Malin Jarvius

The method developer's guide to oligonucleotide design

Wenson, Leonie; Leino, Mattias; Jarvius, Malin; Heldin, Johan et al.

Ingår i Expert Review of Proteomics, s. 65-80, 2024

• DOI för The method developer's guide to oligonucleotide design
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Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models

Selvin, Tove; Berglund, Malin; Akerstrom, Anders; Zia, Marco et al.

Ingår i SLAS TECHNOLOGY, 2024

• DOI för Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models
• Ladda ner fulltext (pdf) av Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models

Discovery of a novel inhibitor of macropinocytosis with antiviral activity

Porebski, Bartlomiej; Christ, Wanda; Corman, Alba; Haraldsson, Martin et al.

Ingår i Molecular Therapy, s. 3012-3024, 2024

• DOI för Discovery of a novel inhibitor of macropinocytosis with antiviral activity
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Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment

Selvin, Tove; Berglund, Malin; Lenhammar, Lena; Lindskog, Magnus et al.

Ingår i BMC Pharmacology & Toxicology, 2024

• DOI för Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment
• Ladda ner fulltext (pdf) av Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment

Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death

Selvin, Tove; Berglund, Malin; Lenhammar, Lena; Jarvius, Malin et al.

Ingår i BMC Cancer, 2023

• DOI för Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death
• Ladda ner fulltext (pdf) av Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death

Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models

Selvin, Tove; Berglund, Malin; Akerstrom, Anders; Zia, Marco et al.

Ingår i SLAS TECHNOLOGY, 2024

• DOI för Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models
• Ladda ner fulltext (pdf) av Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models

Discovery of a novel inhibitor of macropinocytosis with antiviral activity

Porebski, Bartlomiej; Christ, Wanda; Corman, Alba; Haraldsson, Martin et al.

Ingår i Molecular Therapy, s. 3012-3024, 2024

• DOI för Discovery of a novel inhibitor of macropinocytosis with antiviral activity
• Ladda ner fulltext (pdf) av Discovery of a novel inhibitor of macropinocytosis with antiviral activity

Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment

Selvin, Tove; Berglund, Malin; Lenhammar, Lena; Lindskog, Magnus et al.

Ingår i BMC Pharmacology & Toxicology, 2024

• DOI för Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment
• Ladda ner fulltext (pdf) av Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment

Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death

Selvin, Tove; Berglund, Malin; Lenhammar, Lena; Jarvius, Malin et al.

Ingår i BMC Cancer, 2023

• DOI för Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death
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Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Bonagas, Nadilly; Gustafsson, Nina M. S.; Henriksson, Martin; Marttila, Petra et al.

Ingår i Nature Cancer, s. 156, 2022

• DOI för Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
• Ladda ner fulltext (pdf) av Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Single-cell transcriptional pharmacodynamics of trifluridine in a tumor-immune model

Selvin, Tove; Fasterius, Erik; Jarvius, Malin; Fryknäs, Mårten et al.

Ingår i Scientific Reports, 2022

• DOI för Single-cell transcriptional pharmacodynamics of trifluridine in a tumor-immune model
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Sorafenib and nitazoxanide disrupt mitochondrial function and inhibit regrowth capacity in three-dimensional models of hepatocellular and colorectal carcinoma

Nyberg, Frida; Blom, Kristin; Selvin, Tove; Rudfeldt, Jakob et al.

Ingår i Scientific Reports, 2022

• DOI för Sorafenib and nitazoxanide disrupt mitochondrial function and inhibit regrowth capacity in three-dimensional models of hepatocellular and colorectal carcinoma
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Mebendazole is unique among tubulin-active drugs in activating the MEK-ERK pathway

Andersson, Claes; Selvin, Tove; Blom, Kristin; Rubin, Jenny et al.

Ingår i Scientific Reports, 2020

• DOI för Mebendazole is unique among tubulin-active drugs in activating the MEK-ERK pathway
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Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition

Blom, Kristin; Eriksson, Jenny; Berglund, Malin; Jarvius, Malin et al.

Ingår i BMC Research Notes, 2019

• DOI för Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition
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COMBImage2: a parallel computational framework for higher-order drug combination analysis that includes automated plate design, matched filter based object counting and temporal data mining

Chantzi, Efthymia; Jarvius, Malin; Niklasson, Mia; Segerman, Anna et al.

Ingår i BMC Bioinformatics, 2019

• DOI för COMBImage2: a parallel computational framework for higher-order drug combination analysis that includes automated plate design, matched filter based object counting and temporal data mining
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LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Xie, Yuan; Sundström, Anders; Maturi, Naga P; Tan, E-Jean et al.

Ingår i Journal of Pathology, s. 228-240, 2019

• DOI för LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Mesenchymal transition and increased therapy resistance of glioblastoma cells is related to astrocyte reactivity

Niklasson, Mia; Bergström, Tobias; Jarvius, Malin; Sundström, Anders et al.

Ingår i Journal of Pathology, s. 295-307, 2019

• DOI för Mesenchymal transition and increased therapy resistance of glioblastoma cells is related to astrocyte reactivity

COMBImage: a modular parallel processing framework for pairwise drug combination analysis that quantifies temporal changes in label-free video microscopy movies

Chantzi, Efthymia; Jarvius, Malin; Niklasson, Mia; Segerman, Anna et al.

Ingår i BMC Bioinformatics, 2018

• DOI för COMBImage: a modular parallel processing framework for pairwise drug combination analysis that quantifies temporal changes in label-free video microscopy movies
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Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin

Jiang, Yiwen; Marinescu, Voichita Dana; Xie, Yuan; Jarvius, Malin et al.

Ingår i Cell Reports, s. 977-990, 2017

• DOI för Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin
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Mouse models of pediatric supratentorial high-grade glioma reveal how cell-of-origin influences tumor development and phenotype

Sreedharan, Smitha; Maturi, Naga Prathyusha; Xie, Yuan; Sundström, Anders et al.

Ingår i Cancer Research, s. 802-812, 2017

• DOI för Mouse models of pediatric supratentorial high-grade glioma reveal how cell-of-origin influences tumor development and phenotype

Targeting tumor cells based on Phosphodiesterase 3A expression

Nazir, Madiha; Senkowski, Wojciech; Nyberg, Frida; Blom, Kristin et al.

Ingår i Experimental Cell Research, s. 308-315, 2017

• DOI för Targeting tumor cells based on Phosphodiesterase 3A expression

The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation

Blom, Kristin; Senkowski, Wojciech; Jarvius, Malin; Berglund, Malin et al.

Ingår i Immunopharmacology and immunotoxicology, s. 199-210, 2017

• DOI för The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation

Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition

Segerman, Anna; Niklasson, Mia; Haglund, Caroline; Bergström, Tobias et al.

Ingår i Cell Reports, s. 2994-3009, 2016

• DOI för Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition
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Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids

Senkowski, Wojciech; Jarvius, Malin; Rubin, Jenny; Lengqvist, Johan et al.

Ingår i CELL CHEMICAL BIOLOGY, s. 1428-1438, 2016

• DOI för Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids

Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia

Eriksson, Anna; Österroos, Albin; Hassan, Sadia Bashir; Gullbo, Joachim et al.

Ingår i Blood Cancer Journal, 2015

• DOI för Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia
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Evaluation of Intracellular Signaling Downstream Chimeric Antigen Receptors

Karlsson, Hannah; Svensson, Emma; Gigg, Camilla; Jarvius, Malin et al.

Ingår i PLOS ONE, 2015

• DOI för Evaluation of Intracellular Signaling Downstream Chimeric Antigen Receptors
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Antigen Signaling Enhances Proliferation and Cytotoxic Capacity of CD19-Targeting CD28/4-1BB CAR T Cells During Expansion Without Inducing Exhaustion

Karlsson, Hannah; Gigg, Camilla; Svensson, Emma; Larsson, Rolf et al.

Ingår i Molecular Therapy, 2014

AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and a dose dependent reduction of kinase activity in acute myeloid leukemia

Eriksson, Anna; Kalushkova, Antonia; Jarvius, Malin; Hilhorst, Riet et al.

Ingår i Biochemical Pharmacology, s. 284-291, 2014

• DOI för AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and a dose dependent reduction of kinase activity in acute myeloid leukemia
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Repositioning of Quinacrine for Treatment of Acute Myeloid Leukemia

Eriksson, Anna; Osterros, Albin; Hassan, Sadia Bashir; Gullbo, Joachim et al.

Ingår i Blood, 2014

Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance

Fryknäs, Mårten; Gullbo, Joachim; Wang, Xin; Rickardson, Linda et al.

Ingår i BMC Cancer, s. 374, 2013

• DOI för Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance
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Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells

Jarvius, Malin; Fryknäs, Mårten; D'Arcy, Padraig; Sun, Chao et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 117-123, 2013

• DOI för Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells

VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts

Nilsson, Ingrid; Bahram, Fuad; Li, Xiujuan; Gualandi, Laura et al.

Ingår i EMBO Journal, s. 1377-1388, 2010

• DOI för VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts

High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligation

Leuchowius, Karl-Johan; Jarvius, Malin; Wickström, Malin; Rickardson, Linda et al.

Ingår i Molecular & Cellular Proteomics, s. 178-183, 2010

• DOI för High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligation

Platelet-derived growth factor receptor expression and activation in choroid plexus tumors

Koos, Björn; Paulsson, Janna; Jarvius, Malin; Sanchez, Betzabe Chavez et al.

Ingår i American Journal of Pathology, s. 1631-1637, 2009

• DOI för Platelet-derived growth factor receptor expression and activation in choroid plexus tumors

Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay.

Söderberg, Ola; Leuchowius, Karl-Johan; Gullberg, Mats; Jarvius, Malin et al.

Ingår i Methods, s. 227-32, 2008

• DOI för Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay.

In situ detection of phosphorylated platelet-derived growth factor receptor beta using a generalized proximity ligation method

Jarvius, Malin; Paulsson, Janna; Weibrecht, Irene; Leuchowius, Karl-Johan et al.

Ingår i Molecular & Cellular Proteomics, s. 1500-1509, 2007

• DOI för In situ detection of phosphorylated platelet-derived growth factor receptor beta using a generalized proximity ligation method

Direct observation of individual endogenous protein complexes in situ by proximity ligation

Söderberg, Ola; Gullberg, Mats; Jarvius, Malin; Ridderstråle, Karin et al.

Ingår i Nature Methods, s. 995-1000, 2006

• DOI för Direct observation of individual endogenous protein complexes in situ by proximity ligation

The method developer's guide to oligonucleotide design

Wenson, Leonie; Leino, Mattias; Jarvius, Malin; Heldin, Johan et al.

Ingår i Expert Review of Proteomics, s. 65-80, 2024

• DOI för The method developer's guide to oligonucleotide design
• Ladda ner fulltext (pdf) av The method developer's guide to oligonucleotide design

Proximity ligation assays: a recent addition to the proteomics toolbox

Weibrecht, Irene; Leuchowius, Karl-Johan; Clausson, Carl-Magnus; Conze, Tim et al.

Ingår i Expert Reviews of Proteomics, s. 401-409, 2010

• DOI för Proximity ligation assays: a recent addition to the proteomics toolbox

Proximity ligation assays for sensitive and specific protein analyses.

Gustafsdottir, Sigrun M; Schallmeiner, Edith; Fredriksson, Simon; Gullberg, Mats et al.

Ingår i Anal Biochem, s. 2-9, 2005

Protein diagnostics by proximity ligation: Combining multiple recognition and DNA amplification for improved protein analysis

Leuchowius, Karl-Johan; Söderberg, Ola; Kamali-Moghaddam, Masood; Jarvius, Malin et al.

Ingår i Molecular Diagnostics, s. 299-306, Elsevier/Academic Press, 2010

Proximity ligation: a specific and versatile tool for the proteomic era.

Söderberg, Ola; Leuchowius, Karl-Johan; Kamali-Moghaddam, Masood; Jarvius, Malin et al.

Ingår i Genet Eng (N Y)., s. 190, Springer, 2007

Paired glioblastoma cell cultures of the fluorescent bulk tumor and non-fluorescent tumor margin display differential phenotypes and cell states across patients

Neves, Inês; Lu, Xi; Maturi, Nagaprathyusha; Dang, Yonglong et al.

Novel anti-cancer agents targeting NAT2 loss in colorectal cancer

Rameika, Natallia; Tsiara, Ioanna; Haberek, Wawrzyniec; Akcan, Ece et al.