Jin-ping Li
Professor at Department of Medical Biochemistry and Microbiology; Biochemistry and Cancer; Jin-Ping Li
- Telephone:
- +46 18 471 42 41
- E-mail:
- Jin-ping.Li@imbim.uu.se
- Visiting address:
- BMC
Husargatan 3
752 37 UPPSALA - Postal address:
- Box 582
751 23 UPPSALA
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Publications
Recent publications
- A New Synthesized Dicarboxylated Oxy-Heparin Efficiently Attenuates Tumor Growth and Metastasis (2024)
- Inhibitors of dermatan sulfate epimerase 1 decreased accumulation of glycosaminoglycans in mucopolysaccharidosis type I fibroblasts (2024)
- Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue (2024)
- Antiviral Activities of Heparan Sulfate Mimetic RAFT Polymers Against Mosquito-borne Viruses (2024)
- Heparan sulfate-dependent phase separation of CCL5 and its chemotactic activity (2024)
All publications
Articles
- A New Synthesized Dicarboxylated Oxy-Heparin Efficiently Attenuates Tumor Growth and Metastasis (2024)
- Inhibitors of dermatan sulfate epimerase 1 decreased accumulation of glycosaminoglycans in mucopolysaccharidosis type I fibroblasts (2024)
- Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue (2024)
- Antiviral Activities of Heparan Sulfate Mimetic RAFT Polymers Against Mosquito-borne Viruses (2024)
- Heparan sulfate-dependent phase separation of CCL5 and its chemotactic activity (2024)
- Overview of the current procedures in synthesis of heparin saccharides (2024)
- Synthesis of Uronic Acid 1-Azasugars as Putative Inhibitors of α-Iduronidase, β-Glucuronidase and Heparanase (2023)
- Heparin mimetics as potential intervention for COVID-19 and their bio-manufacturing (2023)
- Identification of a Pentasaccharide Lead Compound with High Affinity to the SARS-CoV-2 Spike Protein via In Silico Screening (2023)
- Heparanase Modulates Chromatin Accessibility (2023)
- Heparan sulfate proteoglycan in Alzheimer's disease (2023)
- Low-molecular weight sulfated marine polysaccharides (2023)
- Interacting polymer-modification enzymes in heparan sulfate biosynthesis (2023)
- In-depth characterization of 1,4-butanediol diglycidyl ether substituted hyaluronic acid hydrogels (2023)
- Antiviral Disaccharide Lead Compounds against SARS-CoV-2 through Computer-Aided High-Throughput Screen (2022)
- Is heparan sulfate a target for inhibition of RNA virus infection? (2022)
- Implications of Heparanase on Heparin Synthesis and Metabolism in Mast Cells (2022)
- GRP75-driven, cell-cycle-dependent macropinocytosis of Tat/pDNA-Ca2+ nanoparticles underlies distinct gene therapy effect in ovarian cancer (2022)
- Heparanase Expression Propagates Liver Damage in CCL4-Induced Mouse Model (2022)
- Phase separation on cell surface facilitates bFGF signal transduction with heparan sulphate (2022)
- Disruption of innate defense responses by endoglycosidase HPSE promotes cell survival (2021)
- Re-expression of glucuronyl C5-epimerase in the mutant MEF cells increases heparan sulfate epimerization but has no influence on the Golgi localization and enzymatic activity of 2-O-sulfotransferase (2021)
- Glucuronyl C5-epimerase is crucial for epithelial cell maturation during embryonic lung development (2021)
- Reply to Collins et al (2021)
- Development and Validation of a Nomogram for Assessing Survival in Patients With COVID-19 Pneumonia (2021)
- Inhibition of Tumor-Host Cell Interactions Using Synthetic Heparin Mimetics (2021)
- Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age-dependent manner, normalizes GABA-activated currents in the tg-APPSwe mouse model of Alzheimer's disease (2021)
- Dichotomic role of heparanase in a murine model of metabolic syndrome (2021)
- Inhibition of iduronic acid biosynthesis by ebselen reduces glycosaminoglycan accumulation in mucopolysaccharidosis type I fibroblasts (2021)
- Comprehensive Landscape of Heparin Therapy for COVID-19 (2021)
- Heparanase Deficiency Is Associated with Disruption, Detachment, and Folding of the Retinal Pigment Epithelium (2021)
- Elucidating the Binding Mode between Heparin and Inflammatory Cytokines by Molecular Modeling (2021)
- Elucidating the Interactions Between Heparin/Heparan Sulfate and SARS-CoV-2-Related Proteins (2021)
- Heparanase overexpression impedes perivascular clearance of amyloid-beta from murine brain (2021)
- Diagnostic performance of initial blood urea nitrogen combined with D-dimer levels for predicting in-hospital mortality in COVID-19 patients (2020)
- Implications of Heparan Sulfate and Heparanase in Amyloid Diseases (2020)
- Heparin (2020)
- The Potential of Low Molecular Weight Heparin to Mitigate Cytokine Storm in Severe COVID-19 Patients (2020)
- Heparanase Facilitates PMA-Induced Megakaryocytic Differentiation in K562 Cells via Interleukin 6/STAT3 Pathway (2020)
- High-throughput screening identified mitoxantrone to induce death of hepatocellular carcinoma cells with autophagy involvement (2020)
- Heparanase from triple-negative breast cancer and platelets acts as an enhancer of metastasis (2020)
- Significance of host heparanase in promoting tumor growth and metastasis (2020)
- Characterization of anti-BCG benz[α]anthraquinones and new siderophores from a Xinjiang desert-isolated rare actinomycete Nocardia sp. XJ31 (2020)
- Oligosaccharides mapping of nitrous acid degraded heparin through UHPLC-HILIC/WAX-MS (2020)
- Glycosaminoglycans in biological samples (2020)
- Dual roles of heparanase in human carotid plaque calcification (2019)
- Upregulated BMP-Smad signaling activity in the glucuronyl C5-epimerase knock out MEF cells (2019)
- Heparanase Accelerates Obesity-Associated Breast Cancer Progression (2019)
- Systemic LPS-induced A beta-solubilization and clearance in A beta PP-transgenic mice is diminished by heparanase overexpression (2019)
- Is host heparanase required for the rapid spread of heparan sulfate binding viruses? (2019)
- Establishment and characterization of Drosophila cell lines mutant for heparan sulfate modifying enzymes (2019)
- Heparan sulfate proteoglycan - A common receptor for diverse cytokines (2019)
- Selective binding of heparin oligosaccharides in a magnetic thermoresponsive molecularly imprinted polymer (2019)
- Characterization of epimerization and composition of heparin and dalteparin using a UHPLC-ESI-MS/MS method (2019)
- Involvement of Heparanase in the Pathogenesis of Mesothelioma (2018)
- Role of proteoglycans in neuro-inflammation and central nervous system fibrosis (2018)
- Heparan Sulfate Proteoglycans as Relays of Neuroinflammation (2018)
- Overexpression of heparanase in mice promoted megakaryopoiesis (2018)
- Dual roles of heparanase in vascular calcification associated with human carotid atherosclerosis (2017)
- Overexpression of heparanase attenuated TGF-beta-stimulated signaling in tumor cells (2017)
- Overexpression of heparanase attenuated TGF-beta-stimulated signaling in tumor cells (2017)
- Overexpression of heparanase enhances T lymphocyte activities and intensifies the inflammatory response in a model of murine rheumatoid arthritis (2017)
- Heparan sulfate proteoglycans present PCSK9 to the LDL receptor (2017)
- Heparin antagonizes cisplatin resistance of A2780 ovarian cancer cells by affecting the Wnt signaling pathway (2017)
- Elevated heparanase expression is associated with poor prognosis in breast cancer (2017)
- Heparanase confers a growth advantage to differentiating murine embryonic stem cells, and enhances oligodendrocyte formation. (2017)
- Elemene inhibits the migration and invasion of 4T1 murine breast cancer cells via heparanase (2017)
- Gubenyiliu II Inhibits Breast Tumor Growth and Metastasis Associated with Decreased Heparanase Expression and Phosphorylation of ERK and AKT Pathways (2017)
- Heparanase expression upregulates platelet adhesion activity and thrombogenicity (2016)
- Altered heparan sulfate structure in Glce(-/-) mice leads to increased Hedgehog signaling in endochondral bones (2016)
- Heparin interactions with apoA1 and SAA in inflammation-associated HDL (2016)
- Enzyme overexpression - an exercise toward understanding regulation of heparan sulfate biosynthesis (2016)
- Heparanase Is Essential for the Development of Acute Experimental Glomerulonephritis (2016)
- Heparanase is required for activation and function of macrophages (2016)
- Heparanase Promotes Glioma Progression and is Inversely Correlated with Patient Survival. (2016)
- Lung ICAM-1 and ICAM-2 support spontaneous intravascular effector lymphocyte entrapment but are not required for neutrophil entrapment or emigration inside endotoxin-inflamed lungs (2016)
- Spatholobus suberectus Column Extract Inhibits Estrogen Receptor Positive Breast Cancer via Suppressing ER MAPK PI3K/AKT Pathway (2016)
- Chinese Herbal Medicine as Adjunctive Therapy to Chemotherapy for Breast Cancer (2016)
- Overexpression of Heparanase Lowers the Amyloid Burden in Amyloid-beta Precursor Protein Transgenic Mice (2015)
- The Role of Heparanase in Pulmonary Cell Recruitment in Response to an Allergic but Not Non-Allergic Stimulus (2015)
- Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response (2015)
- Heparan Sulfate Proteoglycans Are Important for Islet Amyloid Formation and Islet Amyloid Polypeptide-induced Apoptosis (2015)
- Structural and Functional Study of D-Glucuronyl C5-epimerase (2015)
- Novel peptides that inhibit heparanase activation of the coagulation system (2014)
- Heparanase Cooperates with Ras to Drive Breast and Skin Tumorigenesis (2014)
- Role of Heparanase-Driven Inflammatory Cascade in Pathogenesis of Diabetic Nephropathy (2014)
- Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors (2014)
- Apolipoprotein E increases cell association of amyloid-β 40 through heparan sulfate and LRP1 dependent pathways (2014)
- Towards Understanding the Roles of Heparan Sulfate Proteoglycans in Alzheimer's Disease (2014)
- Implications of heparan sulfate and heparanase in neuroinflammation (2014)
- Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity (2013)
- A Novel Bacterial Enzyme with D-Glucuronyl C5-epimerase Activity (2013)
- Characterization of Heparanase-induced Phosphatidylinositol 3-Kinase-AKT Activation and Its Integrin Dependence (2013)
- Involvement of heparanase in atherosclerosis and other vessel wall pathologies (2013)
- Increased expression of heparanase in symptomatic carotid atherosclerosis (2013)
- Heparanase Is Essential for the Development of Diabetic Nephropathy in Mice (2012)
- Heparanase Affects Food Intake and Regulates Energy Balance in Mice (2012)
- Expression of heparanase in vascular cells and astrocytes of the mouse brain after focal cerebral ischemia (2012)
- Heparanase overexpression reduces carrageenan-induced mechanical and cold hypersensitivity in mice (2012)
- Heparan sulfate/heparin-HDL interaction dissociates serum amyloid A (SAA) from HDL-SAA complex leading to SAA aggregation (2012)
- Heparan Sulfate Biosynthesis Enzymes in Embryonic Stem Cell Biology (2012)
- Accelerated resolution of AA amyloid in heparanase knockout mice is associated with matrix metalloproteases (2012)
- Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-beta in murine brain (2012)
- Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein (2011)
- Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival (2011)
- Heparanase affects secretory granule homeostasis of murine mast cells through degrading heparin (2011)
- Heparanase Modulation of Early Growth Response Gene Expression (2011)
- Molecular characterization of transcriptome-wide interactions between highly pathogenic porcine reproductive and respiratory syndrome virus and porcine alveolar macrophages in vivo (2011)
- Changes of learning and memory ability and brain nicotinic receptors of rat offspring with coal burning fluorosis (2010)
- Glucuronyl C5-epimerase (2010)
- A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils (2010)
- Impaired lymphoid organ development in mice lacking the heparan sulfate modifying enzyme glucuronyl C5-epimerase (2010)
- Heparan sulfate mediates amyloid-beta internalization and cytotoxicity (2010)
- The heparan sulfate motif (GlcNS6S-IdoA2S)3, common in heparin, has a strict topography and is involved in cell behavior and disease (2010)
- Accumulation of Ym1 and formation of intracellular crystalline bodies in alveolar macrophages lacking heparanase (2010)
- Heparan sulfate proteoglycans in amyloidosis. (2010)
- Amino acid substitutions in the E2 glycoprotein of Sindbis-like virus XJ-160 confer the ability to undergo heparan sulfate-dependent infection of mouse embryonic fibroblasts (2010)
- Interaction of E2 glycoprotein with heparan sulfate is crucial for cellular infection of Sindbis virus (2010)
- Lack of L-iduronic acid in heparan sulfate affects interaction with growth factors and cell signaling (2009)
- Heparin, heparan sulfate and heparanase in inflammatory reactions (2009)
- Interactions Between Heparan Sulfate and Proteins—Design and Functional Implications (2009)
- Molecular Structure of Heparan Sulfate from Spalax (2009)
- Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases (2009)
- Heparan sulfate and syndecan-1 are essential in maintaining murine and human intestinal epithelial barrier function (2008)
- Heparin, heparan sulfate and heparanase in cancer (2008)
- Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells (2008)
- Reduction of anionic sites in the glomerular basement membrane by heparanase does not lead to proteinuria (2008)
- Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development (2007)
- Transgenic or tumor-induced expression of heparanase upregulates sulfation of heparan sulfate (2007)
- Characterization of anti-heparan sulfate phage display antibodies AO4B08 and HS4E4 (2007)
- Heparanase enhances syndecan-1 shedding (2007)
- Heparan sulfate C5-epimerase is essential for heparin biosynthesis in mast cells. (2006)
- Interactions between heparan sulfate and proteins (2006)
- Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment (2006)
- Biosynthesis of dermatan sulfate (2006)
- Heparanase neutralizes the anticoagulation properties of heparin and low-molecular-weight heparin (2006)
- In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis (2005)
- Generation of "neoheparin" from E. coli K5 capsular polysaccharide. (2005)
- Mutational study of human phosphohistidine phosphatase (2005)
- Irreversible glucuronyl C5-epimerization in the biosynthesis of heparan sulfate. (2004)
- Heparan sulfate structure in mice with genetically modified heparan sulfate production. (2004)
- Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior. (2004)
- Processing of macromolecular heparin by heparanase (2003)
- Identification and characterization of a mammalian 14-kDa phosphohistidine phosphatase (2002)
- Substrate specificity of heparanases from human hepatoma and platelets (1998)
- Heparan sulfate - an information package? (1997)
- Biosynthesis of heparin / heparan sulfate (1997)
- Heparanase cleavage of heparin modulates protease storage in mast cells
Chapters
- Heparanase (2020)
- Heparan Sulfate (2016)
- Functions of Heparan Sulfate Proteoglycans in Development (2016)
- Heparan sulfate proteoglycans as multifunctional cell regulators (2012)
- Heparanase, a multifaceted protein involved in cancer, chronic inflammation, and kidney dysfunction (2012)
- D-glucuronyl C5-epimerase in heparin/heparan sulfate biosynthesis (2002)
Conferences
