Christian Sköld

Novel Macrocyclic Peptidomimetics Targeting the Insulin-Regulated Aminopeptidase (IRAP): Design, Synthesis and Evaluation

Olaniran Håkansson, Esther; Balestri, Lorenzo Jacopo Ilic; Puthiyaparambath, Sharathna; Moes, Sebastian et al.

Part of RSC Medicinal chemistry, p. 5059-5069, 2025

• DOI for Novel Macrocyclic Peptidomimetics Targeting the Insulin-Regulated Aminopeptidase (IRAP): Design, Synthesis and Evaluation
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The effect of gem-difluorination on the conformation and properties of a model macrocyclic system

Cogswell, T. J.; Lewis, R. J.; Sköld, Christian; Nordqvist, A. et al.

Part of Chemical Science, p. 19770-19776, 2024

• DOI for The effect of gem-difluorination on the conformation and properties of a model macrocyclic system
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Hybrid Machine Learning Approach to Predict the Site Selectivity of Iridium-Catalyzed Arene Borylation

Caldeweyher, Eike; Elkin, Masha; Gheibi, Golsa; Johansson, Magnus et al.

Part of Journal of the American Chemical Society, p. 17367-17376, 2023

• DOI for Hybrid Machine Learning Approach to Predict the Site Selectivity of Iridium-Catalyzed Arene Borylation

Computational studies of molecular pre-organization through macrocyclization: Conformational distribution analysis of closely related non-macrocyclic and macrocyclic analogs

Olanders, Gustav; Brandt, Peter; Sköld, Christian; Karlen, Anders

Part of Bioorganic & Medicinal Chemistry, 2021

• DOI for Computational studies of molecular pre-organization through macrocyclization: Conformational distribution analysis of closely related non-macrocyclic and macrocyclic analogs
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Organic reactivity from mechanism to machine learning

Jorner, Kjell; Tomberg, Anna; Bauer, Christoph; Sköld, Christian et al.

Part of Nature Reviews Chemistry, p. 240-255, 2021

• DOI for Organic reactivity from mechanism to machine learning

Novel Macrocyclic Peptidomimetics Targeting the Insulin-Regulated Aminopeptidase (IRAP): Design, Synthesis and Evaluation

Olaniran Håkansson, Esther; Balestri, Lorenzo Jacopo Ilic; Puthiyaparambath, Sharathna; Moes, Sebastian et al.

Part of RSC Medicinal chemistry, p. 5059-5069, 2025

• DOI for Novel Macrocyclic Peptidomimetics Targeting the Insulin-Regulated Aminopeptidase (IRAP): Design, Synthesis and Evaluation
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The effect of gem-difluorination on the conformation and properties of a model macrocyclic system

Cogswell, T. J.; Lewis, R. J.; Sköld, Christian; Nordqvist, A. et al.

Part of Chemical Science, p. 19770-19776, 2024

• DOI for The effect of gem-difluorination on the conformation and properties of a model macrocyclic system
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Hybrid Machine Learning Approach to Predict the Site Selectivity of Iridium-Catalyzed Arene Borylation

Caldeweyher, Eike; Elkin, Masha; Gheibi, Golsa; Johansson, Magnus et al.

Part of Journal of the American Chemical Society, p. 17367-17376, 2023

• DOI for Hybrid Machine Learning Approach to Predict the Site Selectivity of Iridium-Catalyzed Arene Borylation

Computational studies of molecular pre-organization through macrocyclization: Conformational distribution analysis of closely related non-macrocyclic and macrocyclic analogs

Olanders, Gustav; Brandt, Peter; Sköld, Christian; Karlen, Anders

Part of Bioorganic & Medicinal Chemistry, 2021

• DOI for Computational studies of molecular pre-organization through macrocyclization: Conformational distribution analysis of closely related non-macrocyclic and macrocyclic analogs
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Enantioselective Synthesis of Atropisomeric Biaryls using Biaryl 2,5-Diphenylphospholanes as Ligands for Palladium-Catalysed Suzuki-Miyaura Reactions

Byrne, Liam; Sköld, Christian; Norrby, Per-Ola; Munday, Rachel H. et al.

Part of Advanced Synthesis and Catalysis, p. 259-267, 2021

• DOI for Enantioselective Synthesis of Atropisomeric Biaryls using Biaryl 2,5-Diphenylphospholanes as Ligands for Palladium-Catalysed Suzuki-Miyaura Reactions

Synthesis and preclinical evaluation of the CRTH2 antagonist [¹¹C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass

Eriksson, Jonas; Roy, Tamal; Sawadjoon, Supaporn; Bachmann, Kim et al.

Part of Nuclear Medicine and Biology, p. 1-10, 2019

• DOI for Synthesis and preclinical evaluation of the CRTH2 antagonist [¹¹C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass
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Relative Strength of Common Directing Groups in Palladium-Catalyzed Aromatic C-H Activation

Tomberg, Anna; Muratore, Michael Eric; Johansson, Magnus Jan; Terstiege, Ina et al.

Part of iScience, p. 373-+, 2019

• DOI for Relative Strength of Common Directing Groups in Palladium-Catalyzed Aromatic C-H Activation
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High affinity rigidified AT(2) receptor ligands with indane scaffolds

Wallinder, Charlotta; Sköld, Christian; Sundholm, Sara; Guimond, Marie-Odile et al.

Part of MedChemComm, p. 2146-2160, 2019

• DOI for High affinity rigidified AT(2) receptor ligands with indane scaffolds
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An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice

Skogh, Anna; Lesniak, Anna; Sköld, Christian; Karlgren, Maria et al.

Part of Bioorganic & Medicinal Chemistry Letters, p. 2446-2450, 2018

• DOI for An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice

Microwave-Assisted Branching Cascades: A Route to Diverse 3,4-Dihydroquinazolinone-Embedded Polyheterocyclic Scaffolds

Sawant, Rajiv T.; Stevens, Marc Y.; Sköld, Christian; Odell, Luke R.

Part of Organic Letters, p. 5392-5395, 2016

• DOI for Microwave-Assisted Branching Cascades: A Route to Diverse 3,4-Dihydroquinazolinone-Embedded Polyheterocyclic Scaffolds

Toward a Benchmarking Data Set Able to Evaluate Ligand- and Structure-based Virtual Screening Using Public HTS Data

Lindh, Martin; Svensson, Fredrik; Schaal, Wesley; Zhang, Jin et al.

Part of Journal of Chemical Information and Modeling, p. 343-353, 2015

• DOI for Toward a Benchmarking Data Set Able to Evaluate Ligand- and Structure-based Virtual Screening Using Public HTS Data

Interconversion of Functional Activity by Minor Structural Alterations in Nonpeptide AT2 Receptor Ligands

Wallinder, Charlotta; Sköld, Christian; Botros, Milad; Guimond, Marie-Odile et al.

Part of ACS Medicinal Chemistry Letters, p. 178-182, 2015

• DOI for Interconversion of Functional Activity by Minor Structural Alterations in Nonpeptide AT2 Receptor Ligands

Virtual Screening for Transition State Analogue Inhibitors of IRAP Based on Quantum Mechanically Derived Reaction Coordinates

Svensson, Fredrik; Engen, Karin; Lundbäck, Thomas; Larhed, Mats et al.

Part of Journal of Chemical Information and Modeling, p. 1984-1993, 2015

• DOI for Virtual Screening for Transition State Analogue Inhibitors of IRAP Based on Quantum Mechanically Derived Reaction Coordinates

Efficient and Selective Palladium-Catalysed C-3 Urea Couplings to 3,5-Dichloro-2(1H)-pyrazinones

Belfrage, Anna Karin; Gising, Johan; Svensson, Fredrik; Åkerblom, Eva et al.

Part of European Journal of Organic Chemistry, p. 978-986, 2015

• DOI for Efficient and Selective Palladium-Catalysed C-3 Urea Couplings to 3,5-Dichloro-2(1H)-pyrazinones

Palladium(II) catalyzed desulfitative coupling reactions of sodium aryl sulfinates and nitriles: Scope, limitations, and mechanistic studies

Skillinghaug, Bobo; Sköld, Christian; Behrends, Malte; Sävmarker, Jonas et al.

Part of Abstracts of Papers of the American Chemical Society, 2014

Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Arylsulfonamides

Borhade, Sanjay R; Rosenström, Ulrika; Sävmarker, Jonas; Lundbäck, Thomas et al.

Part of ChemistryOpen, p. 256-263, 2014

• DOI for Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Arylsulfonamides

Palladium(II)-Catalyzed Desulfitative Synthesis of Aryl Ketones from Sodium Arylsulfinates and Nitriles: Scope, Limitations, and Mechanistic Studies

Skillinghaug, Bobo; Sköld, Christian; Rydfjord, Jonas; Svensson, Fredrik et al.

Part of Journal of Organic Chemistry, p. 12018-12032, 2014

• DOI for Palladium(II)-Catalyzed Desulfitative Synthesis of Aryl Ketones from Sodium Arylsulfinates and Nitriles: Scope, Limitations, and Mechanistic Studies

Aminocarbonylation of 4-Iodo-1H-imidazoles with an Amino Acid Amide Nucleophile: Synthesis of Constrained H-Phe-Phe-NH2 Analogues

Skogh, Anna; Fransson, Rebecca; Sköld, Christian; Larhed, Mats et al.

Part of Journal of Organic Chemistry, p. 12251-12256, 2013

• DOI for Aminocarbonylation of 4-Iodo-1H-imidazoles with an Amino Acid Amide Nucleophile: Synthesis of Constrained H-Phe-Phe-NH2 Analogues

Constrained H-Phe-Phe-NH₂ Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability

Fransson, Rebecca; Sköld, Christian; Kratz, Jadel M; Svensson, Richard et al.

Part of Journal of Medicinal Chemistry, p. 4953-4965, 2013

• DOI for Constrained H-Phe-Phe-NH₂ Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability

Decarboxylative Palladium(II)-Catalyzed Synthesis of Aryl Amidines from Aryl Carboxylic Acids: Development and Mechanistic Investigation

Rydfjord, Jonas; Svensson, Fredrik; Trejos, Alejandro; Sjöberg, Per J. R. et al.

Part of Chemistry - A European Journal, p. 13803-13810, 2013

• DOI for Decarboxylative Palladium(II)-Catalyzed Synthesis of Aryl Amidines from Aryl Carboxylic Acids: Development and Mechanistic Investigation

One-Pot, Two-Step, Microwave-Assisted Palladium-Catalyzed Conversion of Aryl Alcohols to Aryl Fluorides via Aryl Nonaflates

Wannberg, Johan; Wallinder, Charlotta; Unlusoy, Meltem; Sköld, Christian et al.

Part of Journal of Organic Chemistry, p. 4184-4189, 2013

• DOI for One-Pot, Two-Step, Microwave-Assisted Palladium-Catalyzed Conversion of Aryl Alcohols to Aryl Fluorides via Aryl Nonaflates

Theoretical and Experimental Investigation of Palladium(II)-Catalyzed Decarboxylative Addition of Arenecarboxylic Acid to Nitrile

Svensson, Fredrik; Mane, Rajendra S.; Sävmarker, Jonas; Larhed, Mats et al.

Part of Organometallics, p. 490-497, 2013

• DOI for Theoretical and Experimental Investigation of Palladium(II)-Catalyzed Decarboxylative Addition of Arenecarboxylic Acid to Nitrile

Virtual Screening Data Fusion Using Both Structure- and Ligand-Based Methods

Svensson, Fredrik; Karlén, Anders; Sköld, Christian

Part of Journal of Chemical Information and Modeling, p. 225-232, 2012

• DOI for Virtual Screening Data Fusion Using Both Structure- and Ligand-Based Methods

Synthesis of functionalized furopyrazines as restricted dipeptidomimetics

Claerhout, Stijn; Sharma, Sweta; Sköld, Christian; Cavaluzzo, Claudia et al.

Part of Tetrahedron, p. 3019-3029, 2012

• DOI for Synthesis of functionalized furopyrazines as restricted dipeptidomimetics

Transmetallation Versus β-Hydride Elimination: The Role of 1,4 Benzoquinone in Chelation-Controlled Arylation Reactions with Arylboronic Acids

Sköld, Christian; Kleimark, Jonatan; Trejos, Alejandro; Odell, Luke R. et al.

Part of Chemistry - A European Journal, p. 4714-4722, 2012

• DOI for Transmetallation Versus β-Hydride Elimination: The Role of 1,4 Benzoquinone in Chelation-Controlled Arylation Reactions with Arylboronic Acids
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From the First Selective Non-Peptide AT(2) Receptor Agonist to Structurally Related Antagonists

Andappan, Murugaiah M. S.; Wu, Xiongyu; Wallinder, Charlotta; Mahalingam, A. K. et al.

Part of Journal of Medicinal Chemistry, p. 2265-2278, 2012

• DOI for From the First Selective Non-Peptide AT(2) Receptor Agonist to Structurally Related Antagonists

Discovery of Dipeptides with High Affinity to the Specific Binding Site for Substance P1-7

Fransson, Rebecca; Botros, Milad; Sköld, Christian; Nyberg, Fred et al.

Part of Journal of Medicinal Chemistry, p. 2383-2389, 2010

• DOI for Discovery of Dipeptides with High Affinity to the Specific Binding Site for Substance P1-7

Chemistry and folding of photomodulable peptides: stilbene and thioaurone-type candidates for conformational switches

Erdélyi, Máté; Varedian, Miranda; Sköld, Christian; Niklasson, Ida B. et al.

Part of Organic and biomolecular chemistry, p. 4356-4373, 2008

• DOI for Chemistry and folding of photomodulable peptides: stilbene and thioaurone-type candidates for conformational switches

Modeling binding modes of angiotensin II and pseudopeptide analogues to the AT2 receptor

Sköld, Christian; Nikiforovich, Gregory; Karlén, Anders

Part of Journal of Molecular Graphics and Modelling, p. 991-1003, 2008

• DOI for Modeling binding modes of angiotensin II and pseudopeptide analogues to the AT2 receptor

Development of CoMFA models of affinity and selectivity to angiotensin II type-1 and type-2 receptors

Sköld, Christian; Karlén, Anders

Part of Journal of Molecular Graphics and Modelling, p. 145-153, 2007

• DOI for Development of CoMFA models of affinity and selectivity to angiotensin II type-1 and type-2 receptors

Synthesis of a new class of druglike angiotensin II C-terminal mimics with affinity for the AT2 receptor

Georgsson, Jennie; Sköld, Christian; Botros, Milad; Lindeberg, Gunnar et al.

Part of Journal of Medicinal Chemistry, p. 1711-1715, 2007

• DOI for Synthesis of a new class of druglike angiotensin II C-terminal mimics with affinity for the AT2 receptor

Design, synthesis, and incorporation of a beta-turn mimetic in angiotensin II forming novel pseudopeptides with affinity for AT(1) and AT(2) receptors

Rosenström, Ulrika; Sköld, Christian; Lindeberg, Gunnar; Botros, Milad et al.

Part of Journal of Medicinal Chemistry, p. 6133-6137, 2006

• DOI for Design, synthesis, and incorporation of a beta-turn mimetic in angiotensin II forming novel pseudopeptides with affinity for AT(1) and AT(2) receptors

Presentation of a structurally diverse and commercially available drug data set for correlation and benchmarking studies.

Skold, Christian; Winiwarter, Susanne; Wernevik, Johan; Bergstrom, Fredrik et al.

Part of J Med Chem, p. 6660-71, 2006

New selective AT2 receptor ligands encompassing a γ-turn mimetic replacing the amino acid residues 4-5 of angiotensin II act as agonists

Rosenström, Ulrika; Sköld, Christian; Plouffe, Bianca; Beaudry, Hélène et al.

Part of Journal of Medicinal Chemistry, p. 4009-4024, 2005

• DOI for New selective AT2 receptor ligands encompassing a γ-turn mimetic replacing the amino acid residues 4-5 of angiotensin II act as agonists

Synthesis and AT2 receptor-binding properties of angiotensin II analogues

Rosenström, Ulrika; Sköld, Christian; Lindeberg, Gunnar; Botros, Milad et al.

Part of Journal of Peptide Research, p. 194-201, 2004

• DOI for Synthesis and AT2 receptor-binding properties of angiotensin II analogues

A Selective AT2 Receptor Ligand with a γ-Turn-Like Mimetic replacing the Amino Acid Residues 4-5 of Angiotensin II

Rosenström, Ulrika; Sköld, Christian; Lindeberg, Gunnar; Botros, Milad et al.

Part of Journal of Medicinal Chemistry, p. 859-870, 2004

• DOI for A Selective AT2 Receptor Ligand with a γ-Turn-Like Mimetic replacing the Amino Acid Residues 4-5 of Angiotensin II

Organic reactivity from mechanism to machine learning

Jorner, Kjell; Tomberg, Anna; Bauer, Christoph; Sköld, Christian et al.

Part of Nature Reviews Chemistry, p. 240-255, 2021

• DOI for Organic reactivity from mechanism to machine learning

Computational Modeling of the AT₂ Receptor and AT₂ Receptor Ligands: Investigating Ligand Binding, Structure–Activity Relationships, and Receptor-Bound Models

Sköld, Christian

2007

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Multi-targeting the folate pathway is a promising strategy against Leishmania tropica

Vikeved, Elisabet; Sköld, Christian; Alsmark, UCM

Prediction of anti-leishmanial drug targets using metabolite-based target fishing

Vikeved, Elisabet; Alsmark, UCM; Sköld, Christian