Jan Komorowski
Professor at Department of Cell and Molecular Biology; Computational Biology and Bioinformatics
- Telephone:
- +46 18 471 66 92
- Mobile phone:
- +46 70 425 07 75
- E-mail:
- Jan.Komorowski@icm.uu.se
- Visiting address:
- Husargatan 3
752 37 Uppsala - Postal address:
- Box 596
751 24 UPPSALA
- ORCID:
- 0000-0002-0766-8789
Short presentation
Dr. Jan Komorowski is an international leader in the area of Artificial Intelligence for Life Sciences. His research focuses on modelling biological systems from big genomic data with machine learning and statistical methods. At the center of his work are models of complex regulatory mechanisms as they change in response to genetic and environmental factors. Dr. Komorowski has spearheaded applications of rule-based modelling using rough sets and introduced the concept of rule networks.
Keywords
- cancer
- metabolomics
- type 2 diabetes
- machine learning
- transcriptomics
- rosetta
- mcfs
- hiv
- aiv
Biography
Dr. Komorowski received an MSc in Computer Science at the Department of Computer Science at University of Warsaw, Poland, and a PhD in Computer Science at Linköping University, Sweden. Dr. Komorowski was Assistant Professor at Harvard University, Adjunct Professor at MIT, and Full Professor of Computer Science at the Norwegian Institute of Technology in Trondheim, Norway. He was Visiting Professor at Åbo Akademi University in Turku, Finland.
In 2002 he was appointed Full Professor and Chair of Bioinformatics at Uppsala University and Director of the Linnaeus Centre for Bioinformatics that he lead until 2010. In 2018 he received the honorary title of Kurt Mothes Visiting Professorship of Martin Luther University in Halle, Germany. Dr. Komorowski is also a Visiting Professor at the Institute of Computer Science, Polish Academy of Sciences, Warszawa. Currently, Dr. Komorowski is Senior Professor of Bioinformatics and Fellow at the Swedish Collegium for Advanced Study. He also holds an affiliate faculty position Division of Infectious Disease & Translational Medicine Division, University of Washington, Seattle.
Dr. Komorowski has published extensively, among others, in Nature Genetics, Genome Research, Nature, Nucleic Acid Research, Nature Communications and Bioinformatics. He is a well-cited bioinformatician with 7,405 citations at Web of Science and 14,592 at Google Scholar. As of August 2019 his h-indices were: 29 - Web of Science, and 43 - Google Scholar. 20 PhD’s graduated under his advisorship. He contributed to the ENCODE project and is currently a member of the PanCancer consortium. Dr. Komorowski currently holds a prestigious NIH award to develop computational models of immune protection by SIV/HIV vaccines, is a Senior Program Committee Member of the IJCAI 2019 and chaired the 2019 Science for Life Laboratory Summit AI for Life Sciences.

Publications
Recent publications
MindReader: Unsupervised Classification of Electroencephalographic Data
Part of Sensors, 2023
- DOI for MindReader: Unsupervised Classification of Electroencephalographic Data
- Download full text (pdf) of MindReader: Unsupervised Classification of Electroencephalographic Data
Part of Scientific Reports, 2022
Machine Learning-Based Analysis of Glioma Grades Reveals Co-Enrichment
Part of Cancers, 2022
- DOI for Machine Learning-Based Analysis of Glioma Grades Reveals Co-Enrichment
- Download full text (pdf) of Machine Learning-Based Analysis of Glioma Grades Reveals Co-Enrichment
Part of Blood Advances, p. 152-164, 2022
- DOI for Transcriptomic analysis reveals proinflammatory signatures associated with acute myeloid leukemia progression
- Download full text (pdf) of Transcriptomic analysis reveals proinflammatory signatures associated with acute myeloid leukemia progression
Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues
Part of Cell Reports Medicine, 2022
- DOI for Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues
- Download full text (pdf) of Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues
All publications
Articles in journal
MindReader: Unsupervised Classification of Electroencephalographic Data
Part of Sensors, 2023
- DOI for MindReader: Unsupervised Classification of Electroencephalographic Data
- Download full text (pdf) of MindReader: Unsupervised Classification of Electroencephalographic Data
Part of Scientific Reports, 2022
Machine Learning-Based Analysis of Glioma Grades Reveals Co-Enrichment
Part of Cancers, 2022
- DOI for Machine Learning-Based Analysis of Glioma Grades Reveals Co-Enrichment
- Download full text (pdf) of Machine Learning-Based Analysis of Glioma Grades Reveals Co-Enrichment
Part of Blood Advances, p. 152-164, 2022
- DOI for Transcriptomic analysis reveals proinflammatory signatures associated with acute myeloid leukemia progression
- Download full text (pdf) of Transcriptomic analysis reveals proinflammatory signatures associated with acute myeloid leukemia progression
Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues
Part of Cell Reports Medicine, 2022
- DOI for Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues
- Download full text (pdf) of Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues
Part of Nature Communications, 2021
- DOI for Mapping chromatin accessibility and active regulatory elements reveals pathological mechanisms in human gliomas
- Download full text (pdf) of Mapping chromatin accessibility and active regulatory elements reveals pathological mechanisms in human gliomas
Multifaceted regulation of hepatic lipid metabolism by YY1
Part of Life Science Alliance, 2021
- DOI for Multifaceted regulation of hepatic lipid metabolism by YY1
- Download full text (pdf) of Multifaceted regulation of hepatic lipid metabolism by YY1
MetaFetcheR: An R Package for Complete Mapping of Small-Compound Data
Part of Metabolites, 2021
- DOI for MetaFetcheR: An R Package for Complete Mapping of Small-Compound Data
- Download full text (pdf) of MetaFetcheR: An R Package for Complete Mapping of Small-Compound Data
Part of Blood Advances, p. 900-912, 2021
R.ROSETTA: an interpretable machine learning framework
Part of BMC Bioinformatics, 2021
- DOI for R.ROSETTA: an interpretable machine learning framework
- Download full text (pdf) of R.ROSETTA: an interpretable machine learning framework
Nucleolar rDNA folds into condensed foci with a specific combination of epigenetic marks
Part of The Plant Journal, p. 1534-1548, 2021
Interleukin-15 response signature predicts RhCMV/SIV vaccine efficacy
Part of PLoS Pathogens, 2021
- DOI for Interleukin-15 response signature predicts RhCMV/SIV vaccine efficacy
- Download full text (pdf) of Interleukin-15 response signature predicts RhCMV/SIV vaccine efficacy
Interpretable Machine Learning Reveals Dissimilarities Between Subtypes of Autism Spectrum Disorder
Part of Frontiers in Genetics, 2021
- DOI for Interpretable Machine Learning Reveals Dissimilarities Between Subtypes of Autism Spectrum Disorder
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Functional annotation of noncoding mutations in cancer
Part of Life Science Alliance, 2021
- DOI for Functional annotation of noncoding mutations in cancer
- Download full text (pdf) of Functional annotation of noncoding mutations in cancer
Analyses of non-coding somatic drivers in 2,658 cancer whole genomes
Part of Nature, p. 102-111, 2020
- DOI for Analyses of non-coding somatic drivers in 2,658 cancer whole genomes
- Download full text (pdf) of Analyses of non-coding somatic drivers in 2,658 cancer whole genomes
Pan-cancer analysis of whole genomes
Part of Nature, p. 82-93, 2020
- DOI for Pan-cancer analysis of whole genomes
- Download full text (pdf) of Pan-cancer analysis of whole genomes
Part of Omics, p. 180-194, 2020
- DOI for A Multi-Omics Approach to Liver Diseases: Integration of Single Nuclei Transcriptomics with Proteomics and HiCap Bulk Data in Human Liver
- Download full text (pdf) of A Multi-Omics Approach to Liver Diseases: Integration of Single Nuclei Transcriptomics with Proteomics and HiCap Bulk Data in Human Liver
Part of Communications Biology, 2020
- DOI for Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis
- Download full text (pdf) of Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis
Part of Scientific Reports, 2020
- DOI for Integration of whole-body [18F]FDG PET/MRI with non-targeted metabolomics can provide new insights on tissue-specific insulin resistance in type 2 diabetes
- Download full text (pdf) of Integration of whole-body [18F]FDG PET/MRI with non-targeted metabolomics can provide new insights on tissue-specific insulin resistance in type 2 diabetes
Part of Scientific Reports, 2019
- DOI for Allele specific chromatin signals, 3D interactions, and motif predictions for immune and B cell related diseases
- Download full text (pdf) of Allele specific chromatin signals, 3D interactions, and motif predictions for immune and B cell related diseases
Part of Human Genomics, 2019
- DOI for Studies of liver tissue identify functional gene regulatory elements associated to gene expression, type 2 diabetes, and other metabolic diseases
- Download full text (pdf) of Studies of liver tissue identify functional gene regulatory elements associated to gene expression, type 2 diabetes, and other metabolic diseases
Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control
Part of Nature Communications, 2019
- DOI for Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control
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Part of Scientific Reports, 2019
- DOI for Intra- and inter-individual metabolic profiling highlights carnitine and lysophosphatidylcholine pathways as key molecular defects in type 2 diabetes
- Download full text (pdf) of Intra- and inter-individual metabolic profiling highlights carnitine and lysophosphatidylcholine pathways as key molecular defects in type 2 diabetes
Part of Journal of Psychiatric Research, p. 41-47, 2019
Part of Genes, 2018
- DOI for Special Issue Introduction: The Wonders and Mysteries Next Generation Sequencing Technologies Help Reveal
- Download full text (pdf) of Special Issue Introduction: The Wonders and Mysteries Next Generation Sequencing Technologies Help Reveal
Part of Scientific Reports, 2018
- DOI for Unveiling new interdependencies between significant DNA methylation sites, gene expression profiles and glioma patients survival
- Download full text (pdf) of Unveiling new interdependencies between significant DNA methylation sites, gene expression profiles and glioma patients survival
PiiL: visualization of DNA methylation and gene expression data in gene pathways
Part of BMC Genomics, 2017
- DOI for PiiL: visualization of DNA methylation and gene expression data in gene pathways
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Part of International Journal of Cancer, p. 200-209, 2017
Maps of context-dependent putative regulatory regions and genomic signal interactions
Part of Nucleic Acids Research, p. 9110-9120, 2016
- DOI for Maps of context-dependent putative regulatory regions and genomic signal interactions
- Download full text (pdf) of Maps of context-dependent putative regulatory regions and genomic signal interactions
Part of BMC Genomics, 2016
- DOI for Identification of combinatorial host-specific signatures with a potential to affect host adaptation in influenza A H1N1 and H3N2 subtypes
- Download full text (pdf) of Identification of combinatorial host-specific signatures with a potential to affect host adaptation in influenza A H1N1 and H3N2 subtypes
Combinatorial identification of DNA methylation patterns over age in the human brain
Part of BMC Bioinformatics, 2016
- DOI for Combinatorial identification of DNA methylation patterns over age in the human brain
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Part of Human Mutation, p. 904-913, 2016
Part of Molecular Ecology Resources, p. 477-488, 2015
Part of BMC Genomics, 2015
- DOI for Different distribution of histone modifications in genes with unidirectional and bidirectional transcription and a role of CTCF and cohesin in directing transcription
- Download full text (pdf) of Different distribution of histone modifications in genes with unidirectional and bidirectional transcription and a role of CTCF and cohesin in directing transcription
Part of BMC Microbiology, 2015
- DOI for A complete map of potential pathogenicity markers of avian influenza virus subtype H5 predicted from 11 expressed proteins
- Download full text (pdf) of A complete map of potential pathogenicity markers of avian influenza virus subtype H5 predicted from 11 expressed proteins
Ciruvis: a web-based tool for rule networks and interaction detection using rule-based classifiers
Part of BMC Bioinformatics, p. 139, 2014
- DOI for Ciruvis: a web-based tool for rule networks and interaction detection using rule-based classifiers
- Download full text (pdf) of Ciruvis: a web-based tool for rule networks and interaction detection using rule-based classifiers
Nucleosome regulatory dynamics in response to TGF beta
Part of Nucleic Acids Research, p. 6921-6934, 2014
Nucleosome regulatory dynamics in response to TGF-beta treatment in HepG2 cells
Part of Nucleic Acids Research, p. 6921-6934, 2014
Part of Journal of Molecular Medicine, p. 239-254, 2014
- DOI for The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia
- Download full text (pdf) of The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia
Part of Biochimica et Biophysica Acta, p. 1341-1350, 2014
Peak Finder Metaserver - a novel application for finding peaks in ChIP-seq data
Part of BMC Bioinformatics, p. 280, 2013
- DOI for Peak Finder Metaserver - a novel application for finding peaks in ChIP-seq data
- Download full text (pdf) of Peak Finder Metaserver - a novel application for finding peaks in ChIP-seq data
Part of BMC Medical Genomics, p. 50, 2013
Rule-Based Models of the Interplay between Genetic and Environmental Factors in Childhood Allergy
Part of PLOS ONE, 2013
- DOI for Rule-Based Models of the Interplay between Genetic and Environmental Factors in Childhood Allergy
- Download full text (pdf) of Rule-Based Models of the Interplay between Genetic and Environmental Factors in Childhood Allergy
Random Reducts: A Monte Carlo Rough Set-based Method for Feature Selection in Large Datasets
Part of Fundamenta Informaticae, p. 273-288, 2013
Part of Algorithms for Molecular Biology, p. 2, 2012
- DOI for A strand specific high resolution normalization method for chip-sequencing data employing multiple experimental control measurements
- Download full text (pdf) of A strand specific high resolution normalization method for chip-sequencing data employing multiple experimental control measurements
Gis1 and Rph1 Regulate Glycerol and Acetate Metabolism in Glucose Depleted Yeast Cells
Part of PLOS ONE, 2012
- DOI for Gis1 and Rph1 Regulate Glycerol and Acetate Metabolism in Glucose Depleted Yeast Cells
- Download full text (pdf) of Gis1 and Rph1 Regulate Glycerol and Acetate Metabolism in Glucose Depleted Yeast Cells
Combinations of histone modifications mark exon inclusion levels
Part of PLOS ONE, 2012
- DOI for Combinations of histone modifications mark exon inclusion levels
- Download full text (pdf) of Combinations of histone modifications mark exon inclusion levels
Part of Journal of neural transmission, p. 821-831, 2012
Part of BMC Cancer, p. 450, 2011
- DOI for Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosa
- Download full text (pdf) of Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosa
SICTIN: Rapid footprinting of massively parallel sequencing data
Part of BioData Mining, 2010
- DOI for SICTIN: Rapid footprinting of massively parallel sequencing data
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Focal amplifications are associated with high grade and recurrences in stage Ta bladder carcinoma
Part of International Journal of Cancer, p. 1390-1402, 2010
Part of Genome Research, p. 361-371, 2010
Part of Endocrine-Related Cancer, p. 561-579, 2010
Integrative epigenomic and genomic analysis of malignant pheochromocytoma
Part of Experimental and Molecular Medicine, p. 484-502, 2010
A Rough Set-Based Model of HIV-1 Reverse Transcriptase Resistome
Part of Bioinformatics and Biology Insights, p. 109-127, 2009
Part of Epigenetics, p. 107-113, 2009
Part of The FEBS Journal, p. 1878-1890, 2009
Part of Bioinformatics, p. 322-330, 2009
Part of PLoS ONE, 2009
Proteochemometrics mapping of the interaction space for retroviral proteases and their substrates
Part of Bioorganic & Medicinal Chemistry, p. 5229-5237, 2009
Part of Nucleic Acids Research, p. 7498-7508, 2009
Part of Nucleic Acids Research, 2009
Part of Genome Biology, 2009
Characterization of novel and complex genomic aberrations in glioblastoma using a 32K BAC array
Part of Neuro-Oncology, p. 803-818, 2009
Part of Nucleic Acids Research, p. 7498-7508, 2009
Nucleosomes are well positioned in exons and carry characteristic histone modifications
Part of Genome Research, p. 1732-1741, 2009
Part of Genome Research, p. 380-392, 2008
Combinatorial control of gene expression by the three yeast repressors Mig1, Mig2 and Mig3
Part of BMC Genomics, p. 601, 2008
Part of BMC Bioinformatics, p. 484, 2008
Part of American Journal of Human Genetics, p. 763-71, 2008
Somatic mosaicism for copy number variation in differentiated human tissues
Part of Human Mutation, p. 1118-24, 2008
A Segmental Maximum A Posteriori Approach to Genome-wide Copy Number Profiling
Part of Bioinformatics, p. 751-758, 2008
Monte Carlo feature selection for supervised classification
Part of Bioinformatics, p. 110-117, 2008
Part of Molecular Cell, p. 232-46, 2008
Generalized proteochemometric model of multiple cytochrome P450 enzymes and their inhibitors
Part of Journal of chemical information and modeling, p. 1840-1850, 2008
Part of Human Mutation, p. 398-408, 2008
Part of BMC Systems Biology, p. 45, 2007
A look inside HIV resistance through retroviral protease interaction maps
Part of PloS Computational Biology, p. 424-435, 2007
Part of Proteins, p. 83-96, 2007
Computational proteomics analysis of HIV-1 protease interactome
Part of Proteins, p. 305-312, 2007
Part of American journal of medical genetics. Part A, p. 2178-2184, 2007
Endocan is a VEGF-A and PI3K regulated gene with increased expression in human renal cancer
Part of Experimental Cell Research, p. 1285-1294, 2007
Part of Genome Research, p. 708-719, 2007
Part of Nature, p. 799-816, 2007
Part of American Journal of Medical Genetics, Part A, p. 1760-1766, 2007
Rough set-based proteochemometrics modeling of G-protein-coupled receptor-ligand
Part of Proteins, p. 24-34, 2006
Part of Human Molecular Genetics, p. 3435-3447, 2005
Gene expression based classification of gastric carcinoma.
Part of Cancer Lett, p. 227-37, 2004
Feature synthesis and extraction for the construction of generalized properties of amino acids
Part of Rough Sets and Current Trends in Computing, p. 786-791, 2004
Liver gene expression in rats in response to the peroxisome proliferator-activated
Part of Physiol Genomics, p. 9-19, 2003
Learning rough set classifiers from gene expressions and clinical data
Part of Fundamenta Informaticae, p. 155-183, 2002
Articles, review/survey
Part of Transactions on Rough Sets VII: Lecture Notes in Computer Science 4400, p. 225-243, 2007
Chapters in book
Discovering Networks of Interdependent Features in High-Dimensional Problems
Part of Big Data Analysis, p. 285-304, Springer, 2016
Learning Rule-Based Models - The Rough Set Approach
Part of Comprehensive Biomedical Physics, p. 19-39, Elsevier, 2014
Monte Carlo feature selection and interdependency discovery in supervised classification
Part of Advances in Machine Learning, Springer, 2010
Conference papers
Visualization of Rules in Rule-Based Classifiers
Part of INTELLIGENT DECISION TECHNOLOGIES (IDT'2012), VOL 1, p. 329-338, 2012
Part of GRANULAR COMPUTING, p. 249-258, 2008
RoSy: A Rough Knowledge Base System
Part of Rough Sets, Fuzzy Sets, Data Mining, and Granular Computing, p. 48-58, 2005
Altered gene expression in the olfactory bulb following exposure to 2,6-dichlorophenyl methylsulfone
Part of Toxicology Letters 158 Supp 1., p. 61, 2005
Datasets
Manuscripts (preprints)
VisuNet: an interactive tool for rule network visualization of rule-based learning models
Part of SUPPLEMENTARY MATERIAL: VisuNet: an interactive tool for rule network visualization of rule-based learning models
funMotifs: Tissue-specific transcription factor motifs
Part of SUPPLEMENTARY MATERIAL: funMotifs: Tissue-specific transcription factor motifs