhibitio

Ferrucci, Veronica; de Antonellis, Pasqualino; Pennino, Francesco Paolo; Asadzadeh, Fatemeh et al.

Part of Brain, p. 1300-1319, 2018

• DOI for Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1–TGF-β–OTX2–SNAIL via PTEN inhibitio

Mast Cell Infiltration in Human Brain Metastases Modulates the Microenvironment and Contributes to the Metastatic Potential

Roy, Ananya; Libard, Sylwia; Weishaupt, Holger; Gustavsson, Ida et al.

Part of Frontiers in Oncology, 2017

• DOI for Mast Cell Infiltration in Human Brain Metastases Modulates the Microenvironment and Contributes to the Metastatic Potential
• Download full text (pdf) of Mast Cell Infiltration in Human Brain Metastases Modulates the Microenvironment and Contributes to the Metastatic Potential

Serglycin as a potential biomarker for glioma: association of serglycin expression, extent of mast cell recruitment and glioblastoma progression

Roy, Ananya; Attarha, Sanaz; Weishaupt, Holger; Edqvist, Per-Henrik et al.

Part of Oncotarget, p. 24815-24827, 2017

• DOI for Serglycin as a potential biomarker for glioma: association of serglycin expression, extent of mast cell recruitment and glioblastoma progression
• Download full text (pdf) of Serglycin as a potential biomarker for glioma: association of serglycin expression, extent of mast cell recruitment and glioblastoma progression

Mouse models of pediatric supratentorial high-grade glioma reveal how cell-of-origin influences tumor development and phenotype

Sreedharan, Smitha; Maturi, Naga Prathyusha; Xie, Yuan; Sundström, Anders et al.

Part of Cancer Research, p. 802-812, 2017

• DOI for Mouse models of pediatric supratentorial high-grade glioma reveal how cell-of-origin influences tumor development and phenotype

Targeting SOX9 for degradation to inhibit chemoresistance, metastatic spread, and recurrence

Rahmanto, Aldwin Suryo; Swartling, Fredrik J.; Sangfelt, Olle

Part of Molecular & Cellular Oncology, 2017

• DOI for Targeting SOX9 for degradation to inhibit chemoresistance, metastatic spread, and recurrence

Loss of Conservation of Graph Centralities in Reverse-engineered Transcriptional Regulatory Networks

Weishaupt, Holger; Johansson, Patrik; Engström, Christopher; Nelander, Sven et al.

Part of Methodology and Computing in Applied Probability, p. 1089-1105, 2017

• DOI for Loss of Conservation of Graph Centralities in Reverse-engineered Transcriptional Regulatory Networks
• Download full text (pdf) of Loss of Conservation of Graph Centralities in Reverse-engineered Transcriptional Regulatory Networks

Utilizing the Dog Genome in the Search for Novel Candidate Genes Involved in Glioma Development-Genome Wide Association Mapping followed by Targeted Massive Parallel Sequencing Identifies a Strongly Associated Locus

Truve, Katarina; Dickinson, Peter; Xiong, Anqi; York, Daniel et al.

Part of PLOS Genetics, 2016

• DOI for Utilizing the Dog Genome in the Search for Novel Candidate Genes Involved in Glioma Development-Genome Wide Association Mapping followed by Targeted Massive Parallel Sequencing Identifies a Strongly Associated Locus
• Download full text (pdf) of Utilizing the Dog Genome in the Search for Novel Candidate Genes Involved in Glioma Development-Genome Wide Association Mapping followed by Targeted Massive Parallel Sequencing Identifies a Strongly Associated Locus

FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma

Rahmanto, Aldwin Suryo; Savov, Vasil; Brunner, Andrä; Bolin, Sara et al.

Part of EMBO Journal, p. 2192-2212, 2016

• DOI for FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma
• Download full text (pdf) of FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma

Combined MYC and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease

Hill, Rebecca M.; Kuijper, Sanne; Lindsey, Janet C.; Petrie, Kevin et al.

Part of Cancer Cell, p. 72-84, 2015

• DOI for Combined MYC and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease
• Download full text (pdf) of Combined MYC and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease

BET Bromodomain Inhibition of MYC-Amplified Medulloblastoma

Bandopadhayay, Pratiti; Bergthold, Guillaume; Nguyen, Brian; Schubert, Simone et al.

Part of Clinical Cancer Research, p. 912-925, 2014

• DOI for BET Bromodomain Inhibition of MYC-Amplified Medulloblastoma

Metastasis and Tumor Recurrence from Rare SOX9-Positive Cells in MYCN-Driven Medulloblastoma

Swartling, Fredrik J.; Savov, Vasil; Cancer, Matko; Bolin, Sara et al.

Part of Neuro-Oncology, 2014

• DOI for Metastasis and Tumor Recurrence from Rare SOX9-Positive Cells in MYCN-Driven Medulloblastoma

Medulloblastoma models which harbor amplifications of myc family members are sensitive to BET-Bromodomain inhibition

Bandopadhayay, Pratiti; Bergthold, Guillaume; Nguyen, Brian; Schubert, Simone et al.

Part of Neuro-Oncology, p. 90-90, 2014

Glial origin for MYCN-driven medulloblastoma and targeted prosenescence therapies

Bolin, Sara M.; Lau, Jasmine; Chen, Justin; Savov, Vasil et al.

Part of Cancer Research, 2014

• DOI for Glial origin for MYCN-driven medulloblastoma and targeted prosenescence therapies

Metastasis and tumor recurrence from rare SOX9-positive cells in Group 4 medulloblastoma

Savov, Vasil; Fotaki, Grammatiki; Remke, Marc; Dubuc, Adrian M. et al.

Part of Cancer Research, 2014

• DOI for Metastasis and tumor recurrence from rare SOX9-positive cells in Group 4 medulloblastoma

MYC and TP53 defects interact at medulloblastoma relapse to define rapidly progressive disease and can be targeted therapeutically

Hill, Rebecca M.; Kuijper, Sanne; Lindsey, Janet; Schwalbe, Ed C. et al.

Part of Cancer Research, 2014

• DOI for MYC and TP53 defects interact at medulloblastoma relapse to define rapidly progressive disease and can be targeted therapeutically

Targeting the Translational Apparatus in Mycn-Driven Medulloblastoma

Meyerowitz, Justin G.; Gustafson, W. Clay; Nekritz, Erin A.; Swartling, Fredrik et al.

Part of Neuro-Oncology, p. 16-16, 2013

Humanized Mouse Models for Medulloblastoma

Huang, Miller; Persson, Anders; Swartling, Fredrik; Moriarity, Branden et al.

Part of Neuro-Oncology, p. 30-30, 2013

A glial origin for medulloblastoma and inhibition of MYCN stabilization

Bolin, Sara; Lau, Jasmine; Savov, Vasil; Chen, Justin et al.

Part of Cancer Research, 2013

• DOI for A glial origin for medulloblastoma and inhibition of MYCN stabilization

miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma

Põlajeva, Jelena; Swartling, Fredrik; Jiang, Yiwen; Singh, Umashankar et al.

Part of BMC Cancer, p. 378, 2012

• DOI for miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma
• Download full text (pdf) of miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma

Distinct Neural Stem Cell Populations Give Rise to Disparate Brain Tumors in Response to N-MYC

Swartling, Fredrik J.; Savov, Vasil; Persson, Anders I.; Chen, Justin et al.

Part of Cancer Cell, p. 601-613, 2012

• DOI for Distinct Neural Stem Cell Populations Give Rise to Disparate Brain Tumors in Response to N-MYC

Pleiotropic role for MYCN in medulloblastoma

Swartling, Fredrik Johansson; Grimmer, Matthew R; Hackett, Christopher S; Northcott, Paul A et al.

Part of Genes & Development, p. 1059-1072, 2010

• DOI for Pleiotropic role for MYCN in medulloblastoma

Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines

Swartling, Fredrik J.; Ferletta, Maria; Kastemar, Marianne; Weiss, W. A. et al.

Part of Oncogene, p. 3121-3131, 2009

• DOI for Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines

Expression analysis of genes involved in brain tumor progression driven by retroviral insertional mutagenesis in mice

Johansson, Fredrik K; Göransson, Hanna; Westermark, Bengt

Part of Oncogene, p. 3896-3905, 2005

• DOI for Expression analysis of genes involved in brain tumor progression driven by retroviral insertional mutagenesis in mice

Identification of candidate cancer-causing genes in mouse brain tumors by retroviral tagging

Johansson, Fredrik K.; Brodd, Josefin; Eklöf, Charlotta; Ferletta, Maria et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 11334-11337, 2004

• DOI for Identification of candidate cancer-causing genes in mouse brain tumors by retroviral tagging

Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies

Holmberg Olausson, Karl O.; Borgenvik, Anna; Zhao, Miao; Giraud, Géraldine et al.

Part of Cancers, 2024

• DOI for Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies
• Download full text (pdf) of Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies

Targeting MYCN in Molecularly Defined Malignant Brain Tumors

Borgenvik, Anna; Cancer, Matko; Hutter, Sonja; Swartling, Fredrik J.

Part of Frontiers in Oncology, 2021

• DOI for Targeting MYCN in Molecularly Defined Malignant Brain Tumors
• Download full text (pdf) of Targeting MYCN in Molecularly Defined Malignant Brain Tumors

Medulloblastomics revisited: biological and clinical insights from thousands of patients

Hovestadt, Volker; Ayrault, Olivier; Johansson Swartling, Fredrik K.; Robinson, Giles W. et al.

Part of Nature Reviews. Cancer, p. 42-56, 2020

• DOI for Medulloblastomics revisited: biological and clinical insights from thousands of patients

Modeling and Targeting MYC Genes in Childhood Brain Tumors

Hutter, Sonja; Bolin, Sara; Weishaupt, Holger; Johansson, Fredrik K.

Part of Genes, 2017

• DOI for Modeling and Targeting MYC Genes in Childhood Brain Tumors
• Download full text (pdf) of Modeling and Targeting MYC Genes in Childhood Brain Tumors

Medulloblastoma: experimental models and reality

Neumann, Julia E.; Johansson, Fredrik K.; Schueller, Ulrich

Part of Acta Neuropathologica, p. 679-689, 2017

• DOI for Medulloblastoma: experimental models and reality

Deregulated proliferation and differentiation in brain tumors

Swartling, Fredrik J; Cančer, Matko; Frantz, Aaron; Weishaupt, Holger et al.

Part of Cell and Tissue Research, p. 225-254, 2015

• DOI for Deregulated proliferation and differentiation in brain tumors

Signals that regulate the oncogenic fate of neural stem cells and progenitors

Swartling, Fredrik J.; Bolin, Sara; Phillips, Joanna J; Persson, Anders I.

Part of Experimental Neurology, p. 56-68, 2014

• DOI for Signals that regulate the oncogenic fate of neural stem cells and progenitors

Oncoprotein stabilization in brain tumors

Hede, Sanna-Maria; Savov, Vasil; Weishaupt, Holger; Sangfelt, O. et al.

Part of Oncogene, p. 4709-4721, 2014

• DOI for Oncoprotein stabilization in brain tumors

What underlies the diversity of brain tumors?

Swartling, Fredrik J.; Hede, Sanna-Maria; Weiss, William A.

Part of Cancer Metastasis Review, p. 5-24, 2013

• DOI for What underlies the diversity of brain tumors?

Myc proteins in brain tumor development and maintenance

Swartling, Fredrik J.

Part of Upsala Journal of Medical Sciences, p. 122-131, 2012

• DOI for Myc proteins in brain tumor development and maintenance

Identifying Candidate Genes Involved in Brain Tumor Formation

Swartling, Fredrik Johansson

Part of Upsala Journal of Medical Sciences, p. 1-38, 2008

Comparing the Landcapes of Common Retroviral Insertion Sites across Tumor Models

Weishaupt, Holger; Čančer, Matko; Engström, Cristopher; Silvestrov, Sergei et al.

Part of ICNPAA 2016 WORLD CONGRESS, 2017

• DOI for Comparing the Landcapes of Common Retroviral Insertion Sites across Tumor Models

CDK2 as a therapeutic target in MYC-driven medulloblastoma

Borgenvik, Anna; Rosén, Gabriela; Holmberg Olausson, Karl; Larsson, Lars-Gunnar et al.

Photoreceptor-positive cells of tumor origin in MYC-driven Group 3 medulloblastoma

Zhao, Miao; Mainwaring, Oliver; Rosén, Gabriela; Rijpkema, Sanne et al.

Targeting SOX2 in glioblastoma cells reveals heterogeneity in SOX2 dependency

Dalmo, Erika; Rosén, Gabriela; Niklasson, Mia; Bergström, Tobias et al.

Prioritization of candidate cancer genes on chromosome 17q through reverse engineered transcriptional regulatory networks in medulloblastoma groups 3 and 4

Weishaupt, Holger; Johansson, Patrik; Mainwaring, Oliver; Hutter, Sonja et al.

Paired glioblastoma cell cultures of the fluorescent bulk tumor and non-fluorescent tumor margin display differential phenotypes and cell states across patients

Neves, Inês; Lu, Xi; Maturi, Nagaprathyusha; Dang, Yonglong et al.

RAP1GAP Suppression Promotes Stemness and Inhibits Glioblastoma Cell Migration

Põlajeva, Jelena; Kastemar, Marianne; Tchougounova, Elena; Zeller, Kathrin et al.