Peter Bergsten

Advances in CRISPR-Cas technology and its applications: revolutionising precision medicine

Azeez, Sarkar Sardar; Hamad, Rahin Shareef; Hamad, Bahra Kakamin; Shekha, Mudhir Sabir et al.

Part of Frontiers in Genome Editing, 2024

• DOI for Advances in CRISPR-Cas technology and its applications: revolutionising precision medicine
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GABA-mediated inhibition of human CD4⁺ T cell functions is enhanced by insulin but impaired by high glucose levels

Jin, Zhe; Hammoud, Hayma; Bhandage, Amol; Korol, Sergiy Vasylyovych et al.

Part of EBioMedicine, 2024

• DOI for GABA-mediated inhibition of human CD4⁺ T cell functions is enhanced by insulin but impaired by high glucose levels
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Rise in fasting and dynamic glucagon levels in children and adolescents with obesity is moderate in subjects with impaired fasting glucose but accentuated in subjects with impaired glucose tolerance or type 2 diabetes

Pixner, Thomas; Chaikouskaya, Tatsiana; Lauth, Wanda; Zimmermann, Georg et al.

Part of Frontiers in Endocrinology, 2024

• DOI for Rise in fasting and dynamic glucagon levels in children and adolescents with obesity is moderate in subjects with impaired fasting glucose but accentuated in subjects with impaired glucose tolerance or type 2 diabetes
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Studies in children with obesity in two European treatment centres show a high prevalence of impaired glucose metabolism in the Swedish cohort

Ciba, Iris; Dahlbom, Marie; Manell, Hannes; Mörwald, Katharina et al.

Part of Acta Paediatrica, p. 286-295, 2024

• DOI for Studies in children with obesity in two European treatment centres show a high prevalence of impaired glucose metabolism in the Swedish cohort
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Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells

Kopsida, Maria; Clavero, Ada Lerma; Khaled, Jaafar; Balgoma, David et al.

Part of Molecular Metabolism, 2024

• DOI for Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells
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GABA-mediated inhibition of human CD4⁺ T cell functions is enhanced by insulin but impaired by high glucose levels

Jin, Zhe; Hammoud, Hayma; Bhandage, Amol; Korol, Sergiy Vasylyovych et al.

Part of EBioMedicine, 2024

• DOI for GABA-mediated inhibition of human CD4⁺ T cell functions is enhanced by insulin but impaired by high glucose levels
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Rise in fasting and dynamic glucagon levels in children and adolescents with obesity is moderate in subjects with impaired fasting glucose but accentuated in subjects with impaired glucose tolerance or type 2 diabetes

Pixner, Thomas; Chaikouskaya, Tatsiana; Lauth, Wanda; Zimmermann, Georg et al.

Part of Frontiers in Endocrinology, 2024

• DOI for Rise in fasting and dynamic glucagon levels in children and adolescents with obesity is moderate in subjects with impaired fasting glucose but accentuated in subjects with impaired glucose tolerance or type 2 diabetes
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Studies in children with obesity in two European treatment centres show a high prevalence of impaired glucose metabolism in the Swedish cohort

Ciba, Iris; Dahlbom, Marie; Manell, Hannes; Mörwald, Katharina et al.

Part of Acta Paediatrica, p. 286-295, 2024

• DOI for Studies in children with obesity in two European treatment centres show a high prevalence of impaired glucose metabolism in the Swedish cohort
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Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells

Kopsida, Maria; Clavero, Ada Lerma; Khaled, Jaafar; Balgoma, David et al.

Part of Molecular Metabolism, 2024

• DOI for Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells
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Adolescents with obesity treated with exenatide maintain endogenous GLP-1, reduce DPP-4, and improve glycemic control

Stenlid, Rasmus; Cerenius, Sara Y.; Wen, Quan; Aydin, Banu K. et al.

Part of Frontiers in Endocrinology, 2023

• DOI for Adolescents with obesity treated with exenatide maintain endogenous GLP-1, reduce DPP-4, and improve glycemic control
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Screening for inflammatory markers identifies IL18-Rα as a potential link between exenatide and its anti-inflammatory effect: New results from the Combat-JUDO randomized controlled trial

Stenlid, Rasmus; Cerenius, Sara Y.; Manell, Hannes; Aydin, Banu K. et al.

Part of Annals of Nutrition and Metabolism, p. 522-527, 2023

• DOI for Screening for inflammatory markers identifies IL18-Rα as a potential link between exenatide and its anti-inflammatory effect: New results from the Combat-JUDO randomized controlled trial

Low Fasting Concentrations of Glucagon in Patients with Very Long-Chain Acyl-CoA Dehydrogenase Deficiency

Stenlid, Rasmus; Manell, Hannes; Seth, Rikard; Cerenius, Sara Y. et al.

Part of Metabolites, 2023

• DOI for Low Fasting Concentrations of Glucagon in Patients with Very Long-Chain Acyl-CoA Dehydrogenase Deficiency
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Metformin Can Attenuate Beta-Cell Hypersecretion-Implications for Treatment of Children with Obesity

Wen, Quan; Stenlid, Rasmus; Chowdhury, Azazul Islam; Ciba, Iris et al.

Part of Metabolites, 2023

• DOI for Metformin Can Attenuate Beta-Cell Hypersecretion-Implications for Treatment of Children with Obesity
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Metformin restores prohormone processing enzymes and normalizes aberrations in secretion of proinsulin and insulin in palmitate‐exposed human islets

Wen, Quan; Chowdhury, Azazul Islam; Aydin, Banu; Shekha, Mudhir et al.

Part of Diabetes, obesity and metabolism, p. 3757-3765, 2023

• DOI for Metformin restores prohormone processing enzymes and normalizes aberrations in secretion of proinsulin and insulin in palmitate‐exposed human islets
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Short-term effects of canagliflozin on glucose and insulin responses in insulin dysregulated horses: A randomized, placebo-controlled, double-blind, study

Lindåse, Sanna; Nostell, Katarina; Forslund, Anders; Bergsten, Peter et al.

Part of Journal of Veterinary Internal Medicine, p. 2520-2528, 2023

• DOI for Short-term effects of canagliflozin on glucose and insulin responses in insulin dysregulated horses: A randomized, placebo-controlled, double-blind, study
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Altered mitochondrial metabolism in peripheral blood cells from patients with inborn errors of β-oxidation

Stenlid, Rasmus; Olsson, David; Cen, Jing; Manell, Hannes et al.

Part of Clinical and Translational Science, p. 182-194, 2022

• DOI for Altered mitochondrial metabolism in peripheral blood cells from patients with inborn errors of β-oxidation
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Deviating glucose results in an international dual-center study. A root cause investigation

Cadamuro, Janne; Bergsten, Peter; Mörwald, Katharina; Forslund, Anders et al.

Part of Biochemia Medica, 2022

• DOI for Deviating glucose results in an international dual-center study. A root cause investigation
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Association between Metabolic Syndrome Diagnosis and the Physical Activity-Sedentary Profile of Adolescents with Obesity: A Complementary Analysis of the Beta-JUDO Study

Julian, Valerie; Ciba, Iris; Olsson, Roger; Dahlbom, Marie et al.

Part of Nutrients, 2022

• DOI for Association between Metabolic Syndrome Diagnosis and the Physical Activity-Sedentary Profile of Adolescents with Obesity: A Complementary Analysis of the Beta-JUDO Study
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Sedentary time has a stronger impact on metabolic health than moderate to vigorous physical activity in adolescents with obesity: a cross-sectional analysis of the Beta-JUDO study

Julian, Valerie; Bergsten, Peter; Forslund, Anders; Ahlström, Håkan et al.

Part of Pediatric Obesity, 2022

• DOI for Sedentary time has a stronger impact on metabolic health than moderate to vigorous physical activity in adolescents with obesity: a cross-sectional analysis of the Beta-JUDO study

The endoplasmic reticulum-plasma membrane tethering protein TMEM24 is a regulator of cellular Ca2+ homeostasis

Xie, Beichen; Panagiotou, Styliani; Cen, Jing; Gilon, Patrick et al.

Part of Journal of Cell Science, 2022

• DOI for The endoplasmic reticulum-plasma membrane tethering protein TMEM24 is a regulator of cellular Ca2+ homeostasis
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Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions

Westergren Jakobsson, Amanda; Kundu, Snehangshu; Guo, Jing; Chowdhury, Azazul Islam et al.

Part of Cancers, 2022

• DOI for Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions
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Obesity in adolescents associated with vascular aging - a study using ultra-high-resolution ultrasound

Naessén, Tord; Bergsten, Peter; Lundmark, Tobias; Forslund, Anders

Part of Upsala Journal of Medical Sciences, 2022

• DOI for Obesity in adolescents associated with vascular aging - a study using ultra-high-resolution ultrasound
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Determinants of hyperglucagonemia in pediatric non-alcoholic fatty liver disease

Maruszczak, Katharina; Radzikowski, Konrad; Schuetz, Sebastian; Mangge, Harald et al.

Part of Frontiers in Endocrinology, 2022

• DOI for Determinants of hyperglucagonemia in pediatric non-alcoholic fatty liver disease
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Single Point Insulin Sensitivity Estimator in Pediatric Non-Alcoholic Fatty Liver Disease

Furthner, Dieter; Anderwald, Christian-Heinz; Bergsten, Peter; Forslund, Anders et al.

Part of Frontiers in Endocrinology, 2022

• DOI for Single Point Insulin Sensitivity Estimator in Pediatric Non-Alcoholic Fatty Liver Disease
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High levels of FSH before puberty are associated with increased risk of metabolic syndrome during pubertal transition

Aydin, Banu K.; Stenlid, Rasmus; Ciba, Iris; Cerenius, Sara Y. et al.

Part of Pediatric Obesity, 2022

• DOI for High levels of FSH before puberty are associated with increased risk of metabolic syndrome during pubertal transition
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Association between alanine aminotransferase as surrogate of fatty liver disease and physical activity and sedentary time in adolescents with obesity

Julian, Valerie; Bergsten, Peter; Ennequin, Gael; Forslund, Anders et al.

Part of European Journal of Pediatrics, p. 3119-3129, 2022

• DOI for Association between alanine aminotransferase as surrogate of fatty liver disease and physical activity and sedentary time in adolescents with obesity

Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK

Elksnis, Andris; Schiffer, Tomas A.; Palm, Fredrik; Wang, Yun et al.

Part of Clinical Science, p. 2243-2263, 2021

• DOI for Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK

Impaired HMG-CoA reductase activity caused by genetic variants or statin exposure: impact on human adipose tissue, β-cells and metabolome

Sarsenbayeva, Assel; Jui Nandi, Bipasha; Fanni, Giovanni; Barbosa, Pedro et al.

Part of Metabolites, 2021

• DOI for Impaired HMG-CoA reductase activity caused by genetic variants or statin exposure: impact on human adipose tissue, β-cells and metabolome
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Prevalence of different states of glucose intolerance in Sri Lankan children and adolescents with obesity and its relation to other comorbidities.

Ciba, Iris; Warnakulasuriya, Loretta S; Adikaram, Adikaram V N; Bergsten, Peter et al.

Part of Pediatric Diabetes, p. 168-181, 2021

• DOI for Prevalence of different states of glucose intolerance in Sri Lankan children and adolescents with obesity and its relation to other comorbidities.
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Metabolic Abnormalities in a Cohort of Overweight and Obese Children in an Urban Setting of Sri Lanka

Warnakulasuriya, Loretta S.; Samaranayake, Dulani L.; Adikaram, Adikaram V. N.; Fernando, Manel M. A. et al.

Part of International Journal of Endocrinology, 2021

• DOI for Metabolic Abnormalities in a Cohort of Overweight and Obese Children in an Urban Setting of Sri Lanka
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Evaluation of fasting plasma insulin and proxy measurements to assess insulin sensitivity in horses

Lindase, Sanna; Nostell, Katarina; Bergsten, Peter; Forslund, Anders et al.

Part of BMC Veterinary Research, 2021

• DOI for Evaluation of fasting plasma insulin and proxy measurements to assess insulin sensitivity in horses
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The importance of the ZBED6-IGF2 axis for metabolic regulation in mouse myoblast cells

Younis, Shady; Naboulsi, Rakan; Wang, Xuan; Cao, Xiaofang et al.

Part of The FASEB Journal, p. 10250-10266, 2020

• DOI for The importance of the ZBED6-IGF2 axis for metabolic regulation in mouse myoblast cells
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Serum Ferritin Correlates With Liver Fat in Male Adolescents With Obesity.

Mörwald, Katharina; Aigner, Elmar; Bergsten, Peter; Brunner, Susanne M et al.

Part of Frontiers in Endocrinology, 2020

• DOI for Serum Ferritin Correlates With Liver Fat in Male Adolescents With Obesity.

A 6-month randomized, double-blind, placebo-controlled trial of weekly exenatide in adolescents with obesity

Weghuber, D.; Forslund, Anders; Ahlström, Håkan; Alderborn, Anders et al.

Part of Pediatric Obesity, 2020

• DOI for A 6-month randomized, double-blind, placebo-controlled trial of weekly exenatide in adolescents with obesity
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Glucose Appearance Rate Rather than the Blood Glucose Concentrations Explains Differences in Postprandial Insulin Responses between Wholemeal Rye and Refined Wheat Breads-Results from A Cross-Over Meal Study

Ostman, Johnny R.; Mullner, Elisabeth; Eriksson, Jan; Kristinsson, Hjalti et al.

Part of Molecular Nutrition & Food Research, 2019

• DOI for Glucose Appearance Rate Rather than the Blood Glucose Concentrations Explains Differences in Postprandial Insulin Responses between Wholemeal Rye and Refined Wheat Breads-Results from A Cross-Over Meal Study

Brown adipose tissue estimated with the magnetic resonance imaging fat fraction is associated with glucose metabolism in adolescents

Lundström, Elin; Ljungberg, Joy; Andersson, Jonathan; Manell, Hannes et al.

Part of Pediatric Obesity, 2019

• DOI for Brown adipose tissue estimated with the magnetic resonance imaging fat fraction is associated with glucose metabolism in adolescents

Oleate increase neutral lipid accumulation, cellular respiration and rescues palmitate-exposed GLP-1 secreting cells by reducing ceramide-induced ROS

Ntika, Stelia; Thombare, Ketan; Aryapoor, Masood; Kristinsson, Hjalti et al.

Part of Biochimie, p. 23-35, 2019

• DOI for Oleate increase neutral lipid accumulation, cellular respiration and rescues palmitate-exposed GLP-1 secreting cells by reducing ceramide-induced ROS

The protein synthesis inhibitor brusatol normalizes high-fat diet-induced glucose intolerance in male C57BL/6 mice: role of translation factor eIF5A hypusination

Turpaev, Kyril; Krizhanovskii, Camilla; Wang, Xuan; Sargsyan, Ernest et al.

Part of The FASEB Journal, p. 3510-3522, 2019

• DOI for The protein synthesis inhibitor brusatol normalizes high-fat diet-induced glucose intolerance in male C57BL/6 mice: role of translation factor eIF5A hypusination

Fully convolutional networks for automated segmentation of abdominal adipose tissue depots in multicenter water–fat MRI

Langner, Taro; Hedström, Anders; Mörwald, Katharina; Weghuber, Daniel et al.

Part of Magnetic Resonance in Medicine, p. 2736-2745, 2019

• DOI for Fully convolutional networks for automated segmentation of abdominal adipose tissue depots in multicenter water–fat MRI

Developmental exposure to a very low dose of bisphenol A induces persistent islet insulin hypersecretion in Fischer 344 rat offspring

Manukyan, Levon; Dunder, Linda; Lind, P. Monica; Bergsten, Peter et al.

Part of Environmental Research, p. 127-136, 2019

• DOI for Developmental exposure to a very low dose of bisphenol A induces persistent islet insulin hypersecretion in Fischer 344 rat offspring
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Assessment of Nutritional Status in Sri Lankan Children: Validity of Current Anthropometry Cutoffs?

Warnakulasuriya, Loretta S.; Fernando, Manel A. M.; Adikaram, A. V. Nihal; Thawfeek, A. R. M. et al.

Part of Asia-Pacific journal of public health, p. 633-642, 2019

• DOI for Assessment of Nutritional Status in Sri Lankan Children: Validity of Current Anthropometry Cutoffs?

Hyperglucagonemia in youth is associated with high plasma free fatty acids, visceral adiposity and impaired glucose tolerance

Manell, Hannes; Kristinsson, Hjalti; Kullberg, Joel; Ubhayasekera, Sarojini Jayantha Kumari et al.

Part of Pediatric Diabetes, p. 880-891, 2019

• DOI for Hyperglucagonemia in youth is associated with high plasma free fatty acids, visceral adiposity and impaired glucose tolerance

Identification of early biological changes in palmitate-treated isolated human islets.

Sargsyan, Ernest; Cen, Jing; Roomp, Kirsten; Schneider, Reinhard et al.

Part of BMC Genomics, 2018

• DOI for Identification of early biological changes in palmitate-treated isolated human islets.
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High DPP-4 concentrations in adolescents are associated with low intact GLP-1

Stenlid, Rasmus; Manell, Hannes; Halldin, Maria; Kullberg, Joel et al.

Part of Journal of Clinical Endocrinology and Metabolism, p. 2958-2966, 2018

• DOI for High DPP-4 concentrations in adolescents are associated with low intact GLP-1

Mechanisms of beneficial effects of metformin on fatty acid-treated human islets

Cen, Jing; Sargsyan, Ernest; Forslund, Anders; Bergsten, Peter

Part of Journal of Molecular Endocrinology, p. 91-99, 2018

• DOI for Mechanisms of beneficial effects of metformin on fatty acid-treated human islets

Palmitate-Induced Insulin Hypersecretion and Later Secretory Decline Associated with Changes in Protein Expression Patterns in Human Pancreatic Islets

Groebe, Karlfried; Cen, Jing; Schvartz, Domitille; Sargsyan, Ernest et al.

Part of Journal of Proteome Research, p. 3824-3836, 2018

• DOI for Palmitate-Induced Insulin Hypersecretion and Later Secretory Decline Associated with Changes in Protein Expression Patterns in Human Pancreatic Islets

Lysophosphatidylcholine and its phosphorothioate analogues potentiate insulin secretion via GPR40 (FFAR1), GPR55 and GPR119 receptors in a different manner

Drzazga, Anna; Kristinsson, Hjalti; Salaga, Maciej; Zatorski, Hubert et al.

Part of Molecular and Cellular Endocrinology, p. 117-125, 2018

• DOI for Lysophosphatidylcholine and its phosphorothioate analogues potentiate insulin secretion via GPR40 (FFAR1), GPR55 and GPR119 receptors in a different manner

The initial rise in GIP secretion during OGTT correlates with the initial suppression of glucagon secretion in adolescents with obesity and type 2 diabetes

Kristinsson, Hjalti; Manell, Hannes; Dahlbom, Marie; Presto, J. et al.

Part of Diabetologia, 2018

Basal hypersecretion of glucagon and insulin from palmitate-exposed human islets depends on FFAR1 but not decreased somatostatin secretion

Kristinsson, Hjalti; Sargsyan, Ernest; Manell, Hannes; Smith, D. M. et al.

Part of Scientific Reports, 2017

• DOI for Basal hypersecretion of glucagon and insulin from palmitate-exposed human islets depends on FFAR1 but not decreased somatostatin secretion

Automated segmentation of human cervical-supraclavicular adipose tissue in magnetic resonance images

Lundström, Elin; Strand, Robin; Forslund, Anders; Bergsten, Peter et al.

Part of Scientific Reports, 2017

• DOI for Automated segmentation of human cervical-supraclavicular adipose tissue in magnetic resonance images
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Combined lipidomic and proteomic analysis of isolated human islets exposed to palmitate reveals time-dependent changes in insulin secretion and lipid metabolism

Roomp, Kirsten; Kristinsson, Hjalti; Schvartz, Domitille; Ubhayasekera, Kumari et al.

Part of PLOS ONE, 2017

• DOI for Combined lipidomic and proteomic analysis of isolated human islets exposed to palmitate reveals time-dependent changes in insulin secretion and lipid metabolism
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Association Between Non-Alcoholic Fatty Liver Disease (NAFLD) and Iron Metabolism in Obese Children and Adolescents: Results of the Beta-JUDO Study

Paulmichl, K.; Ahlström, Håkan; Bergsten, Peter; Brunner, S. et al.

Part of Acta Paediatrica, p. 13-13, 2017

• DOI for Association Between Non-Alcoholic Fatty Liver Disease (NAFLD) and Iron Metabolism in Obese Children and Adolescents: Results of the Beta-JUDO Study

Exenatide Once Weekly Reduces Weight, Liver Fat And 2-Hour Postprandial Glucose In Obese Adolescents

Forslund, Anders; Weghuber, D.; Paulmichl, K.; Zsoldos, F. et al.

Part of Acta Paediatrica, p. 14-15, 2017

• DOI for Exenatide Once Weekly Reduces Weight, Liver Fat And 2-Hour Postprandial Glucose In Obese Adolescents

TNFSF14: a potential contributor to hyperinsulinaemia in childhood obesity

Manell, Hannes; Shen, Qiujin; Kamali-Moghaddam, Masood; Forslund, Anders et al.

Part of Diabetologia, 2017

Effect of Glucose Load on the Incretin Response (GLP-1) in obese Adolescents compared to the normal-weight Adolescents

Heu, Verena; Aigner, Elmar; Bergsten, Peter; Cadamuro, Janne et al.

Part of Wiener Klinische Wochenschrift, p. 736-736, 2017

Metformin restores insulin secretion from palmitate-treated human islets by normalising mitochondrial metabolism and reducing ER stress and apoptosis

Cen, Jing; Sargsyan, Ernest; Bergsten, Peter

Part of Diabetologia, 2017

GLP-1 analogue recovers impaired insulin secretion from human islets treated with palmitate via down-regulation of SOCS2

Chowdhury, Azazul Islam; Bergsten, Peter

Part of Molecular and Cellular Endocrinology, p. 194-202, 2017

• DOI for GLP-1 analogue recovers impaired insulin secretion from human islets treated with palmitate via down-regulation of SOCS2

Childhood adiposity and risk of type 1 diabetes: A Mendelian randomization study

Censin, J. C.; Nowak, Christoph; Cooper, Nicholas; Bergsten, Peter et al.

Part of PLoS Medicine, 2017

• DOI for Childhood adiposity and risk of type 1 diabetes: A Mendelian randomization study
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EndoC-beta H1 cells display increased sensitivity to sodium palmitate when cultured in DMEM/F12 medium

Krizhanovskii, Camilla; Kristinsson, Hjalti; Elksnis, Andris; Wang, Xuan et al.

Part of Islets, p. 43-48, 2017

• DOI for EndoC-beta H1 cells display increased sensitivity to sodium palmitate when cultured in DMEM/F12 medium

Pancreatic Fat Is Associated With Metabolic Syndrome and Visceral Fat but Not Beta-Cell Function or Body Mass Index in Pediatric Obesity

Staaf, Johan; Labmayr, Viktor; Paulmichl, Katharina; Manell, Hannes et al.

Part of Pancreas, p. 358-365, 2017

• DOI for Pancreatic Fat Is Associated With Metabolic Syndrome and Visceral Fat but Not Beta-Cell Function or Body Mass Index in Pediatric Obesity
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Oleate protects beta-cells from the toxic effect of palmitate by activating pro-survival pathways of the ER stress response

Sargsyan, Ernest; Artemenko, Konstantin; Manukyan, Levon; Bergquist, Jonas et al.

Part of Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, p. 1151-1160, 2016

• DOI for Oleate protects beta-cells from the toxic effect of palmitate by activating pro-survival pathways of the ER stress response

Branched-chain amino acids are associated with cardiometabolic risk profiles found already in lean, overweight and obese young

Mangge, Harald; Zelzer, Sieglinde; Prueller, Florian; Schnedl, Wolfgang J. et al.

Part of Journal of Nutritional Biochemistry, p. 123-127, 2016

• DOI for Branched-chain amino acids are associated with cardiometabolic risk profiles found already in lean, overweight and obese young

Fatty acids stimulate insulin secretion from human pancreatic islets at fasting glucose concentrations via mitochondria-dependent and -independent mechanisms

Cen, Jing; Sargsyan, Ernest; Bergsten, Peter

Part of Nutrition & Metabolism, 2016

• DOI for Fatty acids stimulate insulin secretion from human pancreatic islets at fasting glucose concentrations via mitochondria-dependent and -independent mechanisms
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Altered Plasma Levels of Glucagon, GLP-1 and Glicentin During OGTT in Adolescents With Obesity and Type 2 Diabetes

Manell, Hannes; Staaf, Johan; Manukyan, Levon; Kristinsson, Hjalti et al.

Part of Journal of Clinical Endocrinology and Metabolism, p. 1181-1189, 2016

• DOI for Altered Plasma Levels of Glucagon, GLP-1 and Glicentin During OGTT in Adolescents With Obesity and Type 2 Diabetes

Hyperglucagonemia is associated with a Increase of Plasma Triglycerides as well as visceral Fat Tissue in a pediatric Cohort

Manell, Hannes; Kristinsson, Hjalti; Kullberg, Joel; Paulmichl, Katharina et al.

Part of Wiener Klinische Wochenschrift, p. 747-747, 2016

Eating Behavior In Swedish And Austrian Children And Adolescents With Obesity

Ciba, Iris; Eriksson, J.; Ardelt-Gattinger, E.; Hofmann, J. et al.

Part of Acta Paediatrica, p. 30-31, 2016

Initial hyperinsulinemia and subsequent beta-cell dysfunction is associated with elevated palmitate levels

Staaf, Johan; Ubhayasekera, Sarojini J. K. A.; Sargsyan, Ernest; Chowdhury, Azazul et al.

Part of Pediatric Research, p. 267-274, 2016

• DOI for Initial hyperinsulinemia and subsequent beta-cell dysfunction is associated with elevated palmitate levels

Modification and Validation of the Triglyceride-to-HDL Cholesterol Ratio as a Surrogate of Insulin Sensitivity in White Juveniles and Adults without Diabetes Mellitus: The Single Point Insulin Sensitivity Estimator (SPISE)

Paulmichl, Katharina; Hatunic, Mensud; Hojlund, Kurt; Jotic, Aleksandra et al.

Part of Clinical Chemistry, p. 1211-1219, 2016

• DOI for Modification and Validation of the Triglyceride-to-HDL Cholesterol Ratio as a Surrogate of Insulin Sensitivity in White Juveniles and Adults without Diabetes Mellitus: The Single Point Insulin Sensitivity Estimator (SPISE)

Oleate protects beta cells from the toxic effect of palmitate by restoring pro-survival pathways of the ER stress response

Sargsyan, Ernest; Artemenko, Konstantin A.; Manukyan, Levon; Bergquist, Jonas et al.

Part of Diabetologia, 2016

Hyperglucagonaemia is associated with elevated plasma triglycerides and increased visceral fat in children and adolescents

Manell, Hannes; Kristinsson, Hjalti; Kullberg, Joel; Paulmichl, K. et al.

Part of Diabetologia, 2016

Free fatty acids amplify basal secretion of both glucagon and insulin from isolated human islets at normoglycaemia via metabolic and FFAR1 dependent mechanism

Kristinsson, Hjalti; Sargsyan, Ernest; Bergsten, Peter

Part of Diabetologia, 2016

Role of the AMP kinase in cytokine-induced human EndoC-beta H1 cell death

Fred, Rikard G.; Kappe, Camilla; Ameur, Adam; Cen, Jing et al.

Part of Molecular and Cellular Endocrinology, p. 53-63, 2015

• DOI for Role of the AMP kinase in cytokine-induced human EndoC-beta H1 cell death
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Magnetic resonance imaging cooling–reheating protocol indicates decreased fat fraction via lipid consumption in suspected brown adipose tissue

Lundström, Elin; Strand, Robin; Johansson, Lars; Bergsten, Peter et al.

Part of PLOS ONE, 2015

• DOI for Magnetic resonance imaging cooling–reheating protocol indicates decreased fat fraction via lipid consumption in suspected brown adipose tissue

Free fatty acid receptor 1 (FFAR1/GPR40) signaling affects insulin secretion by enhancing mitochondrial respiration during palmitate exposure

Kristinsson, Hjalti; Bergsten, Peter; Sargsyan, Ernest

Part of Biochimica et Biophysica Acta. Molecular Cell Research, p. 3248-3257, 2015

• DOI for Free fatty acid receptor 1 (FFAR1/GPR40) signaling affects insulin secretion by enhancing mitochondrial respiration during palmitate exposure
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Palmitate-induced impairments of beta-cell function are linked with generation of specific ceramide species via acylation of sphingosine

Manukyan, Levon; Ubhayasekera, Sarojini J.K.A.; Bergquist; Sargsyan, Ernest et al.

Part of Endocrinology, p. 802-812, 2015

• DOI for Palmitate-induced impairments of beta-cell function are linked with generation of specific ceramide species via acylation of sphingosine
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Early Adiposity Rebound and its Association with Obesity and Neuropsychiatric Disorders

Norgren, A.; Ciba, Iris; Manell, Hannes; Stenlid, R. et al.

Part of Acta Paediatrica, p. 16-16, 2015

Dipeptidyl Peptidase-4 is Associated with Elevated Liver Enzymes, Impaired Glucose Tolerance and Lowered Glucagon-Like Peptide-1 in Obese Children

Stenlid, R.; Manell, Hannes; Forslund, Anders; Bergsten, Peter

Part of Acta Paediatrica, p. 15-15, 2015

Development of Glucose Intolerance in Obese Children Studied in the Beta-Judo Cohort

Ciba, Iris; Weghuber, D.; Manell, Hannes; Staaf, Johan et al.

Part of Acta Paediatrica, p. 12-12, 2015

Pancreatic Fat is Associated with Metabolic Syndrome and Visceral Adipose Tissue but not Beta-Cell Function or Body Mass Index in Paediatric Obesity

Staaf, Johan; Labmayr, V.; Paulmichl, K.; Ohlsson, H. et al.

Part of Acta Paediatrica, p. 2-2, 2015

Deep Subcutaneous Adipose Tissue Correlates with Accentuated Insulin Secretion and Poor Insulin Sensitivity in Obese Children and Adolescents

Paulmichl, K.; Binder, S.; Eidherr, A.; Zsoldos, F. et al.

Part of Acta Paediatrica, p. 2-3, 2015

Palmitate stimulates insulin secretion by enhancing mitochondrial respiration via intracellular metabolism and FFAR1 signalling

Kristinsson, Hjalti; Bergsten, Peter; Sargsyan, Ernest

Part of Diabetologia, 2015

Role of PIAS1 in palmitate mediated beta cell dysfunction

Chowdhury, Azazul Islam; Hörnaeus, Katarina; Bergquist, Jonas; Bergsten, Peter

Part of Diabetologia, 2015

Active GLP-1 but not insulin, glicentin or glucagon predicts the 2-hour OGTT glucose value in obese children

Ohlsson, H.; Staaf, Johan; Manukyan, Levon; Cen, J. et al.

Part of Diabetologia, 2015

Uppsala Longitudinal Study of Childhood Obesity: Protocol Description

Forslund, Anders; Staaf, Johan; Kullberg, Joel; Ciba, Iris et al.

Part of Pediatrics, 2014

• DOI for Uppsala Longitudinal Study of Childhood Obesity: Protocol Description

Free fatty acid determination in plasma by GC-MS after conversion to Weinreb amides

Ubhayasekera, Sarojini J.K.A.; Staaf, Johan; Forslund, Anders; Bergsten, Peter et al.

Part of Analytical and Bioanalytical Chemistry, p. 1929-1935, 2013

• DOI for Free fatty acid determination in plasma by GC-MS after conversion to Weinreb amides

FFAR1 is involved in both the acute and chronic effects of palmitate on insulin secretion

Kristinsson, Hjalti; Smith, D.; Bergsten, Peter; Sargsyan, Ernest

Part of Diabetologia, 2013

Signaling in Insulin-Secreting MIN6 Pseudoislets and Monolayer Cells

Chowdhury, Azazul; Satagopam, Venkata P.; Manukyan, Levon; Artemenko, Konstantin A. et al.

Part of Journal of Proteome Research, p. 5954-5962, 2013

• DOI for Signaling in Insulin-Secreting MIN6 Pseudoislets and Monolayer Cells

FFAR1 Is Involved in Both the Acute and Chronic Effects of Palmitate on Insulin Secretion

Kristinsson, Hjalti; Smith, David M.; Bergsten, Peter; Sargsyan, Ernest

Part of Endocrinology, p. 4078-4088, 2013

• DOI for FFAR1 Is Involved in Both the Acute and Chronic Effects of Palmitate on Insulin Secretion

Functional differences between aggregated and dispersed insulin-producing cells

Chowdhury, Azazul Islam; Dyachok, Oleg; Tengholm, Anders; Sandler, Stellan et al.

Part of Diabetologia, p. 1557-1568, 2013

• DOI for Functional differences between aggregated and dispersed insulin-producing cells
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Hög tid att söka till nya MD/PhD-programmet vid Uppsala universitet: Tidig bro mellan preklinisk forskning och klinik

Staaf, Johan; Åkerström, Tobias; Ljungström, Viktor; Larsson, Sune et al.

Part of Läkartidningen, p. 898-898, 2012

UPR in palmitate-treated pancreatic beta-cells is not affected by altering oxidation of the fatty acid

Sargsyan, Ernest; Sol, E-ri Maria; Bergsten, Peter

Part of Nutrition & Metabolism, p. 70, 2011

• DOI for UPR in palmitate-treated pancreatic beta-cells is not affected by altering oxidation of the fatty acid
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Lipotoxicity is glucose-dependent in INS-1E cells but not in human islets and MIN6 cells

Sargsyan, Ernest; Bergsten, Peter

Part of Lipids in Health and Disease, p. 115, 2011

• DOI for Lipotoxicity is glucose-dependent in INS-1E cells but not in human islets and MIN6 cells

Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing beta-cells

Thörn, Kristofer; Hovsepyan, Meri; Bergsten, Peter

Part of Lipids in Health and Disease, p. 108, 2010

• DOI for Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing beta-cells

Rapid alternations in DNA methylation patterns in insulin-producing beta cells correlate with changes in ambient glucose levels

Wallin Öhman, E.; Staaf, Johan; Nilsson, R.; Fraga, M. et al.

Part of Diabetologia, 2010

Fatty acid-induced oxidation and triglyceride formation is higher in insulin-producing MIN6 cells exposed to oleate compared to palmitate

Thörn, Kristofer; Bergsten, Peter

Part of Journal of Cellular Biochemistry, p. 497-507, 2010

• DOI for Fatty acid-induced oxidation and triglyceride formation is higher in insulin-producing MIN6 cells exposed to oleate compared to palmitate

Palmitate-induced changes in protein expression of insulin secreting INS-1E cells

Hovsepyan, Meri; Sargsyan, Ernest; Bergsten, Peter

Part of Journal of Proteomics, p. 1148-1155, 2010

• DOI for Palmitate-induced changes in protein expression of insulin secreting INS-1E cells

Pseudoislets as primary islet replacements for research Report on a symposium at King's College London, London UK

Persaud, Shanta J.; Arden, Catherine; Bergsten, Peter; Bone, Adrian J. et al.

Part of Islets, p. 236-239, 2010

• DOI for Pseudoislets as primary islet replacements for research Report on a symposium at King's College London, London UK

Proteins altered by elevated levels of palmitate or glucose implicated in impaired glucose-stimulated insulin secretion

Sol, E-ri Maria; Hovsepyan, Meri; Bergsten, Peter

Part of Proteome Science, p. 24, 2009

• DOI for Proteins altered by elevated levels of palmitate or glucose implicated in impaired glucose-stimulated insulin secretion

Role of MAPK in apolipoprotein CIII-induced apoptosis in INS-1E cells

Sol, E-ri M; Sundsten, Tea; Bergsten, Peter

Part of Lipids in Health and Disease, p. 3, 2009

• DOI for Role of MAPK in apolipoprotein CIII-induced apoptosis in INS-1E cells

Short-term glucocorticoid treatment increases insulin secretion in islets derived from lean mice through multiple pathways and mechanisms

Hult, Malin; Ortsäter, Henrik; Schuster, Gertrud; Graedler, Florian et al.

Part of Molecular and Cellular Endocrinology, p. 109-116, 2009

• DOI for Short-term glucocorticoid treatment increases insulin secretion in islets derived from lean mice through multiple pathways and mechanisms

Islet protein profiling

Bergsten, P

Part of Diabetes, obesity and metabolism, p. 97-117, 2009

• DOI for Islet protein profiling

Apoptotic, Regenerative, And Immune-Related Signaling in Human Islets from Type 2 Diabetes Individuals

Nyblom, Hanna K; Bugliani, Marco; Fung, Eva; Boggi, Ugo et al.

Part of Journal of Proteome Research, p. 5650-5656, 2009

• DOI for Apoptotic, Regenerative, And Immune-Related Signaling in Human Islets from Type 2 Diabetes Individuals

Diazoxide-induced beta-cell rest reduces endoplasmic reticulum stress in lipotoxic beta-cells

Sargsyan, Ernest; Ortsäter, Henrik; Thorn, Kristofer; Bergsten, Peter

Part of Journal of Endocrinology, p. 41-50, 2008

• DOI for Diazoxide-induced beta-cell rest reduces endoplasmic reticulum stress in lipotoxic beta-cells

Glucose-induced de novo synthesis of fatty acyls causes proportional increases in INS-1E cellular lipids

Nyblom, Hanna K.; Nord, Lars; Andersson, Rolf; Kenne, Lennart et al.

Part of NMR in Biomedicine, p. 357-365, 2008

• DOI for Glucose-induced de novo synthesis of fatty acyls causes proportional increases in INS-1E cellular lipids

AMP-activated protein kinase agonist dose dependently improves function and reduces apoptosis in glucotoxic beta-cells without changing triglyceride levels

Nyblom, Hanna K; Sargsyan, Ernest; Bergsten, Peter

Part of Journal of molecular endocrinology, p. 187-94, 2008

• DOI for AMP-activated protein kinase agonist dose dependently improves function and reduces apoptosis in glucotoxic beta-cells without changing triglyceride levels

Serum protein patterns in newly diagnosed type 2 diabetes mellitus--influence of diabetic environment and family history of diabetes.

Sundsten, Tea; Ostenson, Claes-Göran; Bergsten, Peter

Part of Diabetes/Metabolism Research Reviews, p. 148-154, 2008

• DOI for Serum protein patterns in newly diagnosed type 2 diabetes mellitus--influence of diabetic environment and family history of diabetes.

Plasma proteome changes in subjects with Type 2 diabetes mellitus with a low or high early insulin response

Sundsten, Tea; Zethelius, Björn; Berne, Christian; Bergsten, Peter

Part of Clinical Science, p. 499-507, 2008

• DOI for Plasma proteome changes in subjects with Type 2 diabetes mellitus with a low or high early insulin response

Glucolipotoxicity in INS-1E cells is counteracted by carnitine palmitoyltransferase 1 over-expression

Sol, E-ri Maria; Sargsyan, Ernest; Akusjärvi, Göran; Bergsten, Peter

Part of Biochemical and Biophysical Research Communications - BBRC, p. 517-521, 2008

• DOI for Glucolipotoxicity in INS-1E cells is counteracted by carnitine palmitoyltransferase 1 over-expression

Evaluation of the SELDI-TOF MS technique for protein profiling of pancreatic islets exposed to glucose and oleate

Ortsäter, Henrik; Sundsten, Tea; Lin, Jian-Man; Bergsten, Peter

Part of Proteomics, p. 3105-3115, 2007

• DOI for Evaluation of the SELDI-TOF MS technique for protein profiling of pancreatic islets exposed to glucose and oleate

Mitochondrial protein patterns correlating with impaired insulin secretion from INS-1E cells exposed to elevated glucose concentrations

Nyblom, Hanna; Thorn, Kristofer; Ahmed, Meftun; Bergsten, Peter

Part of Proteomics, p. 5193-5198, 2006

• DOI for Mitochondrial protein patterns correlating with impaired insulin secretion from INS-1E cells exposed to elevated glucose concentrations

Oxo-4-methylpentanoic acid directs the metabolism of GABA into the Krebs cycle in rat pancreatic islets

Hernández-Fisac, Inés; Fernández-Pascual, Sergio; Ortsäter, Henrik; Pizarro-Delgado, Javier et al.

Part of Biochemical Journal, p. 81-89, 2006

• DOI for Oxo-4-methylpentanoic acid directs the metabolism of GABA into the Krebs cycle in rat pancreatic islets

Regulation of 11beta-hydroxysteroid dehydrogenase type 1 and glucose-stimulated insulin secretion in pancreatic islets of Langerhans.

Ortsäter, Henrik; Alberts, Peteris; Warpman, Ulrika; Engblom, Lars O M et al.

Part of Diabetes Metab Res Rev, p. 359-66, 2005

Glucose-induced changes of multiple mouse islet proteins analysed by two-dimensional gel electrophoresis and mass spectrometry.

Ahmed, Meftun; Bergsten, Peter

Part of Diabetologia, p. 477-85, 2005

Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry.

Ahmed, Meftun; Forsberg, Jens; Bergsten, Peter

Part of J Proteome Res, p. 931-40, 2005

Regulation of 11beta-hydroxysterioid dehydrogenase type 1 and glucose-stimulated insulin secretion in pancreatic islets of Langerhans

Ortsater, H; Alberts, P; Warpman, U; Engblom, LO et al.

Part of Diabetes Metab Res Rev, 2004

Phenotyping of individual pancreatic islets locates genetic defects instimulus secretion coupling to Niddm1i within the major diabetes locus inGK rats.

Lin, Jian-Man; Ortsäter, Henrik; Fakhrai-Rad, H; Galli, Joakim et al.

Part of Diabetes, p. 2737, 2001

Glucose-regulated pulsatile insulin release from mouse islets via the K(ATP) channel-independent pathway.

Westerlund, Johanna; Ortsäter, Henrik; Palm, Fredrik; Sundsten, Tea et al.

Part of Eur J Endocrinol, p. 667-75, 2001

Appearance of glucose-induced insulin release in fetal rat β-cells

Bergsten, Peter; Aoyagi, K.; Persson, Erik; Eriksson, Ulf J.

Part of Journal of Endocrinology, p. 115-120, 1998

In vitro regulation of insulin release and biosynthesis of fetal rat pancreatic cells explanted on pregnancy day 16.

Aoyagi, K; Bergsten, Peter; Eriksson, Ulf; Ebendal, Ted et al.

Part of Biol Neonate, p. 60-68, 1997

The GLP-1 receptor agonist exenatide is associated with improved adherence to health behavior and lifestyle treatment in adolescents with obesity, results from a randomized controlled trial

Stenlid, Rasmus; Cerenius, Sara Y.; Torbahn, Gabriel; Aydin, Banu K. et al.

Fasting insulin better predicts cardiometabolic risk factors in children and adolescents with obesity than BMI

Stenlid, Rasmus; El Amrani, Sami; Cerenius, Sara Y.; Aydin, Banu K. et al.

Advances in CRISPR-Cas technology and its applications: revolutionising precision medicine

Azeez, Sarkar Sardar; Hamad, Rahin Shareef; Hamad, Bahra Kakamin; Shekha, Mudhir Sabir et al.

Part of Frontiers in Genome Editing, 2024

• DOI for Advances in CRISPR-Cas technology and its applications: revolutionising precision medicine
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Protein profiling of pancreatic islets

Ortsäter, Henrik; Bergsten, Peter

Part of Expert review of proteomics, p. 665-675, 2006

• DOI for Protein profiling of pancreatic islets

Screening of inflammatory markers finds hepatocyte growth factor to be associated with weight gain in children and adolescents with obesity

Manell, Hannes; Shen, Qiujin; Roomp, Kirsten; Ciba, Iris et al.

Role of mitochondrial metabolism and fission protein DRP-1 in palmitate-induced glucagon secretion

Wen, Quan; Afrin, Nadia; Fathalla, Ashkan; Chowdhury, Azazul Islam et al.

Effect of phthalate metabolite MEHHP on mitochondrial metabolism and dynamics in human endometrial stromal cells

Visser, Nadja; Wen, Quan; Stenlid, Rasmus; Vieira Silva, Antero et al.