Johanna Larsson
Researcher at Department of Medicinal Chemistry; Preparative Medicinal Chemistry
- E-mail:
- johanna.larsson@scilifelab.uu.se
- Visiting address:
- Uppsala Biomedicinska Centrum, BMC, Husarg. 3
- Postal address:
- Box 574
751 23 UPPSALA
- ORCID:
- 0000-0002-7676-6331
Short presentation
I’m an organic chemist working at the SciLifeLab Drug Discovery and Development platform (SciLifeLab DDD) in a team of chemists and biologists. The aim of the platform is to start from academic discoveries and work together with Swedish PI’s to progress drug development projects towards a pre-clinical proof-of-concept. My role is to design and synthesize novel drug candidates in the Hit2Lead – Lead ID phases.
https://www.scilifelab.se/platforms/ddd
Biography
2016 -
Research Scientist, SciLifeLab Drug Discovery and Development platform (DDD)
The aim of the SciLifeLab DDD platform is to start from academic discoveries and work together with Swedish PI’s to develop small molecule and antibody leads towards a pre-clinical proof-of-concept.
The SciLifeLab DDD team consists of chemists and biologists with expertise within e.g. drug design, ADME, toxicology, biochemical and cellular screening, protein expression and crystallization, in-vitro and system pharmacology.
My role is to design and synthesize novel drug candidates in the Hit2Lead – Lead ID phases.
https://www.scilifelab.se/platforms/ddd
2014 - 2016
Research Scientist, OnTarget Chemistry / Recipharm OT Chemistry
Contract research organization, Uppsala
2008 - 2013
PhD in Organic Chemistry, Stockholm University
Development of new transition metal-catalyzed organic transformations and detailed mechanistic investigations in Prof. Kálmán Szabó’s research group
2007
Master of Science in Chemistry, Lund University

Publications
Recent publications
N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
Part of European Journal of Medicinal Chemistry, 2024
- DOI for N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
- Download full text (pdf) of N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
Part of Journal of Medicinal Chemistry, p. 3915-3934, 2020
- DOI for Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability
- Download full text (pdf) of Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability
2-amino-1,3,4-thiadiazine and 2-amino-1,3,4-oxadiazine based antifungal agents
2017
Part of Synlett, p. 969-976, 2016
Part of Journal of the American Chemical Society, p. 443-455, 2013
All publications
Articles in journal
N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
Part of European Journal of Medicinal Chemistry, 2024
- DOI for N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
- Download full text (pdf) of N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands
Part of Journal of Medicinal Chemistry, p. 3915-3934, 2020
- DOI for Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability
- Download full text (pdf) of Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability
Part of Synlett, p. 969-976, 2016
Part of Journal of the American Chemical Society, p. 443-455, 2013
Part of Journal of Organic Chemistry, p. 7330-7336, 2013
Palladium-Catalyzed Oxidative Allylic C-H Silylation.
Part of Organic Letters, p. 1888-1891, 2011
Part of Tetrahedron, p. 1374-1381, 2010
Part of Organic Letters, p. 2852-2854, 2009