Lene Uhrbom

Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival

Lu, Xi; Maturi, Naga Prathyusha; Jarvius, Malin; Yildirim, Irem et al.

Part of Nature Communications, 2022

• DOI for Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival
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A molecularly distinct subset of glioblastoma requires serum-containing media to establish sustainable bona fide glioblastoma stem cell cultures

Maturi, Naga Prathyusha; Tan, E-Jean; Xie, Yuan; Sundström, Anders et al.

Part of Glia, p. 1228-1240, 2020

• DOI for A molecularly distinct subset of glioblastoma requires serum-containing media to establish sustainable bona fide glioblastoma stem cell cultures

LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Xie, Yuan; Sundström, Anders; Maturi, Naga P; Tan, E-Jean et al.

Part of Journal of Pathology, p. 228-240, 2019

• DOI for LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin

Jiang, Yiwen; Marinescu, Voichita Dana; Xie, Yuan; Jarvius, Malin et al.

Part of Cell Reports, p. 977-990, 2017

• DOI for Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin
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Mouse models of pediatric supratentorial high-grade glioma reveal how cell-of-origin influences tumor development and phenotype

Sreedharan, Smitha; Maturi, Naga Prathyusha; Xie, Yuan; Sundström, Anders et al.

Part of Cancer Research, p. 802-812, 2017

• DOI for Mouse models of pediatric supratentorial high-grade glioma reveal how cell-of-origin influences tumor development and phenotype

The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes

Xie, Yuan; Bergström, Tobias; Jiang, Yiwen; Johansson, Patrik et al.

Part of EBioMedicine, p. 1351-1363, 2015

• DOI for The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes
• Download full text (pdf) of The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes

Oncogenic Signaling Is Dominant to Cell of Origin and Dictates Astrocytic or Oligodendroglial Tumor Development from Oligodendrocyte Precursor Cells

Lindberg, Nanna; Jiang, Yiwen; Xie, Yuan; Bolouri, Hamid et al.

Part of Journal of Neuroscience, p. 14644-14651, 2014

• DOI for Oncogenic Signaling Is Dominant to Cell of Origin and Dictates Astrocytic or Oligodendroglial Tumor Development from Oligodendrocyte Precursor Cells

Oligodendroglioma models

Lindberg, Nanna; Uhrbom, Lene

Part of Animal Models of Brain Tumors, p. 57-82, Humana Press, 2013

• DOI for Oligodendroglioma models

On the origin of glioma

Jiang, Yiwen; Uhrbom, Lene

Part of Upsala Journal of Medical Sciences, p. 113-121, 2012

• DOI for On the origin of glioma

RAD51 can inhibit PDGFB-induced gliomagenesis and genomic instability

Westermark, Ulrica K; Lindberg, Nanna; Roswall, Pernilla; Bråsäter, Daniel et al.

Part of Neuro-Oncology, p. 1277-1287, 2011

• DOI for RAD51 can inhibit PDGFB-induced gliomagenesis and genomic instability

Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma

Lindberg, Nanna; Kastemar, Marianne; Olofsson, T; Smits, Anja et al.

Part of Oncogene, p. 2266-2275, 2009

• DOI for Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma

Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence

Tchougounova, Elena; Jiang, Yiwen; Bråsäter, Daniel; Lindberg, Nanna et al.

Part of Oncogene, p. 1537-1548, 2009

• DOI for Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence

Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma

Tchougounova, Elena; Kastemar, Marianne; Bråsäter, Daniel; Holland, E C et al.

Part of Oncogene, p. 6289-6296, 2007

• DOI for Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma

Cell type-specific tumor suppression by Ink4a and Arf in Kras-induced mouse gliomagenesis.

Uhrbom, Lene; Kastemar, Marianne; Johansson, Fredrik K; Westermark, Bengt et al.

Part of Cancer Res, p. 2065-9, 2005

Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model.

Uhrbom, Lene; Nerio, Edward; Holland, Eric C

Part of Nat Med, p. 1257-60, 2004

Somatic cell gene transfer

Uhrbom, Lene; Holland, Eric C

Part of Mouse Models Of Human Cancer, p. 474, Wiley-Liss, Inc., Hoboken, New Jersey, 2004

Complementary effects of platelet-derived growth factor autocrine stimulation and p53 or Ink4a-Arf deletion in a mouse glioma model.

Hesselager, Göran; Uhrbom, Lene; Westermark, Bengt; Nister, Monica

Part of Cancer Research, p. 4305, 2003

Dissecting gliomagemesis using glial-specifictransgenic mouse models

Begemann, Martin; Uhrbom, Lene; Rajasekhar, VK; Fuller, Gregory N et al.

Part of Genomic and Molecular Neuro-Oncology, Jones & Bartlett Publishers, Inc, 2003

Ink4a-Arf loss cooperates with KRas activation in astrocytes and neuralprogenitors to generate glioblastomas of various morphologies depending onactivated Akt.

Uhrbom, Lene; Dai, Chengkai; Celestino, Joseph C; Rosenblum, Marc K et al.

Part of Cancer Res, p. 5551, 2002

Modeling gliomagenesis with somatic cell gene transfer using retroviral vectors.

Uhrbom, Lene; Holland, E C

Part of J Neurooncol, p. 297-305, 2001

Glial tumors of the CNS

Nistér, Monica; Uhrbom, Lene; Hesselager, Göran; Westermark, Bengt

Part of Glial Cell Development, p. 437, Oxford University Press, 2001

Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells

Uhrbom, Lene; Hesselager, Göran; Östman, Arne; Nistér, Monica et al.

Part of Int J Cancer, p. 398-406, 2000

Induction of brain tumors in mice using a recombinant PDGF B retrovirus

Uhrbom, Lene; Hesselager, Göran; Nister, Monica; Westermark, Bengt

Part of Cancer Research, p. 5275-5279, 1998

Induction of senescence in human malignant glioma cells by p16INK4A

Uhrbom, Lene; Nister, Monica; Westermark, Bengt

Part of Oncogene, p. 111, 1997

TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers

Damhofer, Helene; Tatar, Tülin; Southgate, Benjamin; Scarneo, Scott et al.

Part of Cell Death and Disease, 2024

• DOI for TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers
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Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma

Ramachandran, Mohanraj; Vaccaro, Alessandra; van de Walle, Tiarne; Georganaki, Maria et al.

Part of Cancer Cell, p. 1134-1151, 2023

• DOI for Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma
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Live Detection of Neural Progenitors and Glioblastoma Cells by an Oligothiophene Derivative

Ilkhanizadeh, Shirin; Gracias, Aileen; Aslund, Andreas K. O.; Back, Marcus et al.

Part of ACS Applied Bio Materials, p. 3790-3797, 2023

• DOI for Live Detection of Neural Progenitors and Glioblastoma Cells by an Oligothiophene Derivative
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Wnt signaling regulates MFSD2A-dependent drug delivery through endothelial transcytosis in glioma

Xie, Yuan; He, Liqun; Zhang, Yanyu; Huang, Hua et al.

Part of Neuro-Oncology, p. 1073-1084, 2023

• DOI for Wnt signaling regulates MFSD2A-dependent drug delivery through endothelial transcytosis in glioma

Glioblastoma stem cells express non-canonical proteins and exclusive mesenchymal-like or non-mesenchymal-like protein signatures

Babacic, Haris; Galardi, Silvia; Umer, Husen M.; Hellström, Mats et al.

Part of Molecular Oncology, p. 238-260, 2023

• DOI for Glioblastoma stem cells express non-canonical proteins and exclusive mesenchymal-like or non-mesenchymal-like protein signatures
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TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers

Damhofer, Helene; Tatar, Tülin; Southgate, Benjamin; Scarneo, Scott et al.

Part of Cell Death and Disease, 2024

• DOI for TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers
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Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma

Ramachandran, Mohanraj; Vaccaro, Alessandra; van de Walle, Tiarne; Georganaki, Maria et al.

Part of Cancer Cell, p. 1134-1151, 2023

• DOI for Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma
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Live Detection of Neural Progenitors and Glioblastoma Cells by an Oligothiophene Derivative

Ilkhanizadeh, Shirin; Gracias, Aileen; Aslund, Andreas K. O.; Back, Marcus et al.

Part of ACS Applied Bio Materials, p. 3790-3797, 2023

• DOI for Live Detection of Neural Progenitors and Glioblastoma Cells by an Oligothiophene Derivative
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Wnt signaling regulates MFSD2A-dependent drug delivery through endothelial transcytosis in glioma

Xie, Yuan; He, Liqun; Zhang, Yanyu; Huang, Hua et al.

Part of Neuro-Oncology, p. 1073-1084, 2023

• DOI for Wnt signaling regulates MFSD2A-dependent drug delivery through endothelial transcytosis in glioma

Glioblastoma stem cells express non-canonical proteins and exclusive mesenchymal-like or non-mesenchymal-like protein signatures

Babacic, Haris; Galardi, Silvia; Umer, Husen M.; Hellström, Mats et al.

Part of Molecular Oncology, p. 238-260, 2023

• DOI for Glioblastoma stem cells express non-canonical proteins and exclusive mesenchymal-like or non-mesenchymal-like protein signatures
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Novel cancer gene discovery using a forward genetic screen in RCAS-PDGFB-driven gliomas

Weishaupt, Holger; Čančer, Matko; Rosén, Gabriela; Holmberg, Karl O. et al.

Part of Neuro-Oncology, p. 97-107, 2023

• DOI for Novel cancer gene discovery using a forward genetic screen in RCAS-PDGFB-driven gliomas
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Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival

Lu, Xi; Maturi, Naga Prathyusha; Jarvius, Malin; Yildirim, Irem et al.

Part of Nature Communications, 2022

• DOI for Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival
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FACT-seq: profiling histone modifications in formalin-fixed paraffin-embedded samples with low cell numbers

Zhao, Linxuan; Xing, Pengwei; Polavarapu, Vamsi Krishna; Zhao, Miao et al.

Part of Nucleic Acids Research, 2021

• DOI for FACT-seq: profiling histone modifications in formalin-fixed paraffin-embedded samples with low cell numbers
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Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing

Xie, Yuan; He, Liqun; Lugano, Roberta; Zhang, Yanyu et al.

Part of JCI Insight, 2021

• DOI for Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing
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A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma

Johansson, Patrik; Krona, Cecilia; Kundu, Soumi; Doroszko, Milena et al.

Part of Cell Reports, 2020

• DOI for A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma
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A molecularly distinct subset of glioblastoma requires serum-containing media to establish sustainable bona fide glioblastoma stem cell cultures

Maturi, Naga Prathyusha; Tan, E-Jean; Xie, Yuan; Sundström, Anders et al.

Part of Glia, p. 1228-1240, 2020

• DOI for A molecularly distinct subset of glioblastoma requires serum-containing media to establish sustainable bona fide glioblastoma stem cell cultures

BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells

Cancer, Matko; Drews, Lisa F.; Bengtsson, Johan; Bolin, Sara et al.

Part of Cell Death and Disease, 2019

• DOI for BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells
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LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Xie, Yuan; Sundström, Anders; Maturi, Naga P; Tan, E-Jean et al.

Part of Journal of Pathology, p. 228-240, 2019

• DOI for LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors

Kaffes, Ioannis; Szulzewsky, Frank; Chen, Zhihong; Herting, Cameron J. et al.

Part of Oncoimmunology, 2019

• DOI for Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors
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Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells

Caja, Laia; Tzavlaki, Kalliopi; Dadras, Mahsa Shahidi; Tan, E-Jean et al.

Part of Oncogene, p. 2515-2531, 2018

• DOI for Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells
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Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity

Wallmann, Tatjana; Zhang, Xing-Mei; Wallerius, Majken; Bolin, Sara et al.

Part of iScience, p. 71-83, 2018

• DOI for Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity
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Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin

Jiang, Yiwen; Marinescu, Voichita Dana; Xie, Yuan; Jarvius, Malin et al.

Part of Cell Reports, p. 977-990, 2017

• DOI for Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin
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Mast Cell Infiltration in Human Brain Metastases Modulates the Microenvironment and Contributes to the Metastatic Potential

Roy, Ananya; Libard, Sylwia; Weishaupt, Holger; Gustavsson, Ida et al.

Part of Frontiers in Oncology, 2017

• DOI for Mast Cell Infiltration in Human Brain Metastases Modulates the Microenvironment and Contributes to the Metastatic Potential
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Mouse models of pediatric supratentorial high-grade glioma reveal how cell-of-origin influences tumor development and phenotype

Sreedharan, Smitha; Maturi, Naga Prathyusha; Xie, Yuan; Sundström, Anders et al.

Part of Cancer Research, p. 802-812, 2017

• DOI for Mouse models of pediatric supratentorial high-grade glioma reveal how cell-of-origin influences tumor development and phenotype

Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses

Niklasson, Mia; Maddalo, Gianluca; Sramkova, Zuzana; Mutlu, Ercan et al.

Part of Cancer Research, p. 1741-1752, 2017

• DOI for Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses

Case-specific potentiation of glioblastoma drugs by pterostilbene

Schmidt, Linnéa; Baskaran, Sathishkumar; Johansson, Patrik; Padhan, Narendra et al.

Part of Oncotarget, p. 73200-73215, 2016

• DOI for Case-specific potentiation of glioblastoma drugs by pterostilbene

Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition

Segerman, Anna; Niklasson, Mia; Haglund, Caroline; Bergström, Tobias et al.

Part of Cell Reports, p. 2994-3009, 2016

• DOI for Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition
• Download full text (pdf) of Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition

Pleiotrophin enhances PDGFB-induced gliomagenesis through increased proliferation of neural progenitor cells

Zhang, Lei; Laaniste, Liisi; Jiang, Yiwen; Alafuzoff, Irina et al.

Part of Oncotarget, p. 80382-80390, 2016

• DOI for Pleiotrophin enhances PDGFB-induced gliomagenesis through increased proliferation of neural progenitor cells
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ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells

Wee, Boyoung; Pietras, Alexander; Ozawa, Tatsuya; Bazzoli, Elena et al.

Part of Scientific Reports, 2016

• DOI for ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells
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Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates the recruitment of LRP1 positive mast cells

Roy, Ananya; Coum, Antoine; Marinescu, Voichita D; Põlajeva, Jelena et al.

Part of Oncotarget, p. 23647-23661, 2015

• DOI for Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates the recruitment of LRP1 positive mast cells
• Download full text (pdf) of Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates the recruitment of LRP1 positive mast cells

The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes

Xie, Yuan; Bergström, Tobias; Jiang, Yiwen; Johansson, Patrik et al.

Part of EBioMedicine, p. 1351-1363, 2015

• DOI for The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes
• Download full text (pdf) of The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes

Etomidate, propofol and diazepam potentiate GABA-evoked GABAA currents in a cell line derived from Human glioblastoma

Babateen, Omar; Jin, Zhe; Bhandage, Amol K.; Korol, Sergiy V et al.

Part of European Journal of Pharmacology, p. 101-107, 2015

• DOI for Etomidate, propofol and diazepam potentiate GABA-evoked GABAA currents in a cell line derived from Human glioblastoma

GABA-A receptor currents in a cell line (U3047MG) derived from a human glioblastoma tumor are enhanced by etomidate, propofol and diazepam

Babateen, Omar M.; Jin, Zhe; Bhandage, Amol K.; Korol, Sergiy V. et al.

Part of Acta Physiologica, p. 100-100, 2014

Oncogenic Signaling Is Dominant to Cell of Origin and Dictates Astrocytic or Oligodendroglial Tumor Development from Oligodendrocyte Precursor Cells

Lindberg, Nanna; Jiang, Yiwen; Xie, Yuan; Bolouri, Hamid et al.

Part of Journal of Neuroscience, p. 14644-14651, 2014

• DOI for Oncogenic Signaling Is Dominant to Cell of Origin and Dictates Astrocytic or Oligodendroglial Tumor Development from Oligodendrocyte Precursor Cells

Selective Calcium Sensitivity in Immature Glioma Cancer Stem Cells

Wee, Shimei; Niklasson, Maria; Marinescu, Voichita Dana; Segerman, Anna et al.

Part of PLOS ONE, 2014

• DOI for Selective Calcium Sensitivity in Immature Glioma Cancer Stem Cells
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Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures

Yu, Di; Jin, Chuan; Ramachandran, Mohanraj; Xu, Jing et al.

Part of PLOS ONE, 2013

• DOI for Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures
• Download full text (pdf) of Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures

Comparative drug pair screening across multiple glioblastoma cell lines reveals novel drug-drug interactions

Schmidt, Linnea; Kling, Teresia; Monsefi, Naser; Olsson, Maja et al.

Part of Neuro-Oncology, p. 1469-1478, 2013

• DOI for Comparative drug pair screening across multiple glioblastoma cell lines reveals novel drug-drug interactions

miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma

Põlajeva, Jelena; Swartling, Fredrik; Jiang, Yiwen; Singh, Umashankar et al.

Part of BMC Cancer, p. 378, 2012

• DOI for miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma
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On the origin of glioma

Jiang, Yiwen; Uhrbom, Lene

Part of Upsala Journal of Medical Sciences, p. 113-121, 2012

• DOI for On the origin of glioma

CGGBP1 regulates cell cycle in cancer cells

Singh, Umashankar; Roswall, Pernilla; Uhrbom, Lene; Westermark, Bengt

Part of BMC Molecular Biology, p. 28, 2011

• DOI for CGGBP1 regulates cell cycle in cancer cells
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Forced expression of Sox21 inhibits Sox2 and induces apoptosis in human glioma cells

Ferletta, Maria; Caglayan, Demet; Mokvist, Liza; Yiwen, Jiang et al.

Part of International Journal of Cancer, p. 45-60, 2011

• DOI for Forced expression of Sox21 inhibits Sox2 and induces apoptosis in human glioma cells

PDGF-B Can sustain self-renewal and tumorigenicity of experimental glioma-derived cancer-initiating cells by preventing oligodendrocyte differentiation

Jiang, Yiwen; Boije, Maria; Westermark, Bengt; Uhrbom, Lene

Part of Neoplasia, p. 492-503, 2011

• DOI for PDGF-B Can sustain self-renewal and tumorigenicity of experimental glioma-derived cancer-initiating cells by preventing oligodendrocyte differentiation

RAD51 can inhibit PDGFB-induced gliomagenesis and genomic instability

Westermark, Ulrica K; Lindberg, Nanna; Roswall, Pernilla; Bråsäter, Daniel et al.

Part of Neuro-Oncology, p. 1277-1287, 2011

• DOI for RAD51 can inhibit PDGFB-induced gliomagenesis and genomic instability

Mast Cell Accumulation in Glioblastoma with a Potential Role for Stem Cell Factor and Chemokine CXCL12

Põlajeva, Jelena; Sjösten, Anna M; Lager, Nina; Kastemar, Marianne et al.

Part of PLOS ONE, 2011

• DOI for Mast Cell Accumulation in Glioblastoma with a Potential Role for Stem Cell Factor and Chemokine CXCL12
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Histidine-rich glycoprotein can prevent development of mouse experimental glioblastoma

Kärrlander, Maria; Lindberg, Nanna; Olofsson, Tommie; Kastemar, Marianne et al.

Part of PLoS ONE, 2009

• DOI for Histidine-rich glycoprotein can prevent development of mouse experimental glioblastoma

Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma

Lindberg, Nanna; Kastemar, Marianne; Olofsson, T; Smits, Anja et al.

Part of Oncogene, p. 2266-2275, 2009

• DOI for Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma

Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence

Tchougounova, Elena; Jiang, Yiwen; Bråsäter, Daniel; Lindberg, Nanna et al.

Part of Oncogene, p. 1537-1548, 2009

• DOI for Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence

IGFBP2 is a candidate biomarker for Ink4a-Arf status and a therapeutic target for high-grade gliomas

Moore, Lynette M; Holmes, Kristen M; Smith, Sarah M; Wu, Ying et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 16675-16679, 2009

• DOI for IGFBP2 is a candidate biomarker for Ink4a-Arf status and a therapeutic target for high-grade gliomas

Sox10 Has a Broad Expression Pattern in Gliomas and Enhances Platelet-Derived Growth Factor-B–Induced Gliomagenesis

Ferletta, Maria; Uhrbom, Lene; Olofsson, Tommie; Pontén, Fredrik et al.

Part of Molecular Cancer Research, p. 891-897, 2007

• DOI for Sox10 Has a Broad Expression Pattern in Gliomas and Enhances Platelet-Derived Growth Factor-B–Induced Gliomagenesis

Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma

Tchougounova, Elena; Kastemar, Marianne; Bråsäter, Daniel; Holland, E C et al.

Part of Oncogene, p. 6289-6296, 2007

• DOI for Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma

Cell type-specific tumor suppression by Ink4a and Arf in Kras-induced mouse gliomagenesis.

Uhrbom, Lene; Kastemar, Marianne; Johansson, Fredrik K; Westermark, Bengt et al.

Part of Cancer Res, p. 2065-9, 2005

Identification of candidate cancer-causing genes in mouse brain tumors by retroviral tagging

Johansson, Fredrik K.; Brodd, Josefin; Eklöf, Charlotta; Ferletta, Maria et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, p. 11334-11337, 2004

• DOI for Identification of candidate cancer-causing genes in mouse brain tumors by retroviral tagging

Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model.

Uhrbom, Lene; Nerio, Edward; Holland, Eric C

Part of Nat Med, p. 1257-60, 2004

p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3.

Wolf, Rebecca M.; Draghi, Nicole; Liang, Xiquan; Dai, Chengkai et al.

Part of Development, Genes and Evolution, p. 476-487, 2003

• DOI for p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3.

Complementary effects of platelet-derived growth factor autocrine stimulation and p53 or Ink4a-Arf deletion in a mouse glioma model.

Hesselager, Göran; Uhrbom, Lene; Westermark, Bengt; Nister, Monica

Part of Cancer Research, p. 4305, 2003

Ink4a-Arf loss cooperates with KRas activation in astrocytes and neuralprogenitors to generate glioblastomas of various morphologies depending onactivated Akt.

Uhrbom, Lene; Dai, Chengkai; Celestino, Joseph C; Rosenblum, Marc K et al.

Part of Cancer Res, p. 5551, 2002

Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells

Uhrbom, Lene; Hesselager, Göran; Östman, Arne; Nistér, Monica et al.

Part of Int J Cancer, p. 398-406, 2000

Induction of brain tumors in mice using a recombinant PDGF B retrovirus

Uhrbom, Lene; Hesselager, Göran; Nister, Monica; Westermark, Bengt

Part of Cancer Research, p. 5275-5279, 1998

Induction of senescence in human malignant glioma cells by p16INK4A

Uhrbom, Lene; Nister, Monica; Westermark, Bengt

Part of Oncogene, p. 111, 1997

Modeling gliomagenesis with somatic cell gene transfer using retroviral vectors.

Uhrbom, Lene; Holland, E C

Part of J Neurooncol, p. 297-305, 2001

Oligodendroglioma models

Lindberg, Nanna; Uhrbom, Lene

Part of Animal Models of Brain Tumors, p. 57-82, Humana Press, 2013

• DOI for Oligodendroglioma models

Somatic cell gene transfer

Uhrbom, Lene; Holland, Eric C

Part of Mouse Models Of Human Cancer, p. 474, Wiley-Liss, Inc., Hoboken, New Jersey, 2004

Dissecting gliomagemesis using glial-specifictransgenic mouse models

Begemann, Martin; Uhrbom, Lene; Rajasekhar, VK; Fuller, Gregory N et al.

Part of Genomic and Molecular Neuro-Oncology, Jones & Bartlett Publishers, Inc, 2003

Glial tumors of the CNS

Nistér, Monica; Uhrbom, Lene; Hesselager, Göran; Westermark, Bengt

Part of Glial Cell Development, p. 437, Oxford University Press, 2001

Targeting SOX2 in glioblastoma cells reveals heterogeneity in SOX2 dependency

Dalmo, Erika; Rosén, Gabriela; Niklasson, Mia; Bergström, Tobias et al.

Enhancer signatures define glioblastoma stem cell subtypes 1 with divergent patient survival

Xing, Pengwei; Neves, Ines; Salehi, Maede; Yadav, Ram Prakash et al.

Paired glioblastoma cell cultures of the fluorescent bulk tumor and non-fluorescent tumor margin display differential phenotypes and cell states across patients

Neves, Inês; Lu, Xi; Maturi, Nagaprathyusha; Dang, Yonglong et al.