Malin Jarvius

The method developer's guide to oligonucleotide design

Wenson, Leonie; Leino, Mattias; Jarvius, Malin; Heldin, Johan et al.

Part of Expert Review of Proteomics, p. 65-80, 2024

• DOI for The method developer's guide to oligonucleotide design
• Download full text (pdf) of The method developer's guide to oligonucleotide design

Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models

Selvin, Tove; Berglund, Malin; Akerstrom, Anders; Zia, Marco et al.

Part of SLAS TECHNOLOGY, 2024

• DOI for Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models
• Download full text (pdf) of Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models

Discovery of a novel inhibitor of macropinocytosis with antiviral activity

Porebski, Bartlomiej; Christ, Wanda; Corman, Alba; Haraldsson, Martin et al.

Part of Molecular Therapy, p. 3012-3024, 2024

• DOI for Discovery of a novel inhibitor of macropinocytosis with antiviral activity
• Download full text (pdf) of Discovery of a novel inhibitor of macropinocytosis with antiviral activity

Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment

Selvin, Tove; Berglund, Malin; Lenhammar, Lena; Lindskog, Magnus et al.

Part of BMC Pharmacology & Toxicology, 2024

• DOI for Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment
• Download full text (pdf) of Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment

Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death

Selvin, Tove; Berglund, Malin; Lenhammar, Lena; Jarvius, Malin et al.

Part of BMC Cancer, 2023

• DOI for Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death
• Download full text (pdf) of Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death

Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models

Selvin, Tove; Berglund, Malin; Akerstrom, Anders; Zia, Marco et al.

Part of SLAS TECHNOLOGY, 2024

• DOI for Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models
• Download full text (pdf) of Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models

Discovery of a novel inhibitor of macropinocytosis with antiviral activity

Porebski, Bartlomiej; Christ, Wanda; Corman, Alba; Haraldsson, Martin et al.

Part of Molecular Therapy, p. 3012-3024, 2024

• DOI for Discovery of a novel inhibitor of macropinocytosis with antiviral activity
• Download full text (pdf) of Discovery of a novel inhibitor of macropinocytosis with antiviral activity

Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment

Selvin, Tove; Berglund, Malin; Lenhammar, Lena; Lindskog, Magnus et al.

Part of BMC Pharmacology & Toxicology, 2024

• DOI for Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment
• Download full text (pdf) of Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment

Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death

Selvin, Tove; Berglund, Malin; Lenhammar, Lena; Jarvius, Malin et al.

Part of BMC Cancer, 2023

• DOI for Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death
• Download full text (pdf) of Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Bonagas, Nadilly; Gustafsson, Nina M. S.; Henriksson, Martin; Marttila, Petra et al.

Part of Nature Cancer, p. 156, 2022

• DOI for Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
• Download full text (pdf) of Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Single-cell transcriptional pharmacodynamics of trifluridine in a tumor-immune model

Selvin, Tove; Fasterius, Erik; Jarvius, Malin; Fryknäs, Mårten et al.

Part of Scientific Reports, 2022

• DOI for Single-cell transcriptional pharmacodynamics of trifluridine in a tumor-immune model
• Download full text (pdf) of Single-cell transcriptional pharmacodynamics of trifluridine in a tumor-immune model

Sorafenib and nitazoxanide disrupt mitochondrial function and inhibit regrowth capacity in three-dimensional models of hepatocellular and colorectal carcinoma

Nyberg, Frida; Blom, Kristin; Selvin, Tove; Rudfeldt, Jakob et al.

Part of Scientific Reports, 2022

• DOI for Sorafenib and nitazoxanide disrupt mitochondrial function and inhibit regrowth capacity in three-dimensional models of hepatocellular and colorectal carcinoma
• Download full text (pdf) of Sorafenib and nitazoxanide disrupt mitochondrial function and inhibit regrowth capacity in three-dimensional models of hepatocellular and colorectal carcinoma

Mebendazole is unique among tubulin-active drugs in activating the MEK-ERK pathway

Andersson, Claes; Selvin, Tove; Blom, Kristin; Rubin, Jenny et al.

Part of Scientific Reports, 2020

• DOI for Mebendazole is unique among tubulin-active drugs in activating the MEK-ERK pathway
• Download full text (pdf) of Mebendazole is unique among tubulin-active drugs in activating the MEK-ERK pathway

Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition

Blom, Kristin; Eriksson, Jenny; Berglund, Malin; Jarvius, Malin et al.

Part of BMC Research Notes, 2019

• DOI for Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition
• Download full text (pdf) of Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition

COMBImage2: a parallel computational framework for higher-order drug combination analysis that includes automated plate design, matched filter based object counting and temporal data mining

Chantzi, Efthymia; Jarvius, Malin; Niklasson, Mia; Segerman, Anna et al.

Part of BMC Bioinformatics, 2019

• DOI for COMBImage2: a parallel computational framework for higher-order drug combination analysis that includes automated plate design, matched filter based object counting and temporal data mining
• Download full text (pdf) of COMBImage2: a parallel computational framework for higher-order drug combination analysis that includes automated plate design, matched filter based object counting and temporal data mining

LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Xie, Yuan; Sundström, Anders; Maturi, Naga P; Tan, E-Jean et al.

Part of Journal of Pathology, p. 228-240, 2019

• DOI for LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Mesenchymal transition and increased therapy resistance of glioblastoma cells is related to astrocyte reactivity

Niklasson, Mia; Bergström, Tobias; Jarvius, Malin; Sundström, Anders et al.

Part of Journal of Pathology, p. 295-307, 2019

• DOI for Mesenchymal transition and increased therapy resistance of glioblastoma cells is related to astrocyte reactivity

COMBImage: a modular parallel processing framework for pairwise drug combination analysis that quantifies temporal changes in label-free video microscopy movies

Chantzi, Efthymia; Jarvius, Malin; Niklasson, Mia; Segerman, Anna et al.

Part of BMC Bioinformatics, 2018

• DOI for COMBImage: a modular parallel processing framework for pairwise drug combination analysis that quantifies temporal changes in label-free video microscopy movies
• Download full text (pdf) of COMBImage: a modular parallel processing framework for pairwise drug combination analysis that quantifies temporal changes in label-free video microscopy movies

Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin

Jiang, Yiwen; Marinescu, Voichita Dana; Xie, Yuan; Jarvius, Malin et al.

Part of Cell Reports, p. 977-990, 2017

• DOI for Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin
• Download full text (pdf) of Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin

Mouse models of pediatric supratentorial high-grade glioma reveal how cell-of-origin influences tumor development and phenotype

Sreedharan, Smitha; Maturi, Naga Prathyusha; Xie, Yuan; Sundström, Anders et al.

Part of Cancer Research, p. 802-812, 2017

• DOI for Mouse models of pediatric supratentorial high-grade glioma reveal how cell-of-origin influences tumor development and phenotype

Targeting tumor cells based on Phosphodiesterase 3A expression

Nazir, Madiha; Senkowski, Wojciech; Nyberg, Frida; Blom, Kristin et al.

Part of Experimental Cell Research, p. 308-315, 2017

• DOI for Targeting tumor cells based on Phosphodiesterase 3A expression

The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation

Blom, Kristin; Senkowski, Wojciech; Jarvius, Malin; Berglund, Malin et al.

Part of Immunopharmacology and immunotoxicology, p. 199-210, 2017

• DOI for The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation

Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition

Segerman, Anna; Niklasson, Mia; Haglund, Caroline; Bergström, Tobias et al.

Part of Cell Reports, p. 2994-3009, 2016

• DOI for Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition
• Download full text (pdf) of Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition

Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids

Senkowski, Wojciech; Jarvius, Malin; Rubin, Jenny; Lengqvist, Johan et al.

Part of CELL CHEMICAL BIOLOGY, p. 1428-1438, 2016

• DOI for Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids

Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia

Eriksson, Anna; Österroos, Albin; Hassan, Sadia Bashir; Gullbo, Joachim et al.

Part of Blood Cancer Journal, 2015

• DOI for Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia
• Download full text (pdf) of Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia

Evaluation of Intracellular Signaling Downstream Chimeric Antigen Receptors

Karlsson, Hannah; Svensson, Emma; Gigg, Camilla; Jarvius, Malin et al.

Part of PLOS ONE, 2015

• DOI for Evaluation of Intracellular Signaling Downstream Chimeric Antigen Receptors
• Download full text (pdf) of Evaluation of Intracellular Signaling Downstream Chimeric Antigen Receptors

Antigen Signaling Enhances Proliferation and Cytotoxic Capacity of CD19-Targeting CD28/4-1BB CAR T Cells During Expansion Without Inducing Exhaustion

Karlsson, Hannah; Gigg, Camilla; Svensson, Emma; Larsson, Rolf et al.

Part of Molecular Therapy, 2014

AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and a dose dependent reduction of kinase activity in acute myeloid leukemia

Eriksson, Anna; Kalushkova, Antonia; Jarvius, Malin; Hilhorst, Riet et al.

Part of Biochemical Pharmacology, p. 284-291, 2014

• DOI for AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and a dose dependent reduction of kinase activity in acute myeloid leukemia
• Download full text (pdf) of AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and a dose dependent reduction of kinase activity in acute myeloid leukemia

Repositioning of Quinacrine for Treatment of Acute Myeloid Leukemia

Eriksson, Anna; Osterros, Albin; Hassan, Sadia Bashir; Gullbo, Joachim et al.

Part of Blood, 2014

Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance

Fryknäs, Mårten; Gullbo, Joachim; Wang, Xin; Rickardson, Linda et al.

Part of BMC Cancer, p. 374, 2013

• DOI for Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance
• Download full text (pdf) of Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance

Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells

Jarvius, Malin; Fryknäs, Mårten; D'Arcy, Padraig; Sun, Chao et al.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 117-123, 2013

• DOI for Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells

VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts

Nilsson, Ingrid; Bahram, Fuad; Li, Xiujuan; Gualandi, Laura et al.

Part of EMBO Journal, p. 1377-1388, 2010

• DOI for VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts

High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligation

Leuchowius, Karl-Johan; Jarvius, Malin; Wickström, Malin; Rickardson, Linda et al.

Part of Molecular & Cellular Proteomics, p. 178-183, 2010

• DOI for High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligation

Platelet-derived growth factor receptor expression and activation in choroid plexus tumors

Koos, Björn; Paulsson, Janna; Jarvius, Malin; Sanchez, Betzabe Chavez et al.

Part of American Journal of Pathology, p. 1631-1637, 2009

• DOI for Platelet-derived growth factor receptor expression and activation in choroid plexus tumors

Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay.

Söderberg, Ola; Leuchowius, Karl-Johan; Gullberg, Mats; Jarvius, Malin et al.

Part of Methods, p. 227-32, 2008

• DOI for Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay.

In situ detection of phosphorylated platelet-derived growth factor receptor beta using a generalized proximity ligation method

Jarvius, Malin; Paulsson, Janna; Weibrecht, Irene; Leuchowius, Karl-Johan et al.

Part of Molecular & Cellular Proteomics, p. 1500-1509, 2007

• DOI for In situ detection of phosphorylated platelet-derived growth factor receptor beta using a generalized proximity ligation method

Direct observation of individual endogenous protein complexes in situ by proximity ligation

Söderberg, Ola; Gullberg, Mats; Jarvius, Malin; Ridderstråle, Karin et al.

Part of Nature Methods, p. 995-1000, 2006

• DOI for Direct observation of individual endogenous protein complexes in situ by proximity ligation

The method developer's guide to oligonucleotide design

Wenson, Leonie; Leino, Mattias; Jarvius, Malin; Heldin, Johan et al.

Part of Expert Review of Proteomics, p. 65-80, 2024

• DOI for The method developer's guide to oligonucleotide design
• Download full text (pdf) of The method developer's guide to oligonucleotide design

Proximity ligation assays: a recent addition to the proteomics toolbox

Weibrecht, Irene; Leuchowius, Karl-Johan; Clausson, Carl-Magnus; Conze, Tim et al.

Part of Expert Reviews of Proteomics, p. 401-409, 2010

• DOI for Proximity ligation assays: a recent addition to the proteomics toolbox

Proximity ligation assays for sensitive and specific protein analyses.

Gustafsdottir, Sigrun M; Schallmeiner, Edith; Fredriksson, Simon; Gullberg, Mats et al.

Part of Anal Biochem, p. 2-9, 2005

Protein diagnostics by proximity ligation: Combining multiple recognition and DNA amplification for improved protein analysis

Leuchowius, Karl-Johan; Söderberg, Ola; Kamali-Moghaddam, Masood; Jarvius, Malin et al.

Part of Molecular Diagnostics, p. 299-306, Elsevier/Academic Press, 2010

Proximity ligation: a specific and versatile tool for the proteomic era.

Söderberg, Ola; Leuchowius, Karl-Johan; Kamali-Moghaddam, Masood; Jarvius, Malin et al.

Part of Genet Eng (N Y)., p. 190, Springer, 2007

Paired glioblastoma cell cultures of the fluorescent bulk tumor and non-fluorescent tumor margin display differential phenotypes and cell states across patients

Neves, Inês; Lu, Xi; Maturi, Nagaprathyusha; Dang, Yonglong et al.

Novel anti-cancer agents targeting NAT2 loss in colorectal cancer

Rameika, Natallia; Tsiara, Ioanna; Haberek, Wawrzyniec; Akcan, Ece et al.