Nils Welsh

The Welander TIA1 mutation dedifferentiates insulin-producing cells: Reversal by a GLP-1 receptor agonist

Zhao, Tongjian; Cen, Jing; Wang, Xuan; Yang, Mingyu et al.

Part of Journal of Biological Chemistry, 2026

• DOI for The Welander TIA1 mutation dedifferentiates insulin-producing cells: Reversal by a GLP-1 receptor agonist
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GDF15 Protects Insulin-Producing Beta Cells against Pro-Inflammatory Cytokines and Metabolic Stress via Increased Deamination of Intracellular Adenosine

Ngamjariyawat, Anongnad; Cen, Jing; Wang, Xuan; Welsh, Nils

Part of International Journal of Molecular Sciences, 2024

• DOI for GDF15 Protects Insulin-Producing Beta Cells against Pro-Inflammatory Cytokines and Metabolic Stress via Increased Deamination of Intracellular Adenosine
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CLEC11A improves insulin secretion and promotes cell proliferation in human beta-cells

Shi, Ruifeng; Cen, Jing; Westermark, Gunilla; Zhao, Sheng et al.

Part of Journal of Molecular Endocrinology, 2023

• DOI for CLEC11A improves insulin secretion and promotes cell proliferation in human beta-cells
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The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets

Elksnis, Andris; Welsh, Nils; Wikström, Per; Lau, Joey et al.

Part of Free radical research, p. 460-469, 2023

• DOI for The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets
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Metabolic stress-induced human beta-cell death is mediated by increased intracellular levels of adenosine

Ngamjariyawat, Anongnad; Cen, Jing; Said, Romain; Incedal, Ceren et al.

Part of Frontiers in Endocrinology, 2023

• DOI for Metabolic stress-induced human beta-cell death is mediated by increased intracellular levels of adenosine
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The Welander TIA1 mutation dedifferentiates insulin-producing cells: Reversal by a GLP-1 receptor agonist

Zhao, Tongjian; Cen, Jing; Wang, Xuan; Yang, Mingyu et al.

Part of Journal of Biological Chemistry, 2026

• DOI for The Welander TIA1 mutation dedifferentiates insulin-producing cells: Reversal by a GLP-1 receptor agonist
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GDF15 Protects Insulin-Producing Beta Cells against Pro-Inflammatory Cytokines and Metabolic Stress via Increased Deamination of Intracellular Adenosine

Ngamjariyawat, Anongnad; Cen, Jing; Wang, Xuan; Welsh, Nils

Part of International Journal of Molecular Sciences, 2024

• DOI for GDF15 Protects Insulin-Producing Beta Cells against Pro-Inflammatory Cytokines and Metabolic Stress via Increased Deamination of Intracellular Adenosine
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CLEC11A improves insulin secretion and promotes cell proliferation in human beta-cells

Shi, Ruifeng; Cen, Jing; Westermark, Gunilla; Zhao, Sheng et al.

Part of Journal of Molecular Endocrinology, 2023

• DOI for CLEC11A improves insulin secretion and promotes cell proliferation in human beta-cells
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The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets

Elksnis, Andris; Welsh, Nils; Wikström, Per; Lau, Joey et al.

Part of Free radical research, p. 460-469, 2023

• DOI for The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets
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Metabolic stress-induced human beta-cell death is mediated by increased intracellular levels of adenosine

Ngamjariyawat, Anongnad; Cen, Jing; Said, Romain; Incedal, Ceren et al.

Part of Frontiers in Endocrinology, 2023

• DOI for Metabolic stress-induced human beta-cell death is mediated by increased intracellular levels of adenosine
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Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK

Elksnis, Andris; Schiffer, Tomas A.; Palm, Fredrik; Wang, Yun et al.

Part of Clinical Science, p. 2243-2263, 2021

• DOI for Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK

ZBED6 counteracts high-fat diet-induced glucose intolerance by maintaining beta cell area and reducing excess mitochondrial activation

Wang, Xuan; Younis, Shady; Cen, Jing; Wang, Yun et al.

Part of Diabetologia, p. 2292-2305, 2021

• DOI for ZBED6 counteracts high-fat diet-induced glucose intolerance by maintaining beta cell area and reducing excess mitochondrial activation
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Pharmacological Inhibition of NOX4 Improves Mitochondrial Function and Survival in Human Beta-Cells

Elksnis, Andris; Cen, Jing; Wikström, Per; Carlsson, Per-Ola et al.

Part of Biomedicines, 2021

• DOI for Pharmacological Inhibition of NOX4 Improves Mitochondrial Function and Survival in Human Beta-Cells
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The importance of the ZBED6-IGF2 axis for metabolic regulation in mouse myoblast cells

Younis, Shady; Naboulsi, Rakan; Wang, Xuan; Cao, Xiaofang et al.

Part of The FASEB Journal, p. 10250-10266, 2020

• DOI for The importance of the ZBED6-IGF2 axis for metabolic regulation in mouse myoblast cells
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The protein synthesis inhibitor brusatol normalizes high-fat diet-induced glucose intolerance in male C57BL/6 mice: role of translation factor eIF5A hypusination

Turpaev, Kyril; Krizhanovskii, Camilla; Wang, Xuan; Sargsyan, Ernest et al.

Part of The FASEB Journal, p. 3510-3522, 2019

• DOI for The protein synthesis inhibitor brusatol normalizes high-fat diet-induced glucose intolerance in male C57BL/6 mice: role of translation factor eIF5A hypusination

ZBED6 negatively regulates insulin production, neuronal differentiation, and cell aggregation in MIN6 cells

Wang, Xuan; Jiang, Lin; Wallerman, Ola; Younis, Shady et al.

Part of The FASEB Journal, p. 88-100, 2019

• DOI for ZBED6 negatively regulates insulin production, neuronal differentiation, and cell aggregation in MIN6 cells

The BRICHOS domain of Bri2 inhibits islet amyloid polypeptide (IAPP) fibril formation and toxicity in human beta cells

Oskarsson, Marie E.; Hermansson, Erik; Wang, Ye; Welsh, Nils et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2018

• DOI for The BRICHOS domain of Bri2 inhibits islet amyloid polypeptide (IAPP) fibril formation and toxicity in human beta cells

The novel NADPH oxidase 4 selective inhibitor GLX7013114 counteracts human islet cell death in vitro

Wang, Xuan; Elksnis, Andris; Wikström, Per; Walum, Erik et al.

Part of PLOS ONE, 2018

• DOI for The novel NADPH oxidase 4 selective inhibitor GLX7013114 counteracts human islet cell death in vitro
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Addition of exogenous sodium palmitate increases the IAPP/insulin mRNA ratio via GPR40 in human EndoC-beta H1 cells

Krizhanovskii, Camilla; Fred, Rikard G; Oskarsson, Marie E.; Westermark, Gunilla T. et al.

Part of Upsala Journal of Medical Sciences, p. 149-159, 2017

• DOI for Addition of exogenous sodium palmitate increases the IAPP/insulin mRNA ratio via GPR40 in human EndoC-beta H1 cells
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EndoC-beta H1 cells display increased sensitivity to sodium palmitate when cultured in DMEM/F12 medium

Krizhanovskii, Camilla; Kristinsson, Hjalti; Elksnis, Andris; Wang, Xuan et al.

Part of Islets, p. 43-48, 2017

• DOI for EndoC-beta H1 cells display increased sensitivity to sodium palmitate when cultured in DMEM/F12 medium

Knock-down of ZBED6 in insulin-producing cells promotes N-cadherin junctions between beta-cells and neural crest stem cells in vitro

Wang, Xuan; Xie, Beichen; Qi, Yu; Wallerman, Ola et al.

Part of Scientific Reports, 2016

• DOI for Knock-down of ZBED6 in insulin-producing cells promotes N-cadherin junctions between beta-cells and neural crest stem cells in vitro
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Aromatic malononitriles stimulate the resistance of insulin-producing beta-cells to oxidants and inflammatory cytokines

Turpaev, Kyril; Welsh, Nils

Part of European Journal of Pharmacology, p. 69-80, 2016

• DOI for Aromatic malononitriles stimulate the resistance of insulin-producing beta-cells to oxidants and inflammatory cytokines

PTB and TIAR binding to insulin mRNA 3'- and 5'UTRs; implications for insulin biosynthesis and messenger stability.

Fred, Rikard G; Mehrabi, Syrina; Adams, Christopher M; Welsh, Nils

Part of Heliyon, 2016

• DOI for PTB and TIAR binding to insulin mRNA 3'- and 5'UTRs; implications for insulin biosynthesis and messenger stability.
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Imatinib prevents beta cell death in vitro but does not improve islet transplantation outcome

King, Aileen J. F.; Griffiths, Lisa A.; Persaud, Shanta J.; Jones, Peter M. et al.

Part of Upsala Journal of Medical Sciences, p. 140-145, 2016

• DOI for Imatinib prevents beta cell death in vitro but does not improve islet transplantation outcome
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ZBED6 negatively regulates insulin content, glucose-stimulated insulin secretion, neuronal differentiation and cell aggregation in MIN6 cells

Wang, Xuan; Jiang, L.; Wallerman, Ola; Yu, Qian et al.

Part of Diabetologia, 2016

The H1-receptor antagonist cetirizine ameliorates high-fat diet-induced glucose intolerance in male C57BL/6 mice, but not diabetes outcome in female non-obese diabetic (NOD) mice

Anvari, Ebrahim; Wang, Xuan; Sandler, Stellan; Welsh, Nils

Part of Upsala Journal of Medical Sciences, p. 40-46, 2015

• DOI for The H1-receptor antagonist cetirizine ameliorates high-fat diet-induced glucose intolerance in male C57BL/6 mice, but not diabetes outcome in female non-obese diabetic (NOD) mice

Role of the AMP kinase in cytokine-induced human EndoC-beta H1 cell death

Fred, Rikard G.; Kappe, Camilla; Ameur, Adam; Cen, Jing et al.

Part of Molecular and Cellular Endocrinology, p. 53-63, 2015

• DOI for Role of the AMP kinase in cytokine-induced human EndoC-beta H1 cell death
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Activated pancreatic stellate cells can impair pancreatic islet function in mice

Zang, Guangxiang; Sandberg, Monica; Carlsson, Per-Ola; Welsh, Nils et al.

Part of Upsala Journal of Medical Sciences, p. 169-180, 2015

• DOI for Activated pancreatic stellate cells can impair pancreatic islet function in mice

Brusatol inhibits the response of cultured beta-cells to pro-inflammatory cytokines in vitro

Turpaev, Kyril; Welsh, Nils

Part of Biochemical and Biophysical Research Communications - BBRC, p. 868-872, 2015

• DOI for Brusatol inhibits the response of cultured beta-cells to pro-inflammatory cytokines in vitro
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The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice

Anvari, Ebrahim; Wikström, Per; Walum, Erik; Welsh, Nils

Part of Free radical research, p. 1308-1318, 2015

• DOI for The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice
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Imatinib mesylate stimulates low-density lipoprotein receptor-related protein 1-mediated ERK phosphorylation in insulin-producing cells

Fred, Rikard G.; Boddeti, Santosh Kumar; Lundberg, Marcus; Welsh, Nils

Part of Clinical Science, p. 17-28, 2015

• DOI for Imatinib mesylate stimulates low-density lipoprotein receptor-related protein 1-mediated ERK phosphorylation in insulin-producing cells

The H-1-Receptor Antagonist Cetirizine Protects Partially Against Cytokine- and Hydrogen Peroxide-Induced beta-TC6 Cell Death In Vitro

Anvari, Ebrahim; Fred, Rikard G.; Welsh, Nils

Part of Pancreas, p. 624-629, 2014

• DOI for The H-1-Receptor Antagonist Cetirizine Protects Partially Against Cytokine- and Hydrogen Peroxide-Induced beta-TC6 Cell Death In Vitro

Temporal profiling of cytokine-induced genes in pancreatic beta-cells by meta-analysis and network inference

Lopes, Miguel; Kutlu, Burak; Miani, Michela; Bang-Berthelsen, Claus H. et al.

Part of Genomics, p. 264-275, 2014

• DOI for Temporal profiling of cytokine-induced genes in pancreatic beta-cells by meta-analysis and network inference

Bcl-2 maintains the mitochondrial membrane potential, but fails to affect production of reactive oxygen species and endoplasmic reticulum stress, in sodium palmitate-induced beta-cell death

Wang, Xuan; Welsh, Nils

Part of Upsala Journal of Medical Sciences, p. 306-315, 2014

• DOI for Bcl-2 maintains the mitochondrial membrane potential, but fails to affect production of reactive oxygen species and endoplasmic reticulum stress, in sodium palmitate-induced beta-cell death
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Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5'-phosphatase interaction with c-Abl

Mokhtari, Dariush; Al-Amin, Abdullah; Turpaev, Kyrill; Li, Tingting et al.

Part of Diabetologia, p. 1327-1338, 2013

• DOI for Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5'-phosphatase interaction with c-Abl
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Co-Culture of Neural Crest Stem Cells (NCSC) and Insulin Producing Beta-TC6 Cells Results in Cadherin Junctions and Protection against Cytokine-Induced Beta-Cell Death

Ngamjariyawat, Anongnad; Turpaev, Kyril; Vasylovska, Svitlana; Kozlova, Elena N et al.

Part of PLOS ONE, 2013

• DOI for Co-Culture of Neural Crest Stem Cells (NCSC) and Insulin Producing Beta-TC6 Cells Results in Cadherin Junctions and Protection against Cytokine-Induced Beta-Cell Death
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Transcription factor ZBED6 affects gene expression, proliferation, and cell death in pancreatic beta cells

Wang, Xuan; Jiang, Lin; Wallerman, Ola; Engström, Ulla et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 15997-16002, 2013

• DOI for Transcription factor ZBED6 affects gene expression, proliferation, and cell death in pancreatic beta cells

Vascular Heterogeneity Between Native Pancreatic Islets Determines Their Fate of Survival and Revascularization Posttransplantation

Ullsten, Sara; Lau, Joey; Welsh, Nils; Carlsson, Per-Ola

Part of Transplantation, 2013

Cytokine-induced human islet cell death in vitro correlateswith a persistently high phosphorylation of STAT-1, but not with NF-κB activation

Hindlycke, Henrietta; Lu, Tao; Welsh, Nils

Part of Biochemical and Biophysical Research Communications - BBRC, p. 845-850, 2012

• DOI for Cytokine-induced human islet cell death in vitro correlateswith a persistently high phosphorylation of STAT-1, but not with NF-κB activation
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C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in beta-cells

Allagnat, F.; Fukaya, M.; Nogueira, T. C.; Delaroche, D. et al.

Part of Cell Death and Differentiation, p. 1836-1846, 2012

• DOI for C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in beta-cells

Coculture of Insulin-Producing RIN5AH Cells With Neural Crest Stem Cells Protects Partially Against Cytokine-Induced Cell Death

Ngamjariyawat, Anongnad; Turpaev, Kyril; Welsh, Nils; Kozlova, Elena N.

Part of Pancreas, p. 490-492, 2012

• DOI for Coculture of Insulin-Producing RIN5AH Cells With Neural Crest Stem Cells Protects Partially Against Cytokine-Induced Cell Death

Effects of Imatinib Mesylate (Gleevec) on Human Islet NF-kappaB Activation and Chemokine Production In Vitro

Mokhtari, Dariush; Li, Tingting; Lu, Tao; Welsh, Nils

Part of PLOS ONE, 2011

• DOI for Effects of Imatinib Mesylate (Gleevec) on Human Islet NF-kappaB Activation and Chemokine Production In Vitro

The human insulin mRNA is partly translated via a cap- and eIF4A-independent mechanism

Fred, Rikard G.; Sandberg, Monica; Pelletier, Jerry; Welsh, Nils

Part of Biochemical and Biophysical Research Communications - BBRC, p. 693-698, 2011

• DOI for The human insulin mRNA is partly translated via a cap- and eIF4A-independent mechanism

Potential utility of small tyrosine kinase inhibitors in the treatment of diabetes

Mokhtari, Dariush; Welsh, Nils

Part of Clinical Science, p. 241-247, 2010

• DOI for Potential utility of small tyrosine kinase inhibitors in the treatment of diabetes

High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression

Fred, Rikard G; Bang-Berthelsen, Claus H; Mandrup-Poulsen, Thomas; Grunnet, Lars G et al.

Part of PLOS ONE, 2010

• DOI for High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression

Detailed transcriptome atlas of the pancreatic beta cell

Kutlu, Burak; Burdick, David; Baxter, David; Rasschaert, Joanne et al.

Part of BMC Medical Genomics, p. 3, 2009

• DOI for Detailed transcriptome atlas of the pancreatic beta cell

Overexpression of the Nuclear Factor-{kappa}B subunit c-Rel protects against human islet cell death in vitro

Mokhtari, Dariush; Barbu, Andreea; Mehmeti, Ilir; Vercamer, Chantal et al.

Part of American Journal of Physiology. Endocrinology and Metabolism, 2009

• DOI for Overexpression of the Nuclear Factor-{kappa}B subunit c-Rel protects against human islet cell death in vitro

Increased Hsp70 expression attenuates cytokine-induced cell death in islets of Langerhans from Shb knockout mice

Mokhtari, Dariush; Åkerblom, Björn; Mehmeti, Ilir; Wang, Xuan et al.

Part of Biochemical and Biophysical Research Communications - BBRC, p. 553-557, 2009

• DOI for Increased Hsp70 expression attenuates cytokine-induced cell death in islets of Langerhans from Shb knockout mice

Possible role of an ischemic preconditioning-like response mechanism in K(ATP) channel opener-mediated protection against streptozotocin-induced suppression of rat pancreatic islet function

Sandler, Stellan; Andersson, Annika K.; Larsson, Jenny; Makeeva, Natalia et al.

Part of Biochemical Pharmacology, p. 1748-1756, 2008

• DOI for Possible role of an ischemic preconditioning-like response mechanism in K(ATP) channel opener-mediated protection against streptozotocin-induced suppression of rat pancreatic islet function

Transforming growth factor-beta-activated protein kinase 1-binding protein (TAB)-1alpha, but not TAB1beta, mediates cytokine-induced p38 mitogen-activated protein kinase phosphorylation and cell death in insulin-producing cells

Makeeva, Natalia; Roomans, Godfried M; Myers, Jason W; Welsh, Nils

Part of Endocrinology, p. 302-309, 2008

• DOI for Transforming growth factor-beta-activated protein kinase 1-binding protein (TAB)-1alpha, but not TAB1beta, mediates cytokine-induced p38 mitogen-activated protein kinase phosphorylation and cell death in insulin-producing cells

MAPK kinase kinase-1 is essential for cytokine-induced c-Jun NH2-terminal kinase and nuclear factor-kappaB activation in human pancreatic islet cells

Mokhtari, Dariush; Myers, Jason W; Welsh, Nils

Part of Diabetes, p. 1896-1904, 2008

• DOI for MAPK kinase kinase-1 is essential for cytokine-induced c-Jun NH2-terminal kinase and nuclear factor-kappaB activation in human pancreatic islet cells

The MAPK kinase kinase-1 is essential for stress-induced pancreatic islet cell death

Mokhtari, Dariush; Myers, Jason W; Welsh, Nils

Part of Endocrinology, p. 3046-3053, 2008

• DOI for The MAPK kinase kinase-1 is essential for stress-induced pancreatic islet cell death

Imatinib mesylate improves insulin sensitivity and glucose disposal rates in rats fed a high-fat diet

Hägerkvist, Robert; Jansson, Leif; Welsh, Nils

Part of Clinical Science, p. 65-71, 2008

• DOI for Imatinib mesylate improves insulin sensitivity and glucose disposal rates in rats fed a high-fat diet

Improved vascular engraftment and graft function after inhibition of the angiostatic factor thrombospondin-1 in mouse pancreatic islets

Olerud, Johan; Johansson, Magnus; Lawler, Jack; Welsh, Nils et al.

Part of Diabetes, p. 1870-1877, 2008

• DOI for Improved vascular engraftment and graft function after inhibition of the angiostatic factor thrombospondin-1 in mouse pancreatic islets

Role of TAB1 in nitric oxide-induced p38 activation in insulin-producing cells

Makeeva, Natalia; Roomans, Godfried M.; Welsh, Nils

Part of International Journal of Biological Sciences, p. 71-76, 2007

Lipofection of insulin-producing RINm5F cells: methodological improvements

Barbu, Andreea; Welsh, Nils

Part of Journal of liposome research, p. 49-62, 2007

• DOI for Lipofection of insulin-producing RINm5F cells: methodological improvements

Claes Hellerström: a friendly islet explorer

Andersson, Arne; Eriksson, Ulf J.; Jansson, Leif; Sandler, Stellan et al.

Part of Diabetologia, 2007

Consequences of Shb and c-Abl interactions for cell death in response to various stress stimuli

Hägerkvist, Robert; Mokhtari, Dariush; Lindholm, Cecilia; Farnebo, Filip et al.

Part of Experimental Cell Research, p. 284-291, 2007

• DOI for Consequences of Shb and c-Abl interactions for cell death in response to various stress stimuli

Amelioration of diabetes by imatinib mesylate (Gleevec): role of beta-cell NF-kappaB activation and anti-apoptotic preconditioning

Hägerkvist, Robert; Sandler, Stellan; Mokhtari, Dariush; Welsh, Nils

Part of The FASEB Journal, p. 618-628, 2007

• DOI for Amelioration of diabetes by imatinib mesylate (Gleevec): role of beta-cell NF-kappaB activation and anti-apoptotic preconditioning

A perfusion protocol for highly efficient transduction of intact pancreatic islets of Langerhans

Barbu, Andreea R.; Bodin, Birgitta; Welsh, Michael; Jansson, Leif et al.

Part of Diabetologia, p. 2388-2391, 2006

• DOI for A perfusion protocol for highly efficient transduction of intact pancreatic islets of Langerhans

The role of PTB in insulin mRNA stability contol

Fred, R G; Tillmar, L; Welsh, N

Part of Current Diabetes Reviews, p. 363-366, 2006

Adenoviral-mediated transduction of human pancreatic islets: importance of adenoviral genome for cell viability and association with a deficient antiviral response

Barbu, Andreea R; Akusjärvi, Göran; Welsh, Nils

Part of Endocrinology, p. 2406-2414, 2005

• DOI for Adenoviral-mediated transduction of human pancreatic islets: importance of adenoviral genome for cell viability and association with a deficient antiviral response

Increased expression of polypyrimidine tract binding protein results in higher insulin mRNA levels

Fred, Rikard G; Welsh, Nils

Part of Biochemical and Biophysical Research Communications - BBRC, p. 38-42, 2005

• DOI for Increased expression of polypyrimidine tract binding protein results in higher insulin mRNA levels

Mechanisms of Pancreatic {beta}-Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few Similarities.

Cnop, Miriam; Welsh, Nils; Jonas, Jean-Christophe; Jörns, Anne et al.

Part of Diabetes, 2005

siRNA Produced by Recombinant Dicer Mediates Efficient Gene Silencing in Islet Cells.

Hägerkvist, Robert; Mokhtari, Dariush; Myers, Jason W; Tengholm, Anders et al.

Part of Ann N Y Acad Sci, p. 114-22, 2005

Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?

Welsh, Nils; Cnop, Miriam; Kharroubi, Ilham; Bugliani, Marco et al.

Part of Diabetes, p. 3238-44, 2005

P38 MAPK inhibits JMK2 and mediates cytokine-activated iNOS induction and apoptosis independently of NF-kB translocation in insulinproducing cells

Saleen, Johan; Welsh, Nils

Part of Eur Cyt Netw, p. 47-52, 2004

The use of tetrazolium salt-based methods for determination of islet cell viability in response to cytokines: a cautionary note.

Barbu, Andreea; Welsh, Nils

Part of Diabetologia, p. 2042-2043, 2004

Promoting islet cell function after transplantation

Andersson, Arne; Carlsson, Per-Ola; Carlsson, Carina; Olsson, Richard et al.

Part of Cell Biochem Biophys, p. 55-64, 2004

Glucose-induced binding of the polypyrimidine tract-binding protein (PTB) to the 3'-untranslated region of the insulin mRNA (ins-PRS) is inhibited by rapamycin.

Tillmar, Linda; Welsh, Nils

Part of Mol and Cell Biochem, p. 85-90, 2004

Overexpression of the Shb SH2 domain-protein in insulin-producing cells leads to altered signaling through the IRS-1 and IRS-2 proteins

Welsh, Nils; Makeeva, Natalia; Welsh, Michael

Part of Molecular Medicine, p. 695-704, 2002

Developmental damage, increased lipid peroxidation, diminished cyclooxygenase-2 gene expression, and lowered PGE-2 levels in rat embryos exposed to a diabetic environment

Wentzel, Parri; Welsh, Nils; Eriksson, Ulf J.

Part of Diabetes, p. 813-820, 1999

• DOI for Developmental damage, increased lipid peroxidation, diminished cyclooxygenase-2 gene expression, and lowered PGE-2 levels in rat embryos exposed to a diabetic environment

Transgeneic mice expressing the Shb adaptor protein under the control of  rat insulin promoter exhibit altered viability of pancreatic islet cells

Welsh, Michael; Christmansson, L; Karlsson, T; Sandler, Stellan et al.

Part of Molecular Medicine, p. 169-180, 1999

Are off-target effects of imatinib the key to improving beta-cell function in diabetes?

Welsh, Nils

Part of Upsala Journal of Medical Sciences, 2022

• DOI for Are off-target effects of imatinib the key to improving beta-cell function in diabetes?
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Does the small tyrosine kinase inhibitor imatinib mesylate counteract diabetes by affecting pancreatic islet amyloidosis and fibrosis?

Welsh, Nils

Part of Expert Opinion on Investigational Drugs, p. 1743-1750, 2012

• DOI for Does the small tyrosine kinase inhibitor imatinib mesylate counteract diabetes by affecting pancreatic islet amyloidosis and fibrosis?
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The importance of RNA binding proteins in preproinsulin mRNA stability

Fred, Rikard G.; Welsh, Nils

Part of Molecular and Cellular Endocrinology, p. 28-33, 2009

• DOI for The importance of RNA binding proteins in preproinsulin mRNA stability

Gene therapy in diabetes mellitus

Welsh, Nils

Nature publishing group, 2003

Gene Therapy

Barbu, Andrea R; Welsh, Nils

Part of Textbook of Diabetes, p. 1064-1069, Wiley-Blackwell, 2010

Diabetes Mellitus: Gene Therapy

Barbu, Andreea; Welsh, Nils

Part of ENCYCLOPEDIA OF LIFE SCIENCES, John Wiley & Sons, 2007

• DOI for Diabetes Mellitus: Gene Therapy

Department of Medical Cell Biology: Annual Report 2016

Welsh, Nils

Uppsala University, 2017

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Department of Medical Cell Biology: Annual Report 2015

Welsh, Nils

Uppsala University, 2016

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Department of Medical Cell Biology: Annual Report 2014

Welsh, Nils

Uppsala universitet, 2015

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Type III phosphatidylinositol 4-kinases mediate plasma membrane PIP2 synthesis in insulin-secreting cells

Wuttke, Anne; Sagetorp, J.; Welsh, Nils; Tengholm, Anders

Part of 43rd easd annual meeting of the european association for the study of diabetes, 2007

• DOI for Type III phosphatidylinositol 4-kinases mediate plasma membrane PIP2 synthesis in insulin-secreting cells