Fredrik Jernerén

Homocysteine Status Modifies the Treatment Effect of Omega-3 Fatty Acids on Cognition in a Randomized Clinical Trial in Mild to Moderate Alzheimer's Disease: The OmegAD Study

Jernerén, Fredrik; Cederholm, Tommy; Refsum, Helga; Smith, A. David et al.

Part of Journal of Alzheimer's Disease, p. 189-197, 2019

• DOI for Homocysteine Status Modifies the Treatment Effect of Omega-3 Fatty Acids on Cognition in a Randomized Clinical Trial in Mild to Moderate Alzheimer's Disease: The OmegAD Study

Homocysteine concentrations in the cognitive progression of Alzheimer's disease

Farina, Nicolas; Jernerén, Fredrik; Turner, Cheryl; Hart, Kathryn et al.

Part of Experimental Gerontology, p. 146-150, 2017

• DOI for Homocysteine concentrations in the cognitive progression of Alzheimer's disease

Omega-3 Fatty Acid Status Enhances the Prevention of Cognitive Decline by B Vitamins in Mild Cognitive Impairment.

Oulhaj, Abderrahim; Jernerén, Fredrik; Refsum, Helga; Smith, A David et al.

Part of Journal of Alzheimer's Disease, p. 547-57, 2016

• DOI for Omega-3 Fatty Acid Status Enhances the Prevention of Cognitive Decline by B Vitamins in Mild Cognitive Impairment.

A new class of fatty acid allene oxide formed by the DOX-P450 fusion proteins of human and plant pathogenic fungi, C. immitis and Z. tritici.

Oliw, Ernst H; Aragó, Marc; Chen, Yang; Jernerén, Fredrik

Part of Journal of Lipid Research, p. 1518-1528, 2016

• DOI for A new class of fatty acid allene oxide formed by the DOX-P450 fusion proteins of human and plant pathogenic fungi, C. immitis and Z. tritici.

Post-sampling release of free fatty acids -: effects of heat stabilization and methods of euthanasia

Jernerén, Fredrik; Söderquist, Marcus; Karlsson, Oskar

Part of Journal of pharmacological and toxicological methods, p. 13-20, 2015

• DOI for Post-sampling release of free fatty acids -: effects of heat stabilization and methods of euthanasia

Brain atrophy in cognitively impaired elderly: the importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial.

Jernerén, Fredrik; Elshorbagy, Amany K; Oulhaj, Abderrahim; Smith, Stephen M et al.

Part of American Journal of Clinical Nutrition, p. 215-21, 2015

• DOI for Brain atrophy in cognitively impaired elderly: the importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial.

The Fatty Acid 8,11-Diol Synthase of Aspergillus fumigatus is Inhibited by Imidazole Derivatives and Unrelated to PpoB

Jernerén, Fredrik; Oliw, Ernst H.

Part of Lipids, p. 707-717, 2012

• DOI for The Fatty Acid 8,11-Diol Synthase of Aspergillus fumigatus is Inhibited by Imidazole Derivatives and Unrelated to PpoB

Linolenate 9R-Dioxygenase and Allene Oxide Synthase Activities of Lasiodiplodia theobromae

Jernerén, Fredrik; Eng, Felipe; Hamberg, Mats; Oliw, Ernst H

Part of Lipids, p. 65-73, 2012

• DOI for Linolenate 9R-Dioxygenase and Allene Oxide Synthase Activities of Lasiodiplodia theobromae

Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus

Jernerén, Fredrik; Garscha, Ulrike; Hoffmann, Inga; Hamberg, Mats et al.

Part of Biochimica et Biophysica Acta, p. 503-507, 2010

• DOI for Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus

Gene deletion of 7,8-linoleate diol synthase of the rice blast fungus: studies on pathogenicity, stereochemistry, and oxygenation mechanisms

Jernerén, Fredrik; Sesma, Ane; Francheschetti, Marina; Hamberg, Mats et al.

Part of Journal of Biological Chemistry, p. 5308-5316, 2010

• DOI for Gene deletion of 7,8-linoleate diol synthase of the rice blast fungus: studies on pathogenicity, stereochemistry, and oxygenation mechanisms

Linoleate 9R-dioxygenase and allene oxide synthase activities of Aspergillus terreus

Jernerén, Fredrik; Hoffmann, Inga; Oliw, Ernst H

Part of Archives of Biochemistry and Biophysics, p. 67-73, 2010

• DOI for Linoleate 9R-dioxygenase and allene oxide synthase activities of Aspergillus terreus

Role of B vitamins in modulating homocysteine and metabolic pathways linked to brain atrophy: Metabolomics insights from the VITACOG trial

Kacerova, Tereza; Yates, Abi G.; Dai, Jiayi; Shepherd, Dawn et al.

Part of Alzheimer's & Dementia, 2025

• DOI for Role of B vitamins in modulating homocysteine and metabolic pathways linked to brain atrophy: Metabolomics insights from the VITACOG trial
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Elevated homocysteine is associated with increased rates of epigenetic aging in a population with mild cognitive impairment

Holmes, Holly E.; Valentin, Rafael E.; Jernerén, Fredrik; Loots, Celeste A. de Jager et al.

Part of Aging Cell, 2024

• DOI for Elevated homocysteine is associated with increased rates of epigenetic aging in a population with mild cognitive impairment
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Extracellular cystine influences human preadipocyte differentiation and correlates with fat mass in healthy adults

Elkafrawy, Hagar; Mehanna, Radwa; Ali, Fayrouz; Barghash, Ayman et al.

Part of Amino Acids, p. 1623-1634, 2021

• DOI for Extracellular cystine influences human preadipocyte differentiation and correlates with fat mass in healthy adults
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ω-3 fatty acids and their interactions

Smith, A. David; Jernerén, Fredrik; Refsum, Helga

Part of American Journal of Clinical Nutrition, p. 775-778, 2021

• DOI for ω-3 fatty acids and their interactions

Changes in plasma fatty acids and related biomarkers during transition to an exclusively plant- and fish-based diet in healthy adults

Alshahawy, Rasha; El Habachi, Nihal; Allam, Eman; Jernerén, Fredrik et al.

Part of Nutrition, 2021

• DOI for Changes in plasma fatty acids and related biomarkers during transition to an exclusively plant- and fish-based diet in healthy adults

Role of B vitamins in modulating homocysteine and metabolic pathways linked to brain atrophy: Metabolomics insights from the VITACOG trial

Kacerova, Tereza; Yates, Abi G.; Dai, Jiayi; Shepherd, Dawn et al.

Part of Alzheimer's & Dementia, 2025

• DOI for Role of B vitamins in modulating homocysteine and metabolic pathways linked to brain atrophy: Metabolomics insights from the VITACOG trial
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Elevated homocysteine is associated with increased rates of epigenetic aging in a population with mild cognitive impairment

Holmes, Holly E.; Valentin, Rafael E.; Jernerén, Fredrik; Loots, Celeste A. de Jager et al.

Part of Aging Cell, 2024

• DOI for Elevated homocysteine is associated with increased rates of epigenetic aging in a population with mild cognitive impairment
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Extracellular cystine influences human preadipocyte differentiation and correlates with fat mass in healthy adults

Elkafrawy, Hagar; Mehanna, Radwa; Ali, Fayrouz; Barghash, Ayman et al.

Part of Amino Acids, p. 1623-1634, 2021

• DOI for Extracellular cystine influences human preadipocyte differentiation and correlates with fat mass in healthy adults
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ω-3 fatty acids and their interactions

Smith, A. David; Jernerén, Fredrik; Refsum, Helga

Part of American Journal of Clinical Nutrition, p. 775-778, 2021

• DOI for ω-3 fatty acids and their interactions

Changes in plasma fatty acids and related biomarkers during transition to an exclusively plant- and fish-based diet in healthy adults

Alshahawy, Rasha; El Habachi, Nihal; Allam, Eman; Jernerén, Fredrik et al.

Part of Nutrition, 2021

• DOI for Changes in plasma fatty acids and related biomarkers during transition to an exclusively plant- and fish-based diet in healthy adults

Pesticide-induced multigenerational effects on amphibian reproduction and metabolism

Karlsson, Oskar; Svanholm, Sofie; Eriksson, Andreas; Chidiac, Joseph et al.

Part of Science of the Total Environment, 2021

• DOI for Pesticide-induced multigenerational effects on amphibian reproduction and metabolism

Effects of Peroral Omega-3 Fatty Acid Supplementation on Cerebrospinal Fluid Biomarkers in Patients with Alzheimer's Disease: A Randomized Controlled Trial-The OmegAD Study

Tofiq, Avin; Zetterberg, Henrik; Blennow, Kaj; Basun, Hans et al.

Part of Journal of Alzheimer's Disease, p. 1291-1301, 2021

• DOI for Effects of Peroral Omega-3 Fatty Acid Supplementation on Cerebrospinal Fluid Biomarkers in Patients with Alzheimer's Disease: A Randomized Controlled Trial-The OmegAD Study

Exhaustive Exercise and Post-exercise Protein Plus Carbohydrate Supplementation Affect Plasma and Urine Concentrations of Sulfur Amino Acids, the Ratio of Methionine to Homocysteine and Glutathione in Elite Male Cyclists

Olsen, Thomas; Sollie, Ove; Nurk, Eha; Turner, Cheryl et al.

Part of Frontiers in Physiology, 2020

• DOI for Exhaustive Exercise and Post-exercise Protein Plus Carbohydrate Supplementation Affect Plasma and Urine Concentrations of Sulfur Amino Acids, the Ratio of Methionine to Homocysteine and Glutathione in Elite Male Cyclists
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Homocysteine Status Modifies the Treatment Effect of Omega-3 Fatty Acids on Cognition in a Randomized Clinical Trial in Mild to Moderate Alzheimer's Disease: The OmegAD Study

Jernerén, Fredrik; Cederholm, Tommy; Refsum, Helga; Smith, A. David et al.

Part of Journal of Alzheimer's Disease, p. 189-197, 2019

• DOI for Homocysteine Status Modifies the Treatment Effect of Omega-3 Fatty Acids on Cognition in a Randomized Clinical Trial in Mild to Moderate Alzheimer's Disease: The OmegAD Study

Food Overconsumption in Healthy Adults Triggers Early and Sustained Increases in Serum Branched-Chain Amino Acids and Changes in Cysteine Linked to Fat Gain

Elshorbagy, Amany K.; Samocha-Bonet, Dorit; Jernerén, Fredrik; Turner, Cheryl et al.

Part of Journal of Nutrition, p. 1073-1080, 2018

• DOI for Food Overconsumption in Healthy Adults Triggers Early and Sustained Increases in Serum Branched-Chain Amino Acids and Changes in Cysteine Linked to Fat Gain

Protein intake in the early recovery period after exhaustive exercise improves performance the following day.

Sollie, Ove; Jeppesen, Per Bendix; Tangen, Daniel Steensen; Jernerén, Fredrik et al.

Part of Journal of applied physiology, p. 1731-1742, 2018

• DOI for Protein intake in the early recovery period after exhaustive exercise improves performance the following day.

Perfluorooctanoic acid (PFOA) exposure promotes proliferation, migration and invasion potential in human breast epithelial cells

Pierozan, Paula; Jernerén, Fredrik; Karlsson, Oskar

Part of Archives of Toxicology, p. 1729-1739, 2018

• DOI for Perfluorooctanoic acid (PFOA) exposure promotes proliferation, migration and invasion potential in human breast epithelial cells
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Purification and site-directed mutagenesis of linoleate 9S-dioxygenase-allene oxide synthase of Fusarium oxysporum confirms the oxygenation mechanism

Chen, Yang; Jernerén, Fredrik; Oliw, Ernst

Part of Archives of Biochemistry and Biophysics, p. 24-29, 2017

• DOI for Purification and site-directed mutagenesis of linoleate 9S-dioxygenase-allene oxide synthase of Fusarium oxysporum confirms the oxygenation mechanism

Homocysteine concentrations in the cognitive progression of Alzheimer's disease

Farina, Nicolas; Jernerén, Fredrik; Turner, Cheryl; Hart, Kathryn et al.

Part of Experimental Gerontology, p. 146-150, 2017

• DOI for Homocysteine concentrations in the cognitive progression of Alzheimer's disease

Cysteine deprivation prevents induction of peroxisome proliferator-activated receptor gamma-2 and adipose differentiation of 3T3-L1 cells.

Haj-Yasein, Nadia Nabil; Berg, Ole; Jernerén, Fredrik; Refsum, Helga et al.

Part of Biochimica et Biophysica Acta, p. 623-635, 2017

• DOI for Cysteine deprivation prevents induction of peroxisome proliferator-activated receptor gamma-2 and adipose differentiation of 3T3-L1 cells.

Amino acid changes during transition to a vegan diet supplemented with fish in healthy humans.

Elshorbagy, Amany; Jernerén, Fredrik; Basta, Marianne; Basta, Caroline et al.

Part of European Journal of Nutrition, p. 1953-1962, 2017

• DOI for Amino acid changes during transition to a vegan diet supplemented with fish in healthy humans.

The Choice of Euthanasia Method Affects Metabolic Serum Biomarkers

Pierozan, Paula; Jernerén, Fredrik; Ransome, Yusuf; Karlsson, Oskar

Part of Basic & Clinical Pharmacology & Toxicology, p. 113-118, 2017

• DOI for The Choice of Euthanasia Method Affects Metabolic Serum Biomarkers

Serum S-adenosylmethionine, but not methionine, increases in response to overfeeding in humans.

Elshorbagy, A K; Jernerén, Fredrik; Samocha-Bonet, D; Refsum, H et al.

Part of Nutrition & Diabetes, 2016

• DOI for Serum S-adenosylmethionine, but not methionine, increases in response to overfeeding in humans.

Exploring the Lean Phenotype of Glutathione-Depleted Mice: Thiol, Amino Acid and Fatty Acid Profiles.

Elshorbagy, Amany K; Jernerén, Fredrik; Scudamore, Cheryl L; McMurray, Fiona et al.

Part of PLOS ONE, 2016

• DOI for Exploring the Lean Phenotype of Glutathione-Depleted Mice: Thiol, Amino Acid and Fatty Acid Profiles.

Genome-wide association reveals that common genetic variation in the kallikrein-kinin system is associated with serum L-arginine levels.

Zhang, Weihua; Jernerén, Fredrik; Lehne, Benjamin C; Chen, Ming-Huei et al.

Part of Thrombosis and haemostasis, p. 1041-1049, 2016

• DOI for Genome-wide association reveals that common genetic variation in the kallikrein-kinin system is associated with serum L-arginine levels.

Omega-3 Fatty Acid Status Enhances the Prevention of Cognitive Decline by B Vitamins in Mild Cognitive Impairment.

Oulhaj, Abderrahim; Jernerén, Fredrik; Refsum, Helga; Smith, A David et al.

Part of Journal of Alzheimer's Disease, p. 547-57, 2016

• DOI for Omega-3 Fatty Acid Status Enhances the Prevention of Cognitive Decline by B Vitamins in Mild Cognitive Impairment.

A new class of fatty acid allene oxide formed by the DOX-P450 fusion proteins of human and plant pathogenic fungi, C. immitis and Z. tritici.

Oliw, Ernst H; Aragó, Marc; Chen, Yang; Jernerén, Fredrik

Part of Journal of Lipid Research, p. 1518-1528, 2016

• DOI for A new class of fatty acid allene oxide formed by the DOX-P450 fusion proteins of human and plant pathogenic fungi, C. immitis and Z. tritici.

Post-sampling release of free fatty acids -: effects of heat stabilization and methods of euthanasia

Jernerén, Fredrik; Söderquist, Marcus; Karlsson, Oskar

Part of Journal of pharmacological and toxicological methods, p. 13-20, 2015

• DOI for Post-sampling release of free fatty acids -: effects of heat stabilization and methods of euthanasia

Expression and characterization of manganese lipoxygenase of the rice blast fungus reveals prominent sequential lipoxygenation of α-linolenic acid

Wennman, Anneli; Jernerén, Fredrik; Magnuson, Ann; Oliw, Ernst H

Part of Archives of Biochemistry and Biophysics, p. 87-95, 2015

• DOI for Expression and characterization of manganese lipoxygenase of the rice blast fungus reveals prominent sequential lipoxygenation of α-linolenic acid

Brain atrophy in cognitively impaired elderly: the importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial.

Jernerén, Fredrik; Elshorbagy, Amany K; Oulhaj, Abderrahim; Smith, Stephen M et al.

Part of American Journal of Clinical Nutrition, p. 215-21, 2015

• DOI for Brain atrophy in cognitively impaired elderly: the importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial.

Epoxy alcohol synthase of the rice blast fungus represents a novel subfamily of dioxygenase-cytochrome P450 fusion enzymes

Hoffmann, Inga; Jernerén, Fredrik; Oliw, Ernst H.

Part of Journal of Lipid Research, p. 2113-2123, 2014

• DOI for Epoxy alcohol synthase of the rice blast fungus represents a novel subfamily of dioxygenase-cytochrome P450 fusion enzymes

Expression of Fusion Proteins of Aspergillus terreus Reveals a Novel Allene Oxide Synthase

Hoffmann, Inga; Jernerén, Fredrik; Oliw, Ernst H.

Part of Journal of Biological Chemistry, p. 11459-11469, 2013

• DOI for Expression of Fusion Proteins of Aspergillus terreus Reveals a Novel Allene Oxide Synthase

Catalytic convergence of manganese and iron lipoxygenases by replacement of a single amino Acid

Wennman, Anneli; Jernerén, Fredrik; Hamberg, Mats; Oliw, Ernst H

Part of Journal of Biological Chemistry, p. 31757-31765, 2012

• DOI for Catalytic convergence of manganese and iron lipoxygenases by replacement of a single amino Acid

The Fatty Acid 8,11-Diol Synthase of Aspergillus fumigatus is Inhibited by Imidazole Derivatives and Unrelated to PpoB

Jernerén, Fredrik; Oliw, Ernst H.

Part of Lipids, p. 707-717, 2012

• DOI for The Fatty Acid 8,11-Diol Synthase of Aspergillus fumigatus is Inhibited by Imidazole Derivatives and Unrelated to PpoB

Linolenate 9R-Dioxygenase and Allene Oxide Synthase Activities of Lasiodiplodia theobromae

Jernerén, Fredrik; Eng, Felipe; Hamberg, Mats; Oliw, Ernst H

Part of Lipids, p. 65-73, 2012

• DOI for Linolenate 9R-Dioxygenase and Allene Oxide Synthase Activities of Lasiodiplodia theobromae

Expression of 5,8-LDS of Aspergillus fumigatus and its dioxygenase domain: a comparison with 7,8-LDS, 10-dioxygenase, and cyclooxygenase

Hoffmann, Inga; Jernerén, Fredrik; Garscha, Ulrike; Oliw, Ernst H.

Part of Archives of Biochemistry and Biophysics, p. 216-222, 2011

• DOI for Expression of 5,8-LDS of Aspergillus fumigatus and its dioxygenase domain: a comparison with 7,8-LDS, 10-dioxygenase, and cyclooxygenase

Stereoselective oxidation of regioisomeric octadecenoic acids by fatty acid dioxygenases

Oliw, Ernst H.; Wennman, Anneli; Hoffmann, Inga; Garscha, Ulrike et al.

Part of Journal of Lipid Research, p. 1995-2004, 2011

• DOI for Stereoselective oxidation of regioisomeric octadecenoic acids by fatty acid dioxygenases

Manganese lipoxygenase oxidizes bis-allylic hydroperoxides and octadecenoic acids by different mechanisms

Oliw, Ernst H.; Jernerén, Fredrik; Hoffmann, Inga; Sahlin, Margareta et al.

Part of Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, p. 138-147, 2011

• DOI for Manganese lipoxygenase oxidizes bis-allylic hydroperoxides and octadecenoic acids by different mechanisms

Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus

Jernerén, Fredrik; Garscha, Ulrike; Hoffmann, Inga; Hamberg, Mats et al.

Part of Biochimica et Biophysica Acta, p. 503-507, 2010

• DOI for Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus

Gene deletion of 7,8-linoleate diol synthase of the rice blast fungus: studies on pathogenicity, stereochemistry, and oxygenation mechanisms

Jernerén, Fredrik; Sesma, Ane; Francheschetti, Marina; Hamberg, Mats et al.

Part of Journal of Biological Chemistry, p. 5308-5316, 2010

• DOI for Gene deletion of 7,8-linoleate diol synthase of the rice blast fungus: studies on pathogenicity, stereochemistry, and oxygenation mechanisms

Linoleate 9R-dioxygenase and allene oxide synthase activities of Aspergillus terreus

Jernerén, Fredrik; Hoffmann, Inga; Oliw, Ernst H

Part of Archives of Biochemistry and Biophysics, p. 67-73, 2010

• DOI for Linoleate 9R-dioxygenase and allene oxide synthase activities of Aspergillus terreus

Identification of dioxygenases required for Aspergillus development: Studies of products, stereochemistry, and the reaction mechanism

Garscha, Ulrike; Jernerén, Fredrik; Chung, D.; Keller, N.P. et al.

Part of Journal of Biological Chemistry, p. 34707-34718, 2007

• DOI for Identification of dioxygenases required for Aspergillus development: Studies of products, stereochemistry, and the reaction mechanism

Novel Fatty Acid Dioxygenases of Human and Plant Pathogenic Fungi: Studies by Gene Deletion and Expression

Jernerén, Fredrik

2011

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