Nicole Metzendorf

Somatostatin therapy, neprilysin activation, and amyloid beta reduction: A novel approach for Alzheimer's treatment

Metzendorf, Nicole G.; Godec, Ana; Petrovic, Alex; Chourlia, Aikaterini et al.

Part of Biomedicine and Pharmacotherapy, 2025

• DOI for Somatostatin therapy, neprilysin activation, and amyloid beta reduction: A novel approach for Alzheimer's treatment
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Updated transient gene expression protocol in Expi293F cells using PEI

Hederoth, Gustaf; de la Rosa, Andrés; Godec, Ana; Aguilar, Ximena et al.

Part of Frontiers in Bioengineering and Biotechnology, 2025

• DOI for Updated transient gene expression protocol in Expi293F cells using PEI
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Key considerations for ELISA-based quantification of diverse amyloid beta forms in murine brain homogenates

Metzendorf, Nicole G.; Sehlin, Dag; Hultqvist, Greta

Part of Frontiers in Neuroscience, 2025

• DOI for Key considerations for ELISA-based quantification of diverse amyloid beta forms in murine brain homogenates
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Enhancing therapeutic antibody profiling: orthogonal strategies for stability and quality assessment

Metzendorf, Nicole G.; Petersen, Inga; Hultqvist, Greta

Part of Frontiers in Pharmacology, 2025

• DOI for Enhancing therapeutic antibody profiling: orthogonal strategies for stability and quality assessment
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Serotransferrin enhances transferrin receptor-mediated brain uptake of antibodies

Morrison, Jamie; Metzendorf, Nicole G.; Liu, Jielu; Hultqvist, Greta

Part of Drug Delivery and Translational Research, p. 3321-3337, 2025

• DOI for Serotransferrin enhances transferrin receptor-mediated brain uptake of antibodies
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Somatostatin therapy, neprilysin activation, and amyloid beta reduction: A novel approach for Alzheimer's treatment

Metzendorf, Nicole G.; Godec, Ana; Petrovic, Alex; Chourlia, Aikaterini et al.

Part of Biomedicine and Pharmacotherapy, 2025

• DOI for Somatostatin therapy, neprilysin activation, and amyloid beta reduction: A novel approach for Alzheimer's treatment
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Updated transient gene expression protocol in Expi293F cells using PEI

Hederoth, Gustaf; de la Rosa, Andrés; Godec, Ana; Aguilar, Ximena et al.

Part of Frontiers in Bioengineering and Biotechnology, 2025

• DOI for Updated transient gene expression protocol in Expi293F cells using PEI
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Key considerations for ELISA-based quantification of diverse amyloid beta forms in murine brain homogenates

Metzendorf, Nicole G.; Sehlin, Dag; Hultqvist, Greta

Part of Frontiers in Neuroscience, 2025

• DOI for Key considerations for ELISA-based quantification of diverse amyloid beta forms in murine brain homogenates
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Enhancing therapeutic antibody profiling: orthogonal strategies for stability and quality assessment

Metzendorf, Nicole G.; Petersen, Inga; Hultqvist, Greta

Part of Frontiers in Pharmacology, 2025

• DOI for Enhancing therapeutic antibody profiling: orthogonal strategies for stability and quality assessment
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Serotransferrin enhances transferrin receptor-mediated brain uptake of antibodies

Morrison, Jamie; Metzendorf, Nicole G.; Liu, Jielu; Hultqvist, Greta

Part of Drug Delivery and Translational Research, p. 3321-3337, 2025

• DOI for Serotransferrin enhances transferrin receptor-mediated brain uptake of antibodies
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Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration

de la Rosa, Andrés; Metzendorf, Nicole G.; Efverström, Jonathan; Godec, Ana et al.

Part of Neurotherapeutics, 2025

• DOI for Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration
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Paralemmin-1 controls the nanoarchitecture of the neuronal submembrane cytoskeleton

Macarron-Palacios, Victor; Hubrich, Jasmine; Lima, Maria Augusta do Rego Barros Fernandes; Metzendorf, Nicole G. et al.

Part of Science Advances, 2025

• DOI for Paralemmin-1 controls the nanoarchitecture of the neuronal submembrane cytoskeleton
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A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro

Petersen, Inga; Morrison, Jamie I.; Petrovic, Alex; Babic, Neira et al.

Part of Scientific Reports, 2024

• DOI for A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro
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Early Astrocytic Dysfunction Is Associated with Mistuned Synapses as well as Anxiety and Depressive-Like Behavior in the App^NL-F Mouse Model of Alzheimer's Disease

Portal, Benjamin; Södergren, Moa; Parés i Borrell, Teo; Giraud, Romain et al.

Part of Journal of Alzheimer's Disease, p. 1017-1037, 2024

• DOI for Early Astrocytic Dysfunction Is Associated with Mistuned Synapses as well as Anxiety and Depressive-Like Behavior in the App^NL-F Mouse Model of Alzheimer's Disease
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Standardized Preclinical In Vitro Blood-Brain Barrier Mouse Assay Validates Endocytosis-Dependent Antibody Transcytosis Using Transferrin-Receptor-Mediated Pathways

Morrison, Jamie; Petrovic, Alex; Metzendorf, Nicole G.; Rofo, Fadi et al.

Part of Molecular Pharmaceutics, p. 1564-1576, 2023

• DOI for Standardized Preclinical In Vitro Blood-Brain Barrier Mouse Assay Validates Endocytosis-Dependent Antibody Transcytosis Using Transferrin-Receptor-Mediated Pathways
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A single-chain fragment constant design enables easy production of a monovalent blood-brain barrier transporter and provides an improved brain uptake at elevated doses

Morrison, Jamie I.; Metzendorf, Nicole G.; Rofo, Fadi; Petrovic, Alex et al.

Part of Journal of Neurochemistry, p. 413-425, 2023

• DOI for A single-chain fragment constant design enables easy production of a monovalent blood-brain barrier transporter and provides an improved brain uptake at elevated doses
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Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease

Gustavsson, Tobias; Metzendorf, Nicole G.; Wik, Elin; Roshanbin, Sahar et al.

Part of Alzheimer's Research & Therapy, 2023

• DOI for Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease
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A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice

Rofo, Fadi; Meier, Silvio R.; Metzendorf, Nicole G.; Morrison, Jamie et al.

Part of Neurotherapeutics, p. 1588-1602, 2022

• DOI for A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice
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Destination and Specific Impact of Different Bile Acids in the Intestinal Pathogen Clostridioides difficile

Metzendorf, Nicole G.; Lange, Lena Melanie; Lainer, Nina; Schlüter, Rabea et al.

Part of Frontiers in Microbiology, 2022

• DOI for Destination and Specific Impact of Different Bile Acids in the Intestinal Pathogen Clostridioides difficile
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Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3

de la Rosa, Andres; Metzendorf, Nicole G.; Morrison, Jamie; Faresjö, Rebecca et al.

Part of Scientific Reports, 2022

• DOI for Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3
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Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease

Rofo, Fadi; Metzendorf, Nicole; Saubi, Cristina; Suominen, Laura et al.

Part of Alzheimer's Research & Therapy, 2022

• DOI for Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease
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Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta

Rofo, Fadi; Buijs, Jos; Falk, Ronny; Honek, Ken et al.

Part of Translational Neurodegeneration, 2021

• DOI for Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta
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Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain

Rofo, Fadi; Yilmaz, Canan Ugur; Metzendorf, Nicole G.; Gustavsson, Tobias et al.

Part of Theranostics, p. 789-804, 2021

• DOI for Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain
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Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide

Rofo, Fadi; Sandbaumhüter, Friederike A.; Chourlia, Aikaterini; Metzendorf, Nicole G. et al.

Part of ACS Chemical Neuroscience, p. 2529-2541, 2021

• DOI for Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide
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Updated transient gene expression (TGE) protocol and the development of a small-scale TGE protocol: evaluated by testing longevity molecules as potential protein expression enhancers

de la Rosa, Andrés; Petrovic, Alex; Godec, Ana; Napoleone, Antonino et al.

The paralemmin protein family: Phosphoproteins involved in filopodia and dendritic spine formation

Neumann, Nicole G.

2011