Miao Zhao
- E-mail:
- miao.zhao@igp.uu.se
- Visiting address:
- Dag Hammarskjölds väg 20
751 85 Uppsala - Postal address:
- Rudbecklaboratoriet
751 85 UPPSALA
Keywords
- Photoreceptor tumors: Medulloblastoma; Pineoblastoma; Retinoblastoma
- Mouse models
- Photoreceptor gene therapy
Research
Researcher / Project leader
Medulloblastoma (MB), Pineoblastoma (PB) and Retinoblastoma (RB), three types of malignant pediatric neural brain tumors, are anatomically situated in different parts of the brain but share a common feature: an elevated expression of a photoreceptor “program”. MYC/MYCN-amplified MBs, PBs, and RBs are often histologically indistinguishable, exhibiting aggressive growth, frequent relapse after standard treatment, and a dismal prognosis. It is crucial to comprehend the origin of these photoreceptor-positive tumors and explore whether similar treatment approaches could be effective.
RESEARCH FUNDING
- SciLifeLab (2019 - 2021)
- Swedish Childhood Cancer Foundation: Post-doc fellowship (2021-2023)
- Swedish Childhood Cancer Foundation: Childhood cancer research position (2025-2029)
- Swedish Childhood Cancer Foundation: Project grant (2026-2029)
- NIH (2024-2029)
EDUCATIONAL BACKGROUND
2018: Ph.D. in Cancer Cell Biology, Department of Biosciences and Nutrition, Karolinska Institutet, Sweden.

Publications
Recent publications
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Part of Biochemical Pharmacology, 2026
- DOI for Albacarcin V adds EPLIN as a novel and promising target for the treatment of female cancers and pediatric medulloblastoma
- Download full text (pdf) of Albacarcin V adds EPLIN as a novel and promising target for the treatment of female cancers and pediatric medulloblastoma
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Part of Nature Communications, 2025
- DOI for scFFPE-ATAC enables high-throughput single cell chromatin accessibility profiling in formalin-fixed paraffin-embedded samples
- Download full text (pdf) of scFFPE-ATAC enables high-throughput single cell chromatin accessibility profiling in formalin-fixed paraffin-embedded samples
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Part of Nature Communications, 2025
- DOI for An injury-associated lobular microniche is associated with the classical tumor cell phenotype in pancreatic cancer
- Download full text (pdf) of An injury-associated lobular microniche is associated with the classical tumor cell phenotype in pancreatic cancer
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Part of Cell Death and Disease, 2025
- DOI for Identification of a small molecule targeting EPLIN as a novel strategy for the treatment of pediatric neuroblastoma and medulloblastoma
- Download full text (pdf) of Identification of a small molecule targeting EPLIN as a novel strategy for the treatment of pediatric neuroblastoma and medulloblastoma
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Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies
Part of Cancers, 2024
- DOI for Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies
- Download full text (pdf) of Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies
All publications
Articles in journal
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Part of Biochemical Pharmacology, 2026
- DOI for Albacarcin V adds EPLIN as a novel and promising target for the treatment of female cancers and pediatric medulloblastoma
- Download full text (pdf) of Albacarcin V adds EPLIN as a novel and promising target for the treatment of female cancers and pediatric medulloblastoma
-
Part of Nature Communications, 2025
- DOI for scFFPE-ATAC enables high-throughput single cell chromatin accessibility profiling in formalin-fixed paraffin-embedded samples
- Download full text (pdf) of scFFPE-ATAC enables high-throughput single cell chromatin accessibility profiling in formalin-fixed paraffin-embedded samples
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Part of Nature Communications, 2025
- DOI for An injury-associated lobular microniche is associated with the classical tumor cell phenotype in pancreatic cancer
- Download full text (pdf) of An injury-associated lobular microniche is associated with the classical tumor cell phenotype in pancreatic cancer
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Part of Cell Death and Disease, 2025
- DOI for Identification of a small molecule targeting EPLIN as a novel strategy for the treatment of pediatric neuroblastoma and medulloblastoma
- Download full text (pdf) of Identification of a small molecule targeting EPLIN as a novel strategy for the treatment of pediatric neuroblastoma and medulloblastoma
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An Indolin-3-imine Photobase and pH Sensitive Fluorophore
Part of ChemPhotoChem, 2023
- DOI for An Indolin-3-imine Photobase and pH Sensitive Fluorophore
- Download full text (pdf) of An Indolin-3-imine Photobase and pH Sensitive Fluorophore
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Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells
Part of Cell Death and Disease, 2023
- DOI for Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells
- Download full text (pdf) of Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells
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Part of Nature Communications, 2023
- DOI for ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors
- Download full text (pdf) of ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors
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Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma
Part of Cancer Research, p. 4586-4603, 2022
- DOI for Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma
- Download full text (pdf) of Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma
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Part of Cancers, 2022
- DOI for Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions
- Download full text (pdf) of Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions
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Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples
Part of Genome Research, p. 150-161, 2022
- DOI for Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples
- Download full text (pdf) of Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples
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Part of Nucleic Acids Research, 2021
- DOI for FACT-seq: profiling histone modifications in formalin-fixed paraffin-embedded samples with low cell numbers
- Download full text (pdf) of FACT-seq: profiling histone modifications in formalin-fixed paraffin-embedded samples with low cell numbers
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Part of Nature Communications, 2021
- DOI for Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma
- Download full text (pdf) of Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma
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PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer
Part of Nature Communications, 2019
- DOI for PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer
- Download full text (pdf) of PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer
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Normal mammary gland development after MMTV-Cre mediated conditional PAK4 gene depletion
Part of Scientific Reports, 2019
- DOI for Normal mammary gland development after MMTV-Cre mediated conditional PAK4 gene depletion
- Download full text (pdf) of Normal mammary gland development after MMTV-Cre mediated conditional PAK4 gene depletion
Articles, review/survey
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Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies
Part of Cancers, 2024
- DOI for Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies
- Download full text (pdf) of Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies