Mikael Sellin
Professor at Department of Medical Biochemistry and Microbiology; Infection and Immunity; Mikael Sellin
- Telephone:
- +46 73 913 52 53
- Mobile phone:
- +46 73 913 52 53
- E-mail:
- mikael.sellin@imbim.uu.se
- Visiting address:
- BMC
Husargatan 3
752 37 UPPSALA - Postal address:
- Box 582
751 23 UPPSALA
Short presentation
Professor of Molecular Medicine, Infection Biology
SciLifeLab Principal Investigator

Publications
Recent publications
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Recombinant Spider Silk Membranes Promote Human Renal Epithelial Differentiation and Function
Part of Biofabrication, 2026
- DOI for Recombinant Spider Silk Membranes Promote Human Renal Epithelial Differentiation and Function
- Download full text (pdf) of Recombinant Spider Silk Membranes Promote Human Renal Epithelial Differentiation and Function
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High-efficiency transfection of Acanthamoeba castellanii using a cationic polymer
Part of Cell Reports Methods, 2026
- DOI for High-efficiency transfection of Acanthamoeba castellanii using a cationic polymer
- Download full text (pdf) of High-efficiency transfection of Acanthamoeba castellanii using a cationic polymer
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Part of Nature Genetics, p. 1730-1741, 2025
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Part of Cell Reports, 2025
- DOI for Maturation of Human Intestinal Epithelial Cell Layers Fortifies the Apical Surface against Salmonella Attack
- Download full text (pdf) of Maturation of Human Intestinal Epithelial Cell Layers Fortifies the Apical Surface against Salmonella Attack
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The pcnB gene sustains Shigella flexneri virulence
Part of PLoS Pathogens, 2025
All publications
Articles in journal
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Recombinant Spider Silk Membranes Promote Human Renal Epithelial Differentiation and Function
Part of Biofabrication, 2026
- DOI for Recombinant Spider Silk Membranes Promote Human Renal Epithelial Differentiation and Function
- Download full text (pdf) of Recombinant Spider Silk Membranes Promote Human Renal Epithelial Differentiation and Function
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High-efficiency transfection of Acanthamoeba castellanii using a cationic polymer
Part of Cell Reports Methods, 2026
- DOI for High-efficiency transfection of Acanthamoeba castellanii using a cationic polymer
- Download full text (pdf) of High-efficiency transfection of Acanthamoeba castellanii using a cationic polymer
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Part of Nature Genetics, p. 1730-1741, 2025
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Part of Cell Reports, 2025
- DOI for Maturation of Human Intestinal Epithelial Cell Layers Fortifies the Apical Surface against Salmonella Attack
- Download full text (pdf) of Maturation of Human Intestinal Epithelial Cell Layers Fortifies the Apical Surface against Salmonella Attack
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The pcnB gene sustains Shigella flexneri virulence
Part of PLoS Pathogens, 2025
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Part of Molecular Pharmaceutics, p. 4032-4045, 2025
- DOI for Optimized Artificial Colonic Mucus Enabling Physiologically Relevant Diffusion Studies of Drugs, Particles, and Delivery Systems
- Download full text (pdf) of Optimized Artificial Colonic Mucus Enabling Physiologically Relevant Diffusion Studies of Drugs, Particles, and Delivery Systems
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Part of European Journal of Immunology, 2025
- DOI for Mast Cell Phenotypic Heterogeneity Impacts the Interplay with Pathogenic Salmonella Typhimurium Bacteria
- Download full text (pdf) of Mast Cell Phenotypic Heterogeneity Impacts the Interplay with Pathogenic Salmonella Typhimurium Bacteria
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Part of Cell Reports, 2025
- DOI for NAIP/NLRC4 inflammasome dynamics in murine enteroids are tuned by NAIP ligand concentration and epithelial cell differentiation
- Download full text (pdf) of NAIP/NLRC4 inflammasome dynamics in murine enteroids are tuned by NAIP ligand concentration and epithelial cell differentiation
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Part of mBio, p. 1-22, 2025
- DOI for Determinants of divergent Salmonella and Shigella epithelial colonization strategies resolved in human enteroids and colonoids
- Download full text (pdf) of Determinants of divergent Salmonella and Shigella epithelial colonization strategies resolved in human enteroids and colonoids
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Part of npj Vaccines, 2025
- DOI for Matrix-M adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilization
- Download full text (pdf) of Matrix-M adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilization
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Part of Cell Reports, 2024
- DOI for Salmonella T3SS-2 virulence enhances gut-luminal colonization by enabling chemotaxis-dependent exploitation of intestinal inflammation
- Download full text (pdf) of Salmonella T3SS-2 virulence enhances gut-luminal colonization by enabling chemotaxis-dependent exploitation of intestinal inflammation
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Part of Nature Communications, 2024
- DOI for A two-step activation mechanism enables mast cells to differentiate their response between extracellular and invasive enterobacterial infection
- Download full text (pdf) of A two-step activation mechanism enables mast cells to differentiate their response between extracellular and invasive enterobacterial infection
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OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids
Part of Scientific Reports, 2024
- DOI for OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids
- Download full text (pdf) of OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids
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Part of mSphere, 2024
- DOI for ProQ-dependent activation of Salmonella virulence genes mediated by post-transcriptional control of PhoP synthesis
- Download full text (pdf) of ProQ-dependent activation of Salmonella virulence genes mediated by post-transcriptional control of PhoP synthesis
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Part of PLoS biology, 2024
- DOI for Direct Salmonella injection into enteroid cells allows the study of host-pathogen interactions in the cytosol with high spatiotemporal resolution
- Download full text (pdf) of Direct Salmonella injection into enteroid cells allows the study of host-pathogen interactions in the cytosol with high spatiotemporal resolution
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Part of Veterinary research (Print), 2024
- DOI for Equine enteroid-derived monolayers recapitulate key features of parasitic intestinal nematode infection
- Download full text (pdf) of Equine enteroid-derived monolayers recapitulate key features of parasitic intestinal nematode infection
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Part of Proceedings of the National Academy of Sciences of the United States of America, 2023
- DOI for Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice
- Download full text (pdf) of Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice
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Part of Chemical Science, p. 5291-5301, 2023
- DOI for Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites
- Download full text (pdf) of Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites
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Part of PLoS Pathogens, 2023
- DOI for Intraluminal neutrophils limit epithelium damage by reducing pathogen assault on intestinal epithelial cells during Salmonella gut infection
- Download full text (pdf) of Intraluminal neutrophils limit epithelium damage by reducing pathogen assault on intestinal epithelial cells during Salmonella gut infection
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Part of PLoS Pathogens, 2023
- DOI for Trophozoite fitness dictates the intestinal epithelial cell response to Giardia intestinalis infection
- Download full text (pdf) of Trophozoite fitness dictates the intestinal epithelial cell response to Giardia intestinalis infection
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Part of Journal of Cellular Physiology, p. 790-812, 2023
- DOI for The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition
- Download full text (pdf) of The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition
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Epithelial and microbial determinants of colonic drug distribution
Part of European Journal of Pharmaceutical Sciences, 2023
- DOI for Epithelial and microbial determinants of colonic drug distribution
- Download full text (pdf) of Epithelial and microbial determinants of colonic drug distribution
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Part of FEMS Microbiology Letters, 2022
- DOI for The VirF(21):VirF(30) protein ratio is affected by temperature and impacts Shigella flexneri host cell invasion
- Download full text (pdf) of The VirF(21):VirF(30) protein ratio is affected by temperature and impacts Shigella flexneri host cell invasion
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Part of Molecular Microbiology, p. 1156-1172, 2022
- DOI for A motile doublet form of Salmonella Typhimurium diversifies target search behavior at the epithelial surface
- Download full text (pdf) of A motile doublet form of Salmonella Typhimurium diversifies target search behavior at the epithelial surface
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IgE cross-linking induces activation of human and mouse mast cell progenitors
Part of Journal of Allergy and Clinical Immunology, p. 1458-1463, 2022
- DOI for IgE cross-linking induces activation of human and mouse mast cell progenitors
- Download full text (pdf) of IgE cross-linking induces activation of human and mouse mast cell progenitors
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Part of Molecular Oncology, p. 2330-2354, 2022
- DOI for TGF beta selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition
- Download full text (pdf) of TGF beta selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition
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Part of mBio, 2022
- DOI for High-Definition DIC Imaging Uncovers Transient Stages of Pathogen Infection Cycles on the Surface of Human Adult Stem Cell-Derived Intestinal Epithelium
- Download full text (pdf) of High-Definition DIC Imaging Uncovers Transient Stages of Pathogen Infection Cycles on the Surface of Human Adult Stem Cell-Derived Intestinal Epithelium
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Bacterial detection by NAIP/NLRC4 elicits prompt contractions of intestinal epithelial cell layers
Part of Proceedings of the National Academy of Sciences of the United States of America, 2021
- DOI for Bacterial detection by NAIP/NLRC4 elicits prompt contractions of intestinal epithelial cell layers
- Download full text (pdf) of Bacterial detection by NAIP/NLRC4 elicits prompt contractions of intestinal epithelial cell layers
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Part of mBio, 2021
- DOI for Salmonella enterica Serovar Typhimurium Exploits Cycling through Epithelial Cells To Colonize Human and Murine Enteroids
- Download full text (pdf) of Salmonella enterica Serovar Typhimurium Exploits Cycling through Epithelial Cells To Colonize Human and Murine Enteroids
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Part of Journal of Experimental Medicine, 2021
- DOI for Intercrypt sentinel macrophages tune antibacterial NF-kappa B responses in gut epithelial cells via TNF
- Download full text (pdf) of Intercrypt sentinel macrophages tune antibacterial NF-kappa B responses in gut epithelial cells via TNF
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Dynamin inhibition causes context-dependent cell death of leukemia and lymphoma cells
Part of PLOS ONE, 2021
- DOI for Dynamin inhibition causes context-dependent cell death of leukemia and lymphoma cells
- Download full text (pdf) of Dynamin inhibition causes context-dependent cell death of leukemia and lymphoma cells
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Part of Mucosal Immunology, p. 615-629, 2021
- DOI for Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice
- Download full text (pdf) of Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice
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Salmonella Typhimurium discreet-invasion of the murine gut absorptive epithelium
Part of PLoS Pathogens, 2020
- DOI for Salmonella Typhimurium discreet-invasion of the murine gut absorptive epithelium
- Download full text (pdf) of Salmonella Typhimurium discreet-invasion of the murine gut absorptive epithelium
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Part of Mucosal Immunology, p. 530-544, 2020
- DOI for Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression
- Download full text (pdf) of Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression
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Part of Cellular Microbiology, 2020
- DOI for Germ-free and microbiota-associated mice yield small intestinal epithelial organoids with equivalent and robust transcriptome/proteome expression phenotypes
- Download full text (pdf) of Germ-free and microbiota-associated mice yield small intestinal epithelial organoids with equivalent and robust transcriptome/proteome expression phenotypes
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Part of Cell Reports, p. 2665-26788.e1–e3, 2019
- DOI for Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract
- Download full text (pdf) of Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract
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Streptococcal sagA activates a proinflammatory response in mast cells by a sublytic mechanism
Part of Cellular Microbiology, 2019
- DOI for Streptococcal sagA activates a proinflammatory response in mast cells by a sublytic mechanism
- Download full text (pdf) of Streptococcal sagA activates a proinflammatory response in mast cells by a sublytic mechanism
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Part of mBio, 2019
- DOI for The Major RNA-Binding Protein ProQ Impacts Virulence Gene Expression in Salmonella enterica Serovar Typhimurium
- Download full text (pdf) of The Major RNA-Binding Protein ProQ Impacts Virulence Gene Expression in Salmonella enterica Serovar Typhimurium
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Part of mBio, 2019
- DOI for Barcoded Consortium Infections Resolve Cell Type-Dependent Salmonella enterica Serovar Typhimurium Entry Mechanisms
- Download full text (pdf) of Barcoded Consortium Infections Resolve Cell Type-Dependent Salmonella enterica Serovar Typhimurium Entry Mechanisms
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Lysosomotropic challenge of mast cells causes intra-granular reactive oxygen species production
Part of Cell Death Discovery, 2019
- DOI for Lysosomotropic challenge of mast cells causes intra-granular reactive oxygen species production
- Download full text (pdf) of Lysosomotropic challenge of mast cells causes intra-granular reactive oxygen species production
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Mucispirillum schaedleri Antagonizes Salmonella Virulence to Protect Mice against Colitis
Part of Cell Host and Microbe, p. 681-69400000000, 2019
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Salmonella persisters promote the spread of antibiotic resistance plasmids in the gut
Part of Nature, p. 276-280, 2019
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High-avidity IgA protects the intestine by enchaining growing bacteria
Part of Nature, p. 498-+, 2017
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Inflammation boosts bacteriophage transfer between Salmonella spp.
Part of Science, p. 1211-1215, 2017
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Part of PLoS Pathogens, 2016
- DOI for An NK Cell Perforin Response Elicited via IL-18 Controls Mucosal Inflammation Kinetics during Salmonella Gut Infection
- Download full text (pdf) of An NK Cell Perforin Response Elicited via IL-18 Controls Mucosal Inflammation Kinetics during Salmonella Gut Infection
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Part of Cell Host and Microbe, 2016
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Inflammasomes of the intestinal epithelium
Part of Trends in immunology, p. 442-450, 2015
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A Generic Method for Design of Oligomer-Specific Antibodies
Part of PLOS ONE, 2014
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Part of Cell Host and Microbe, p. 237-248, 2014
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Antibiotic treatment selects for cooperative virulence of Salmonella typhimurium.
Part of Current Biology, 2014
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Part of PLoS Pathogens, 2014
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Part of Molecular Biology of the Cell, p. 1594-1607, 2014
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Part of Cellular Microbiology, 2014
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Part of Cellular Microbiology, 2013
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Mammalian SEPT9 isoforms direct microtubule-dependent arrangements of septin core heteromers
Part of Molecular Biology of the Cell, p. 4242-4255, 2012
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Part of PLOS ONE, 2011
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Deciphering the rules governing assembly order of mammalian septin complexes
Part of Molecular Biology of the Cell, p. 3152-3164, 2011
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Microtubules support a disc-like septin arrangement at the plasma membrane of mammalian cells
Part of Molecular Biology of the Cell, p. 4588-4601, 2011
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Part of Experimental Cell Research, p. 2017-2026, 2010
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Part of Cellular and Molecular Life Sciences (CMLS), p. 3263-3276, 2009
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Part of Infection and Immunity, p. 1144-1154, 2009
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Part of Experimental Cell Research, p. 1367-77, 2008
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Global regulation of the interphase microtubule system by abundantly expressed Op18/stathmin
Part of Molecular Biology of the Cell, p. 2897-906, 2008
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Part of Molecular and biochemical parasitology (Print), p. 225-234, 2007
Articles, review/survey
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Part of Seminars in Immunology, 2023
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Salmonella effector driven invasion of the gut epithelium: breaking in and setting the house on fire
Part of Current Opinion in Microbiology, p. 9-18, 2021
- DOI for Salmonella effector driven invasion of the gut epithelium: breaking in and setting the house on fire
- Download full text (pdf) of Salmonella effector driven invasion of the gut epithelium: breaking in and setting the house on fire
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Epithelial inflammasomes in the defense against Salmonella gut infection
Part of Current Opinion in Microbiology, p. 86-94, 2021
- DOI for Epithelial inflammasomes in the defense against Salmonella gut infection
- Download full text (pdf) of Epithelial inflammasomes in the defense against Salmonella gut infection
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Consequences of Epithelial Inflammasome Activation by Bacterial Pathogens
Part of Journal of Molecular Biology, p. 193-206, 2018
Chapters in book
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Part of Bacterial Pathogenesis, p. 295-311, Humana Press, 2023
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Part of Pyroptosis, p. 203-221, Humana Press, 2023