Sergiy Korol

GLP-1 selectively enhances tonic GABA_A receptor-mediated currents in mouse dentate gyrus granule cells of the ventral hippocampus

Netsyk, Olga; Korol, Sergiy; Birnir, Bryndis; Jin, Zhe

Part of Frontiers in Cellular Neuroscience, 2025

• DOI for GLP-1 selectively enhances tonic GABA_A receptor-mediated currents in mouse dentate gyrus granule cells of the ventral hippocampus
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GABA-activated slow spontaneous inhibitory postsynaptic currents are decreased in dorsal hippocampal dentate gyrus granule cells in an aged mouse model of Alzheimer's disease

Netsyk, Olga; Korol, Sergiy V; Li, Jin-ping; Birnir, Bryndis et al.

Part of Journal of Alzheimer's Disease, p. 420-428, 2025

• DOI for GABA-activated slow spontaneous inhibitory postsynaptic currents are decreased in dorsal hippocampal dentate gyrus granule cells in an aged mouse model of Alzheimer's disease

Rodent islet amyloid polypeptide (IAPP) selectively enhances GABA_A receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells

Netsyk, Olga; Korol, Sergiy; Westermark, Gunilla; Birnir, Bryndis et al.

Part of Frontiers in Cellular Neuroscience, 2025

• DOI for Rodent islet amyloid polypeptide (IAPP) selectively enhances GABA_A receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells
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GABA-mediated inhibition of human CD4⁺ T cell functions is enhanced by insulin but impaired by high glucose levels

Jin, Zhe; Hammoud, Hayma; Bhandage, Amol; Korol, Sergiy Vasylyovych et al.

Part of EBioMedicine, 2024

• DOI for GABA-mediated inhibition of human CD4⁺ T cell functions is enhanced by insulin but impaired by high glucose levels
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GABA signalling in human pancreatic islets

Jin, Zhe; Korol, Sergiy V.

Part of Frontiers in Endocrinology, 2023

• DOI for GABA signalling in human pancreatic islets
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GLP-1 selectively enhances tonic GABA_A receptor-mediated currents in mouse dentate gyrus granule cells of the ventral hippocampus

Netsyk, Olga; Korol, Sergiy; Birnir, Bryndis; Jin, Zhe

Part of Frontiers in Cellular Neuroscience, 2025

• DOI for GLP-1 selectively enhances tonic GABA_A receptor-mediated currents in mouse dentate gyrus granule cells of the ventral hippocampus
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GABA-activated slow spontaneous inhibitory postsynaptic currents are decreased in dorsal hippocampal dentate gyrus granule cells in an aged mouse model of Alzheimer's disease

Netsyk, Olga; Korol, Sergiy V; Li, Jin-ping; Birnir, Bryndis et al.

Part of Journal of Alzheimer's Disease, p. 420-428, 2025

• DOI for GABA-activated slow spontaneous inhibitory postsynaptic currents are decreased in dorsal hippocampal dentate gyrus granule cells in an aged mouse model of Alzheimer's disease

Rodent islet amyloid polypeptide (IAPP) selectively enhances GABA_A receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells

Netsyk, Olga; Korol, Sergiy; Westermark, Gunilla; Birnir, Bryndis et al.

Part of Frontiers in Cellular Neuroscience, 2025

• DOI for Rodent islet amyloid polypeptide (IAPP) selectively enhances GABA_A receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells
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GABA-mediated inhibition of human CD4⁺ T cell functions is enhanced by insulin but impaired by high glucose levels

Jin, Zhe; Hammoud, Hayma; Bhandage, Amol; Korol, Sergiy Vasylyovych et al.

Part of EBioMedicine, 2024

• DOI for GABA-mediated inhibition of human CD4⁺ T cell functions is enhanced by insulin but impaired by high glucose levels
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Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa

Cotman, Andrej Emanuel; Durcik, Martina; Tiz, Davide Benedetto; Fulgheri, Federica et al.

Part of Journal of Medicinal Chemistry, p. 1380-1425, 2023

• DOI for Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa
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New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus

Durcik, Martina; Cotman, Andrej Emanuel; Toplak, Zan; Mozina, Stefan et al.

Part of Journal of Medicinal Chemistry, p. 3968-3994, 2023

• DOI for New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus
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Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age-dependent manner, normalizes GABA-activated currents in the tg-APPSwe mouse model of Alzheimer's disease

Hammoud, Hayma; Netsyk, Olga; Tafreshiha, Atieh S.; Korol, Sergiy V. et al.

Part of Acta Physiologica, 2021

• DOI for Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age-dependent manner, normalizes GABA-activated currents in the tg-APPSwe mouse model of Alzheimer's disease
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Tonic GABA-activated synaptic and extrasynaptic currents in dentate gyrus granule cells and CA3 pyramidal neurons along the mouse hippocampal dorsoventral axis

Netsyk, Olga; Hammoud, Hayma; Korol, Sergiy; Jin, Zhe et al.

Part of Hippocampus, p. 1146-1157, 2020

• DOI for Tonic GABA-activated synaptic and extrasynaptic currents in dentate gyrus granule cells and CA3 pyramidal neurons along the mouse hippocampal dorsoventral axis
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GABA(A) Receptor-Mediated Currents and Hormone mRNAs in Cells Expressing More Than One Hormone Transcript in Intact Human Pancreatic Islets

Korol, Sergiy; Jin, Zhe; Birnir, Bryndis

Part of International Journal of Molecular Sciences, 2020

• DOI for GABA(A) Receptor-Mediated Currents and Hormone mRNAs in Cells Expressing More Than One Hormone Transcript in Intact Human Pancreatic Islets
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Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers

Bhandage, Amol K.; Cunningham, Janet L.; Jin, Zhe; Shen, Qiujin et al.

Part of International Journal of Molecular Sciences, 2019

• DOI for Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers
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Interferon-gamma potentiates GABA(A) receptor-mediated inhibitory currents in rat hippocampal CA1 pyramidal neurons

Flood, Louise; Korol, Sergiy; Ekselius, Lisa; Birnir, Bryndis et al.

Part of Journal of Neuroimmunology, 2019

• DOI for Interferon-gamma potentiates GABA(A) receptor-mediated inhibitory currents in rat hippocampal CA1 pyramidal neurons
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Transcriptomes of Dravet syndrome iPSC derived GABAergic cells reveal dysregulated pathways for chromatin remodeling and neurodevelopment

Schuster, Jens; Laan, Loora; Klar, Joakim; Jin, Zhe et al.

Part of Neurobiology of Disease, 2019

• DOI for Transcriptomes of Dravet syndrome iPSC derived GABAergic cells reveal dysregulated pathways for chromatin remodeling and neurodevelopment
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Single cell analysis of autism patient with bi-allelic NRXN1-alpha deletion reveals skewed fate choice in neural progenitors and impaired neuronal functionality

Lam, Matti; Moslem, Mohsen; Bryois, Julien; Pronk, Robin J. et al.

Part of Experimental Cell Research, 2019

• DOI for Single cell analysis of autism patient with bi-allelic NRXN1-alpha deletion reveals skewed fate choice in neural progenitors and impaired neuronal functionality
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Expression of calcium release-activated and voltage-gated calcium channels genes in peripheral blood mononuclear cells is altered in pregnancy and in type 1 diabetes

Bhandage, Amol; Jin, Zhe; Korol, Sergiy V; Tafreshiha, Atieh et al.

Part of PLOS ONE, 2018

• DOI for Expression of calcium release-activated and voltage-gated calcium channels genes in peripheral blood mononuclear cells is altered in pregnancy and in type 1 diabetes
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Insulin enhances GABA_A receptor-mediated inhibitory currents in rat central amygdala neurons

Korol, Sergiy V.; Tafreshiha, Atieh; Bhandage, Amol K.; Birnir, Bryndis et al.

Part of Neuroscience Letters, p. 76-81, 2018

• DOI for Insulin enhances GABA_A receptor-mediated inhibitory currents in rat central amygdala neurons
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GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4⁺ T Cells and Is Immunosuppressive in Type 1 Diabetes

Bhandage, Amol K.; Jin, Zhe; Korol, Sergiy V.; Shen, Qiujin et al.

Part of EBioMedicine, p. 283-294, 2018

• DOI for GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4⁺ T Cells and Is Immunosuppressive in Type 1 Diabetes
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Functional Characterization of Native, High-Affinity GABA_A Receptors in Human Pancreatic β Cells

Korol, Sergiy V; Jin, Zhe; Jin, Yang; Bhandage, Amol K. et al.

Part of EBioMedicine, 2018

• DOI for Functional Characterization of Native, High-Affinity GABA_A Receptors in Human Pancreatic β Cells
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Liraglutide modulates GABAergic signaling in rat hippocampal CA3 pyramidal neurons predominantly by presynaptic mechanism

Babateen, Omar; Korol, Sergiy V.; Jin, Zhe; Bhandage, Amol K. et al.

Part of BMC Pharmacology & Toxicology, 2017

• DOI for Liraglutide modulates GABAergic signaling in rat hippocampal CA3 pyramidal neurons predominantly by presynaptic mechanism
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AMPA, NMDA and kainate glutamate receptor subunits are expressed in human peripheral blood mononuclear cells (PBMCs) where the expression of GluK4 is altered by pregnancy and GluN2D by depression in pregnant women

Bhandage, Amol K.; Jin, Zhe; Hellgren, Charlotte; Korol, Sergiy V. et al.

Part of Journal of Neuroimmunology, p. 51-58, 2017

• DOI for AMPA, NMDA and kainate glutamate receptor subunits are expressed in human peripheral blood mononuclear cells (PBMCs) where the expression of GluK4 is altered by pregnancy and GluN2D by depression in pregnant women

Normal human CD4⁺ helper T cells express Kv1.1 voltage-gated K⁺ channels, and selective Kv1.1 block in T cells induces by itself robust TNFα production and secretion and activation of the NFκB non-canonical pathway

Fellerhoff-Losch, Barbara; Korol, Sergiy V.; Ganor, Yonatan; Gu, Songhai et al.

Part of Journal of neural transmission, p. 137-157, 2016

• DOI for Normal human CD4⁺ helper T cells express Kv1.1 voltage-gated K⁺ channels, and selective Kv1.1 block in T cells induces by itself robust TNFα production and secretion and activation of the NFκB non-canonical pathway

GLP-1 and Exendin-4 Transiently Enhance GABA(A) Receptor-Mediated Synaptic and Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons

Korol, Sergiy V.; Jin, Zhe; Babateen, Omar; Birnir, Bryndis

Part of Diabetes, p. 79-89, 2015

• DOI for GLP-1 and Exendin-4 Transiently Enhance GABA(A) Receptor-Mediated Synaptic and Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons
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Insulin modulates GABAA receptor-mediated neuronal inhibition in rat hippocampus and amygdala

Jin, Zhe; Korol, Sergiy V.; Jin, Yang; Birnir, Bryndis

Part of Acta Physiologica, p. 90-90, 2015

Modulation of GABAA receptor-mediated synaptic and tonic currents in the rat hippocampus by GLP-1, exendin-4 and diazepam

Korol, Sergiy V.; Jin, Zhe; Babateen, Omar; Birnir, Bryndis

Part of Acta Physiologica, p. 89-90, 2015

The GLP-1 Receptor Agonist Exendin-4 and Diazepam Differentially Regulate GABA_A Receptor-Mediated Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons

Korol, Sergiy V.; Jin, Zhe; Birnir, Bryndis

Part of PLOS ONE, 2015

• DOI for The GLP-1 Receptor Agonist Exendin-4 and Diazepam Differentially Regulate GABA_A Receptor-Mediated Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons
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Etomidate, propofol and diazepam potentiate GABA-evoked GABAA currents in a cell line derived from Human glioblastoma

Babateen, Omar; Jin, Zhe; Bhandage, Amol K.; Korol, Sergiy V et al.

Part of European Journal of Pharmacology, p. 101-107, 2015

• DOI for Etomidate, propofol and diazepam potentiate GABA-evoked GABAA currents in a cell line derived from Human glioblastoma

GABA(A) receptor-mediated currents in the hippocampus are transiently enhanced by glucagon-like peptide-1 receptor (GLP-1R) agonists

Korol, Sergiy V.; Jin, Zhe; Babateen, Omar M.; Birnir, Bryndis

Part of Acta Physiologica, p. 83-83, 2014

Insulin modulates GABA(A) receptor-mediated inhibition in rat amygdala neurons

Jin, Zhe; Korol, Sergiy V.; Birnir, Bryndis

Part of Acta Physiologica, p. 83-83, 2014

GABA-A receptor currents in a cell line (U3047MG) derived from a human glioblastoma tumor are enhanced by etomidate, propofol and diazepam

Babateen, Omar M.; Jin, Zhe; Bhandage, Amol K.; Korol, Sergiy V. et al.

Part of Acta Physiologica, p. 100-100, 2014

In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in alpha-Cells

Jin, Yang; Korol, Sergiy V; Jin, Zhe; Barg, Sebastian et al.

Part of PLOS ONE, 2013

• DOI for In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in alpha-Cells
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GABA signalling in human pancreatic islets

Jin, Zhe; Korol, Sergiy V.

Part of Frontiers in Endocrinology, 2023

• DOI for GABA signalling in human pancreatic islets
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In a cell-type specific manner, high-affinity GABA-A receptors participate in autocrine and paracrine GABA signaling in human pancreatic islets

Jin, Yang; Korol, Sergiy; Jin, Zhe; Laver, Derek et al.

GABA, insulin and glucose orchestrate effector functions of human CD4+ T cells

Jin, Zhe; Hammoud, Hayma; Bhandage, Amol; Korol, Sergiy et al.