Ulrika Segersten

Comprehensive genomic characterization of early-stage bladder cancer

Prip, Frederik; Lamy, Philippe; Lindskrog, Sia Viborg; Strandgaard, Trine et al.

Part of Nature Genetics, p. 115-125, 2025

• DOI for Comprehensive genomic characterization of early-stage bladder cancer
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Elevated levels of MMP12 sourced from macrophages are associated with poor prognosis in urothelial bladder cancer

Kerzeli, Iliana Kyriaki; Kostakis, Alexandros; Türker, Polat; Malmström, Per-Uno et al.

Part of BMC Cancer, 2023

• DOI for Elevated levels of MMP12 sourced from macrophages are associated with poor prognosis in urothelial bladder cancer
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An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers

Mezheyeuski, Artur; Backman, Max; Mattsson, Johanna Sofia Margareta; Martin-Bernabe, Alfonso et al.

Part of EBioMedicine, 2023

• DOI for An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers
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Re: An Integrated Multi-Omics Analysis Identifies Prognostic Molecular Subtypes of Non-Muscle Invasive Bladder Cancer: Editorial Comment

Lindskrog, S. ; Prip, F.; Lamy, P.; Taber, A. et al.

Part of Journal of Urology, p. 733-733, 2022

PAI-1 is a potential transcriptional silencer that supports bladder cancer cell activity

Furuya, Hideki; Sasaki, Yuka; Chen, Runpu; Peres, Rafael et al.

Part of Scientific Reports, 2022

• DOI for PAI-1 is a potential transcriptional silencer that supports bladder cancer cell activity
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Comprehensive genomic characterization of early-stage bladder cancer

Prip, Frederik; Lamy, Philippe; Lindskrog, Sia Viborg; Strandgaard, Trine et al.

Part of Nature Genetics, p. 115-125, 2025

• DOI for Comprehensive genomic characterization of early-stage bladder cancer
• Download full text (pdf) of Comprehensive genomic characterization of early-stage bladder cancer

Elevated levels of MMP12 sourced from macrophages are associated with poor prognosis in urothelial bladder cancer

Kerzeli, Iliana Kyriaki; Kostakis, Alexandros; Türker, Polat; Malmström, Per-Uno et al.

Part of BMC Cancer, 2023

• DOI for Elevated levels of MMP12 sourced from macrophages are associated with poor prognosis in urothelial bladder cancer
• Download full text (pdf) of Elevated levels of MMP12 sourced from macrophages are associated with poor prognosis in urothelial bladder cancer

An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers

Mezheyeuski, Artur; Backman, Max; Mattsson, Johanna Sofia Margareta; Martin-Bernabe, Alfonso et al.

Part of EBioMedicine, 2023

• DOI for An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers
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Re: An Integrated Multi-Omics Analysis Identifies Prognostic Molecular Subtypes of Non-Muscle Invasive Bladder Cancer: Editorial Comment

Lindskrog, S. ; Prip, F.; Lamy, P.; Taber, A. et al.

Part of Journal of Urology, p. 733-733, 2022

PAI-1 is a potential transcriptional silencer that supports bladder cancer cell activity

Furuya, Hideki; Sasaki, Yuka; Chen, Runpu; Peres, Rafael et al.

Part of Scientific Reports, 2022

• DOI for PAI-1 is a potential transcriptional silencer that supports bladder cancer cell activity
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An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer

Viborg Lindskrog, Sia; Prip, Frederik; Lamy, Philippe; Taber, Ann et al.

Part of Nature Communications, 2021

• DOI for An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer
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Combination of biomarkers for neoadjuvant systemic chemotherapy before cystectomy in patients with urinary bladder cancer

Turker, Polat; Wernroth, Mona-Lisa; Malmström, Per-Uno; Segersten, Ulrika et al.

Part of Translational Research, p. 77-84, 2021

• DOI for Combination of biomarkers for neoadjuvant systemic chemotherapy before cystectomy in patients with urinary bladder cancer

The prognostic impact of the tumour stroma fraction: A machine learning-based analysis in 16 human solid tumour types

Micke, Patrick; Strell, Carina; Mattsson, Johanna Sofia Margareta; Martin-Bernabe, Alfonso et al.

Part of EBioMedicine, 2021

• DOI for The prognostic impact of the tumour stroma fraction: A machine learning-based analysis in 16 human solid tumour types
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Single-cell RNAseq and longitudinal proteomic analysis of a novel semi-spontaneous urothelial cancer model reveals tumor cell heterogeneity and pretumoral urine protein alterations

Kerzeli, Iliana Kyriaki; Lord, Martin; Doroszko, Milena; Elgendy, Ramy et al.

Part of PLOS ONE, 2021

• DOI for Single-cell RNAseq and longitudinal proteomic analysis of a novel semi-spontaneous urothelial cancer model reveals tumor cell heterogeneity and pretumoral urine protein alterations
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Proteomic comparison between different tissue preservation methods for identification of promising biomarkers of urothelial bladder cancer

Valdés, Alberto; Bitzios, Athanasios; Kassa, Eszter; Shevchenko, Ganna et al.

Part of Scientific Reports, 2021

• DOI for Proteomic comparison between different tissue preservation methods for identification of promising biomarkers of urothelial bladder cancer
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Fibroblasts in urothelial bladder cancer define stroma phenotypes that are associated with clinical outcome

Mezheyeuski, Artur; Segersten, Ulrika; Leiss, Lina Wik; Malmström, Per-Uno et al.

Part of Scientific Reports, 2020

• DOI for Fibroblasts in urothelial bladder cancer define stroma phenotypes that are associated with clinical outcome
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Is Bcl-2 a predictive marker of neoadjuvant chemotherapy response in patients with urothelial bladder cancer undergoing radical cystectomy?

Turker, Polat; Segersten, Ulrika; Malmström, Per-Uno; Hemdan, Tammer

Part of Scandinavian journal of urology, p. 45-50, 2019

• DOI for Is Bcl-2 a predictive marker of neoadjuvant chemotherapy response in patients with urothelial bladder cancer undergoing radical cystectomy?
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Molecular Markers Increase Precision of the European Association of Urology Non-Muscle-Invasive Bladder Cancer Progression Risk Groups

van Kessel, Kim E. M.; van der Keur, Kirstin A.; Dyrskjot, Lars; Algaba, Ferran et al.

Part of Clinical Cancer Research, p. 1586-1593, 2018

• DOI for Molecular Markers Increase Precision of the European Association of Urology Non-Muscle-Invasive Bladder Cancer Progression Risk Groups

Choline-phosphate cytidylyltransferase-alpha as a possible predictor of survival and response to cisplatin neoadjuvant chemotherapy in urothelial cancer of the bladder

Hemdan, Tammer; Turker, Polat; Malmström, Per-Uno; Segersten, Ulrika

Part of Scandinavian journal of urology, p. 200-205, 2018

• DOI for Choline-phosphate cytidylyltransferase-alpha as a possible predictor of survival and response to cisplatin neoadjuvant chemotherapy in urothelial cancer of the bladder
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Parallel Proteomic Workflow for Mass Spectrometric Analysis of Tissue Samples Preserved by Different Methods

Holfeld, Aleš; Valdés, Alberto; Malmström, Per-Uno; Segersten, Ulrika et al.

Part of Analytical Chemistry, p. 5841-5849, 2018

• DOI for Parallel Proteomic Workflow for Mass Spectrometric Analysis of Tissue Samples Preserved by Different Methods

Validation of a DNA Methylation-Mutation Urine Assay to Select Patients with Hematuria for Cystoscopy

van Kessel, Kim E. M.; Beukers, Willemien; Lurkin, Irene; Ziel-van der Made, Angelique et al.

Part of Journal of Urology, p. 590-595, 2017

• DOI for Validation of a DNA Methylation-Mutation Urine Assay to Select Patients with Hematuria for Cystoscopy

FGFR3, TERT and OTX1 as a Urinary Biomarker Combination for Surveillance of Patients with Bladder Cancer in a Large Prospective Multicenter Study

Beukers, Willemien; van der Keur, Kirstin A.; Kandimalla, Raju; Vergouwe, Yvonne et al.

Part of Journal of Urology, p. 1410-1418, 2017

• DOI for FGFR3, TERT and OTX1 as a Urinary Biomarker Combination for Surveillance of Patients with Bladder Cancer in a Large Prospective Multicenter Study

Prognostic Impact of a 12-gene Progression Score in Non-muscle-invasive Bladder Cancer: A Prospective Multicentre Validation Study

Dyrskjot, Lars; Reinert, Thomas; Algaba, Ferran; Christensen, Emil et al.

Part of European Urology, p. 461-469, 2017

• DOI for Prognostic Impact of a 12-gene Progression Score in Non-muscle-invasive Bladder Cancer: A Prospective Multicentre Validation Study

Validation of the ezrin, CK20, and Ki-67 as potential predictive markers for BCG instillation therapy of non-muscle-invasive bladder cancer

Malmström, Per-Uno; Hemdan, Tammer; Segersten, Ulrika

Part of Urologic Oncology, p. 5320-532000000, 2017

• DOI for Validation of the ezrin, CK20, and Ki-67 as potential predictive markers for BCG instillation therapy of non-muscle-invasive bladder cancer

Association of MMP-2, RB and PAI-1 with decreased recurrence-free survival and overall survival in bladder cancer patients

Chan, Owen T. M.; Furuya, Hideki; Pagano, Ian; Shimizu, Yoshiko et al.

Part of Oncotarget, p. 99707-99721, 2017

• DOI for Association of MMP-2, RB and PAI-1 with decreased recurrence-free survival and overall survival in bladder cancer patients
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Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma

Hedegaard, Jakob; Lamy, Philippe; Nordentoft, Iver; Algaba, Ferran et al.

Part of Cancer Cell, p. 27-42, 2016

• DOI for Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma

Emmprin Expression Predicts Response and Survival following Cisplatin Containing Chemotherapy for Bladder Cancer: A Validation Study.

Hemdan, Tammer; Malmström, Per-Uno; Jahnson, Staffan; Segersten, Ulrika

Part of Journal of Urology, p. 1575-1581, 2015

• DOI for Emmprin Expression Predicts Response and Survival following Cisplatin Containing Chemotherapy for Bladder Cancer: A Validation Study.

A urine based assay to select patients for initial cystoscopy

van Kessel, Kim E. M.; Beukers, Willemien; Lurkin, Irene; van der Keur, Kirstin A. et al.

Part of Cancer Research, 2015

• DOI for A urine based assay to select patients for initial cystoscopy

Risk Prediction Scores for Recurrence and Progression of Non-Muscle Invasive Bladder Cancer: An International Validation in Primary Tumours

Vedder, Moniek M.; Marquez, Mirari; de Bekker-Grob, Esther W.; Calle, Malu L. et al.

Part of PLOS ONE, 2014

• DOI for Risk Prediction Scores for Recurrence and Progression of Non-Muscle Invasive Bladder Cancer: An International Validation in Primary Tumours
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Reduced expression of ezrin in urothelial bladder cancer signifies more advanced tumours and an impaired survival: validatory study of two independent patient cohorts

Andersson, Gustav; Wennersten, Christoffer; Gaber, Alexander; Boman, Karolina et al.

Part of BMC Urology, p. 36, 2014

• DOI for Reduced expression of ezrin in urothelial bladder cancer signifies more advanced tumours and an impaired survival: validatory study of two independent patient cohorts
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The role of microRNA profiling in prognosticating progression in Ta and T1 urinary bladder cancer

Segersten, Ulrika; Spector, Yael; Goren, Yaron; Tabak, Sarit et al.

Part of Urologic Oncology, p. 613-618, 2014

• DOI for The role of microRNA profiling in prognosticating progression in Ta and T1 urinary bladder cancer

The prognostic value and therapeutic target role of stathmin-1 in urinary bladder cancer

Hemdan, Tammer; Lindén, Mårten; Lind, Sara; Namuduri, Arvind et al.

Part of British Journal of Cancer, p. 1180-1187, 2014

• DOI for The prognostic value and therapeutic target role of stathmin-1 in urinary bladder cancer
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Decreased expression of RNA-binding motif protein 3 correlates with tumour progression and poor prognosis in urothelial bladder cancer

Boman, Karolina; Segersten, Ulrika; Ahlgren, Göran; Eberhard, Jakob et al.

Part of BMC Urology, p. 17, 2013

• DOI for Decreased expression of RNA-binding motif protein 3 correlates with tumour progression and poor prognosis in urothelial bladder cancer
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Tumour expression of bladder cancer-associated urinary proteins

Lindén, Mårten; Segersten, Ulrika; Runeson, Marcus; Wester, Kenneth et al.

Part of BJU International, p. 407-415, 2013

• DOI for Tumour expression of bladder cancer-associated urinary proteins

Membranous expression of podocalyxin-like protein is an independent factor of poor prognosis in urothelial bladder cancer

Boman, K; Larsson, A H; Segersten, Ulrika; Kuteeva, E et al.

Part of British Journal of Cancer, p. 2321-2328, 2013

• DOI for Membranous expression of podocalyxin-like protein is an independent factor of poor prognosis in urothelial bladder cancer

Multicenter Validation of Cyclin D1, MCM7, TRIM29, and UBE2C as Prognostic Protein Markers in Non-Muscle Invasive Bladder Cancer

Fristrup, Niels; Birkenkamp-Demtröder, Karin; Reinert, Thomas; Sanchez-Carbayo, Marta et al.

Part of American Journal of Pathology, p. 339-349, 2013

• DOI for Multicenter Validation of Cyclin D1, MCM7, TRIM29, and UBE2C as Prognostic Protein Markers in Non-Muscle Invasive Bladder Cancer

Proteomic analysis of urinary biomarker candidates for nonmuscle invasive bladder cancer

Lindén, Mårten; Lind, Sara Bergström; Mayrhofer, Corina; Segersten, Ulrika et al.

Part of Proteomics, p. 135-144, 2012

• DOI for Proteomic analysis of urinary biomarker candidates for nonmuscle invasive bladder cancer

Analysis of molecular intra-patient variation and delineation of a prognostic 12-gene signature in non-muscle invasive bladder cancer; technology transfer from microarrays to PCR

Dyrskjot, L.; Reinert, T.; Novoradovsky, A.; Zuiverloon, T. C. M. et al.

Part of British Journal of Cancer, p. 1392-1398, 2012

• DOI for Analysis of molecular intra-patient variation and delineation of a prognostic 12-gene signature in non-muscle invasive bladder cancer; technology transfer from microarrays to PCR

Cathepsin E, Maspin, Plk1, and Survivin Are Promising Prognostic Protein Markers for Progression in Non-Muscle Invasive Bladder Cancer

Fristrup, Niels; Ulhoi, Benedicte P.; Birkenkamp-Demtroder, Karin; Mansilla, Francisco et al.

Part of American Journal of Pathology, p. 1824-1834, 2012

• DOI for Cathepsin E, Maspin, Plk1, and Survivin Are Promising Prognostic Protein Markers for Progression in Non-Muscle Invasive Bladder Cancer

Focal amplifications are associated with high grade and recurrences in stage Ta bladder carcinoma

Nord, Helena; Segersten, Ulrika; Sandgren, Johanna; Wester, Kenneth et al.

Part of International Journal of Cancer, p. 1390-1402, 2010

• DOI for Focal amplifications are associated with high grade and recurrences in stage Ta bladder carcinoma

Impact of thawing on RNA integrity and gene expression analysis in fresh frozen tissue

Botling, Johan; Edlund, Karolina; Segersten, Ulrika; Tahmasebpoor, Simin et al.

Part of Diagnostic molecular pathology (Print), p. 44-52, 2009

• DOI for Impact of thawing on RNA integrity and gene expression analysis in fresh frozen tissue

Molecular genetics of bladder cancer: an update

Díaz de Ståhl, Teresita; Segersten, Ulrika; Malmström, Per-Uno

Part of Minerva Urologica e Nefrologica, p. 205-16, 2008

Potentiating effects of non-active/active vitamin D analogues and ketoconazole in parathyroid cells

Segersten, Ulrika; Björklund, Peyman; Hellman, Per; Åkerström, Göran et al.

Part of Clinical Endocrinology, p. 399-404, 2007

• DOI for Potentiating effects of non-active/active vitamin D analogues and ketoconazole in parathyroid cells

25-hydroxyvitamin D3 1alpha-hydroxylase expression in breast cancer and use of non-hydroxylated vitamin D analogue

Segersten, Ulrika; Kaae Holm, Pernille; Björklund, Peyman; Hessman, Ola et al.

Part of Breast Cancer Research, 2005

• DOI for 25-hydroxyvitamin D3 1alpha-hydroxylase expression in breast cancer and use of non-hydroxylated vitamin D analogue
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Vitamin D3 polyunsaturated side-chain analogues (EB1089, GS1590) and the 20-epi-vitamin D3 analogue CB1393 suppress parathyroid hormone secretion and mRNA level in bovine parathyroid cells

Segersten, Ulrika; Kaae Holm, Pernille; Binderup, Lise; Åkerström, Göran et al.

Part of Journal of Steroid Biochemistry & Molecular Biology, p. 289-294, 2004

25-hydroxyvitamin D(3)-1alpha-hydroxylase expression in normal and pathological paratahyroid glands

Segersten, Ulrika; Correa, Pamela; Hewison, M; Hellman, Per et al.

Part of J Clin Endocrinol Metab, p. 2967, 2002

Increased 25-hydroxyvitamin D3 1a-hydroxylase and reduced 25-hydroxyvitamin D3 24-hydroxylase expression in parathyroid tumors—New prospects for treatment of hyperparathyroidism with vitamin D.

Correa, P; Segersten, Ulrika; Åkerström, Göran; Westin, Gunnar

Part of J Clin Endocrinol Metab,, p. 5826, 2002

Increased 25-hydroxyvitamin D3 1α-hydroxylase and reduced 25-hydroxyvitamin D3 24-hydroxylase expression in parathyroid tumors: new prospects for treatment of hyperparathyroidism with vitamin D

Correa, Pamela; Segersten, Ulrika; Hellman, Per; Åkerström, Göran et al.

Part of Journal of Clinical Endocrinology & Metabolism, p. 5826-5829, 2002

Potentiating inhibitory effects of the non-1α-hydroxylated precursor vitamin D analogue of EB1089 (EB1285) and ketoconazole in parathyroid cells

Segersten, Ulrika; Hellman, Per; Åkerström, Göran; Westin, Gunnar

An overview on preclinical and clinical experiences with photodynamic therapy for bladder cancer

Yavari, Nazila; Andersson-Engels, Stefan; Segersten, Ulrika; Malmström, Per-Uno

Part of Canadian Journal of Urology, p. 5778-5786, 2011

Parathyroid glands in calcium regulation and human disease

Åkerström, Göran; Hellman, Per; Hessman, Ola; Segersten, Ulrika et al.

Part of Trends in Comparative Endocrinology and Neurobiology, p. 53-58, 2005

Galectin-1, a potential therapeutic target, in primary tumors and metastases of urinary bladder carcinomas

Lindén, Mårten; Hemdan, Tammer; Ugge, Henrik; Bergström Lind, Sara et al.

2013

Stathmin-1 is a promising prognostic factor and potential therapeutic target in urinary bladder cancer

Hemdan, Tammer; Lindén, Mårten; Bergström Lind, Sara; Namuduri, Arvind Venkat et al.

The tumour microenvironment across tumour evolution in bladder cancer profiled by single-cell RNA-sequencing analysis and spatial transcriptomics

Kostakis, Alexandros; Beháňová, Andrea; Kyriaki Kerzeli, Iliana; Elgendy, Ramy et al.