Ulrika Segersten

Comprehensive genomic characterization of early-stage bladder cancer

Prip, Frederik; Lamy, Philippe; Lindskrog, Sia Viborg; Strandgaard, Trine et al.

Ingår i Nature Genetics, s. 115-125, 2025

• DOI för Comprehensive genomic characterization of early-stage bladder cancer
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Elevated levels of MMP12 sourced from macrophages are associated with poor prognosis in urothelial bladder cancer

Kerzeli, Iliana Kyriaki; Kostakis, Alexandros; Türker, Polat; Malmström, Per-Uno et al.

Ingår i BMC Cancer, 2023

• DOI för Elevated levels of MMP12 sourced from macrophages are associated with poor prognosis in urothelial bladder cancer
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An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers

Mezheyeuski, Artur; Backman, Max; Mattsson, Johanna Sofia Margareta; Martin-Bernabe, Alfonso et al.

Ingår i EBioMedicine, 2023

• DOI för An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers
• Ladda ner fulltext (pdf) av An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers

Re: An Integrated Multi-Omics Analysis Identifies Prognostic Molecular Subtypes of Non-Muscle Invasive Bladder Cancer: Editorial Comment

Lindskrog, S. ; Prip, F.; Lamy, P.; Taber, A. et al.

Ingår i Journal of Urology, s. 733-733, 2022

PAI-1 is a potential transcriptional silencer that supports bladder cancer cell activity

Furuya, Hideki; Sasaki, Yuka; Chen, Runpu; Peres, Rafael et al.

Ingår i Scientific Reports, 2022

• DOI för PAI-1 is a potential transcriptional silencer that supports bladder cancer cell activity
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Comprehensive genomic characterization of early-stage bladder cancer

Prip, Frederik; Lamy, Philippe; Lindskrog, Sia Viborg; Strandgaard, Trine et al.

Ingår i Nature Genetics, s. 115-125, 2025

• DOI för Comprehensive genomic characterization of early-stage bladder cancer
• Ladda ner fulltext (pdf) av Comprehensive genomic characterization of early-stage bladder cancer

Elevated levels of MMP12 sourced from macrophages are associated with poor prognosis in urothelial bladder cancer

Kerzeli, Iliana Kyriaki; Kostakis, Alexandros; Türker, Polat; Malmström, Per-Uno et al.

Ingår i BMC Cancer, 2023

• DOI för Elevated levels of MMP12 sourced from macrophages are associated with poor prognosis in urothelial bladder cancer
• Ladda ner fulltext (pdf) av Elevated levels of MMP12 sourced from macrophages are associated with poor prognosis in urothelial bladder cancer

An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers

Mezheyeuski, Artur; Backman, Max; Mattsson, Johanna Sofia Margareta; Martin-Bernabe, Alfonso et al.

Ingår i EBioMedicine, 2023

• DOI för An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers
• Ladda ner fulltext (pdf) av An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers

Re: An Integrated Multi-Omics Analysis Identifies Prognostic Molecular Subtypes of Non-Muscle Invasive Bladder Cancer: Editorial Comment

Lindskrog, S. ; Prip, F.; Lamy, P.; Taber, A. et al.

Ingår i Journal of Urology, s. 733-733, 2022

PAI-1 is a potential transcriptional silencer that supports bladder cancer cell activity

Furuya, Hideki; Sasaki, Yuka; Chen, Runpu; Peres, Rafael et al.

Ingår i Scientific Reports, 2022

• DOI för PAI-1 is a potential transcriptional silencer that supports bladder cancer cell activity
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An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer

Viborg Lindskrog, Sia; Prip, Frederik; Lamy, Philippe; Taber, Ann et al.

Ingår i Nature Communications, 2021

• DOI för An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer
• Ladda ner fulltext (pdf) av An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer

Combination of biomarkers for neoadjuvant systemic chemotherapy before cystectomy in patients with urinary bladder cancer

Turker, Polat; Wernroth, Mona-Lisa; Malmström, Per-Uno; Segersten, Ulrika et al.

Ingår i Translational Research, s. 77-84, 2021

• DOI för Combination of biomarkers for neoadjuvant systemic chemotherapy before cystectomy in patients with urinary bladder cancer

The prognostic impact of the tumour stroma fraction: A machine learning-based analysis in 16 human solid tumour types

Micke, Patrick; Strell, Carina; Mattsson, Johanna Sofia Margareta; Martin-Bernabe, Alfonso et al.

Ingår i EBioMedicine, 2021

• DOI för The prognostic impact of the tumour stroma fraction: A machine learning-based analysis in 16 human solid tumour types
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Single-cell RNAseq and longitudinal proteomic analysis of a novel semi-spontaneous urothelial cancer model reveals tumor cell heterogeneity and pretumoral urine protein alterations

Kerzeli, Iliana Kyriaki; Lord, Martin; Doroszko, Milena; Elgendy, Ramy et al.

Ingår i PLOS ONE, 2021

• DOI för Single-cell RNAseq and longitudinal proteomic analysis of a novel semi-spontaneous urothelial cancer model reveals tumor cell heterogeneity and pretumoral urine protein alterations
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Proteomic comparison between different tissue preservation methods for identification of promising biomarkers of urothelial bladder cancer

Valdés, Alberto; Bitzios, Athanasios; Kassa, Eszter; Shevchenko, Ganna et al.

Ingår i Scientific Reports, 2021

• DOI för Proteomic comparison between different tissue preservation methods for identification of promising biomarkers of urothelial bladder cancer
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Fibroblasts in urothelial bladder cancer define stroma phenotypes that are associated with clinical outcome

Mezheyeuski, Artur; Segersten, Ulrika; Leiss, Lina Wik; Malmström, Per-Uno et al.

Ingår i Scientific Reports, 2020

• DOI för Fibroblasts in urothelial bladder cancer define stroma phenotypes that are associated with clinical outcome
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Is Bcl-2 a predictive marker of neoadjuvant chemotherapy response in patients with urothelial bladder cancer undergoing radical cystectomy?

Turker, Polat; Segersten, Ulrika; Malmström, Per-Uno; Hemdan, Tammer

Ingår i Scandinavian journal of urology, s. 45-50, 2019

• DOI för Is Bcl-2 a predictive marker of neoadjuvant chemotherapy response in patients with urothelial bladder cancer undergoing radical cystectomy?
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Molecular Markers Increase Precision of the European Association of Urology Non-Muscle-Invasive Bladder Cancer Progression Risk Groups

van Kessel, Kim E. M.; van der Keur, Kirstin A.; Dyrskjot, Lars; Algaba, Ferran et al.

Ingår i Clinical Cancer Research, s. 1586-1593, 2018

• DOI för Molecular Markers Increase Precision of the European Association of Urology Non-Muscle-Invasive Bladder Cancer Progression Risk Groups

Choline-phosphate cytidylyltransferase-alpha as a possible predictor of survival and response to cisplatin neoadjuvant chemotherapy in urothelial cancer of the bladder

Hemdan, Tammer; Turker, Polat; Malmström, Per-Uno; Segersten, Ulrika

Ingår i Scandinavian journal of urology, s. 200-205, 2018

• DOI för Choline-phosphate cytidylyltransferase-alpha as a possible predictor of survival and response to cisplatin neoadjuvant chemotherapy in urothelial cancer of the bladder
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Parallel Proteomic Workflow for Mass Spectrometric Analysis of Tissue Samples Preserved by Different Methods

Holfeld, Aleš; Valdés, Alberto; Malmström, Per-Uno; Segersten, Ulrika et al.

Ingår i Analytical Chemistry, s. 5841-5849, 2018

• DOI för Parallel Proteomic Workflow for Mass Spectrometric Analysis of Tissue Samples Preserved by Different Methods

Validation of a DNA Methylation-Mutation Urine Assay to Select Patients with Hematuria for Cystoscopy

van Kessel, Kim E. M.; Beukers, Willemien; Lurkin, Irene; Ziel-van der Made, Angelique et al.

Ingår i Journal of Urology, s. 590-595, 2017

• DOI för Validation of a DNA Methylation-Mutation Urine Assay to Select Patients with Hematuria for Cystoscopy

FGFR3, TERT and OTX1 as a Urinary Biomarker Combination for Surveillance of Patients with Bladder Cancer in a Large Prospective Multicenter Study

Beukers, Willemien; van der Keur, Kirstin A.; Kandimalla, Raju; Vergouwe, Yvonne et al.

Ingår i Journal of Urology, s. 1410-1418, 2017

• DOI för FGFR3, TERT and OTX1 as a Urinary Biomarker Combination for Surveillance of Patients with Bladder Cancer in a Large Prospective Multicenter Study

Prognostic Impact of a 12-gene Progression Score in Non-muscle-invasive Bladder Cancer: A Prospective Multicentre Validation Study

Dyrskjot, Lars; Reinert, Thomas; Algaba, Ferran; Christensen, Emil et al.

Ingår i European Urology, s. 461-469, 2017

• DOI för Prognostic Impact of a 12-gene Progression Score in Non-muscle-invasive Bladder Cancer: A Prospective Multicentre Validation Study

Validation of the ezrin, CK20, and Ki-67 as potential predictive markers for BCG instillation therapy of non-muscle-invasive bladder cancer

Malmström, Per-Uno; Hemdan, Tammer; Segersten, Ulrika

Ingår i Urologic Oncology, s. 5320-532000000, 2017

• DOI för Validation of the ezrin, CK20, and Ki-67 as potential predictive markers for BCG instillation therapy of non-muscle-invasive bladder cancer

Association of MMP-2, RB and PAI-1 with decreased recurrence-free survival and overall survival in bladder cancer patients

Chan, Owen T. M.; Furuya, Hideki; Pagano, Ian; Shimizu, Yoshiko et al.

Ingår i Oncotarget, s. 99707-99721, 2017

• DOI för Association of MMP-2, RB and PAI-1 with decreased recurrence-free survival and overall survival in bladder cancer patients
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Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma

Hedegaard, Jakob; Lamy, Philippe; Nordentoft, Iver; Algaba, Ferran et al.

Ingår i Cancer Cell, s. 27-42, 2016

• DOI för Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma

Emmprin Expression Predicts Response and Survival following Cisplatin Containing Chemotherapy for Bladder Cancer: A Validation Study.

Hemdan, Tammer; Malmström, Per-Uno; Jahnson, Staffan; Segersten, Ulrika

Ingår i Journal of Urology, s. 1575-1581, 2015

• DOI för Emmprin Expression Predicts Response and Survival following Cisplatin Containing Chemotherapy for Bladder Cancer: A Validation Study.

A urine based assay to select patients for initial cystoscopy

van Kessel, Kim E. M.; Beukers, Willemien; Lurkin, Irene; van der Keur, Kirstin A. et al.

Ingår i Cancer Research, 2015

• DOI för A urine based assay to select patients for initial cystoscopy

Risk Prediction Scores for Recurrence and Progression of Non-Muscle Invasive Bladder Cancer: An International Validation in Primary Tumours

Vedder, Moniek M.; Marquez, Mirari; de Bekker-Grob, Esther W.; Calle, Malu L. et al.

Ingår i PLOS ONE, 2014

• DOI för Risk Prediction Scores for Recurrence and Progression of Non-Muscle Invasive Bladder Cancer: An International Validation in Primary Tumours
• Ladda ner fulltext (pdf) av Risk Prediction Scores for Recurrence and Progression of Non-Muscle Invasive Bladder Cancer: An International Validation in Primary Tumours

Reduced expression of ezrin in urothelial bladder cancer signifies more advanced tumours and an impaired survival: validatory study of two independent patient cohorts

Andersson, Gustav; Wennersten, Christoffer; Gaber, Alexander; Boman, Karolina et al.

Ingår i BMC Urology, s. 36, 2014

• DOI för Reduced expression of ezrin in urothelial bladder cancer signifies more advanced tumours and an impaired survival: validatory study of two independent patient cohorts
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The role of microRNA profiling in prognosticating progression in Ta and T1 urinary bladder cancer

Segersten, Ulrika; Spector, Yael; Goren, Yaron; Tabak, Sarit et al.

Ingår i Urologic Oncology, s. 613-618, 2014

• DOI för The role of microRNA profiling in prognosticating progression in Ta and T1 urinary bladder cancer

The prognostic value and therapeutic target role of stathmin-1 in urinary bladder cancer

Hemdan, Tammer; Lindén, Mårten; Lind, Sara; Namuduri, Arvind et al.

Ingår i British Journal of Cancer, s. 1180-1187, 2014

• DOI för The prognostic value and therapeutic target role of stathmin-1 in urinary bladder cancer
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Decreased expression of RNA-binding motif protein 3 correlates with tumour progression and poor prognosis in urothelial bladder cancer

Boman, Karolina; Segersten, Ulrika; Ahlgren, Göran; Eberhard, Jakob et al.

Ingår i BMC Urology, s. 17, 2013

• DOI för Decreased expression of RNA-binding motif protein 3 correlates with tumour progression and poor prognosis in urothelial bladder cancer
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Tumour expression of bladder cancer-associated urinary proteins

Lindén, Mårten; Segersten, Ulrika; Runeson, Marcus; Wester, Kenneth et al.

Ingår i BJU International, s. 407-415, 2013

• DOI för Tumour expression of bladder cancer-associated urinary proteins

Membranous expression of podocalyxin-like protein is an independent factor of poor prognosis in urothelial bladder cancer

Boman, K; Larsson, A H; Segersten, Ulrika; Kuteeva, E et al.

Ingår i British Journal of Cancer, s. 2321-2328, 2013

• DOI för Membranous expression of podocalyxin-like protein is an independent factor of poor prognosis in urothelial bladder cancer

Multicenter Validation of Cyclin D1, MCM7, TRIM29, and UBE2C as Prognostic Protein Markers in Non-Muscle Invasive Bladder Cancer

Fristrup, Niels; Birkenkamp-Demtröder, Karin; Reinert, Thomas; Sanchez-Carbayo, Marta et al.

Ingår i American Journal of Pathology, s. 339-349, 2013

• DOI för Multicenter Validation of Cyclin D1, MCM7, TRIM29, and UBE2C as Prognostic Protein Markers in Non-Muscle Invasive Bladder Cancer

Proteomic analysis of urinary biomarker candidates for nonmuscle invasive bladder cancer

Lindén, Mårten; Lind, Sara Bergström; Mayrhofer, Corina; Segersten, Ulrika et al.

Ingår i Proteomics, s. 135-144, 2012

• DOI för Proteomic analysis of urinary biomarker candidates for nonmuscle invasive bladder cancer

Analysis of molecular intra-patient variation and delineation of a prognostic 12-gene signature in non-muscle invasive bladder cancer; technology transfer from microarrays to PCR

Dyrskjot, L.; Reinert, T.; Novoradovsky, A.; Zuiverloon, T. C. M. et al.

Ingår i British Journal of Cancer, s. 1392-1398, 2012

• DOI för Analysis of molecular intra-patient variation and delineation of a prognostic 12-gene signature in non-muscle invasive bladder cancer; technology transfer from microarrays to PCR

Cathepsin E, Maspin, Plk1, and Survivin Are Promising Prognostic Protein Markers for Progression in Non-Muscle Invasive Bladder Cancer

Fristrup, Niels; Ulhoi, Benedicte P.; Birkenkamp-Demtroder, Karin; Mansilla, Francisco et al.

Ingår i American Journal of Pathology, s. 1824-1834, 2012

• DOI för Cathepsin E, Maspin, Plk1, and Survivin Are Promising Prognostic Protein Markers for Progression in Non-Muscle Invasive Bladder Cancer

Focal amplifications are associated with high grade and recurrences in stage Ta bladder carcinoma

Nord, Helena; Segersten, Ulrika; Sandgren, Johanna; Wester, Kenneth et al.

Ingår i International Journal of Cancer, s. 1390-1402, 2010

• DOI för Focal amplifications are associated with high grade and recurrences in stage Ta bladder carcinoma

Impact of thawing on RNA integrity and gene expression analysis in fresh frozen tissue

Botling, Johan; Edlund, Karolina; Segersten, Ulrika; Tahmasebpoor, Simin et al.

Ingår i Diagnostic molecular pathology (Print), s. 44-52, 2009

• DOI för Impact of thawing on RNA integrity and gene expression analysis in fresh frozen tissue

Molecular genetics of bladder cancer: an update

Díaz de Ståhl, Teresita; Segersten, Ulrika; Malmström, Per-Uno

Ingår i Minerva Urologica e Nefrologica, s. 205-16, 2008

Potentiating effects of non-active/active vitamin D analogues and ketoconazole in parathyroid cells

Segersten, Ulrika; Björklund, Peyman; Hellman, Per; Åkerström, Göran et al.

Ingår i Clinical Endocrinology, s. 399-404, 2007

• DOI för Potentiating effects of non-active/active vitamin D analogues and ketoconazole in parathyroid cells

25-hydroxyvitamin D3 1alpha-hydroxylase expression in breast cancer and use of non-hydroxylated vitamin D analogue

Segersten, Ulrika; Kaae Holm, Pernille; Björklund, Peyman; Hessman, Ola et al.

Ingår i Breast Cancer Research, 2005

• DOI för 25-hydroxyvitamin D3 1alpha-hydroxylase expression in breast cancer and use of non-hydroxylated vitamin D analogue
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Vitamin D3 polyunsaturated side-chain analogues (EB1089, GS1590) and the 20-epi-vitamin D3 analogue CB1393 suppress parathyroid hormone secretion and mRNA level in bovine parathyroid cells

Segersten, Ulrika; Kaae Holm, Pernille; Binderup, Lise; Åkerström, Göran et al.

Ingår i Journal of Steroid Biochemistry & Molecular Biology, s. 289-294, 2004

25-hydroxyvitamin D(3)-1alpha-hydroxylase expression in normal and pathological paratahyroid glands

Segersten, Ulrika; Correa, Pamela; Hewison, M; Hellman, Per et al.

Ingår i J Clin Endocrinol Metab, s. 2967, 2002

Increased 25-hydroxyvitamin D3 1a-hydroxylase and reduced 25-hydroxyvitamin D3 24-hydroxylase expression in parathyroid tumors—New prospects for treatment of hyperparathyroidism with vitamin D.

Correa, P; Segersten, Ulrika; Åkerström, Göran; Westin, Gunnar

Ingår i J Clin Endocrinol Metab,, s. 5826, 2002

Increased 25-hydroxyvitamin D3 1α-hydroxylase and reduced 25-hydroxyvitamin D3 24-hydroxylase expression in parathyroid tumors: new prospects for treatment of hyperparathyroidism with vitamin D

Correa, Pamela; Segersten, Ulrika; Hellman, Per; Åkerström, Göran et al.

Ingår i Journal of Clinical Endocrinology & Metabolism, s. 5826-5829, 2002

Potentiating inhibitory effects of the non-1α-hydroxylated precursor vitamin D analogue of EB1089 (EB1285) and ketoconazole in parathyroid cells

Segersten, Ulrika; Hellman, Per; Åkerström, Göran; Westin, Gunnar

An overview on preclinical and clinical experiences with photodynamic therapy for bladder cancer

Yavari, Nazila; Andersson-Engels, Stefan; Segersten, Ulrika; Malmström, Per-Uno

Ingår i Canadian Journal of Urology, s. 5778-5786, 2011

Parathyroid glands in calcium regulation and human disease

Åkerström, Göran; Hellman, Per; Hessman, Ola; Segersten, Ulrika et al.

Ingår i Trends in Comparative Endocrinology and Neurobiology, s. 53-58, 2005

Galectin-1, a potential therapeutic target, in primary tumors and metastases of urinary bladder carcinomas

Lindén, Mårten; Hemdan, Tammer; Ugge, Henrik; Bergström Lind, Sara et al.

2013

Stathmin-1 is a promising prognostic factor and potential therapeutic target in urinary bladder cancer

Hemdan, Tammer; Lindén, Mårten; Bergström Lind, Sara; Namuduri, Arvind Venkat et al.

The tumour microenvironment across tumour evolution in bladder cancer profiled by single-cell RNA-sequencing analysis and spatial transcriptomics

Kostakis, Alexandros; Beháňová, Andrea; Kyriaki Kerzeli, Iliana; Elgendy, Ramy et al.