Enzymology and Bioorganic Catalysis

15 credits

Course, Master's level, 1KB424

Autumn 2024 Autumn 2024, Uppsala, 100%, On-campus, English Only available as part of a programme

Location: Uppsala
Pace of study: 100%
Teaching form: On-campus
Instructional time: Daytime
Study period: 4 November 2024–19 January 2025
Language of instruction: English
Entry requirements: 120 credits. 60 credits in chemistry of which at least 5 at Master's level and including 30 credits in biochemistry. Proficiency in English equivalent to the Swedish upper secondary course English 6.
Application deadline: 15 April 2024
Application code: UU-16004

Location: Uppsala
Pace of study: 100%
Teaching form: On-campus
Instructional time: Daytime
Study period: 4 November 2024–19 January 2025
Language of instruction: English
Entry requirements: 120 credits. 60 credits in chemistry of which at least 5 at Master's level and including 30 credits in biochemistry. Proficiency in English equivalent to the Swedish upper secondary course English 6.

Reaction kinetics of simple and complex reactions (rate equations, reaction order, molecularity, rate-limiting step)
Thermodynamic aspects of reactions (reaction coordinates, activated complexes and transition states)
Enzyme kinetics (steady state kinetics, pre-steady-state kinetics)
Reaction mechanisms (ligand binding; catalytic groups: acid/base, nucleophiles, electrophiles, cofactors, metals and entropic effects)
Experimental analysis of catalytic and kinetic mechanisms (spectrometry, X-ray crystallography, stopped-flow, isotope effects, structure/reactivity relationships)
Mathematical data analysis (regression analysis, model discrimination)
Modelling of enzymatic reactions
Stereo chemistry (mechanisms)
Structure/function relationships (protein folding, mutagenesis, enzyme inhibition, evolution of catalytic mechanism, catalytic antibodies)
Catalytic nucleic acids (ribozymes, catalytic DNA)