David Dahlgren

Column coupling for chiral LC-MS separation resolves triacylglycerol enantiomers and regioisomers in complex samples without flow recycling

Nilsson, Jenny M.; Balgoma, David; Stephansson, Edvin Dedering; Landström, Sofia et al.

Part of Talanta, 2027

• DOI for Column coupling for chiral LC-MS separation resolves triacylglycerol enantiomers and regioisomers in complex samples without flow recycling
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Characterization of hepatocellular carcinoma patient-derived organoids from patients receiving transarterial chemoembolization as a model for preclinical drug response assessment

Khaled, Jaafar; Sennefelt Nyman, Sofi; Dahlgren, David; Rorsman, Fredrik et al.

Part of Scientific Reports, 2026

• DOI for Characterization of hepatocellular carcinoma patient-derived organoids from patients receiving transarterial chemoembolization as a model for preclinical drug response assessment
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A comprehensive mechanistic investigation of factors affecting intestinal absorption and bioavailability of two PROTACs in rats

Niessen, Janis; Arendt, Nathalie; Sjöblom, Markus; Dubbelboer, Ilse R. et al.

Part of European journal of pharmaceutics and biopharmaceutics, 2025

• DOI for A comprehensive mechanistic investigation of factors affecting intestinal absorption and bioavailability of two PROTACs in rats
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Medicinal grade opium tincture for severe diarrhea: effect revisited in observational study

Dahlgren, David; Hellström, Per M.

Part of Current Opinion in Gastroenterology, p. 196-202, 2024

• DOI for Medicinal grade opium tincture for severe diarrhea: effect revisited in observational study

Melatonin mitigates chemotherapy-induced small intestinal atrophy in rats and reduces cytotoxicity in murine intestinal organoids

Peters, Karsten; Clavero, Ada Lerma; Kullenberg, Fredrik; Kopsida, Maria et al.

Part of PLOS ONE, 2024

• DOI for Melatonin mitigates chemotherapy-induced small intestinal atrophy in rats and reduces cytotoxicity in murine intestinal organoids
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Column coupling for chiral LC-MS separation resolves triacylglycerol enantiomers and regioisomers in complex samples without flow recycling

Nilsson, Jenny M.; Balgoma, David; Stephansson, Edvin Dedering; Landström, Sofia et al.

Part of Talanta, 2027

• DOI for Column coupling for chiral LC-MS separation resolves triacylglycerol enantiomers and regioisomers in complex samples without flow recycling
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Characterization of hepatocellular carcinoma patient-derived organoids from patients receiving transarterial chemoembolization as a model for preclinical drug response assessment

Khaled, Jaafar; Sennefelt Nyman, Sofi; Dahlgren, David; Rorsman, Fredrik et al.

Part of Scientific Reports, 2026

• DOI for Characterization of hepatocellular carcinoma patient-derived organoids from patients receiving transarterial chemoembolization as a model for preclinical drug response assessment
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A comprehensive mechanistic investigation of factors affecting intestinal absorption and bioavailability of two PROTACs in rats

Niessen, Janis; Arendt, Nathalie; Sjöblom, Markus; Dubbelboer, Ilse R. et al.

Part of European journal of pharmaceutics and biopharmaceutics, 2025

• DOI for A comprehensive mechanistic investigation of factors affecting intestinal absorption and bioavailability of two PROTACs in rats
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Medicinal grade opium tincture for severe diarrhea: effect revisited in observational study

Dahlgren, David; Hellström, Per M.

Part of Current Opinion in Gastroenterology, p. 196-202, 2024

• DOI for Medicinal grade opium tincture for severe diarrhea: effect revisited in observational study

Melatonin mitigates chemotherapy-induced small intestinal atrophy in rats and reduces cytotoxicity in murine intestinal organoids

Peters, Karsten; Clavero, Ada Lerma; Kullenberg, Fredrik; Kopsida, Maria et al.

Part of PLOS ONE, 2024

• DOI for Melatonin mitigates chemotherapy-induced small intestinal atrophy in rats and reduces cytotoxicity in murine intestinal organoids
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Development and validation of LC-MS/MS methods for the pharmacokinetic assessment of the PROTACs bavdeglutamide (ARV-110) and vepdegestrant (ARV-471)

Niessen, Janis; Nilsson, Jenny M.; Peters, Karsten; Indulkar, Anura et al.

Part of Journal of Pharmaceutical and Biomedical Analysis, 2024

• DOI for Development and validation of LC-MS/MS methods for the pharmacokinetic assessment of the PROTACs bavdeglutamide (ARV-110) and vepdegestrant (ARV-471)
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Hypotonicity-Induced Increase in Duodenal Mucosal Permeability Is Regulated by Cholinergic Receptors in Rats

Dahlgren, David; Nylander, Olof; Sjöblom, Markus

Part of Digestive Diseases and Sciences, p. 1815-1823, 2023

• DOI for Hypotonicity-Induced Increase in Duodenal Mucosal Permeability Is Regulated by Cholinergic Receptors in Rats
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The progression of doxorubicin-induced intestinal mucositis in rats

Kullenberg, Fredrik; Peters, Karsten; Luna-Marco, C.; Salomonsson, A. et al.

Part of Naunyn-Schmiedeberg's Archives of Pharmacology, p. 247-260, 2023

• DOI for The progression of doxorubicin-induced intestinal mucositis in rats
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Anakinra and dexamethasone treatment of idarubicin-induced mucositis and diarrhoea in rats

Kullenberg, Fredrik; Peters, Karsten; Sjöblom, Markus; Heindryckx, Femke et al.

Part of Basic & Clinical Pharmacology & Toxicology, p. 507-516, 2023

• DOI for Anakinra and dexamethasone treatment of idarubicin-induced mucositis and diarrhoea in rats
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Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival

Sennefelt Nyman, Sofi; Ahlström, Håkan; Dimopoulou, Angeliki; Dahlgren, David et al.

Part of BMJ Open, 2022

• DOI for Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival
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Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding

Balgoma, David; Kullenberg, Fredrik; Peters, Karsten; Dahlgren, David et al.

Part of Metabolites, 2022

• DOI for Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding
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Ulcerative colitis progression: a retrospective analysis of disease burden using electronic medical records

Dahlgren, David; Agreus, Lars; Stålhammar, Jan; Hellström, Per M.

Part of Upsala Journal of Medical Sciences, 2022

• DOI for Ulcerative colitis progression: a retrospective analysis of disease burden using electronic medical records
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Evaluation and validation of chemotherapy‐specific diarrhoea and histopathology in rats

Dahlgren, David; Rosenqvist, Evelina; Hellström, Per M.; Nygren, Peter et al.

Part of Basic & Clinical Pharmacology & Toxicology, p. 536-546, 2022

• DOI for Evaluation and validation of chemotherapy‐specific diarrhoea and histopathology in rats
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Effects of α₂-adrenoceptor stimulation on luminal alkalinisation and net fluid flux in rat duodenum

Nylander, Olof; Sjöblom, Markus; Sedin, John; Dahlgren, David

Part of PLOS ONE, 2022

• DOI for Effects of α₂-adrenoceptor stimulation on luminal alkalinisation and net fluid flux in rat duodenum
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Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats

Cano-Cebrian, Maria-Jose; Dahlgren, David; Kullenberg, Fredrik; Peters, Karsten et al.

Part of International Journal of Molecular Sciences, 2022

• DOI for Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats
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Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats

Peters, Karsten; Dahlgren, David; Egerszegi, Peter Pal; Lennernäs, Hans et al.

Part of International Journal of Molecular Sciences, 2022

• DOI for Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats
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Melatonin-Activated Receptor Signaling Pathways Mediate Protective Effects on Surfactant-Induced Increase in Jejunal Mucosal Permeability in Rats

Peters, Karsten; Dahlgren, David; Lennernäs, Hans; Sjöblom, Markus

Part of International Journal of Molecular Sciences, 2021

• DOI for Melatonin-Activated Receptor Signaling Pathways Mediate Protective Effects on Surfactant-Induced Increase in Jejunal Mucosal Permeability in Rats
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The Impact of alpha-Adrenoceptors in the Regulation of the Hypotonicity-Induced Increase in Duodenal Mucosal Permeability In Vivo

Sedin, John; Dahlgren, David; Sjöblom, Markus; Nylander, Olof

Part of Pharmaceutics, 2021

• DOI for The Impact of alpha-Adrenoceptors in the Regulation of the Hypotonicity-Induced Increase in Duodenal Mucosal Permeability In Vivo
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Fasted and fed state human duodenal fluids: Characterization, drug solubility, and comparison to simulated fluids and with human bioavailability

Dahlgren, David; Venczel, M.; Ridoux, J. -P; Skjöld, C. et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 240-251, 2021

• DOI for Fasted and fed state human duodenal fluids: Characterization, drug solubility, and comparison to simulated fluids and with human bioavailability
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Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats

Dahlgren, David; Olander, Tobias; Sjöblom, Markus; Hedeland, Mikael et al.

Part of Acta Pharmaceutica Sinica B, p. 1667-1675, 2021

• DOI for Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats
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Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol

Dahlgren, David; Cano-Cebrian, Maria-Jose; Hellström, Per M.; Wanders, Alkwin et al.

Part of International Journal of Molecular Sciences, 2020

• DOI for Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol
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Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat

Dahlgren, David; Cano-Cebrian, Maria-Jose; Olander, Tobias; Hedeland, Mikael et al.

Part of Pharmaceutics, 2020

• DOI for Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat
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The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin

Dahlgren, David; Sjöblom, Markus; Hedeland, Mikael; Lennernäs, Hans

Part of Pharmaceutics, 2020

• DOI for The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin
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Rat intestinal drug permeability: A status report and summary of repeated determinations

Dubbelboer, Ilse R; Dahlgren, David; Sjögren, Erik; Lennernäs, Hans

Part of European journal of pharmaceutics and biopharmaceutics, p. 364-376, 2019

• DOI for Rat intestinal drug permeability: A status report and summary of repeated determinations

Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model

Dahlgren, David; Roos, Carl; Peters, Karsten; Lundqvist, A. et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 31-37, 2019

• DOI for Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model

Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 387-395, 2019

• DOI for Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

Intestinal absorption-modifying excipients: A current update on preclinical in vivo evaluations

Dahlgren, David; Sjöblom, Markus; Lennernäs, Hans

Part of European journal of pharmaceutics and biopharmaceutics, p. 411-420, 2019

• DOI for Intestinal absorption-modifying excipients: A current update on preclinical in vivo evaluations

Time-dependent effects on small intestinal transport by absorption-modifying excipients

Dahlgren, David; Roos, Carl; Lundqvist, A.; Tannergren, C. et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 19-28, 2018

• DOI for Time-dependent effects on small intestinal transport by absorption-modifying excipients

Mechanistic modelling of intestinal drug absorption: the in vivo effects of nanoparticles, hydrodynamics, and colloidal structures

Roos, Carl; Westergren, Jan; Dahlgren, David; Lennernäs, Hans et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 70-76, 2018

• DOI for Mechanistic modelling of intestinal drug absorption: the in vivo effects of nanoparticles, hydrodynamics, and colloidal structures

Jejunal absorption of aprepitant from nanosuspensions: Role of particle size, prandial state and mucus layer.

Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 222-230, 2018

• DOI for Jejunal absorption of aprepitant from nanosuspensions: Role of particle size, prandial state and mucus layer.

Effect of absorption-modifying excipients, hypotonicity, and enteric neural activity in an in vivo model for small intestinal transport.

Dahlgren, David; Roos, Carl; Lundqvist, A; Tannergren, C et al.

Part of International Journal of Pharmaceutics, p. 239-248, 2018

• DOI for Effect of absorption-modifying excipients, hypotonicity, and enteric neural activity in an in vivo model for small intestinal transport.

The effects of three absorption-modifying critical excipients on the in vivo intestinal absorption of six model compounds in rats and dogs.

Dahlgren, David; Roos, Carl; Johansson, P; Tannergren, C et al.

Part of International Journal of Pharmaceutics, p. 158-168, 2018

• DOI for The effects of three absorption-modifying critical excipients on the in vivo intestinal absorption of six model compounds in rats and dogs.

Preclinical Effect of Absorption Modifying Excipients on Rat Intestinal Transport of Model Compounds and the Mucosal Barrier Marker ⁵¹Cr-EDTA

Dahlgren, David; Roos, Carl; Lundqvist, Anders; Tannergren, Christer et al.

Part of Molecular Pharmaceutics, p. 4243-4251, 2017

• DOI for Preclinical Effect of Absorption Modifying Excipients on Rat Intestinal Transport of Model Compounds and the Mucosal Barrier Marker ⁵¹Cr-EDTA

In Vivo Mechanisms of Intestinal Drug Absorption from Aprepitant Nanoformulations

Roos, Carl; Dahlgren, David; Berg, Staffan; Westergren, Jan et al.

Part of Molecular Pharmaceutics, p. 4233-4242, 2017

• DOI for In Vivo Mechanisms of Intestinal Drug Absorption from Aprepitant Nanoformulations

Regional Intestinal Permeability in Rats: A Comparison of Methods

Roos, Carl; Dahlgren, David; Sjögren, Erik; Tannergren, Christer et al.

Part of Molecular Pharmaceutics, p. 4252-4261, 2017

• DOI for Regional Intestinal Permeability in Rats: A Comparison of Methods

Optimization of the Ussing chamber setup with excised rat intestinal segments for dissolution/permeation experiments of poorly soluble drugs

Forner, Kristin; Roos, Carl; Dahlgren, David; Kesisoglou, Filippos et al.

Part of Drug Development and Industrial Pharmacy, p. 338-346, 2017

• DOI for Optimization of the Ussing chamber setup with excised rat intestinal segments for dissolution/permeation experiments of poorly soluble drugs

Regional Intestinal Permeability of Three Model Drugs in Human

Dahlgren, David; Roos, Carl; Lundqvist, Anders; Abrahamsson, Bertil et al.

Part of Molecular Pharmaceutics, p. 3013-3021, 2016

• DOI for Regional Intestinal Permeability of Three Model Drugs in Human

Regional Intestinal Permeability in Dogs: Biopharmaceutical Aspects for Development of Oral Modified-Release Dosage Forms

Dahlgren, David; Roos, Carl; Johansson, Pernilla; Lundqvist, Anders et al.

Part of Molecular Pharmaceutics, p. 3022-3033, 2016

• DOI for Regional Intestinal Permeability in Dogs: Biopharmaceutical Aspects for Development of Oral Modified-Release Dosage Forms

Human in Vivo Regional Intestinal Permeability: Quantitation Using Site-Specific Drug Absorption Data

Sjögren, Erik; Dahlgren, David; Roos, Carl; Lennernas, Hans

Part of Molecular Pharmaceutics, p. 2026-2039, 2015

• DOI for Human in Vivo Regional Intestinal Permeability: Quantitation Using Site-Specific Drug Absorption Data

Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

Part of European journal of pharmaceutics and biopharmaceutics

Review on the effect of chemotherapy on the intestinal barrier: Epithelial permeability, mucus and bacterial translocation

Dahlgren, David; Lennernäs, Hans

Part of Biomedicine and Pharmacotherapy, 2023

• DOI for Review on the effect of chemotherapy on the intestinal barrier: Epithelial permeability, mucus and bacterial translocation
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Challenges in Permeability Assessment for Oral Drug Product Development

Koziolek, Mirko; Augustijns, Patrick; Berger, Constantin; Cristofoletti, Rodrigo et al.

Part of Pharmaceutics, 2023

• DOI for Challenges in Permeability Assessment for Oral Drug Product Development
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Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies

Dahlgren, David; Sjöblom, Markus; Hellström, Per M.; Lennernäs, Hans

Part of Frontiers in Pharmacology, 2021

• DOI for Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies
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Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective

Dahlgren, David; Lennernäs, Hans

Part of Molecules, 2020

• DOI for Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective
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Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models

Dahlgren, David; Sjögren, Erik; Lennernäs, Hans

Part of ADMET & DMPK, p. 375-390, 2020

• DOI for Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models
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Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches

Dahlgren, David; Lennernäs, Hans

Part of Pharmaceutics, 2019

• DOI for Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches
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Direct In Vivo Human Intestinal Permeability (P-eff) Determined with Different Clinical Perfusion and Intubation Methods

Dahlgren, David; Roos, Carl; Sjögren, Erik; Lennernäs, Hans

Part of Journal of Pharmaceutical Sciences, p. 2702-2726, 2015

• DOI for Direct In Vivo Human Intestinal Permeability (P-eff) Determined with Different Clinical Perfusion and Intubation Methods

Biopharmaceutical aspects of intestinal drug absorption: Regional permeability and absorption-modifying excipients

Dahlgren, David

2018

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Pharmacokinetics and safety profile of idarubicin-lipiodol chemoembolization of hepatocellular carcinoma

Dahlgren, David; Sennefelt Nyman, Sofi; Niessen, Janis; Dimopoulou, Angeliki et al.

Imaging-assessed tumor aggressiveness is associated with response to Transarterial chemoembolization in Hepatocellular carcinoma patients

Sennefelt Nyman, Sofi; Westin, Anna; Ingelhammar, Fritiof; Ahlström, Håkan et al.