Hans Lennernäs

Physiologically based pharmacokinetics modeling and transporter proteomics to predict systemic and local liver and muscle disposition of statins

Garcia, Luna Prieto; Vildhede, Anna; Nordell, Pär; Ahlström, Christine et al.

Part of CPT, p. 1029-1043, 2024

• DOI for Physiologically based pharmacokinetics modeling and transporter proteomics to predict systemic and local liver and muscle disposition of statins
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Enhanced Bioavailability and Reduced Variability of Dasatinib and Sorafenib with a Novel Amorphous Solid Dispersion Technology Platform

Lennernäs, Hans; Brisander, Magnus; Liljebris, Charlotta; Jesson, Gerald et al.

Part of Clinical Pharmacology in Drug Development, p. 985-999, 2024

• DOI for Enhanced Bioavailability and Reduced Variability of Dasatinib and Sorafenib with a Novel Amorphous Solid Dispersion Technology Platform
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Parameterization of Physiologically Based Biopharmaceutics Models: Workshop Summary Report

Pepin, Xavier; Arora, Sumit; Borges, Luiza; Cano-Vega, Mario et al.

Part of Molecular Pharmaceutics, p. 3697-3731, 2024

• DOI for Parameterization of Physiologically Based Biopharmaceutics Models: Workshop Summary Report
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Melatonin mitigates chemotherapy-induced small intestinal atrophy in rats and reduces cytotoxicity in murine intestinal organoids

Peters, Karsten; Clavero, Ada Lerma; Kullenberg, Fredrik; Kopsida, Maria et al.

Part of PLOS ONE, 2024

• DOI for Melatonin mitigates chemotherapy-induced small intestinal atrophy in rats and reduces cytotoxicity in murine intestinal organoids
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Model-based interspecies scaling for predicting human pharmacokinetics of CB 4332, a complement factor I protein

Ayoun Alsoud, Rami; Le Moan, Natacha; Holten-Andersen, Lars; Knudsen, Tom et al.

Part of Journal of Pharmaceutical Sciences, p. 2895-2903, 2024

• DOI for Model-based interspecies scaling for predicting human pharmacokinetics of CB 4332, a complement factor I protein
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Physiologically based pharmacokinetics modeling and transporter proteomics to predict systemic and local liver and muscle disposition of statins

Garcia, Luna Prieto; Vildhede, Anna; Nordell, Pär; Ahlström, Christine et al.

Part of CPT, p. 1029-1043, 2024

• DOI for Physiologically based pharmacokinetics modeling and transporter proteomics to predict systemic and local liver and muscle disposition of statins
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Enhanced Bioavailability and Reduced Variability of Dasatinib and Sorafenib with a Novel Amorphous Solid Dispersion Technology Platform

Lennernäs, Hans; Brisander, Magnus; Liljebris, Charlotta; Jesson, Gerald et al.

Part of Clinical Pharmacology in Drug Development, p. 985-999, 2024

• DOI for Enhanced Bioavailability and Reduced Variability of Dasatinib and Sorafenib with a Novel Amorphous Solid Dispersion Technology Platform
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Parameterization of Physiologically Based Biopharmaceutics Models: Workshop Summary Report

Pepin, Xavier; Arora, Sumit; Borges, Luiza; Cano-Vega, Mario et al.

Part of Molecular Pharmaceutics, p. 3697-3731, 2024

• DOI for Parameterization of Physiologically Based Biopharmaceutics Models: Workshop Summary Report
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Melatonin mitigates chemotherapy-induced small intestinal atrophy in rats and reduces cytotoxicity in murine intestinal organoids

Peters, Karsten; Clavero, Ada Lerma; Kullenberg, Fredrik; Kopsida, Maria et al.

Part of PLOS ONE, 2024

• DOI for Melatonin mitigates chemotherapy-induced small intestinal atrophy in rats and reduces cytotoxicity in murine intestinal organoids
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Model-based interspecies scaling for predicting human pharmacokinetics of CB 4332, a complement factor I protein

Ayoun Alsoud, Rami; Le Moan, Natacha; Holten-Andersen, Lars; Knudsen, Tom et al.

Part of Journal of Pharmaceutical Sciences, p. 2895-2903, 2024

• DOI for Model-based interspecies scaling for predicting human pharmacokinetics of CB 4332, a complement factor I protein
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Development and validation of LC-MS/MS methods for the pharmacokinetic assessment of the PROTACs bavdeglutamide (ARV-110) and vepdegestrant (ARV-471)

Niessen, Janis; Nilsson, Jenny M.; Peters, Karsten; Indulkar, Anura et al.

Part of Journal of Pharmaceutical and Biomedical Analysis, 2024

• DOI for Development and validation of LC-MS/MS methods for the pharmacokinetic assessment of the PROTACs bavdeglutamide (ARV-110) and vepdegestrant (ARV-471)
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Ammonium bicarbonate buffers combined with hybrid surface technology columns improve the peak shape of strongly tailing lipids

Nilsson, Jenny M.; Balgoma, David; Pettersson, Curt; Lennernäs, Hans et al.

Part of Analytica Chimica Acta, 2024

• DOI for Ammonium bicarbonate buffers combined with hybrid surface technology columns improve the peak shape of strongly tailing lipids
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Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells

Kopsida, Maria; Clavero, Ada Lerma; Khaled, Jaafar; Balgoma, David et al.

Part of Molecular Metabolism, 2024

• DOI for Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells
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Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma

Calitz, Carlemi; Rosenquist, Jenny; Degerstedt, Oliver; Khaled, Jaafar et al.

Part of Scientific Reports, 2023

• DOI for Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma
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Novel food drug interaction mechanism involving acyclovir, chitosan and endogenous mucus

Garcia, Mauricio A.; Hensler, Gonul; Al-Gousous, Jozef; Pielenhofer, Jonas et al.

Part of Drug Metabolism and Pharmacokinetics, 2023

• DOI for Novel food drug interaction mechanism involving acyclovir, chitosan and endogenous mucus

Quantitative imaging of doxorubicin diffusion and cellular uptake in biomimetic gels with human liver tumor cells

Degerstedt, Oliver; O'Callaghan, Paul; Lerma Clavero, Ada; Gråsjö, Johan et al.

Part of Drug Delivery and Translational Research, p. 970-983, 2023

• DOI for Quantitative imaging of doxorubicin diffusion and cellular uptake in biomimetic gels with human liver tumor cells
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The progression of doxorubicin-induced intestinal mucositis in rats

Kullenberg, Fredrik; Peters, Karsten; Luna-Marco, C.; Salomonsson, A. et al.

Part of Naunyn-Schmiedeberg's Archives of Pharmacology, p. 247-260, 2023

• DOI for The progression of doxorubicin-induced intestinal mucositis in rats
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Anakinra and dexamethasone treatment of idarubicin-induced mucositis and diarrhoea in rats

Kullenberg, Fredrik; Peters, Karsten; Sjöblom, Markus; Heindryckx, Femke et al.

Part of Basic & Clinical Pharmacology & Toxicology, p. 507-516, 2023

• DOI for Anakinra and dexamethasone treatment of idarubicin-induced mucositis and diarrhoea in rats
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Despite warnings, co-medication with proton pump inhibitors and dasatinib is common in chronic myeloid leukemia, but XS004, a novel oral dasatinib formulation, provides reduced pH-dependence, minimizing undesirable drug-drug interactions.

Larfors, Gunnar; Andersson, Per; Jesson, Gérald; Liljebris, Charlotta et al.

Part of European Journal of Haematology, 2023

• DOI for Despite warnings, co-medication with proton pump inhibitors and dasatinib is common in chronic myeloid leukemia, but XS004, a novel oral dasatinib formulation, provides reduced pH-dependence, minimizing undesirable drug-drug interactions.
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Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma

Khaled, Jaafar; Kopsida, Maria; Lennernäs, Hans; Heindryckx, Femke

Part of Cells, 2022

• DOI for Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma
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Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding

Balgoma, David; Kullenberg, Fredrik; Peters, Karsten; Dahlgren, David et al.

Part of Metabolites, 2022

• DOI for Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding
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Evaluation and validation of chemotherapy‐specific diarrhoea and histopathology in rats

Dahlgren, David; Rosenqvist, Evelina; Hellström, Per M.; Nygren, Peter et al.

Part of Basic & Clinical Pharmacology & Toxicology, p. 536-546, 2022

• DOI for Evaluation and validation of chemotherapy‐specific diarrhoea and histopathology in rats
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Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats

Peters, Karsten; Dahlgren, David; Egerszegi, Peter Pal; Lennernäs, Hans et al.

Part of International Journal of Molecular Sciences, 2022

• DOI for Protective Effects of Melatonin and Misoprostol against Experimentally Induced Increases in Intestinal Permeability in Rats
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Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats

Cano-Cebrian, Maria-Jose; Dahlgren, David; Kullenberg, Fredrik; Peters, Karsten et al.

Part of International Journal of Molecular Sciences, 2022

• DOI for Chemotherapeutics Combined with Luminal Irritants: Effects on Small-Intestinal Mannitol Permeability and Villus Length in Rats
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Drug diffusion in biomimetic hydrogels: importance for drug transport and delivery in non-vascular tumor tissue

Degerstedt, Oliver; Gråsjö, Johan; Norberg, Anton; Sjögren, Erik et al.

Part of European Journal of Pharmaceutical Sciences, 2022

• DOI for Drug diffusion in biomimetic hydrogels: importance for drug transport and delivery in non-vascular tumor tissue
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Does the choice of applied physiologically-based pharmacokinetics platform matter?: A case study on simvastatin disposition and drug-drug interaction

Garcia, Luna Prieto; Lundahl, Anna; Ahlstrom, Christine; Vildhede, Anna et al.

Part of CPT, p. 1194-1209, 2022

• DOI for Does the choice of applied physiologically-based pharmacokinetics platform matter?: A case study on simvastatin disposition and drug-drug interaction
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Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival

Sennefelt Nyman, Sofi; Ahlström, Håkan; Dimopoulou, Angeliki; Dahlgren, David et al.

Part of BMJ Open, 2022

• DOI for Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival
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Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death

Balgoma, David; Kullenberg, Fredrik; Calitz, Carlemi; Kopsida, Maria et al.

Part of Cells, 2021

• DOI for Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death
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Melatonin-Activated Receptor Signaling Pathways Mediate Protective Effects on Surfactant-Induced Increase in Jejunal Mucosal Permeability in Rats

Peters, Karsten; Dahlgren, David; Lennernäs, Hans; Sjöblom, Markus

Part of International Journal of Molecular Sciences, 2021

• DOI for Melatonin-Activated Receptor Signaling Pathways Mediate Protective Effects on Surfactant-Induced Increase in Jejunal Mucosal Permeability in Rats
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Fasted and fed state human duodenal fluids: Characterization, drug solubility, and comparison to simulated fluids and with human bioavailability

Dahlgren, David; Venczel, M.; Ridoux, J. -P; Skjöld, C. et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 240-251, 2021

• DOI for Fasted and fed state human duodenal fluids: Characterization, drug solubility, and comparison to simulated fluids and with human bioavailability
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In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma

Kullenberg, Fredrik; Degerstedt, Oliver; Calitz, Carlemi; Pavlovic, Natasa et al.

Part of Cells, 2021

• DOI for In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma
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Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats

Dahlgren, David; Olander, Tobias; Sjöblom, Markus; Hedeland, Mikael et al.

Part of Acta Pharmaceutica Sinica B, p. 1667-1675, 2021

• DOI for Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats
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Effects of a novel combination of orlistat and acarbose on tolerability, appetite, and glucose metabolism in persons with obesity

Holmbäck, Ulf; Forslund, Anders; Gruden, Stefan; Alderborn, Göran et al.

Part of Obesity Science & Practice, p. 313-323, 2020

• DOI for Effects of a novel combination of orlistat and acarbose on tolerability, appetite, and glucose metabolism in persons with obesity
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Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat

Dahlgren, David; Cano-Cebrian, Maria-Jose; Olander, Tobias; Hedeland, Mikael et al.

Part of Pharmaceutics, 2020

• DOI for Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat
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Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol

Dahlgren, David; Cano-Cebrian, Maria-Jose; Hellström, Per M.; Wanders, Alkwin et al.

Part of International Journal of Molecular Sciences, 2020

• DOI for Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol
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The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin

Dahlgren, David; Sjöblom, Markus; Hedeland, Mikael; Lennernäs, Hans

Part of Pharmaceutics, 2020

• DOI for The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin
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Model-informed drug discovery and development strategy for the rapid development of anti-tuberculosis drug combinations

Van Wijk, Rob C; Ayoun Alsoud, Rami; Lennernäs, Hans; Simonsson, Ulrika S H

Part of Applied Sciences, 2020

• DOI for Model-informed drug discovery and development strategy for the rapid development of anti-tuberculosis drug combinations
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Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption

Eriksson, Johanna; Sjögren, Erik; Lennernäs, Hans; Thörn, Helena

Part of AAPS Journal, 2020

• DOI for Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption
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Pulmonary drug absorption and systemic exposure in human: Predictions using physiologically based biopharmaceutics modeling

Eriksson, Johanna; Thorn, Helena; Lennernäs, Hans; Sjögren, Erik

Part of European journal of pharmaceutics and biopharmaceutics, p. 191-202, 2020

• DOI for Pulmonary drug absorption and systemic exposure in human: Predictions using physiologically based biopharmaceutics modeling

Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: History, methodology and applications

Augustijns, Patrick; Vertzoni, Maria; Reppas, Christos; Langguth, Peter et al.

Part of European Journal of Pharmaceutical Sciences, 2020

• DOI for Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: History, methodology and applications
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Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project

Abrahamsson, B.; McAllister, M.; Augustijns, P.; Zane, P. et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 236-247, 2020

• DOI for Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project

ICH M9 Guideline in Development on Biopharmaceutics Classification System-Based Biowaivers: An Industrial Perspective from the IQ Consortium

Bransford, Philip; Cook, Jack; Gupta, Manish; Haertter, Sebastian et al.

Part of Molecular Pharmaceutics, p. 361-372, 2020

• DOI for ICH M9 Guideline in Development on Biopharmaceutics Classification System-Based Biowaivers: An Industrial Perspective from the IQ Consortium

Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality

Ahnfelt, Emelie; Degerstedt, Oliver; Lilienberg, Elsa; Sjögren, Erik et al.

Part of Journal of Drug Delivery Science and Technology, 2019

• DOI for Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality
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Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile

Dubbelboer, Ilse R; Pavlovic, Natasa; Heindryckx, Femke; Sjögren, Erik et al.

Part of Cancers, 2019

• DOI for Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile
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Pulmonary Dissolution of Poorly Soluble Compounds Studied in an ex Vivo Rat Lung Model

Eriksson, Johanna; Thorn, Helena; Sjögren, Erik; Holmsten, Lisa et al.

Part of Molecular Pharmaceutics, p. 3053-3064, 2019

• DOI for Pulmonary Dissolution of Poorly Soluble Compounds Studied in an ex Vivo Rat Lung Model

Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 387-395, 2019

• DOI for Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

Rat intestinal drug permeability: A status report and summary of repeated determinations

Dubbelboer, Ilse R; Dahlgren, David; Sjögren, Erik; Lennernäs, Hans

Part of European journal of pharmaceutics and biopharmaceutics, p. 364-376, 2019

• DOI for Rat intestinal drug permeability: A status report and summary of repeated determinations

Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model

Dahlgren, David; Roos, Carl; Peters, Karsten; Lundqvist, A. et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 31-37, 2019

• DOI for Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model

Intestinal absorption-modifying excipients: A current update on preclinical in vivo evaluations

Dahlgren, David; Sjöblom, Markus; Lennernäs, Hans

Part of European journal of pharmaceutics and biopharmaceutics, p. 411-420, 2019

• DOI for Intestinal absorption-modifying excipients: A current update on preclinical in vivo evaluations

Physiologically based pharmacokinetic model predictions of ivosidenib (AG-120) as a victim and perpetrator of drug–drug interactions

Garcia, Luna Prieto; Janzen, David; Kanebratt, Kajsa; Ericsson, Hans et al.

Part of Drug Metabolism and Pharmacokinetics, 2019

• DOI for Physiologically based pharmacokinetic model predictions of ivosidenib (AG-120) as a victim and perpetrator of drug–drug interactions

Physiologically Based Pharmacokinetic Model of Itraconazole and Two of Its Metabolites to Improve the Predictions and the Mechanistic Understanding of CYP3A4 Drug-Drug Interactions

Garcia, Luna Prieto; Janzén, David; Kanebratt, Kajsa P.; Ericsson, Hans et al.

Part of Drug Metabolism And Disposition, p. 1420-1433, 2018

• DOI for Physiologically Based Pharmacokinetic Model of Itraconazole and Two of Its Metabolites to Improve the Predictions and the Mechanistic Understanding of CYP3A4 Drug-Drug Interactions

Porcine and Human In Vivo Simulations for Doxorubicin-Containing Formulations Used in Locoregional Hepatocellular Carcinoma Treatment

Dubbelboer, Ilse R; Sjögren, Erik; Lennernäs, Hans

Part of AAPS Journal, 2018

• DOI for Porcine and Human In Vivo Simulations for Doxorubicin-Containing Formulations Used in Locoregional Hepatocellular Carcinoma Treatment
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Single bead investigation of a clinical drug delivery system – a novel release mechanism

Ahnfelt, Emelie; Al-Tikriti, Yassir; Sjögren, Erik; Lennernäs, Hans et al.

Part of Journal of Controlled Release, p. 235-247, 2018

• DOI for Single bead investigation of a clinical drug delivery system – a novel release mechanism
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Time-dependent effects on small intestinal transport by absorption-modifying excipients

Dahlgren, David; Roos, Carl; Lundqvist, A.; Tannergren, C. et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 19-28, 2018

• DOI for Time-dependent effects on small intestinal transport by absorption-modifying excipients

Mechanistic modelling of intestinal drug absorption: the in vivo effects of nanoparticles, hydrodynamics, and colloidal structures

Roos, Carl; Westergren, Jan; Dahlgren, David; Lennernäs, Hans et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 70-76, 2018

• DOI for Mechanistic modelling of intestinal drug absorption: the in vivo effects of nanoparticles, hydrodynamics, and colloidal structures

Jejunal absorption of aprepitant from nanosuspensions: Role of particle size, prandial state and mucus layer.

Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 222-230, 2018

• DOI for Jejunal absorption of aprepitant from nanosuspensions: Role of particle size, prandial state and mucus layer.

Summary of the In Vivo Predictive Dissolution (iPD) - Oral Drug Delivery (ODD) Conference 2018

Hens, Bart; Al-Gousous, Jozef; Wang, Kai; Salehi, Niloufar et al.

Part of DISSOLUTION TECHNOLOGIES, p. 50-53, 2018

• DOI for Summary of the In Vivo Predictive Dissolution (iPD) - Oral Drug Delivery (ODD) Conference 2018

Effect of absorption-modifying excipients, hypotonicity, and enteric neural activity in an in vivo model for small intestinal transport.

Dahlgren, David; Roos, Carl; Lundqvist, A; Tannergren, C et al.

Part of International Journal of Pharmaceutics, p. 239-248, 2018

• DOI for Effect of absorption-modifying excipients, hypotonicity, and enteric neural activity in an in vivo model for small intestinal transport.

The effects of three absorption-modifying critical excipients on the in vivo intestinal absorption of six model compounds in rats and dogs.

Dahlgren, David; Roos, Carl; Johansson, P; Tannergren, C et al.

Part of International Journal of Pharmaceutics, p. 158-168, 2018

• DOI for The effects of three absorption-modifying critical excipients on the in vivo intestinal absorption of six model compounds in rats and dogs.

Pulmonary absorption - estimation of effective pulmonary permeability and tissue retention of ten drugs using an ex vivo rat model and computational analysis

Eriksson, Johanna; Sjögren, Erik; Thörn, Helena; Rubin, Katarina et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 1-12, 2018

• DOI for Pulmonary absorption - estimation of effective pulmonary permeability and tissue retention of ten drugs using an ex vivo rat model and computational analysis

Reply to "Comment on 'In Vivo Drug Delivery Performance of Lipiodol-Based Emulsion or Drug-Eluting Beads in Patients with Hepatocellular Carcinoma'"

Dubbelboer, Ilse R; Lilienberg, Elsa; Karalli, Amar; Axelsson, Rimma et al.

Part of Molecular Pharmaceutics, p. 336-340, 2018

• DOI for Reply to "Comment on 'In Vivo Drug Delivery Performance of Lipiodol-Based Emulsion or Drug-Eluting Beads in Patients with Hepatocellular Carcinoma'"

An Intraprostatic Modified Release Formulation of Antiandrogen 2-Hydroxyflutamide for Localized Prostate Cancer

Tammela, T L; Häggman, Michael; Ladjevardi, Sam; Taari, K et al.

Part of Journal of Urology, p. 1333-1339, 2017

• DOI for An Intraprostatic Modified Release Formulation of Antiandrogen 2-Hydroxyflutamide for Localized Prostate Cancer

Preclinical Effect of Absorption Modifying Excipients on Rat Intestinal Transport of Model Compounds and the Mucosal Barrier Marker ⁵¹Cr-EDTA

Dahlgren, David; Roos, Carl; Lundqvist, Anders; Tannergren, Christer et al.

Part of Molecular Pharmaceutics, p. 4243-4251, 2017

• DOI for Preclinical Effect of Absorption Modifying Excipients on Rat Intestinal Transport of Model Compounds and the Mucosal Barrier Marker ⁵¹Cr-EDTA

Computational fluid dynamics (CFD) studies of a miniaturized dissolution system

Frenning, Göran; Ahnfelt, Emelie; Sjögren, Erik; Lennernäs, Hans

Part of International Journal of Pharmaceutics, p. 274-281, 2017

• DOI for Computational fluid dynamics (CFD) studies of a miniaturized dissolution system
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In vivo Drug Delivery Performance of Lipiodol-based Emulsion or Drug-eluting Beads in Patients with Hepatocellular Carcinoma

Lilienberg, Elsa; Dubbelboer, Ilse R.; Karalli, Amar; Axelsson, Rimma et al.

Part of Molecular Pharmaceutics, p. 448-458, 2017

• DOI for In vivo Drug Delivery Performance of Lipiodol-based Emulsion or Drug-eluting Beads in Patients with Hepatocellular Carcinoma

In Vivo Mechanisms of Intestinal Drug Absorption from Aprepitant Nanoformulations

Roos, Carl; Dahlgren, David; Berg, Staffan; Westergren, Jan et al.

Part of Molecular Pharmaceutics, p. 4233-4242, 2017

• DOI for In Vivo Mechanisms of Intestinal Drug Absorption from Aprepitant Nanoformulations

Regional Intestinal Permeability in Rats: A Comparison of Methods

Roos, Carl; Dahlgren, David; Sjögren, Erik; Tannergren, Christer et al.

Part of Molecular Pharmaceutics, p. 4252-4261, 2017

• DOI for Regional Intestinal Permeability in Rats: A Comparison of Methods

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

Margolskee, Alison; Darwich, Adam S.; Pepin, Xavier; Aarons, Leon et al.

Part of European Journal of Pharmaceutical Sciences, p. 610-625, 2017

• DOI for IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

Darwich, Adam S.; Margolskee, Alison; Pepin, Xavier; Aarons, Leon et al.

Part of European Journal of Pharmaceutical Sciences, p. 626-642, 2017

• DOI for IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

IMI - oral biopharmaceutics tools project - evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

Margolskee, Alison; Darwich, Adam S.; Pepin, Xavier; Pathak, Shriram M. et al.

Part of European Journal of Pharmaceutical Sciences, p. 598-609, 2017

• DOI for IMI - oral biopharmaceutics tools project - evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

Lipiodol does not affect the tissue distribution of intravenous doxorubicin infusion in pigs

Lilienberg, Elsa; Dubbelboer, Ilse R; Sjögren, Erik; Lennernäs, Hans

Part of Journal of Pharmacy and Pharmacology (JPP), p. 135-142, 2017

• DOI for Lipiodol does not affect the tissue distribution of intravenous doxorubicin infusion in pigs

A Model -Based Approach To Assessing the Importance of Intracellular Binding Sites in Doxorubicin Disposition

Dubbelboer, Ilse R.; Lilienberg, Elsa; Sjögren, Erik; Lennernäs, Hans

Part of Molecular Pharmaceutics, p. 686-698, 2017

• DOI for A Model -Based Approach To Assessing the Importance of Intracellular Binding Sites in Doxorubicin Disposition

In Vivo Predictive Dissolution (IPD) and Biopharmaceutical Modeling and Simulation: Future Use of Modern Approaches and Methodologies in a Regulatory Context

Lennernäs, Hans; Lindahl, A.; Van Peer, A.; Ollier, C. et al.

Part of Molecular Pharmaceutics, p. 1307-1314, 2017

• DOI for In Vivo Predictive Dissolution (IPD) and Biopharmaceutical Modeling and Simulation: Future Use of Modern Approaches and Methodologies in a Regulatory Context

Optimization of the Ussing chamber setup with excised rat intestinal segments for dissolution/permeation experiments of poorly soluble drugs

Forner, Kristin; Roos, Carl; Dahlgren, David; Kesisoglou, Filippos et al.

Part of Drug Development and Industrial Pharmacy, p. 338-346, 2017

• DOI for Optimization of the Ussing chamber setup with excised rat intestinal segments for dissolution/permeation experiments of poorly soluble drugs

Regional Intestinal Permeability of Three Model Drugs in Human

Dahlgren, David; Roos, Carl; Lundqvist, Anders; Abrahamsson, Bertil et al.

Part of Molecular Pharmaceutics, p. 3013-3021, 2016

• DOI for Regional Intestinal Permeability of Three Model Drugs in Human

In Vitro Release Mechanisms of Doxorubicin From a Clinical Bead Drug-Delivery System

Ahnfelt, Emelie; Sjögren, Erik; Hansson, Per; Lennernäs, Hans

Part of Journal of Pharmaceutical Sciences, p. 3387-3398, 2016

• DOI for In Vitro Release Mechanisms of Doxorubicin From a Clinical Bead Drug-Delivery System

Regional Intestinal Permeability in Dogs: Biopharmaceutical Aspects for Development of Oral Modified-Release Dosage Forms

Dahlgren, David; Roos, Carl; Johansson, Pernilla; Lundqvist, Anders et al.

Part of Molecular Pharmaceutics, p. 3022-3033, 2016

• DOI for Regional Intestinal Permeability in Dogs: Biopharmaceutical Aspects for Development of Oral Modified-Release Dosage Forms

Achieving a physiological cortisol profile with once-daily dual-release hydrocortisone: a pharmacokinetic study

Johannsson, Gudmundur; Lennernäs, Hans; Marelli, Claudio; Rockich, Kevin et al.

Part of European Journal of Endocrinology, p. 85-93, 2016

• DOI for Achieving a physiological cortisol profile with once-daily dual-release hydrocortisone: a pharmacokinetic study
• Download full text (pdf) of Achieving a physiological cortisol profile with once-daily dual-release hydrocortisone: a pharmacokinetic study

Translating Human Effective Jejunal Intestinal Permeability to Surface-Dependent Intrinsic Permeability: a Pragmatic Method for a More Mechanistic Prediction of Regional Oral Drug Absorption

Olivares-Morales, Andres; Lennernäs, Hans; Aarons, Leon; Rostami-Hodjegan, Amin

Part of AAPS Journal, p. 1177-1192, 2015

• DOI for Translating Human Effective Jejunal Intestinal Permeability to Surface-Dependent Intrinsic Permeability: a Pragmatic Method for a More Mechanistic Prediction of Regional Oral Drug Absorption

A miniaturized in vitro release method for investigating drug-release mechanisms

Ahnfelt, Emelie; Sjögren, Erik; Axén, N.; Lennernäs, Hans

Part of International Journal of Pharmaceutics, p. 339-349, 2015

• DOI for A miniaturized in vitro release method for investigating drug-release mechanisms
• Download full text (pdf) of A miniaturized in vitro release method for investigating drug-release mechanisms

Human in Vivo Regional Intestinal Permeability: Quantitation Using Site-Specific Drug Absorption Data

Sjögren, Erik; Dahlgren, David; Roos, Carl; Lennernas, Hans

Part of Molecular Pharmaceutics, p. 2026-2039, 2015

• DOI for Human in Vivo Regional Intestinal Permeability: Quantitation Using Site-Specific Drug Absorption Data

Effect on the Gastrointestinal Absorption of Drugs from Different Classes in the Biopharmaceutics Classification System, When Treating with Liraglutide

Malm-Erjefalt, Monika; Ekblom, Marianne; Vouis, Jan; Zdravkovic, Milan et al.

Part of Molecular Pharmaceutics, p. 4166-4173, 2015

• DOI for Effect on the Gastrointestinal Absorption of Drugs from Different Classes in the Biopharmaceutics Classification System, When Treating with Liraglutide

Treatment of intermediate stage hepatocellular carcinoma: a review of intrahepatic doxorubicin drug-delivery systems

Dubbelboer, Ilse R; Lilienberg, Elsa; Ahnfelt, Emelie; Sjögren, Erik et al.

Part of Therapeutic delivery, p. 447-466, 2014

• DOI for Treatment of intermediate stage hepatocellular carcinoma: a review of intrahepatic doxorubicin drug-delivery systems

The Biopharmaceutics Risk Assessment Roadmap for Optimizing Clinical Drug Product Performance

Selen, Arzu; Dickinson, Paul A.; Mullertz, Anette; Crison, John R. et al.

Part of Journal of Pharmaceutical Sciences, p. 3377-3397, 2014

• DOI for The Biopharmaceutics Risk Assessment Roadmap for Optimizing Clinical Drug Product Performance

Theme Issue 5th World Conference on Drug Absorption, Transport and Delivery

Lennernäs, Hans; Langguth, Peter; Yamashita, Shinji; Crommelin, Daan J. A.

Part of European Journal of Pharmaceutical Sciences, p. 1-1, 2014

• DOI for Theme Issue 5th World Conference on Drug Absorption, Transport and Delivery

Effects of verapamil on the pharmacokinetics and hepatobiliary disposition of fexofenadine in pigs

Sjögren, Erik; Hedeland, Mikael; Bondesson, Ulf; Lennernäs, Hans

Part of European Journal of Pharmaceutical Sciences, p. 214-223, 2014

• DOI for Effects of verapamil on the pharmacokinetics and hepatobiliary disposition of fexofenadine in pigs

The Effects of Lipiodol and Cyclosporin A on the Hepatobiliary Disposition of Doxorubicin in Pigs

Dubbelboer, Ilse R; Lilienberg, Elsa; Hedeland, Mikael; Bondesson, Ulf et al.

Part of Molecular Pharmaceutics, p. 1301-1313, 2014

• DOI for The Effects of Lipiodol and Cyclosporin A on the Hepatobiliary Disposition of Doxorubicin in Pigs

In vivo methods for drug absorption - Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects

Sjögren, Erik; Abrahamsson, Bertil; Augustijns, Patrick; Becker, Dieter et al.

Part of European Journal of Pharmaceutical Sciences, p. 99-151, 2014

• DOI for In vivo methods for drug absorption - Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects

High-resolution mass spectrometric investigation of the phase I and II metabolites of finasteride in pig plasma, urine and bile

Lundahl, Anna; Åberg, Annica Tevell; Bondesson, Ulf; Lennernäs, Hans et al.

Part of Xenobiotica, p. 498-510, 2014

• DOI for High-resolution mass spectrometric investigation of the phase I and II metabolites of finasteride in pig plasma, urine and bile

Pharmacokinetics of an Injectable Modified-Release 2-Hydroxyflutamide Formulation in the Human Prostate Gland Using a Semiphysiologically Based Biopharmaceutical Model

Sjögren, Erik; Tammela, Teuvo L.; Lennernas, Bo; Taari, Kimmo et al.

Part of Molecular Pharmaceutics, p. 3097-3111, 2014

• DOI for Pharmacokinetics of an Injectable Modified-Release 2-Hydroxyflutamide Formulation in the Human Prostate Gland Using a Semiphysiologically Based Biopharmaceutical Model

Oral biopharmaceutics-current status and identified gaps of understanding

Lennernäs, Hans; Abrahamsson, Peter; Langguth, Bertil

Part of European Journal of Pharmaceutical Sciences, p. 98-98, 2014

• DOI for Oral biopharmaceutics-current status and identified gaps of understanding

Investigation of Hepatobiliary Disposition of Doxorubicin Following Intrahepatic Delivery of Different Dosage Forms

Lilienberg, Elsa; Ebeling-Barbier, Charlotte; Nyman, Rickard; Hedeland, Mikael et al.

Part of Molecular Pharmaceutics, p. 131-144, 2014

• DOI for Investigation of Hepatobiliary Disposition of Doxorubicin Following Intrahepatic Delivery of Different Dosage Forms

Evaluation of the use of Classical Nucleation Theory for predicting intestinal crystalline precipitation of two weakly basic BSC class II drugs

Carlert, Sara; Lennernäs, Hans; Abrahamsson, Bertil

Part of European Journal of Pharmaceutical Sciences, p. 17-27, 2014

• DOI for Evaluation of the use of Classical Nucleation Theory for predicting intestinal crystalline precipitation of two weakly basic BSC class II drugs

Carbon Dioxide-Mediated Generation of Hybrid Nanoparticles for Improved Bioavailability of Protein Kinase Inhibitors

Jesson, Gerald; Brisander, Magnus; Andersson, Per; Demirbuker, Mustafa et al.

Part of Pharmaceutical research, p. 694-705, 2014

• DOI for Carbon Dioxide-Mediated Generation of Hybrid Nanoparticles for Improved Bioavailability of Protein Kinase Inhibitors

Prospective evaluation of long-term safety of dual-release hydrocortisone replacement administered once daily in patients with adrenal insufficiency

Nilsson, A. G.; Marelli, C.; Fitts, D.; Bergthorsdottir, R. et al.

Part of European Journal of Endocrinology, p. 369-377, 2014

• DOI for Prospective evaluation of long-term safety of dual-release hydrocortisone replacement administered once daily in patients with adrenal insufficiency

In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: Application of the mechanistic absorption model GI-Sim

Sjögren, Erik; Westergren, Jan; Grant, Iain; Hanisch, Gunilla et al.

Part of European Journal of Pharmaceutical Sciences, p. 679-698, 2013

• DOI for In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: Application of the mechanistic absorption model GI-Sim

Combined in Vitro-in Vivo Approach To Assess the Hepatobiliary Disposition of a Novel Oral Thrombin Inhibitor

Matsson, Elin M.; Eriksson, Ulf G.; Palm, Johan E.; Artursson, Per et al.

Part of Molecular Pharmaceutics, p. 4252-4262, 2013

• DOI for Combined in Vitro-in Vivo Approach To Assess the Hepatobiliary Disposition of a Novel Oral Thrombin Inhibitor

Binding processes determine the stereoselective intestinal and hepatic extraction of verapamil in vivo

Thörn, Helena Anna; Sjögren, Erik; Dickinson, Paul Alfred; Lennernäs, Hans

Part of Molecular Pharmaceutics, p. 3034-3045, 2012

• DOI for Binding processes determine the stereoselective intestinal and hepatic extraction of verapamil in vivo

The pharmacokinetics and hepatic disposition of repaglinide in pigs: mechanistic modeling of metabolism and transport

Sjögren, Erik; Bredberg, Ulf; Lennernäs, Hans

Part of Molecular Pharmaceutics, p. 823-841, 2012

• DOI for The pharmacokinetics and hepatic disposition of repaglinide in pigs: mechanistic modeling of metabolism and transport

In Vivo Dog Intestinal Precipitation of Mebendazole: A Basic BCS Class II Drug

Carlert, Sara; Åkesson, Pernilla; Jerndal, Gunilla; Lindfors, Lennart et al.

Part of Molecular Pharmaceutics, p. 2903-2911, 2012

• DOI for In Vivo Dog Intestinal Precipitation of Mebendazole: A Basic BCS Class II Drug

Extensive intestinal glucuronidation of raloxifene in vivo in pigs and impact for oral drug delivery

Thörn, Helena Anna; Yasin, Mohammed; Dickinson, Paul Alfred; Lennernäs, Hans

Part of Xenobiotica, p. 917-928, 2012

• DOI for Extensive intestinal glucuronidation of raloxifene in vivo in pigs and impact for oral drug delivery

Assessment of enzymatic prodrug stability in human, dog and simulated intestinal fluids

Borde, A. S.; Karlsson, E. M.; Andersson, K.; Bjorhall, K. et al.

Part of European journal of pharmaceutics and biopharmaceutics, p. 630-637, 2012

• DOI for Assessment of enzymatic prodrug stability in human, dog and simulated intestinal fluids

Levodopa infusion combined with entacapone or tolcapone in Parkinson disease: a pilot trial

Nyholm, Dag; Johansson, Anders; Lennernäs, Hans; Askmark, Håkan

Part of European Journal of Neurology, p. 820-826, 2012

• DOI for Levodopa infusion combined with entacapone or tolcapone in Parkinson disease: a pilot trial

Improved Cortisol Exposure-Time Profile and Outcome in Patients with Adrenal Insufficiency: A Prospective Randomized Trial of a Novel Hydrocortisone Dual-Release Formulation

Johannsson, G.; Nilsson, A. G.; Bergthorsdottir, R.; Burman, P. et al.

Part of Journal of Clinical Endocrinology and Metabolism, p. 473-481, 2012

• DOI for Improved Cortisol Exposure-Time Profile and Outcome in Patients with Adrenal Insufficiency: A Prospective Randomized Trial of a Novel Hydrocortisone Dual-Release Formulation

The Fraction Dose Absorbed, in Humans, and High Jejunal Human Permeability Relationship

Dahan, Arik; Lennernäs, Hans; Amidon, Gordon L.

Part of Molecular Pharmaceutics, p. 1847-1851, 2012

• DOI for The Fraction Dose Absorbed, in Humans, and High Jejunal Human Permeability Relationship

Drug metabolism of CYP3A4, CYP2C9 and CYP2D6 substrates in pigs and humans

Thörn, Helena Anna; Lundahl, Anna; Schrickx, Johannes Antonius; Dickinson, Paul Alfred et al.

Part of European Journal of Pharmaceutical Sciences, p. 89-98, 2011

• DOI for Drug metabolism of CYP3A4, CYP2C9 and CYP2D6 substrates in pigs and humans

The BCS, BDDCS, and regulatory guidances

Chen, Mei-Ling; Amidon, Gordon L; Benet, Leslie Z; Lennernäs, Hans et al.

Part of Pharmaceutical research, p. 1774-1778, 2011

• DOI for The BCS, BDDCS, and regulatory guidances

Bioequivalence of Oral Products and the Biopharmaceutics Classification System: Science, Regulation, and Public Policy

Amidon, K. S.; Langguth, P.; Lennernäs, Hans; Yu, L. et al.

Part of Clinical Pharmacology and Therapeutics, p. 467-470, 2011

• DOI for Bioequivalence of Oral Products and the Biopharmaceutics Classification System: Science, Regulation, and Public Policy

Effects of ketoconazole on the in vivo biotransformation and hepatobiliary transport of the thrombin inhibitor AZD0837 in pigs

Matsson, Elin; Palm, Johan E.; Eriksson, Ulf; Bottner, Pernilla et al.

Part of Drug Metabolism And Disposition, p. 239-246, 2011

• DOI for Effects of ketoconazole on the in vivo biotransformation and hepatobiliary transport of the thrombin inhibitor AZD0837 in pigs

Biliary Excretion of Ximelagatran and Its Metabolites and the Influence of Erythromycin Following Intraintestinal Administration to Healthy Volunteers

Matsson, Elin; Eriksson, Ulf; Knutson, Lars; Hoffmann, Kurt-Jurgen et al.

Part of Journal of clinical pharmacology, p. 770-783, 2011

• DOI for Biliary Excretion of Ximelagatran and Its Metabolites and the Influence of Erythromycin Following Intraintestinal Administration to Healthy Volunteers

Optimal experimental design for assessment of enzyme kinetics in a drug discovery screening environment

Sjögren, Erik; Nyberg, Joakim; Magnusson, Mats O.; Lennernäs, Hans et al.

Part of Drug Metabolism And Disposition, p. 858-863, 2011

• DOI for Optimal experimental design for assessment of enzyme kinetics in a drug discovery screening environment

In Vivo Investigation in Pigs of Intestinal Absorption, Hepatobiliary Disposition, and Metabolism of the 5 alpha-Reductase Inhibitor Finasteride and the Effects of Coadministered Ketoconazole

Lundahl, Anna; Hedeland, Mikael; Bondesson, Ulf; Lennernäs, Hans

Part of Drug Metabolism And Disposition, p. 847-857, 2011

• DOI for In Vivo Investigation in Pigs of Intestinal Absorption, Hepatobiliary Disposition, and Metabolism of the 5 alpha-Reductase Inhibitor Finasteride and the Effects of Coadministered Ketoconazole

Predicting intestinal precipitation: a case example for a basic BCS class II drug

Carlert, Sara; Pålsson, Anna; Hanisch, Gunilla; von Corswant, Christian et al.

Part of Pharmaceutical research, p. 2119-2130, 2010

• DOI for Predicting intestinal precipitation: a case example for a basic BCS class II drug

The Effect of Acute Administration of Rifampicin and Imatinib on the Enterohepatic Transport of Rosuvastatin In Vivo

Bergman, Ebba; Hedeland, Mikael; Bondesson, Ulf; Lennernäs, Hans

Part of Xenobiotica, p. 558-568, 2010

• DOI for The Effect of Acute Administration of Rifampicin and Imatinib on the Enterohepatic Transport of Rosuvastatin In Vivo

Sublingual administration of fentanyl to cancer patients is an effective treatment for breakthrough pain: results from a randomized phase II study

Lennernäs, Bo; Frank-Lissbrant, Ingela; Lennernäs, Hans; Kälkner, Karl Mikael et al.

Part of Palliative Medicine, p. 286-293, 2010

• DOI for Sublingual administration of fentanyl to cancer patients is an effective treatment for breakthrough pain: results from a randomized phase II study

The metabolic impact of improving diurnal cortisol exposure in patients with adrenal insufficiency

Johannsson, Gudmundur; Lennernäs, Hans; Skrtic, Stanko

Part of Endocrine journal, 2010

Effect of a Single Gemfibrozil Dose on the Pharmacokinetics of Rosuvastatin in Bile and Plasma in Healthy Volunteers

Bergman, Ebba; Matsson, Elin M; Hedeland, Mikael; Bondesson, Ulf et al.

Part of Journal of clinical pharmacology, p. 1039-1049, 2010

• DOI for Effect of a Single Gemfibrozil Dose on the Pharmacokinetics of Rosuvastatin in Bile and Plasma in Healthy Volunteers

Hepatic disposition of ximelagatran and its metabolites in pig; prediction of the impact of membrane transporters through a simple disposition model

Sjögren, Erik; Bredberg, Ulf; Allard, Erik; Arvidsson, Björn et al.

Part of Pharmaceutical research, p. 597-607, 2010

• DOI for Hepatic disposition of ximelagatran and its metabolites in pig; prediction of the impact of membrane transporters through a simple disposition model

Gastrointestinal metabolism of a vegetable-oil emulsion in healthy subjects

Knutson, Lars; Koenders, Damiet J. P. C.; Fridblom, Helle; Viberg, Annika et al.

Part of American Journal of Clinical Nutrition, p. 515-524, 2010

• DOI for Gastrointestinal metabolism of a vegetable-oil emulsion in healthy subjects

High-Permeability Criterion for BCS Classification: Segmental/pH Dependent Permeability Considerations

Dahan, Arik; Miller, Jonathan M.; Hilfinger, John M.; Yamashita, Shinji et al.

Part of Molecular pharmaceutics, p. 1827-1834, 2010

• DOI for High-Permeability Criterion for BCS Classification: Segmental/pH Dependent Permeability Considerations

Coexistence of passive and carrier-mediated processes in drug transport

Sugano, Kiyohiko; Kansy, Manfred; Artursson, Per; Avdeef, Alex et al.

Part of Nature reviews. Drug discovery, p. 597-614, 2010

• DOI for Coexistence of passive and carrier-mediated processes in drug transport

Circadian rhythmicity in levodopa pharmacokinetics in patients with Parkinson disease

Nyholm, Dag; Lennernäs, Hans; Johansson, Anders; Estrada, Matias et al.

Part of Clinical neuropharmacology, p. 181-185, 2010

• DOI for Circadian rhythmicity in levodopa pharmacokinetics in patients with Parkinson disease

Online capillary solid phase extraction and liquid chromatographic separation with quantitative tandem mass spectrometric detection (SPE-LC-MS/MS) of ximelagatran and its metabolites in a complex matrix.

Arvidsson, Björn; Allard, Erik; Sjögren, Erik; Lennernäs, Hans et al.

Part of Journal of chromatography. B, p. 291-297, 2009

• DOI for Online capillary solid phase extraction and liquid chromatographic separation with quantitative tandem mass spectrometric detection (SPE-LC-MS/MS) of ximelagatran and its metabolites in a complex matrix.

The effect of St. John's wort on the pharmacokinetics, metabolism and biliary excretion of finasteride and its metabolites in healthy men

Lundahl, Anna; Hedeland, Mikael; Bondesson, Ulf; Knutson, Lars et al.

Part of European Journal of Pharmaceutical Sciences, p. 433-443, 2009

• DOI for The effect of St. John's wort on the pharmacokinetics, metabolism and biliary excretion of finasteride and its metabolites in healthy men

Toward an increased understanding of the barriers to colonic drug absorption in humans: implications for early controlled release candidate assessment

Tannergren, Christer; Bergendal, Anna; Lennernäs, Hans; Abrahamsson, Bertil

Part of Molecular pharmaceutics, p. 60-73, 2009

• DOI for Toward an increased understanding of the barriers to colonic drug absorption in humans: implications for early controlled release candidate assessment

The multiple depletion curves method provides accurate estimates of intrinsic clearance (CLint), maximum velocity of the metabolic reaction (Vmax), and Michaelis constant (Km): accuracy and robustness evaluated through experimental data and Monte Carlo simulations

Sjögren, Erik; Lennernäs, Hans; Andersson, Tommy B; Gråsjö, Johan et al.

Part of Drug Metabolism And Disposition, p. 47-58, 2009

• DOI for The multiple depletion curves method provides accurate estimates of intrinsic clearance (CLint), maximum velocity of the metabolic reaction (Vmax), and Michaelis constant (Km): accuracy and robustness evaluated through experimental data and Monte Carlo simulations

Ethanol-drug absorption interaction: potential for a significant effect on the plasma pharmacokinetics of ethanol vulnerable formulations

Lennernäs, Hans

Part of Molecular pharmaceutics, p. 1429-1440, 2009

• DOI for Ethanol-drug absorption interaction: potential for a significant effect on the plasma pharmacokinetics of ethanol vulnerable formulations

Impact of carriers in oral absorption: Permeation across Caco-2 cells for the organic anions estrone-3-sulfate and glipizide

Gram, Luise K; Rist, Gerda Marie; Lennernäs, Hans; Steffansen, Bente

Part of European Journal of Pharmaceutical Sciences, p. 378-386, 2009

• DOI for Impact of carriers in oral absorption: Permeation across Caco-2 cells for the organic anions estrone-3-sulfate and glipizide

Improving glucocorticoid replacement therapy using a novel modified-release hydrocortisone tablet: a pharmacokinetic study

Johannsson, Gudmundur; Bergthorsdottir, Ragnhildur; Nilsson, Anna G; Lennernäs, Hans et al.

Part of European Journal of Endocrinology, p. 119-130, 2009

• DOI for Improving glucocorticoid replacement therapy using a novel modified-release hydrocortisone tablet: a pharmacokinetic study

Increased understanding of intestinal drug permeability determined by the LOC-I-GUT approach using multislice computed tomography

Knutson, Tina; Fridblom, Patrik; Ahlström, Håkan; Magnusson, Anders et al.

Part of Molecular pharmaceutics, p. 2-10, 2009

• DOI for Increased understanding of intestinal drug permeability determined by the LOC-I-GUT approach using multislice computed tomography

Identification of Finasteride Metabolites in Human Bile and Urine by High-Performance Liquid Chromatography/Tandem Mass Spectrometry

Lundahl, Anna; Lennernäs, Hans; Knutson, Lars; Bondesson, Ulf et al.

Part of Drug Metabolism And Disposition, p. 2008-2017, 2009

• DOI for Identification of Finasteride Metabolites in Human Bile and Urine by High-Performance Liquid Chromatography/Tandem Mass Spectrometry

Different effects of ketoconazole on the stereoselective first-pass metabolism of R/S-verapamil in the intestine and the liver: important for the mechanistic understanding of first-pass drug-drug interactions

Thörn, Helena Anna; Hedeland, Mikael; Bondesson, Ulf; Knutson, Lars et al.

Part of Drug Metabolism And Disposition, p. 2186-2196, 2009

• DOI for Different effects of ketoconazole on the stereoselective first-pass metabolism of R/S-verapamil in the intestine and the liver: important for the mechanistic understanding of first-pass drug-drug interactions

The Enterohepatic Disposition of Rosuvastatin in Pigs and The Impact of Concomitant Dosing with Cyclosporine and Gemfibrozil

Bergman, Ebba; Lundahl, Anna; Fridblom, Patrik; Hedeland, Mikael et al.

Part of Drug Metabolism And Disposition, p. 2349-2358, 2009

• DOI for The Enterohepatic Disposition of Rosuvastatin in Pigs and The Impact of Concomitant Dosing with Cyclosporine and Gemfibrozil

Intestinal and hepatobiliary transport of ximelagatran and its metabolites in pigs

Sjödin, Elin; Fritsch, Holger; Eriksson, Ulf G; Logren, Ulrika et al.

Part of Drug Metabolism And Disposition, p. 1519-1528, 2008

• DOI for Intestinal and hepatobiliary transport of ximelagatran and its metabolites in pigs

Improved understanding of the effect of food on drug absorption and bioavailability for lipophilic compounds using an intestinal pig perfusion model

Persson, Eva M.; Nordgren, Anders; Forsell, Patrik; Knutson, Lars et al.

Part of European Journal of Pharmaceutical Sciences, p. 22-29, 2008

• DOI for Improved understanding of the effect of food on drug absorption and bioavailability for lipophilic compounds using an intestinal pig perfusion model

The use of BDDCS in classifying the permeability of marketed drugs

Benet, Leslie Z.; Amidon, Gordon L.; Barends, Dirk M.; Lennernäs, Hans et al.

Part of Pharmaceutical research, p. 483-488, 2008

• DOI for The use of BDDCS in classifying the permeability of marketed drugs

Is there an effect of food on the biliary secretion of cyclosporine and three in vivo formed metabolites in a porcine model?

Persson, Eva M.; Nordgren, A.; Forsell, P.; Knutson, L. et al.

Part of Journal of Drug Delivery Science and Technology, p. 253-258, 2007

Gene and protein expression of P-glycoprotein, MRP1, MRP2 and CYP3A4 in the small and large human intestine

Berggren, Sofia; Gall, Christine; Wollnitz, Nadine; Ekelund, Mats et al.

Part of Molecular Pharmaceutics, p. 252-257, 2007

• DOI for Gene and protein expression of P-glycoprotein, MRP1, MRP2 and CYP3A4 in the small and large human intestine

Simultaneous assessment of lipid classes and bile acids in human intestinal fluid by solid-phase extraction and HPLC methods

Persson, Eva; Löfgren, Lars; Hansson, Göran; Abrahamsson, Bertil et al.

Part of Journal of Lipid Research, p. 242-251, 2007

• DOI for Simultaneous assessment of lipid classes and bile acids in human intestinal fluid by solid-phase extraction and HPLC methods

Pharmacokinetics of gefitinib in humans: the influence of gastrointestinal factors

Bergman, Ebba; Forsell, Patrik; Persson, Eva M.; Knutson, Lars et al.

Part of International Journal of Pharmaceutics, p. 134-142, 2007

• DOI for Pharmacokinetics of gefitinib in humans: the influence of gastrointestinal factors

Physiologically-based Kinetic Modelling (PBK Modelling): Meeting the 3Rs agenda. The report and recommendations of ECVAM Workshop 63

Bouvier d'Yvoire, Michel; Prieto, Pilar; Blaauboer, Bas; Bois, Frederic et al.

Part of ATLA (Alternatives to Laboratory Animals), p. 661-671, 2007

Intestinal permeability and its relevance for absorption and elimination

Lennernäs, H

Part of Xenobiotica, p. 1015-1051, 2007

• DOI for Intestinal permeability and its relevance for absorption and elimination

Long-acting hydrocortisone for glucocorticoid replacement therapy

Johannsson, Gudmundur; Filipsson, Helena; Bergthorsdottir, Ragnhildur; Lennernäs, Hans et al.

Part of Hormone Research, p. 182-188, 2007

• DOI for Long-acting hydrocortisone for glucocorticoid replacement therapy

A clinical single-pass perfusion investigation of the dynamic in vivo secretory response to a dietary meal in human proximal small intestine

Persson, Eva M; Nilsson, Ralf G; Hansson, Göran I; Löfgren, Lars J et al.

Part of Pharmaceutical research, p. 742-751, 2006

• DOI for A clinical single-pass perfusion investigation of the dynamic in vivo secretory response to a dietary meal in human proximal small intestine

Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model

Cao, Xianhua; Gibbs, Seth T.; Fang, Lanyan; Miller, Heather A. et al.

Part of Pharmaceutical research, p. 1675-1686, 2006

• DOI for Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model

First-pass effects of verapamil on the intestinal absorption and liver disposition of fexofenadine in the porcine model.

Petri, Niclas; Bergman, Ebba; Forsell, Patrik; Hedeland, Mikael et al.

Part of Drug Metab Dispos, p. 1182-9, 2006

Preface.

Langguth, P; Bermejo, M; Lennernäs, H

Part of Eur J Pharm Sci, p. 173, 2006

Flutamide metabolism in four different species in vitro and identification of flutamide metabolites in human patient urine by high performance liquid chromatography/tandem mass spectrometry.

Tevell, Annica; Lennernäs, Hans; Jönsson, Mats; Norlin, Maria et al.

Part of Drug Metab Dispos, p. 984-92, 2006

Effect of erythromycin on the absorption of fexofenadine in the jejunum, ileum and colon determined using local intubation in healthy volunteers.

Petri, N; Borga, O; Nyberg, L; Hedeland, M et al.

Part of Int J Clin Pharmacol Ther, p. 71-9, 2006

Biliary secretion of rosuvastatin and bile acids in humans during the absorption phase.

Bergman, Ebba; Forsell, Patrik; Tevell, Annica; Persson, Eva M et al.

Part of Eur J Pharm Sci, p. 205-14, 2006

Presentation of a structurally diverse and commercially available drug data set for correlation and benchmarking studies.

Skold, Christian; Winiwarter, Susanne; Wernevik, Johan; Bergstrom, Fredrik et al.

Part of J Med Chem, p. 6660-71, 2006

Folate absorption from folate-fortified and processed foods using a human ileostomy model.

Witthöft, Cornelia M; Arkbåge, Karin; Johansson, Madelene; Lundin, Eva et al.

Part of Br J Nutr, p. 181-7, 2006

The effect of pancreatic and biliary depletion on the in vivo pharmacokinetics of digoxin in pigs.

Tannergren, Christer; Evilevitch, Lena; Pierzynowski, Stefan; Piedra, Jose Valverde et al.

Part of Eur J Pharm Sci, p. 198-204, 2006

The effects of food on the dissolution of poorly soluble drugs in human and in model small intestinal fluids

Persson, Eva M; Gustafsson, Ann-Sofie; Carlsson, Anders S; Nilsson, Ralf G et al.

Part of Pharmaceutical research, p. 2141-2151, 2005

• DOI for The effects of food on the dissolution of poorly soluble drugs in human and in model small intestinal fluids

The use of biopharmaceutic classification of drugs in drug discovery and development: current status and future extension.

Lennernäs, Hans; Abrahamsson, Bertil

Part of J Pharm Pharmacol, p. 273-85, 2005

Pharmacokinetics and tolerability of different doses of fentanyl following sublingual administration of a rapidly dissolving tablet to cancer patients: a new approach to treatment of incident pain.

Lennernäs, B; Hedner, T; Holmberg, M; Bredenberg, S et al.

Part of Br J Clin Pharmacol, p. 249-53, 2005

EUFEPS conference on drug transporters at Copenhagen: integrative approaches in ADME research.

Meijer, Dirk K F; Lennernäs, Hans

Part of Eur J Pharm Sci, p. 130-43, 2005

Transport characteristics of fexofenadine in the Caco-2 cell model

Petri, Niclas; Tannergren, Christer; Rungstad, David; Lennernäs, Hans

Part of Pharmaceutical research, p. 1398-1404, 2004

• DOI for Transport characteristics of fexofenadine in the Caco-2 cell model

St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism

Tannergren, Christer; Engman, Helena; Knutson, Lars; Hedeland, Mikael et al.

Part of Clinical Pharmacology and Therapeutics, p. 298-309, 2004

• DOI for St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism

Simultaneous quantification of the enantiomers of verapamil and its N-demethylated metabolite in human plasma using liquid chromatography-tandem mass spectrometry

Hedeland, Mikael; Fredriksson, Elisabeth; Lennernäs, Hans; Bondesson, Ulf

Part of Journal of chromatography. B, p. 303-311, 2004

• DOI for Simultaneous quantification of the enantiomers of verapamil and its N-demethylated metabolite in human plasma using liquid chromatography-tandem mass spectrometry

Regional intestinal absorption and biliary excretion of fluvastatin in the rat: Possible involvement of mrp2.

Lindahl, A; Sjöberg, Å; Bredberg, U; Ungell, A-L et al.

Part of Molecular Pharmaceutics 1, p. 347, 2004

Characterization of jejunal absorption and apical efflux of ropivacaine, lidocaine and bupivacaine in the rat using in situ and in vitro absorption models.

Berggren, Sofia; Hoogstraate, Janet; Fagerholm, Urban; Lennernäs, Hans

Part of Eur J Pharm Sci, p. 553-60, 2004

Intestinal and blood-brain barrier drug transport: beyond involvement of a single transport function.

Lennernäs, H; Lundgren, E

Part of Drug Discovery Today 1, p. 417, 2004

Molecular properties of WHO essential drugs and provisional biopharmaceutical classification.

Kasim, Nehal A; Whitehouse, Marc; Ramachandran, Chandrasekharan; Bermejo, Marival et al.

Part of Mol Pharm, p. 85-96, 2004

Drug transporters: Where is the research taking us?

Lennernäs, H

Part of Eur J Pharm Sci, 2004

Proposals on the innovation policy by Ostros--correct diagnosis but wrong treatment

Hedner, Thomas; Lennernäs, Hans; Ottosson, Pontus

Part of Lakartidningen, p. 2287-8, 2004

Optimizing levodopa pharmacokinetics: intestinal infusion versus oral sustained-release tablets

Nyholm, Dag; Askmark, Håkan; Gomes-Trolin, Cecilia; Knutson, Tina et al.

Part of Clinical neuropharmacology, p. 156-163, 2003

Expression of genes encoding for drug metabolising cytochrome P450 enzymes and P-glycoprotein in the rat small intestine: comparison to the liver

Lindell, Monica; Lang, Matti; Lennernäs, Hans

Part of Eur. J. Drug Metab. & Pharmacokin., p. 41-48, 2003

Multiple transport mechanisms involved in the intestinal absorption and first-pass extraction of fexofenadine.

Tannergren, Christer; Petri, Niclas; Knutson, Lars; Hedeland, Mikael et al.

Part of Clin Pharmacol Ther, p. 423-36, 2003

Levodopa pharmacokinetics and motor performance during activities of daily living in patients with Parkinson's disease on individual drug combinations

Nyholm, Dag; Lennernäs, Hans; Gomes-Trolin, Cecilia; Aquilonius, Sten-Magnus

Part of Clinical neuropharmacology, p. 89-96, 2002

• DOI for Levodopa pharmacokinetics and motor performance during activities of daily living in patients with Parkinson's disease on individual drug combinations

Effects of cholesterol and model transmembrane proteins on drugpartitioning into lipid bilayers as analysed by immobilized-liposomechromatography.

Lagerquist, C; Beigi, F; Karlen, A; Lennernas, H et al.

Part of J Pharm Pharmacol, p. 1477, 2001

Absorption of L-DOPA from the proximal small intestine studied in the rhesus monkey by positron emission tomography

Nilsson, Dag; Lennernäs, Hans; Fasth, Karl Johan; Sundin, Anders et al.

Part of European Journal of Pharmaceutical Sciences, p. 185-189, 1999

• DOI for Absorption of L-DOPA from the proximal small intestine studied in the rhesus monkey by positron emission tomography

Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

Part of European journal of pharmaceutics and biopharmaceutics

Review on the effect of chemotherapy on the intestinal barrier: Epithelial permeability, mucus and bacterial translocation

Dahlgren, David; Lennernäs, Hans

Part of Biomedicine and Pharmacotherapy, 2023

• DOI for Review on the effect of chemotherapy on the intestinal barrier: Epithelial permeability, mucus and bacterial translocation
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Application of In Vivo Imaging Techniques and Diagnostic Tools in Oral Drug Delivery Research

Senekowitsch, Stefan; Schick, Philipp; Abrahamsson, Bertil; Augustijns, Patrick et al.

Part of Pharmaceutics, 2022

• DOI for Application of In Vivo Imaging Techniques and Diagnostic Tools in Oral Drug Delivery Research
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Best practices in current models mimicking drug permeability in the gastrointestinal tract - An UNGAP review

O'Shea, Joseph P.; Augustijns, Patrick; Brandl, Martin; Brayden, David J. et al.

Part of European Journal of Pharmaceutical Sciences, 2022

• DOI for Best practices in current models mimicking drug permeability in the gastrointestinal tract - An UNGAP review
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Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies

Dahlgren, David; Sjöblom, Markus; Hellström, Per M.; Lennernäs, Hans

Part of Frontiers in Pharmacology, 2021

• DOI for Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies
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Limitations and Possibilities of Transarterial Chemotherapeutic Treatment of Hepatocellular Carcinoma

Ebeling Barbier, Charlotte; Heindryckx, Femke; Lennernäs, Hans

Part of International Journal of Molecular Sciences, 2021

• DOI for Limitations and Possibilities of Transarterial Chemotherapeutic Treatment of Hepatocellular Carcinoma
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Leveraging Oral Drug Development to a Next Level: Impact of the IMI-Funded OrBiTo Project on Patient Healthcare

Hens, Bart; Augustijns, Patrick; Lennernäs, Hans; McAllister, Mark et al.

Part of Frontiers in Medicine, 2021

• DOI for Leveraging Oral Drug Development to a Next Level: Impact of the IMI-Funded OrBiTo Project on Patient Healthcare
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Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective

Dahlgren, David; Lennernäs, Hans

Part of Molecules, 2020

• DOI for Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective
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The Critical Role of Passive Permeability in Designing Successful Drugs

Di, Li; Artursson, Per; Avdeef, Alex; Benet, Leslie Z. et al.

Part of ChemMedChem, p. 1862-1874, 2020

• DOI for The Critical Role of Passive Permeability in Designing Successful Drugs

Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models

Dahlgren, David; Sjögren, Erik; Lennernäs, Hans

Part of ADMET & DMPK, p. 375-390, 2020

• DOI for Intestinal absorption of BCS class II drugs administered as nanoparticles: A review based on in vivo data from intestinal perfusion models
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Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches

Dahlgren, David; Lennernäs, Hans

Part of Pharmaceutics, 2019

• DOI for Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches
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Formulation predictive dissolution (fPD) testing to advance oral drug product development: An introduction to the US FDA funded '21st Century BA/BE' project

Hens, Bart; Sinko, Patrick D.; Job, Nicholas; Dean, Meagan et al.

Part of International Journal of Pharmaceutics, p. 120-127, 2018

• DOI for Formulation predictive dissolution (fPD) testing to advance oral drug product development: An introduction to the US FDA funded '21st Century BA/BE' project

Direct In Vivo Human Intestinal Permeability (P-eff) Determined with Different Clinical Perfusion and Intubation Methods

Dahlgren, David; Roos, Carl; Sjögren, Erik; Lennernäs, Hans

Part of Journal of Pharmaceutical Sciences, p. 2702-2726, 2015

• DOI for Direct In Vivo Human Intestinal Permeability (P-eff) Determined with Different Clinical Perfusion and Intubation Methods

Adrenal insufficiency: review of clinical outcomes with current glucocorticoid replacement therapy

Johannsson, Gudmundur; Falorni, Alberto; Skrtic, Stanko; Lennernäs, Hans et al.

Part of Clinical Endocrinology, p. 2-11, 2015

• DOI for Adrenal insufficiency: review of clinical outcomes with current glucocorticoid replacement therapy

Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition

Smith, Dennis; Artursson, Per; Avdeef, Alex; Di, Li et al.

Part of Molecular Pharmaceutics, p. 1727-1738, 2014

• DOI for Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition

Regional intestinal drug permeation: Biopharmaceutics and drug development

Lennernas, Hans

Part of European Journal of Pharmaceutical Sciences, p. 333-341, 2014

• DOI for Regional intestinal drug permeation: Biopharmaceutics and drug development

Oral biopharmaceutics tools - Time for a new initiative - An introduction to the IMI project OrBiTo

Lennernäs, Hans; Aarons, L.; Augustijns, P.; Beato, S. et al.

Part of European Journal of Pharmaceutical Sciences, p. 292-299, 2014

• DOI for Oral biopharmaceutics tools - Time for a new initiative - An introduction to the IMI project OrBiTo

Improving outcomes in patients with adrenal insufficiency: a review of current and future treatments

Johannsson, Gudmundur; Skrtic, Stanko; Lennernäs, Hans; Quinkler, Marcus et al.

Part of Current Medical Research and Opinion, p. 1833-1847, 2014

• DOI for Improving outcomes in patients with adrenal insufficiency: a review of current and future treatments

Human in Vivo Regional Intestinal Permeability: Importance for Pharmaceutical Drug Development

Lennernäs, Hans

Part of Molecular Pharmaceutics, p. 12-23, 2014

• DOI for Human in Vivo Regional Intestinal Permeability: Importance for Pharmaceutical Drug Development

Complexity of Motor Response to Different Doses of Duodenal Levodopa Infusion in Parkinson Disease

Nyholm, Dag; Johansson, Anders; Aquilonius, Sten-Magnus; Hellquist, Elisabeth et al.

Part of Clinical neuropharmacology, p. 6-14, 2012

• DOI for Complexity of Motor Response to Different Doses of Duodenal Levodopa Infusion in Parkinson Disease

Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

Di, Li; Artursson, Per; Avdeef, Alex; Ecker, Gerhard F. et al.

Part of Drug Discovery Today, p. 905-912, 2012

• DOI for Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

Replacement therapy of oral hydrocortisone in adrenal insufficiency: the influence of gastrointestinal factors

Lennernäs, Hans; Skrtic, Stanko; Johannsson, Gudmundur

Part of Expert Opinion on Drug Metabolism and Toxicology, p. 749-758, 2008

• DOI for Replacement therapy of oral hydrocortisone in adrenal insufficiency: the influence of gastrointestinal factors

Irregular gastrointestinal drug absorption in Parkinson's disease

Nyholm, Dag; Lennernäs, Hans

Part of Expert Opinion on Drug Metabolism and Toxicology, p. 193-203, 2008

• DOI for Irregular gastrointestinal drug absorption in Parkinson's disease

Modeling gastrointestinal drug absorption requires more in vivo biopharmaceutical data: experience from in vivo dissolution and permeability studies in humans

Lennernäs, Hans

Part of Current drug metabolism, p. 645-657, 2007

Oral drug absorption and the biopharmaceutics classification system

Lennernäs, Hans; Abrahamsson, Bertil; Persson, EM; Knutson, Lars

Part of Journal of drug delivery science and technology, p. 237-244, 2007

Animal data: The contributions of the Ussing Chamber and perfusion systems to predicting human oral drug delivery in vivo

Lennernäs, Hans

Part of Advanced Drug Delivery Reviews, p. 1103-1120, 2007

• DOI for Animal data: The contributions of the Ussing Chamber and perfusion systems to predicting human oral drug delivery in vivo

The biopharmaceutical classification system

Lennernäs, H; Abrahamsson, B

Part of Comprehensive medicinal chemistry, Elsevier, 2006

Integrated Physiologically-Based Pharmacokinetic Model with a Quantitative Systems Pharmacology and Toxicology Model for Statins in Disease Population

Garcia, Luna Prieto; Nordell, Pär; Ahlström, Christine; Lennernäs, Hans et al.