Bryndis Birnir

GABAA receptor agonists modulate intracellular Ca2+ levels in activated human CD4+ T cells

Korol, Sergiy; Jin, Zhe; Bhandage, Amol; Hammoud, Hayma et al.

Part of Frontiers in Immunology, 2026

• DOI for GABAA receptor agonists modulate intracellular Ca2+ levels in activated human CD4+ T cells
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GLP-1 selectively enhances tonic GABA_A receptor-mediated currents in mouse dentate gyrus granule cells of the ventral hippocampus

Netsyk, Olga; Korol, Sergiy; Birnir, Bryndis; Jin, Zhe

Part of Frontiers in Cellular Neuroscience, 2025

• DOI for GLP-1 selectively enhances tonic GABA_A receptor-mediated currents in mouse dentate gyrus granule cells of the ventral hippocampus
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Inhibition of the Na⁺-glucose transporter SGLT2 reduces glucose uptake and IFNγ release from activated human CD4⁺ T cells

Jin, Zhe; Hammoud, Hayma; Bhandage, Amol K.; Koreli, Stasini et al.

Part of Frontiers in Immunology, 2025

• DOI for Inhibition of the Na⁺-glucose transporter SGLT2 reduces glucose uptake and IFNγ release from activated human CD4⁺ T cells
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Long-term treatment with gamma-aminobutyric acid (GABA) fails to regain beta-cell function in longstanding type 1 diabetes: results from a randomized trial

Hill, Henrik; Lundkvist, Per; Tsatsaris, Georgios; Birnir, Bryndis et al.

Part of Scientific Reports, 2025

• DOI for Long-term treatment with gamma-aminobutyric acid (GABA) fails to regain beta-cell function in longstanding type 1 diabetes: results from a randomized trial
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GABA-activated slow spontaneous inhibitory postsynaptic currents are decreased in dorsal hippocampal dentate gyrus granule cells in an aged mouse model of Alzheimer's disease

Netsyk, Olga; Korol, Sergiy V; Li, Jin-ping; Birnir, Bryndis et al.

Part of Journal of Alzheimer's Disease, p. 420-428, 2025

• DOI for GABA-activated slow spontaneous inhibitory postsynaptic currents are decreased in dorsal hippocampal dentate gyrus granule cells in an aged mouse model of Alzheimer's disease

GABAA receptor agonists modulate intracellular Ca2+ levels in activated human CD4+ T cells

Korol, Sergiy; Jin, Zhe; Bhandage, Amol; Hammoud, Hayma et al.

Part of Frontiers in Immunology, 2026

• DOI for GABAA receptor agonists modulate intracellular Ca2+ levels in activated human CD4+ T cells
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GLP-1 selectively enhances tonic GABA_A receptor-mediated currents in mouse dentate gyrus granule cells of the ventral hippocampus

Netsyk, Olga; Korol, Sergiy; Birnir, Bryndis; Jin, Zhe

Part of Frontiers in Cellular Neuroscience, 2025

• DOI for GLP-1 selectively enhances tonic GABA_A receptor-mediated currents in mouse dentate gyrus granule cells of the ventral hippocampus
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Inhibition of the Na⁺-glucose transporter SGLT2 reduces glucose uptake and IFNγ release from activated human CD4⁺ T cells

Jin, Zhe; Hammoud, Hayma; Bhandage, Amol K.; Koreli, Stasini et al.

Part of Frontiers in Immunology, 2025

• DOI for Inhibition of the Na⁺-glucose transporter SGLT2 reduces glucose uptake and IFNγ release from activated human CD4⁺ T cells
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Long-term treatment with gamma-aminobutyric acid (GABA) fails to regain beta-cell function in longstanding type 1 diabetes: results from a randomized trial

Hill, Henrik; Lundkvist, Per; Tsatsaris, Georgios; Birnir, Bryndis et al.

Part of Scientific Reports, 2025

• DOI for Long-term treatment with gamma-aminobutyric acid (GABA) fails to regain beta-cell function in longstanding type 1 diabetes: results from a randomized trial
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GABA-activated slow spontaneous inhibitory postsynaptic currents are decreased in dorsal hippocampal dentate gyrus granule cells in an aged mouse model of Alzheimer's disease

Netsyk, Olga; Korol, Sergiy V; Li, Jin-ping; Birnir, Bryndis et al.

Part of Journal of Alzheimer's Disease, p. 420-428, 2025

• DOI for GABA-activated slow spontaneous inhibitory postsynaptic currents are decreased in dorsal hippocampal dentate gyrus granule cells in an aged mouse model of Alzheimer's disease

Rodent islet amyloid polypeptide (IAPP) selectively enhances GABA_A receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells

Netsyk, Olga; Korol, Sergiy; Westermark, Gunilla; Birnir, Bryndis et al.

Part of Frontiers in Cellular Neuroscience, 2025

• DOI for Rodent islet amyloid polypeptide (IAPP) selectively enhances GABA_A receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells
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GABA-mediated inhibition of human CD4⁺ T cell functions is enhanced by insulin but impaired by high glucose levels

Jin, Zhe; Hammoud, Hayma; Bhandage, Amol; Korol, Sergiy Vasylyovych et al.

Part of EBioMedicine, 2024

• DOI for GABA-mediated inhibition of human CD4⁺ T cell functions is enhanced by insulin but impaired by high glucose levels
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Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa

Cotman, Andrej Emanuel; Durcik, Martina; Tiz, Davide Benedetto; Fulgheri, Federica et al.

Part of Journal of Medicinal Chemistry, p. 1380-1425, 2023

• DOI for Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa
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Endogenous Levels of Gamma Amino-Butyric Acid Are Correlated to Glutamic-Acid Decarboxylase Antibody Levels in Type 1 Diabetes

Hill, Henrik; Elksnis, Andris; Lundkvist, Per; Ubhayasekera, Kumari et al.

Part of Biomedicines, 2022

• DOI for Endogenous Levels of Gamma Amino-Butyric Acid Are Correlated to Glutamic-Acid Decarboxylase Antibody Levels in Type 1 Diabetes
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ZEB2 haploinsufficient Mowat-Wilson syndrome induced pluripotent stem cells show disrupted GABAergic transcriptional regulation and function

Schuster, Jens; Klar, Joakim; Khalfallah, Ayda; Laan, Loora et al.

Part of Frontiers in Molecular Neuroscience, 2022

• DOI for ZEB2 haploinsufficient Mowat-Wilson syndrome induced pluripotent stem cells show disrupted GABAergic transcriptional regulation and function
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Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age-dependent manner, normalizes GABA-activated currents in the tg-APPSwe mouse model of Alzheimer's disease

Hammoud, Hayma; Netsyk, Olga; Tafreshiha, Atieh S.; Korol, Sergiy V. et al.

Part of Acta Physiologica, 2021

• DOI for Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age-dependent manner, normalizes GABA-activated currents in the tg-APPSwe mouse model of Alzheimer's disease
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Monoallelic and bi-allelic variants in NCDN cause neurodevelopmental delay, intellectual disability, and epilepsy

Fatima, Ambrin; Hoeber, Jan; Schuster, Jens; Koshimizu, Eriko et al.

Part of American Journal of Human Genetics, p. 739-748, 2021

• DOI for Monoallelic and bi-allelic variants in NCDN cause neurodevelopmental delay, intellectual disability, and epilepsy
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Tonic GABA-activated synaptic and extrasynaptic currents in dentate gyrus granule cells and CA3 pyramidal neurons along the mouse hippocampal dorsoventral axis

Netsyk, Olga; Hammoud, Hayma; Korol, Sergiy; Jin, Zhe et al.

Part of Hippocampus, p. 1146-1157, 2020

• DOI for Tonic GABA-activated synaptic and extrasynaptic currents in dentate gyrus granule cells and CA3 pyramidal neurons along the mouse hippocampal dorsoventral axis
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GABA(A) Receptor-Mediated Currents and Hormone mRNAs in Cells Expressing More Than One Hormone Transcript in Intact Human Pancreatic Islets

Korol, Sergiy; Jin, Zhe; Birnir, Bryndis

Part of International Journal of Molecular Sciences, 2020

• DOI for GABA(A) Receptor-Mediated Currents and Hormone mRNAs in Cells Expressing More Than One Hormone Transcript in Intact Human Pancreatic Islets
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Gunnar Flemström's legacy in intestinal bicarbonate secretion: A homage to Gunnar Flemström and his work in intestinal bicarbonate secretion

Seidler, Ursula; Nylander, Olof; Sjöblom, Markus; Birnir, Bryndis et al.

Part of Acta Physiologica, 2019

• DOI for Gunnar Flemström's legacy in intestinal bicarbonate secretion: A homage to Gunnar Flemström and his work in intestinal bicarbonate secretion

Ataxia in Patients With Bi-Allelic NFASC Mutations and Absence of Full-Length NF186

Kvarnung, Malin; Shahsavani, Mansoureh; Taylan, Fulya; Moslem, Mohsen et al.

Part of Frontiers in Genetics, 2019

• DOI for Ataxia in Patients With Bi-Allelic NFASC Mutations and Absence of Full-Length NF186
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Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers

Bhandage, Amol K.; Cunningham, Janet L.; Jin, Zhe; Shen, Qiujin et al.

Part of International Journal of Molecular Sciences, 2019

• DOI for Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers
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Interferon-gamma potentiates GABA(A) receptor-mediated inhibitory currents in rat hippocampal CA1 pyramidal neurons

Flood, Louise; Korol, Sergiy; Ekselius, Lisa; Birnir, Bryndis et al.

Part of Journal of Neuroimmunology, 2019

• DOI for Interferon-gamma potentiates GABA(A) receptor-mediated inhibitory currents in rat hippocampal CA1 pyramidal neurons
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Transcriptomes of Dravet syndrome iPSC derived GABAergic cells reveal dysregulated pathways for chromatin remodeling and neurodevelopment

Schuster, Jens; Laan, Loora; Klar, Joakim; Jin, Zhe et al.

Part of Neurobiology of Disease, 2019

• DOI for Transcriptomes of Dravet syndrome iPSC derived GABAergic cells reveal dysregulated pathways for chromatin remodeling and neurodevelopment
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Expression of calcium release-activated and voltage-gated calcium channels genes in peripheral blood mononuclear cells is altered in pregnancy and in type 1 diabetes

Bhandage, Amol; Jin, Zhe; Korol, Sergiy V; Tafreshiha, Atieh et al.

Part of PLOS ONE, 2018

• DOI for Expression of calcium release-activated and voltage-gated calcium channels genes in peripheral blood mononuclear cells is altered in pregnancy and in type 1 diabetes
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Insulin enhances GABA_A receptor-mediated inhibitory currents in rat central amygdala neurons

Korol, Sergiy V.; Tafreshiha, Atieh; Bhandage, Amol K.; Birnir, Bryndis et al.

Part of Neuroscience Letters, p. 76-81, 2018

• DOI for Insulin enhances GABA_A receptor-mediated inhibitory currents in rat central amygdala neurons
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She is in science to stay!

Birnir, Bryndis; Eliasson, L.

Part of Acta Physiologica, 2018

• DOI for She is in science to stay!

GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4⁺ T Cells and Is Immunosuppressive in Type 1 Diabetes

Bhandage, Amol K.; Jin, Zhe; Korol, Sergiy V.; Shen, Qiujin et al.

Part of EBioMedicine, p. 283-294, 2018

• DOI for GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4⁺ T Cells and Is Immunosuppressive in Type 1 Diabetes
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Functional Characterization of Native, High-Affinity GABA_A Receptors in Human Pancreatic β Cells

Korol, Sergiy V; Jin, Zhe; Jin, Yang; Bhandage, Amol K. et al.

Part of EBioMedicine, 2018

• DOI for Functional Characterization of Native, High-Affinity GABA_A Receptors in Human Pancreatic β Cells
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Characterization of the gamma-aminobutyric acid signaling system in the zebrafish (danio rerio hamilton) central nervous system by reverse transcription-quantitative polymerase chain reaction

Cocco, Arianna; Rönnberg, A. M. Carolina; Jin, Zhe; André, Goncalo Igreja et al.

Part of Neuroscience, p. 300-321, 2017

• DOI for Characterization of the gamma-aminobutyric acid signaling system in the zebrafish (danio rerio hamilton) central nervous system by reverse transcription-quantitative polymerase chain reaction
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Liraglutide modulates GABAergic signaling in rat hippocampal CA3 pyramidal neurons predominantly by presynaptic mechanism

Babateen, Omar; Korol, Sergiy V.; Jin, Zhe; Bhandage, Amol K. et al.

Part of BMC Pharmacology & Toxicology, 2017

• DOI for Liraglutide modulates GABAergic signaling in rat hippocampal CA3 pyramidal neurons predominantly by presynaptic mechanism
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AMPA, NMDA and kainate glutamate receptor subunits are expressed in human peripheral blood mononuclear cells (PBMCs) where the expression of GluK4 is altered by pregnancy and GluN2D by depression in pregnant women

Bhandage, Amol K.; Jin, Zhe; Hellgren, Charlotte; Korol, Sergiy V. et al.

Part of Journal of Neuroimmunology, p. 51-58, 2017

• DOI for AMPA, NMDA and kainate glutamate receptor subunits are expressed in human peripheral blood mononuclear cells (PBMCs) where the expression of GluK4 is altered by pregnancy and GluN2D by depression in pregnant women

Normal human CD4⁺ helper T cells express Kv1.1 voltage-gated K⁺ channels, and selective Kv1.1 block in T cells induces by itself robust TNFα production and secretion and activation of the NFκB non-canonical pathway

Fellerhoff-Losch, Barbara; Korol, Sergiy V.; Ganor, Yonatan; Gu, Songhai et al.

Part of Journal of neural transmission, p. 137-157, 2016

• DOI for Normal human CD4⁺ helper T cells express Kv1.1 voltage-gated K⁺ channels, and selective Kv1.1 block in T cells induces by itself robust TNFα production and secretion and activation of the NFκB non-canonical pathway

GLP-1 and Exendin-4 Transiently Enhance GABA(A) Receptor-Mediated Synaptic and Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons

Korol, Sergiy V.; Jin, Zhe; Babateen, Omar; Birnir, Bryndis

Part of Diabetes, p. 79-89, 2015

• DOI for GLP-1 and Exendin-4 Transiently Enhance GABA(A) Receptor-Mediated Synaptic and Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons
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Expression of GABA receptors subunits in peripheral blood mononuclear cells is gender dependent, altered in pregnancy and modified by mental health

Bhandage, Amol K.; Hellgren, Charlotte; Jin, Zhe; Olafsson, Einar B et al.

Part of Acta Physiologica, p. 575-585, 2015

• DOI for Expression of GABA receptors subunits in peripheral blood mononuclear cells is gender dependent, altered in pregnancy and modified by mental health

Modulation of GABAA receptor-mediated synaptic and tonic currents in the rat hippocampus by GLP-1, exendin-4 and diazepam

Korol, Sergiy V.; Jin, Zhe; Babateen, Omar; Birnir, Bryndis

Part of Acta Physiologica, p. 89-90, 2015

Insulin modulates GABAA receptor-mediated neuronal inhibition in rat hippocampus and amygdala

Jin, Zhe; Korol, Sergiy V.; Jin, Yang; Birnir, Bryndis

Part of Acta Physiologica, p. 90-90, 2015

The mRNA expression of GABA-A, GABA-B receptor subunits and chloride transporters in peripheral blood mononuclear cells is influenced by gender, pregnancy and depression

Bhandage, Amol; Hellgren, Charlotte; Jin, Zhe; Ólafsson, Einar et al.

Part of Acta Physiologica, p. 91-91, 2015

The GLP-1 Receptor Agonist Exendin-4 and Diazepam Differentially Regulate GABA_A Receptor-Mediated Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons

Korol, Sergiy V.; Jin, Zhe; Birnir, Bryndis

Part of PLOS ONE, 2015

• DOI for The GLP-1 Receptor Agonist Exendin-4 and Diazepam Differentially Regulate GABA_A Receptor-Mediated Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons
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Etomidate, propofol and diazepam potentiate GABA-evoked GABAA currents in a cell line derived from Human glioblastoma

Babateen, Omar; Jin, Zhe; Bhandage, Amol K.; Korol, Sergiy V et al.

Part of European Journal of Pharmacology, p. 101-107, 2015

• DOI for Etomidate, propofol and diazepam potentiate GABA-evoked GABAA currents in a cell line derived from Human glioblastoma

GABA-A and NMDA receptor subunit mRNA expression is altered in the caudate but not the putamen of the postmortem brains of alcoholics

Bhandage, Amol K.; Jin, Zhe; Bazov, Igor; Kononenko, Olga et al.

Part of Frontiers in Cellular Neuroscience, 2014

• DOI for GABA-A and NMDA receptor subunit mRNA expression is altered in the caudate but not the putamen of the postmortem brains of alcoholics

Selective increases of AMPA, NMDA, and kainate receptor subunit mRNAs in the hippocampus and orbitofrontal cortex but not in prefrontal cortex of human alcoholics

Jin, Zhe; Bhandage, Amol K; Bazov, Igor; Kononenko, Olga et al.

Part of Frontiers in Cellular Neuroscience, p. 11, 2014

• DOI for Selective increases of AMPA, NMDA, and kainate receptor subunit mRNAs in the hippocampus and orbitofrontal cortex but not in prefrontal cortex of human alcoholics

GABA-A receptor currents in a cell line (U3047MG) derived from a human glioblastoma tumor are enhanced by etomidate, propofol and diazepam

Babateen, Omar M.; Jin, Zhe; Bhandage, Amol K.; Korol, Sergiy V. et al.

Part of Acta Physiologica, p. 100-100, 2014

GABA-A receptor subunit expression in human peripheral blood mononuclear cells

Bhandage, Amol K.; Hellgren, Charlotte; Jin, Zhe; Olafsson, Einar et al.

Part of Acta Physiologica, p. 86-86, 2014

GABA(A) receptor-mediated currents in the hippocampus are transiently enhanced by glucagon-like peptide-1 receptor (GLP-1R) agonists

Korol, Sergiy V.; Jin, Zhe; Babateen, Omar M.; Birnir, Bryndis

Part of Acta Physiologica, p. 83-83, 2014

Insulin modulates GABA(A) receptor-mediated inhibition in rat amygdala neurons

Jin, Zhe; Korol, Sergiy V.; Birnir, Bryndis

Part of Acta Physiologica, p. 83-83, 2014

Expression of specific ionotropic glutamate and GABA-A receptor subunits is decreased in central amygdala of alcoholics

Jin, Zhe; Bhandage, Amol K.; Bazov, Igor; Kononenko, Olga et al.

Part of Frontiers in Cellular Neuroscience, p. 288, 2014

• DOI for Expression of specific ionotropic glutamate and GABA-A receptor subunits is decreased in central amygdala of alcoholics

Absence of Shb impairs insulin secretion by elevated FAK activity in pancreatic islets

Alenkvist, Ida; Dyachok, Oleg; Tian, Geng; Li, Jia et al.

Part of Journal of Endocrinology, p. 267-275, 2014

• DOI for Absence of Shb impairs insulin secretion by elevated FAK activity in pancreatic islets
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GABA is an effective immunomodulatory molecule

Jin, Zhe; Mendu, Suresh Kumar; Birnir, Bryndis

Part of Amino Acids, p. 87-94, 2013

• DOI for GABA is an effective immunomodulatory molecule

In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in alpha-Cells

Jin, Yang; Korol, Sergiy V; Jin, Zhe; Barg, Sebastian et al.

Part of PLOS ONE, 2013

• DOI for In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in alpha-Cells
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Monoacylglycerols Activate TRPV1-A Link between Phospholipase C and TRPV1

Zygmunt, Peter M.; Ermund, Anna; Movahed, Pouya; Andersson, David A. et al.

Part of PLOS ONE, 2013

• DOI for Monoacylglycerols Activate TRPV1-A Link between Phospholipase C and TRPV1
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Selective Changes of GABA(A) Channel Subunit mRNAs in the Hippocampus and Orbitofrontal Cortex but not in Prefrontal Cortex of Human Alcoholics

Jin, Zhe; Bazov, Igor; Kononenko, Olga; Korpi, Esa R et al.

Part of Frontiers in Cellular Neuroscience, 2012

• DOI for Selective Changes of GABA(A) Channel Subunit mRNAs in the Hippocampus and Orbitofrontal Cortex but not in Prefrontal Cortex of Human Alcoholics
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GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium:      

Ring, Henrik; Mendu, Suresh Kumar; Shirazi-Fard, Shahrzad; Birnir, Bryndis et al.

Part of PLOS ONE, 2012

• DOI for GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium:      
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GABA-A channel subunit expression in human glioma correlates with tumour histology and clinical outcome

Pedder, H.; Jin, Zhe; Aronica, E.; Birnir, Bryndis et al.

Part of European Journal of Neurology, p. 67-67, 2012

Different subtypes of GABA-A receptors are expressed in human, mouse and rat T lymphocytes

Mendu, Suresh Kumar; Bhandage, Amol; Jin, Zhe; Birnir, Bryndis

Part of PLOS ONE, 2012

• DOI for Different subtypes of GABA-A receptors are expressed in human, mouse and rat T lymphocytes
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GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome

Smits, Anja; Jin, Zhe; Elsir, Tamador; Pedder, Hugo et al.

Part of PLOS ONE, 2012

• DOI for GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome
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GABAergic Signaling Is Linked to a Hypermigratory Phenotype in Dendritic Cells Infected by Toxoplasma gondii

Fuks, Jonas M; Arrighi, Romanico B G; Weidner, Jessica M; Kumar Mendu, Suresh et al.

Part of PLoS pathogens, 2012

• DOI for GABAergic Signaling Is Linked to a Hypermigratory Phenotype in Dendritic Cells Infected by Toxoplasma gondii
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gamma-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes

Taneera, J.; Jin, Zhe; Jin, Yang; Muhammed, S. J. et al.

Part of Diabetologia, p. 1985-1994, 2012

• DOI for gamma-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes

GABA-activated single-channel and tonic currents in rat brain slices

Jin, Zhe; Jin, Yang; Birnir, Bryndis

Part of Journal of Visualized Experiments, 2011

• DOI for GABA-activated single-channel and tonic currents in rat brain slices

Insulin reduces neuronal excitability by turning on GABA(A) channels that generate tonic current

Jin, Zhe; Jin, Yang; Kumar-Mendu, Suresh; Degerman, Eva et al.

Part of PLOS ONE, 2011

• DOI for Insulin reduces neuronal excitability by turning on GABA(A) channels that generate tonic current

Increased GABA(A) channel subunits expression in CD8(+) but not in CD4(+) T cells in BB rats developing diabetes compared to their congenic littermates

Mendu, Suresh Kumar; Åkesson, Lina; Jin, Zhe; Edlund, Anna et al.

Part of Molecular Immunology, p. 399-407, 2011

• DOI for Increased GABA(A) channel subunits expression in CD8(+) but not in CD4(+) T cells in BB rats developing diabetes compared to their congenic littermates

GABA, a natural immunomodulator of T lymphocytes

Bjurstöm, Helen; Wang, JunYang; Ericsson, Ida; Bengtsson, Martin et al.

Part of Journal of Neuroimmunology, p. 44-50, 2008

• DOI for GABA, a natural immunomodulator of T lymphocytes

The impact of sub-cellular location and intracellular neuronal proteins on properties of GABA(A) receptors.

Birnir, Bryndis; Korpi, Esa R

Part of Current pharmaceutical design, p. 3169-77, 2007

Graded response to GABA by native extrasynaptic GABA receptors.

Lindquist, Catarina E L; Birnir, Bryndis

Part of Journal of Neurochemistry, p. 1349-56, 2006

• DOI for Graded response to GABA by native extrasynaptic GABA receptors.

Neuron-mediated generation of regulatory T cells from encephalitogenic T cells suppresses EAE.

Liu, Yawei; Teige, Ingrid; Birnir, Bryndis; Issazadeh-Navikas, Shohreh

Part of Nature Medicine, p. 518-25, 2006

• DOI for Neuron-mediated generation of regulatory T cells from encephalitogenic T cells suppresses EAE.

The mechanism of SR95531 inhibition at GABA receptors examined in human alpha1beta1 and alpha1beta1gamma2S receptors.

Lindquist, Catarina E L; Laver, Derek R; Birnir, Bryndis

Part of Journal of Neurochemistry, p. 491-501, 2005

• DOI for The mechanism of SR95531 inhibition at GABA receptors examined in human alpha1beta1 and alpha1beta1gamma2S receptors.

Endogenous unsaturated C18 N-acylethanolamines are vanilloid receptor (TRPV1) agonists.

Movahed, Pouya; Jönsson, Bo A G; Birnir, Bryndis; Wingstrand, Johan A et al.

Part of Journal of Biological Chemistry, p. 38496-504, 2005

• DOI for Endogenous unsaturated C18 N-acylethanolamines are vanilloid receptor (TRPV1) agonists.

Penicillin blocks human alpha 1 beta 1 and alpha 1 beta 1 gamma 2S GABAA channels that open spontaneously.

Lindquist, Catarina E L; Dalziel, Julie E; Cromer, Brett A; Birnir, Bryndis

Part of European Journal of Pharmacology, p. 23-32, 2004

• DOI for Penicillin blocks human alpha 1 beta 1 and alpha 1 beta 1 gamma 2S GABAA channels that open spontaneously.

Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells.

Wendt, Anna; Birnir, Bryndis; Buschard, Karsten; Gromada, Jesper et al.

Part of Diabetes, p. 1038-45, 2004

Conductance of recombinant GABA (A) channels is increased in cells co-expressing GABA(A) receptor-associated protein.

Everitt, Andrea B; Luu, Tien; Cromer, Brett; Tierney, M Louise et al.

Part of Journal of Biological Chemistry, p. 21701-6, 2004

• DOI for Conductance of recombinant GABA (A) channels is increased in cells co-expressing GABA(A) receptor-associated protein.

Regulated exocytosis of GABA-containing synaptic-like microvesicles in pancreatic beta-cells.

Braun, Matthias; Wendt, Anna; Birnir, Bryndis; Broman, Jonas et al.

Part of The Journal of General Physiology, p. 191-204, 2004

• DOI for Regulated exocytosis of GABA-containing synaptic-like microvesicles in pancreatic beta-cells.

Conductance of GABAA channels activated by pentobarbitone in hippocampal neurons from newborn rats.

Eghbali, Mansoureh; Birnir, Bryndis; Gage, Peter W

Part of Journal of Physiology, p. 13-22, 2003

• DOI for Conductance of GABAA channels activated by pentobarbitone in hippocampal neurons from newborn rats.

Effects of pentobarbital on GABA-activated currents in acutely-isolated rat dentate gyrus granule neurons.

Lim, M S F; Lindquist, C E L; Birnir, B

Part of Neuroscience Letters, p. 139-42, 2003

Evidence for inhibitory effect of the agonist gaboxadol at human alpha 1 beta 2 gamma 2S GABAA receptors.

Smith, Morten; Lindquist, Catarina E L; Birnir, Bryndis

Part of European Journal of Pharmacology, p. 21-6, 2003

Extrasynaptic GABA(A) channels activated by THIP are modulated by diazepam in CA1 pyramidal neurons in the rat brain hippocampal slice.

Lindquist, Catarina E L; Ebert, Bjarke; Birnir, Bryndis

Part of Molecular and Cellular Neuroscience, p. 250-7, 2003

Effects of propofol on GABAA channel conductance in rat-cultured hippocampal neurons.

Eghbali, Mansoureh; Gage, Peter W; Birnir, Bryndis

Part of European Journal of Pharmacology, p. 75-82, 2003

GABA concentration sets the conductance of delayed GABAA channels in outside-out patches from rat hippocampal neurons.

Birnir, Bryndis; Eghbali, M; Cox, G B; Gage, P W

Part of Journal of Membrane Biology, p. 171-83, 2001

Heterogeneity of functional GABA(A) receptors in rat dentate gyrus neurons revealed by a change in response to drugs during the whole-cell current time-course.

Lim, M S; Birnir, Bryndis

Part of Neuropharmacology, p. 1034-43, 2001

Bicuculline, pentobarbital and diazepam modulate spontaneous GABA(A) channels in rat hippocampal neurons.

Birnir, Bryndis; Eghbali, M; Everitt, A B; Gage, P W

Part of British Journal of Pharmacology, p. 695-704, 2000

• DOI for Bicuculline, pentobarbital and diazepam modulate spontaneous GABA(A) channels in rat hippocampal neurons.

Pentobarbital modulates gamma-aminobutyric acid-activated single-channel conductance in rat cultured hippocampal neurons.

Eghbali, M; Gage, P W; Birnir, Bryndis

Part of Molecular Pharmacology, p. 463-9, 2000

Mutating the highly conserved second membrane-spanning region 9' leucine residue in the alpha(1) or beta(1) subunit produces subunit-specific changes in the function of human alpha(1)beta(1) gamma-aminobutyric Acid(A) receptors.

Dalziel, J E; Cox, G B; Gage, P W; Birnir, Bryndis

Part of Molecular Pharmacology, p. 875-82, 2000

Spontaneously opening GABA(A) channels in CA1 pyramidal neurones of rat hippocampus.

Birnir, Bryndis; Everitt, A B; Lim, M S; Gage, P W

Part of Journal of Membrane Biology, p. 21-9, 2000

Mutant human alpha(1)beta(1)(T262Q) GABA(A) receptors are directly activated but not modulated by pentobarbital.

Dalziel, J E; Cox, G B; Gage, P W; Birnir, Bryndis

Part of European Journal of Pharmacology, p. 283-6, 1999

A threonine residue in the M2 region of the beta1 subunit is needed for expression of functional alpha1beta1 GABA(A) receptors.

Dalziel, J E; Birnir, Bryndis; Everitt, A B; Tierney, M L et al.

Part of European Journal of Pharmacology, p. 345-8, 1999

Two threonine residues in the M2 segment of the alpha 1 beta 1 GABAA receptor are critical for ion channel function.

Tierney, M L; Birnir, Bryndis; Cromer, B; Howitt, S M et al.

Part of Receptors and Channels, p. 113-24, 1998

Hippocampal GABA(A) channel conductance increased by diazepam.

Eghbali, M; Curmi, J P; Birnir, Bryndis; Gage, P W

Part of Nature, p. 71-5, 1997

• DOI for Hippocampal GABA(A) channel conductance increased by diazepam.

Nature of the 5' residue in the M2 domain affects function of the human alpha 1 beta 1 GABAA receptor.

Birnir, Bryndis; Tierney, M L; Lim, M; Cox, G B et al.

Part of Synapse, p. 324-7, 1997

• DOI for Nature of the 5' residue in the M2 domain affects function of the human alpha 1 beta 1 GABAA receptor.

A structural determinant of desensitization and allosteric regulation by pentobarbitone of the GABAA receptor.

Birnir, Bryndis; Tierney, M L; Dalziel, J E; Cox, G B et al.

Part of Journal of Membrane Biology, p. 157-66, 1997

Effects of mutating leucine to threonine in the M2 segment of alpha1 and beta1 subunits of GABAA alpha1beta1 receptors.

Tierney, M L; Birnir, Bryndis; Pillai, N P; Clements, J D et al.

Part of Journal of Membrane Biology, p. 11-21, 1996

Rapid desensitization of alpha 1 beta 1 GABA A receptors expressed in Sf9 cells under optimized conditions.

Birnir, Bryndis; Tierney, M L; Pillai, N P; Cox, G B et al.

Part of Journal of Membrane Biology, p. 193-202, 1995

Characteristics of GABAA channels in rat dentate gyrus.

Birnir, Bryndis; Everitt, A B; Gage, P W

Part of Journal of Membrane Biology, p. 93-102, 1994

The influence of membrane potential on chloride channels activated by GABA in rat cultured hippocampal neurons.

Curmi, J P; Premkumar, L S; Birnir, Bryndis; Gage, P W

Part of Journal of Membrane Biology, p. 273-80, 1993

A combination of human alpha 1 and beta 1 subunits is required for formation of detectable GABA-activated chloride channels in Sf9 cells.

Birnir, Bryndis; Tierney, M L; Howitt, S M; Cox, G B et al.

Part of Proceedings of the Royal Society of London. Biological Sciences, p. 307-12, 1992

• DOI for A combination of human alpha 1 and beta 1 subunits is required for formation of detectable GABA-activated chloride channels in Sf9 cells.

Voltage-clamp studies of the Na+/glucose cotransporter cloned from rabbit small intestine.

Birnir, Bryndis; Loo, D D; Wright, E M

Part of Pflügers Archiv, p. 79-85, 1991

Expression and characterization of the intestinal Na+/glucose cotransporter in COS-7 cells.

Birnir, Bryndis; Lee, H S; Hediger, M A; Wright, E M

Part of Biochimica et Biophysica Acta, p. 100-4, 1990

Serum chemistry and evidence of renal failure in the North Atlantic fin whale population.

Lambertsen, R H; Birnir, Bryndis; Bauer, J E

Part of Journal of Wildlife Diseases, p. 389-96, 1986

GABAergic signalling in the immune system

Barragan, A.; Weidner, J. M.; Jin, Zhe; Korpi, E. R. et al.

Part of Acta Physiologica, p. 819-827, 2015

• DOI for GABAergic signalling in the immune system

GABA is an efficient immunomodulator molecule

Jin, Zhe; Mendu, Suresh Kumar; Bhandage, Amol K.; Birnir, Bryndis

Part of Nerve-Driven Immunity, p. 163-173, Springer, 2012

• DOI for GABA is an efficient immunomodulator molecule

In a cell-type specific manner, high-affinity GABA-A receptors participate in autocrine and paracrine GABA signaling in human pancreatic islets

Jin, Yang; Korol, Sergiy; Jin, Zhe; Laver, Derek et al.

GABA, insulin and glucose orchestrate effector functions of human CD4+ T cells

Jin, Zhe; Hammoud, Hayma; Bhandage, Amol; Korol, Sergiy et al.