Christian Sköld

Novel Macrocyclic Peptidomimetics Targeting the Insulin-Regulated Aminopeptidase (IRAP): Design, Synthesis and Evaluation

Olaniran Håkansson, Esther; Balestri, Lorenzo Jacopo Ilic; Puthiyaparambath, Sharathna; Moes, Sebastian et al.

Ingår i RSC Medicinal chemistry, s. 5059-5069, 2025

• DOI för Novel Macrocyclic Peptidomimetics Targeting the Insulin-Regulated Aminopeptidase (IRAP): Design, Synthesis and Evaluation
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The effect of gem-difluorination on the conformation and properties of a model macrocyclic system

Cogswell, T. J.; Lewis, R. J.; Sköld, Christian; Nordqvist, A. et al.

Ingår i Chemical Science, s. 19770-19776, 2024

• DOI för The effect of gem-difluorination on the conformation and properties of a model macrocyclic system
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Hybrid Machine Learning Approach to Predict the Site Selectivity of Iridium-Catalyzed Arene Borylation

Caldeweyher, Eike; Elkin, Masha; Gheibi, Golsa; Johansson, Magnus et al.

Ingår i Journal of the American Chemical Society, s. 17367-17376, 2023

• DOI för Hybrid Machine Learning Approach to Predict the Site Selectivity of Iridium-Catalyzed Arene Borylation

Computational studies of molecular pre-organization through macrocyclization: Conformational distribution analysis of closely related non-macrocyclic and macrocyclic analogs

Olanders, Gustav; Brandt, Peter; Sköld, Christian; Karlen, Anders

Ingår i Bioorganic & Medicinal Chemistry, 2021

• DOI för Computational studies of molecular pre-organization through macrocyclization: Conformational distribution analysis of closely related non-macrocyclic and macrocyclic analogs
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Organic reactivity from mechanism to machine learning

Jorner, Kjell; Tomberg, Anna; Bauer, Christoph; Sköld, Christian et al.

Ingår i Nature Reviews Chemistry, s. 240-255, 2021

• DOI för Organic reactivity from mechanism to machine learning

Novel Macrocyclic Peptidomimetics Targeting the Insulin-Regulated Aminopeptidase (IRAP): Design, Synthesis and Evaluation

Olaniran Håkansson, Esther; Balestri, Lorenzo Jacopo Ilic; Puthiyaparambath, Sharathna; Moes, Sebastian et al.

Ingår i RSC Medicinal chemistry, s. 5059-5069, 2025

• DOI för Novel Macrocyclic Peptidomimetics Targeting the Insulin-Regulated Aminopeptidase (IRAP): Design, Synthesis and Evaluation
• Ladda ner fulltext (pdf) av Novel Macrocyclic Peptidomimetics Targeting the Insulin-Regulated Aminopeptidase (IRAP): Design, Synthesis and Evaluation

The effect of gem-difluorination on the conformation and properties of a model macrocyclic system

Cogswell, T. J.; Lewis, R. J.; Sköld, Christian; Nordqvist, A. et al.

Ingår i Chemical Science, s. 19770-19776, 2024

• DOI för The effect of gem-difluorination on the conformation and properties of a model macrocyclic system
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Hybrid Machine Learning Approach to Predict the Site Selectivity of Iridium-Catalyzed Arene Borylation

Caldeweyher, Eike; Elkin, Masha; Gheibi, Golsa; Johansson, Magnus et al.

Ingår i Journal of the American Chemical Society, s. 17367-17376, 2023

• DOI för Hybrid Machine Learning Approach to Predict the Site Selectivity of Iridium-Catalyzed Arene Borylation

Computational studies of molecular pre-organization through macrocyclization: Conformational distribution analysis of closely related non-macrocyclic and macrocyclic analogs

Olanders, Gustav; Brandt, Peter; Sköld, Christian; Karlen, Anders

Ingår i Bioorganic & Medicinal Chemistry, 2021

• DOI för Computational studies of molecular pre-organization through macrocyclization: Conformational distribution analysis of closely related non-macrocyclic and macrocyclic analogs
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Enantioselective Synthesis of Atropisomeric Biaryls using Biaryl 2,5-Diphenylphospholanes as Ligands for Palladium-Catalysed Suzuki-Miyaura Reactions

Byrne, Liam; Sköld, Christian; Norrby, Per-Ola; Munday, Rachel H. et al.

Ingår i Advanced Synthesis and Catalysis, s. 259-267, 2021

• DOI för Enantioselective Synthesis of Atropisomeric Biaryls using Biaryl 2,5-Diphenylphospholanes as Ligands for Palladium-Catalysed Suzuki-Miyaura Reactions

Synthesis and preclinical evaluation of the CRTH2 antagonist [¹¹C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass

Eriksson, Jonas; Roy, Tamal; Sawadjoon, Supaporn; Bachmann, Kim et al.

Ingår i Nuclear Medicine and Biology, s. 1-10, 2019

• DOI för Synthesis and preclinical evaluation of the CRTH2 antagonist [¹¹C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass
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Relative Strength of Common Directing Groups in Palladium-Catalyzed Aromatic C-H Activation

Tomberg, Anna; Muratore, Michael Eric; Johansson, Magnus Jan; Terstiege, Ina et al.

Ingår i iScience, s. 373-+, 2019

• DOI för Relative Strength of Common Directing Groups in Palladium-Catalyzed Aromatic C-H Activation
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High affinity rigidified AT(2) receptor ligands with indane scaffolds

Wallinder, Charlotta; Sköld, Christian; Sundholm, Sara; Guimond, Marie-Odile et al.

Ingår i MedChemComm, s. 2146-2160, 2019

• DOI för High affinity rigidified AT(2) receptor ligands with indane scaffolds
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An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice

Skogh, Anna; Lesniak, Anna; Sköld, Christian; Karlgren, Maria et al.

Ingår i Bioorganic & Medicinal Chemistry Letters, s. 2446-2450, 2018

• DOI för An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice

Microwave-Assisted Branching Cascades: A Route to Diverse 3,4-Dihydroquinazolinone-Embedded Polyheterocyclic Scaffolds

Sawant, Rajiv T.; Stevens, Marc Y.; Sköld, Christian; Odell, Luke R.

Ingår i Organic Letters, s. 5392-5395, 2016

• DOI för Microwave-Assisted Branching Cascades: A Route to Diverse 3,4-Dihydroquinazolinone-Embedded Polyheterocyclic Scaffolds

Toward a Benchmarking Data Set Able to Evaluate Ligand- and Structure-based Virtual Screening Using Public HTS Data

Lindh, Martin; Svensson, Fredrik; Schaal, Wesley; Zhang, Jin et al.

Ingår i Journal of Chemical Information and Modeling, s. 343-353, 2015

• DOI för Toward a Benchmarking Data Set Able to Evaluate Ligand- and Structure-based Virtual Screening Using Public HTS Data

Interconversion of Functional Activity by Minor Structural Alterations in Nonpeptide AT2 Receptor Ligands

Wallinder, Charlotta; Sköld, Christian; Botros, Milad; Guimond, Marie-Odile et al.

Ingår i ACS Medicinal Chemistry Letters, s. 178-182, 2015

• DOI för Interconversion of Functional Activity by Minor Structural Alterations in Nonpeptide AT2 Receptor Ligands

Virtual Screening for Transition State Analogue Inhibitors of IRAP Based on Quantum Mechanically Derived Reaction Coordinates

Svensson, Fredrik; Engen, Karin; Lundbäck, Thomas; Larhed, Mats et al.

Ingår i Journal of Chemical Information and Modeling, s. 1984-1993, 2015

• DOI för Virtual Screening for Transition State Analogue Inhibitors of IRAP Based on Quantum Mechanically Derived Reaction Coordinates

Efficient and Selective Palladium-Catalysed C-3 Urea Couplings to 3,5-Dichloro-2(1H)-pyrazinones

Belfrage, Anna Karin; Gising, Johan; Svensson, Fredrik; Åkerblom, Eva et al.

Ingår i European Journal of Organic Chemistry, s. 978-986, 2015

• DOI för Efficient and Selective Palladium-Catalysed C-3 Urea Couplings to 3,5-Dichloro-2(1H)-pyrazinones

Palladium(II) catalyzed desulfitative coupling reactions of sodium aryl sulfinates and nitriles: Scope, limitations, and mechanistic studies

Skillinghaug, Bobo; Sköld, Christian; Behrends, Malte; Sävmarker, Jonas et al.

Ingår i Abstracts of Papers of the American Chemical Society, 2014

Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Arylsulfonamides

Borhade, Sanjay R; Rosenström, Ulrika; Sävmarker, Jonas; Lundbäck, Thomas et al.

Ingår i ChemistryOpen, s. 256-263, 2014

• DOI för Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Arylsulfonamides

Palladium(II)-Catalyzed Desulfitative Synthesis of Aryl Ketones from Sodium Arylsulfinates and Nitriles: Scope, Limitations, and Mechanistic Studies

Skillinghaug, Bobo; Sköld, Christian; Rydfjord, Jonas; Svensson, Fredrik et al.

Ingår i Journal of Organic Chemistry, s. 12018-12032, 2014

• DOI för Palladium(II)-Catalyzed Desulfitative Synthesis of Aryl Ketones from Sodium Arylsulfinates and Nitriles: Scope, Limitations, and Mechanistic Studies

Aminocarbonylation of 4-Iodo-1H-imidazoles with an Amino Acid Amide Nucleophile: Synthesis of Constrained H-Phe-Phe-NH2 Analogues

Skogh, Anna; Fransson, Rebecca; Sköld, Christian; Larhed, Mats et al.

Ingår i Journal of Organic Chemistry, s. 12251-12256, 2013

• DOI för Aminocarbonylation of 4-Iodo-1H-imidazoles with an Amino Acid Amide Nucleophile: Synthesis of Constrained H-Phe-Phe-NH2 Analogues

Constrained H-Phe-Phe-NH₂ Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability

Fransson, Rebecca; Sköld, Christian; Kratz, Jadel M; Svensson, Richard et al.

Ingår i Journal of Medicinal Chemistry, s. 4953-4965, 2013

• DOI för Constrained H-Phe-Phe-NH₂ Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability

Decarboxylative Palladium(II)-Catalyzed Synthesis of Aryl Amidines from Aryl Carboxylic Acids: Development and Mechanistic Investigation

Rydfjord, Jonas; Svensson, Fredrik; Trejos, Alejandro; Sjöberg, Per J. R. et al.

Ingår i Chemistry - A European Journal, s. 13803-13810, 2013

• DOI för Decarboxylative Palladium(II)-Catalyzed Synthesis of Aryl Amidines from Aryl Carboxylic Acids: Development and Mechanistic Investigation

One-Pot, Two-Step, Microwave-Assisted Palladium-Catalyzed Conversion of Aryl Alcohols to Aryl Fluorides via Aryl Nonaflates

Wannberg, Johan; Wallinder, Charlotta; Unlusoy, Meltem; Sköld, Christian et al.

Ingår i Journal of Organic Chemistry, s. 4184-4189, 2013

• DOI för One-Pot, Two-Step, Microwave-Assisted Palladium-Catalyzed Conversion of Aryl Alcohols to Aryl Fluorides via Aryl Nonaflates

Theoretical and Experimental Investigation of Palladium(II)-Catalyzed Decarboxylative Addition of Arenecarboxylic Acid to Nitrile

Svensson, Fredrik; Mane, Rajendra S.; Sävmarker, Jonas; Larhed, Mats et al.

Ingår i Organometallics, s. 490-497, 2013

• DOI för Theoretical and Experimental Investigation of Palladium(II)-Catalyzed Decarboxylative Addition of Arenecarboxylic Acid to Nitrile

Virtual Screening Data Fusion Using Both Structure- and Ligand-Based Methods

Svensson, Fredrik; Karlén, Anders; Sköld, Christian

Ingår i Journal of Chemical Information and Modeling, s. 225-232, 2012

• DOI för Virtual Screening Data Fusion Using Both Structure- and Ligand-Based Methods

Synthesis of functionalized furopyrazines as restricted dipeptidomimetics

Claerhout, Stijn; Sharma, Sweta; Sköld, Christian; Cavaluzzo, Claudia et al.

Ingår i Tetrahedron, s. 3019-3029, 2012

• DOI för Synthesis of functionalized furopyrazines as restricted dipeptidomimetics

Transmetallation Versus β-Hydride Elimination: The Role of 1,4 Benzoquinone in Chelation-Controlled Arylation Reactions with Arylboronic Acids

Sköld, Christian; Kleimark, Jonatan; Trejos, Alejandro; Odell, Luke R. et al.

Ingår i Chemistry - A European Journal, s. 4714-4722, 2012

• DOI för Transmetallation Versus β-Hydride Elimination: The Role of 1,4 Benzoquinone in Chelation-Controlled Arylation Reactions with Arylboronic Acids
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From the First Selective Non-Peptide AT(2) Receptor Agonist to Structurally Related Antagonists

Andappan, Murugaiah M. S.; Wu, Xiongyu; Wallinder, Charlotta; Mahalingam, A. K. et al.

Ingår i Journal of Medicinal Chemistry, s. 2265-2278, 2012

• DOI för From the First Selective Non-Peptide AT(2) Receptor Agonist to Structurally Related Antagonists

Discovery of Dipeptides with High Affinity to the Specific Binding Site for Substance P1-7

Fransson, Rebecca; Botros, Milad; Sköld, Christian; Nyberg, Fred et al.

Ingår i Journal of Medicinal Chemistry, s. 2383-2389, 2010

• DOI för Discovery of Dipeptides with High Affinity to the Specific Binding Site for Substance P1-7

Chemistry and folding of photomodulable peptides: stilbene and thioaurone-type candidates for conformational switches

Erdélyi, Máté; Varedian, Miranda; Sköld, Christian; Niklasson, Ida B. et al.

Ingår i Organic and biomolecular chemistry, s. 4356-4373, 2008

• DOI för Chemistry and folding of photomodulable peptides: stilbene and thioaurone-type candidates for conformational switches

Modeling binding modes of angiotensin II and pseudopeptide analogues to the AT2 receptor

Sköld, Christian; Nikiforovich, Gregory; Karlén, Anders

Ingår i Journal of Molecular Graphics and Modelling, s. 991-1003, 2008

• DOI för Modeling binding modes of angiotensin II and pseudopeptide analogues to the AT2 receptor

Development of CoMFA models of affinity and selectivity to angiotensin II type-1 and type-2 receptors

Sköld, Christian; Karlén, Anders

Ingår i Journal of Molecular Graphics and Modelling, s. 145-153, 2007

• DOI för Development of CoMFA models of affinity and selectivity to angiotensin II type-1 and type-2 receptors

Synthesis of a new class of druglike angiotensin II C-terminal mimics with affinity for the AT2 receptor

Georgsson, Jennie; Sköld, Christian; Botros, Milad; Lindeberg, Gunnar et al.

Ingår i Journal of Medicinal Chemistry, s. 1711-1715, 2007

• DOI för Synthesis of a new class of druglike angiotensin II C-terminal mimics with affinity for the AT2 receptor

Design, synthesis, and incorporation of a beta-turn mimetic in angiotensin II forming novel pseudopeptides with affinity for AT(1) and AT(2) receptors

Rosenström, Ulrika; Sköld, Christian; Lindeberg, Gunnar; Botros, Milad et al.

Ingår i Journal of Medicinal Chemistry, s. 6133-6137, 2006

• DOI för Design, synthesis, and incorporation of a beta-turn mimetic in angiotensin II forming novel pseudopeptides with affinity for AT(1) and AT(2) receptors

Presentation of a structurally diverse and commercially available drug data set for correlation and benchmarking studies.

Skold, Christian; Winiwarter, Susanne; Wernevik, Johan; Bergstrom, Fredrik et al.

Ingår i J Med Chem, s. 6660-71, 2006

New selective AT2 receptor ligands encompassing a γ-turn mimetic replacing the amino acid residues 4-5 of angiotensin II act as agonists

Rosenström, Ulrika; Sköld, Christian; Plouffe, Bianca; Beaudry, Hélène et al.

Ingår i Journal of Medicinal Chemistry, s. 4009-4024, 2005

• DOI för New selective AT2 receptor ligands encompassing a γ-turn mimetic replacing the amino acid residues 4-5 of angiotensin II act as agonists

Synthesis and AT2 receptor-binding properties of angiotensin II analogues

Rosenström, Ulrika; Sköld, Christian; Lindeberg, Gunnar; Botros, Milad et al.

Ingår i Journal of Peptide Research, s. 194-201, 2004

• DOI för Synthesis and AT2 receptor-binding properties of angiotensin II analogues

A Selective AT2 Receptor Ligand with a γ-Turn-Like Mimetic replacing the Amino Acid Residues 4-5 of Angiotensin II

Rosenström, Ulrika; Sköld, Christian; Lindeberg, Gunnar; Botros, Milad et al.

Ingår i Journal of Medicinal Chemistry, s. 859-870, 2004

• DOI för A Selective AT2 Receptor Ligand with a γ-Turn-Like Mimetic replacing the Amino Acid Residues 4-5 of Angiotensin II

Organic reactivity from mechanism to machine learning

Jorner, Kjell; Tomberg, Anna; Bauer, Christoph; Sköld, Christian et al.

Ingår i Nature Reviews Chemistry, s. 240-255, 2021

• DOI för Organic reactivity from mechanism to machine learning

Computational Modeling of the AT₂ Receptor and AT₂ Receptor Ligands: Investigating Ligand Binding, Structure–Activity Relationships, and Receptor-Bound Models

Sköld, Christian

2007

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Multi-targeting the folate pathway is a promising strategy against Leishmania tropica

Vikeved, Elisabet; Sköld, Christian; Alsmark, UCM

Prediction of anti-leishmanial drug targets using metabolite-based target fishing

Vikeved, Elisabet; Alsmark, UCM; Sköld, Christian