Avhandlingar och publikationer

Timed Up-and-Go Dual-Task Tests for Early Detection of Dementia Disorder

Åhman, Hanna Bozkurt

2021

Doktorsavhandling, sammanläggning

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Independent Ageing in Very Old Swedish Men

Franzon, Kristin

2019

Doktorsavhandling, sammanläggning

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Cathepsin S as a Biomarker of Low-grade Inflammation, Insulin Resistance, and Cardiometabolic Disease Risk

Jobs, Elisabeth

2014

Doktorsavhandling, sammanläggning

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Physical Activity and Alzheimer's Disease: Measurements, Observations and Subjective Experiences

Cedervall, Ylva

2014

Doktorsavhandling, sammanläggning

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The Kidney in Different Stages of the Cardiovascular Continuum

Nerpin, Elisabet

2013

Doktorsavhandling, sammanläggning

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Biomarkers as Monitors of Drug Effect, Diagnostic Tools and Predictors of Deterioration Rate in Alzheimer’s Disease

Degerman Gunnarsson, Malin

2013

Doktorsavhandling, sammanläggning

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Prostate Cancer; Metabolic Risk Factors, Drug Utilisation, Adverse Drug Reactions

Grundmark, Birgitta

2013

Doktorsavhandling, sammanläggning

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Predictors of Dementia: Insulin, Fatty Acids and Vascular Risk Factors

Rönnemaa, Elina

2012

Doktorsavhandling, sammanläggning

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Amyloid β-protein, Cystatin C and Cathepsin B as Biomarkers of Alzheimer's Disease

Sundelöf, Johan

2010

Doktorsavhandling, sammanläggning

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Risk Factors for Stroke in Adult Men: A Population-based Study

Wiberg, Bernice

2010

Doktorsavhandling, sammanläggning

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The Impact of Bariatric Surgery on Obesity related Metabolic Traits with Specific Emphasis on Glucose, Insulin and Proinsulin

Johansson, Hans-Erik

2010

Doktorsavhandling, sammanläggning

• Ladda ner fulltext (pdf) av The Impact of Bariatric Surgery on Obesity related Metabolic Traits with Specific Emphasis on Glucose, Insulin and Proinsulin

Measurement Variability Related to Insulin Secretion and Sensitivity: Assessment and Implications in Epidemiological Studies

Berglund, Lars

2009

Doktorsavhandling, sammanläggning

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Insulin Resistance and Inflammation as Risk Factors for Congestive Heart Failure

Ingelsson, Erik

2005

Doktorsavhandling, sammanläggning

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Clinical Manifestations of Coronary Heart Disease and the Metabolic Syndrome: A Population-based Study in Middle-aged Men in Uppsala

Dunder, Kristina

2004

Doktorsavhandling, sammanläggning

• Ladda ner fulltext (pdf) av Clinical Manifestations of Coronary Heart Disease and the Metabolic Syndrome: A Population-based Study in Middle-aged Men in Uppsala

General Motor Function Assessment and Perceptions of Life Satisfaction during and after Geriatric Rehabilitation

Åberg, Anna Cristina

2003

Doktorsavhandling, sammanläggning

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Proinsulin and Insulin Sensitivity as Predictors of Type 2 Diabetes Mellitus and Coronary Heart Disease: Clinical Epidemiological Studies with up to 27 Years of Follow-Up

Zethelius, Björn

2002

Doktorsavhandling, sammanläggning

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Left Ventricular Function in Elderly Men: Metabolic, Hormonal, Genetic and Prognostic Implications

Ärnlöv, Johan

2002

Doktorsavhandling, sammanläggning

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24-hour Ambulatory Blood Pressure - Relation to the Insulin Resistance Syndrome and Cardiovascular Disease

Björklund, Kristina

2002

Doktorsavhandling, sammanläggning

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Plasminogen Activator Inhibitor-1 and the Insulin Resistance Syndrome

Byberg, Liisa

2002

Doktorsavhandling, sammanläggning

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Magnesium and the Insulin Resistance Syndrome

Hänni, Arvo

2001

Doktorsavhandling, sammanläggning

Muscle Morphology and the Insulin Resistance Syndrome: A Population-Based Study of 70 Year-Old-Men in Uppsala

Hedman, Anu

2001

Doktorsavhandling, sammanläggning

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Left ventricular hypertrophy and the insulin resistance syndrome

Sundström, Johan

2001

Doktorsavhandling, sammanläggning

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Machine Learning Approaches for Dementia Detection Through Speech and Gait Analysis: A Systematic Literature Review

Al-Hammadi, Mustafa; Fleyeh, Hasan; Åberg, Anna Cristina; Halvorsen, Kjartan et al.

Ingår i Journal of Alzheimer's Disease, s. 1-27, 2024

Artikel, forskningsöversikt

• DOI för Machine Learning Approaches for Dementia Detection Through Speech and Gait Analysis: A Systematic Literature Review
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Health dialogue intervention versus opportunistic screening in primary care for type 2 diabetes and cardiovascular disease prevention in settings with low socioeconomic status (DETECT): study protocol for a pragmatic cluster-randomized trial

Ballin, Marcel; Enelius, Moa Backman; Dini, Samira; Galanti, Maria Rosaria et al.

Ingår i Trials, 2024

Artikel i tidskrift

• DOI för Health dialogue intervention versus opportunistic screening in primary care for type 2 diabetes and cardiovascular disease prevention in settings with low socioeconomic status (DETECT): study protocol for a pragmatic cluster-randomized trial
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Adaptation of a guided low-intensity behavioral activation intervention for people with dementia in Sweden: a qualitative study exploring the needs and preferences of key stakeholders

Blomberg, Oscar; Svedin, Frida; Farrand, Paul; Brantnell, Anders et al.

Ingår i BMC Geriatrics, 2024

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• DOI för Adaptation of a guided low-intensity behavioral activation intervention for people with dementia in Sweden: a qualitative study exploring the needs and preferences of key stakeholders
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DepActive: study protocol for a randomised controlled multicentre trial of telephone-delivered behavioural activation for the treatment of depression in older adults in primary care

Byström, Elin; Wennlöf, Björn; Johansson, Inger; Lönnberg, Lena et al.

Ingår i Trials, 2024

Artikel i tidskrift

• DOI för DepActive: study protocol for a randomised controlled multicentre trial of telephone-delivered behavioural activation for the treatment of depression in older adults in primary care
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'You're Just Thinking About Going Home': Exploring Person-Centred Medication Communication With Older Patients at Hospital Discharge

Cam, Henrik; Franzon, Kristin; Kälvemark Sporrong, Sofia; Kempen, Thomas Gerardus Hendrik et al.

Ingår i Health Expectations, 2024

Artikel i tidskrift

• DOI för 'You're Just Thinking About Going Home': Exploring Person-Centred Medication Communication With Older Patients at Hospital Discharge
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Failure to Involve Older Hospitalised Patients in Medication Decisions: A Change of Approach is Called For

Cam, Henrik; Gillespie, Ulrika; Kälvemark Sporrong, Sofia; Nielsen, Elisabet I. et al.

Ingår i Research in Social and Administrative Pharmacy, s. 216-217, 2024

Artikel i tidskrift

• DOI för Failure to Involve Older Hospitalised Patients in Medication Decisions: A Change of Approach is Called For

Day-to-day variability of stress biomarkers during a music intervention in people living with dementia and their family caregivers

Emami, Azita; Jun, Jeehye; Theorell, Töres; Engström, Gabriella et al.

Ingår i Science Progress, 2024

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• DOI för Day-to-day variability of stress biomarkers during a music intervention in people living with dementia and their family caregivers
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Characteristics of and Risk Factors for Depressive Symptoms Preceding Dementia: A Study of 82-Year-Old Men From the Uppsala Longitudinal Study of Adult Men

Kallström, Angelica; Giedraitis, Vilmantas; Franzon, Kristin; Löwenmark, Malin et al.

Ingår i International Journal of Geriatric Psychiatry, 2024

Artikel i tidskrift

• DOI för Characteristics of and Risk Factors for Depressive Symptoms Preceding Dementia: A Study of 82-Year-Old Men From the Uppsala Longitudinal Study of Adult Men
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Panel stacking is a threat to consensus statement validity

Kepp, Kasper P.; Aavitsland, Preben; Ballin, Marcel; Balloux, Francois et al.

Ingår i Journal of Clinical Epidemiology, 2024

Artikel i tidskrift

• DOI för Panel stacking is a threat to consensus statement validity

Prognostic Value of Cardiovascular Biomarkers in the Population

Neumann, Johannes Tobias; Twerenbold, Raphael; Weimann, Jessica; Ballantyne, Christie M. et al.

Ingår i Journal of the American Medical Association (JAMA), s. 1898-1909, 2024

Artikel i tidskrift

• DOI för Prognostic Value of Cardiovascular Biomarkers in the Population

Impaired Balance Predicts Cardiovascular Disease in 70-Year-Old Individuals-An Observational Study From the Healthy Aging Initiative

Nordström, Anna; Nordström, Peter

Ingår i Journal of the American Heart Association, 2024

Artikel i tidskrift

• DOI för Impaired Balance Predicts Cardiovascular Disease in 70-Year-Old Individuals-An Observational Study From the Healthy Aging Initiative
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A novel clinical prediction model for hip fractures: a development and validation study in the total population of Sweden

Nordström, Peter; Ahlqvist, Viktor H.; Ballin, Marcel; Nordström, Anna

Ingår i eClinicalMedicine, 2024

Artikel i tidskrift

• DOI för A novel clinical prediction model for hip fractures: a development and validation study in the total population of Sweden
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Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion

Pagnon de la Vega, María; Syvänen, Stina; Giedraitis, Vilmantas; Hooley, Monique et al.

Ingår i Acta neuropathologica communications, 2024

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• DOI för Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
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Validation of a web-based self-administered test for cognitive assessment in a Swedish geriatric setting

Rystedt, Einar; Moren, Jakob; Lindbäck, Johan; Tedim Cruz, Vitor et al.

Ingår i PLOS ONE, 2024

Artikel i tidskrift

• DOI för Validation of a web-based self-administered test for cognitive assessment in a Swedish geriatric setting
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Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Suzuki, Ken; Giedraitis, Vilmantas; Ingelsson, Martin; Lind, Lars et al.

Ingår i Nature, s. 347-357, 2024

Artikel i tidskrift

• DOI för Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
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Obstructive sleep apnea during rapid eye movement sleep and cognitive performance in adults

Tan, Xiao; Ljunggren, Mirjam; Kilander, Lena; Benedict, Christian et al.

Ingår i Sleep Medicine, s. 34-40, 2024

Artikel i tidskrift

• DOI för Obstructive sleep apnea during rapid eye movement sleep and cognitive performance in adults
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Factors associated with changes in walking performance in individuals 3 months after stroke or TIA: secondary analyses from a randomised controlled trial of SMS-delivered training instructions in Sweden

Vahlberg, Birgit; Eriksson, Staffan; Holmbäck, Ulf; Lundström, Erik

Ingår i BMJ Open, 2024

Artikel i tidskrift

• DOI för Factors associated with changes in walking performance in individuals 3 months after stroke or TIA: secondary analyses from a randomised controlled trial of SMS-delivered training instructions in Sweden
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A meta-analysis of previous falls and subsequent fracture risk in cohort studies

Vandenput, Liesbeth; Johansson, Helena; McCloskey, Eugene V.; Liu, Enwu et al.

Ingår i Osteoporosis International, s. 469-494, 2024

Artikel i tidskrift

• DOI för A meta-analysis of previous falls and subsequent fracture risk in cohort studies

Plasma and CSF biomarkers of aging and cognitive decline in Caribbean vervets

Varma, Curran; Luo, Eva; Boström, Gustaf; Bathini, Praveen et al.

Ingår i Alzheimer's & Dementia, s. 5460-5480, 2024

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• DOI för Plasma and CSF biomarkers of aging and cognitive decline in Caribbean vervets
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Herpes Simplex Viral Infection Doubles the Risk of Dementia in a Contemporary Cohort of Older Adults: A Prospective Study

Vestin, Erika; Boström, Gustaf; Olsson, Jan; Elgh, Fredrik et al.

Ingår i Journal of Alzheimer's Disease, s. 1841-1850, 2024

Artikel i tidskrift

• DOI för Herpes Simplex Viral Infection Doubles the Risk of Dementia in a Contemporary Cohort of Older Adults: A Prospective Study
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Genetic and Environmental Factors and Cardiovascular Disease Risk in Adolescents

Ballin, Marcel; Neovius, Martin; Ortega, Francisco B.; Henriksson, Pontus et al.

Ingår i JAMA Network Open, 2023

Artikel i tidskrift

• DOI för Genetic and Environmental Factors and Cardiovascular Disease Risk in Adolescents
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Loci for insulin processing and secretion provide insight into type 2 diabetes risk.

Broadaway, K Alaine; Yin, Xianyong; Williamson, Alice; Parsons, Victoria A et al.

Ingår i American Journal of Human Genetics, s. 284-299, 2023

Artikel i tidskrift

• DOI för Loci for insulin processing and secretion provide insight into type 2 diabetes risk.

The complexities of communication at hospital discharge of older patients: a qualitative study of healthcare professionals' views

Cam, Henrik; Wennlöf, Björn; Gillespie, Ulrika; Franzon, Kristin et al.

Ingår i BMC Health Services Research, 2023

Artikel i tidskrift

• DOI för The complexities of communication at hospital discharge of older patients: a qualitative study of healthcare professionals' views
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Response to comment on "Assessment of executive functions in older adults: Translation and initial validation of the Swedish version of the frontal assessment battery, FAB-Swe"

Damberg, Mattias; Pellas, Johnny

Ingår i Applied neuropsychology. Adult, s. 636-637, 2023

Artikel i tidskrift

• DOI för Response to comment on "Assessment of executive functions in older adults: Translation and initial validation of the Swedish version of the frontal assessment battery, FAB-Swe"

Associations between lifestyle factors and levels of per- and polyfluoroalkyl substances (PFASs), phthalates and parabens in follicular fluid in women undergoing fertility treatment

Hallberg, Ida; Duque Björvang, Richelle; Hadziosmanovic, Nermin; Koekkoekk, Jacco et al.

Ingår i Journal of Exposure Science and Environmental Epidemiology, s. 699-709, 2023

Artikel i tidskrift

• DOI för Associations between lifestyle factors and levels of per- and polyfluoroalkyl substances (PFASs), phthalates and parabens in follicular fluid in women undergoing fertility treatment
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Feasibility of PURPOSE T in clinical practice and patient participation: a mixed-method study

Hultin, Lisa; Karlsson, Ann-Christin; Löwenmark, Malin; Coleman, Susanne et al.

Ingår i International Wound Journal, s. 633-647, 2023

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• DOI för Feasibility of PURPOSE T in clinical practice and patient participation: a mixed-method study
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Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX

Kanis, J. A.; Johansson, H.; McCloskey, E. , V; Liu, E. et al.

Ingår i Osteoporosis International, s. 2027-2045, 2023

Artikel i tidskrift

• DOI för Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX

Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Le Guen, Yann; Luo, Guo; Ambati, Aditya; Damotte, Vincent et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2023

Artikel i tidskrift

• DOI för Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
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Association between atherogenic lipids and GnRH agonists for prostate cancer in men with T2DM: a nationwide, population-based cohort study in Sweden

Lin, E.; Garmo, Hans; Hagström, Emil; Van Hemelrijck, Mieke et al.

Ingår i British Journal of Cancer, s. 814-824, 2023

Artikel i tidskrift

• DOI för Association between atherogenic lipids and GnRH agonists for prostate cancer in men with T2DM: a nationwide, population-based cohort study in Sweden
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The impact of stroke on the ability to live an independent life at old age: a community-based cohort study of Swedish men

Lindvall, Elias; Franzon, Kristin; Lundström, Erik; Kilander, Lena

Ingår i BMC Geriatrics, 2023

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• DOI för The impact of stroke on the ability to live an independent life at old age: a community-based cohort study of Swedish men
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Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease

Luo, Jiao; Thomassen, Jesper Qvist; Bellenguez, Celine; Grenier-Boley, Benjamin et al.

Ingår i JAMA Network Open, 2023

Artikel i tidskrift

• DOI för Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease
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Safety and effectiveness of monovalent COVID-19 mRNA vaccination and risk factors for hospitalisation caused by the omicron variant in 0.8 million adolescents: A nationwide cohort study in Sweden

Nordstrom, Peter; Ballin, Marcel; Nordstrom, Anna

Ingår i PLoS Medicine, 2023

Artikel i tidskrift

• DOI för Safety and effectiveness of monovalent COVID-19 mRNA vaccination and risk factors for hospitalisation caused by the omicron variant in 0.8 million adolescents: A nationwide cohort study in Sweden
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Neuromuscular controller models for quantifying standing balance in older people: A systematic review

Olsson, Fredrik; Halvorsen, Kjartan; Åberg, Anna Cristina

Ingår i IEEE Reviews in Biomedical Engineering, s. 560-578, 2023

Artikel i tidskrift

• DOI för Neuromuscular controller models for quantifying standing balance in older people: A systematic review

Blood Pressure Level in Late Adolescence and Risk for Cardiovascular Events

Rietz, Helene; Pennlert, Johanna; Nordström, Peter; Brunström, Mattias

Ingår i Annals of Internal Medicine, s. 1289-1298, 2023

Artikel i tidskrift

• DOI för Blood Pressure Level in Late Adolescence and Risk for Cardiovascular Events

Healthcare and community stakeholders' perceptions of barriers and facilitators to implementing a behavioral activation intervention for people with dementia and depression: a qualitative study using Normalization Process Theory

Svedin, Frida; Blomberg, Oscar; Brantnell, Anders; Farrand, Paul et al.

Ingår i BMC Geriatrics, 2023

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• DOI för Healthcare and community stakeholders' perceptions of barriers and facilitators to implementing a behavioral activation intervention for people with dementia and depression: a qualitative study using Normalization Process Theory
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Effectiveness, acceptability, and completeness and quality of intervention reporting of psychological interventions for people with dementia or mild cognitive impairment: protocol for a mixed-methods systematic review

Svedin, Frida; Blomberg, Oscar; Farrand, Paul; Brantnell, Anders et al.

Ingår i BMJ Open, 2023

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• DOI för Effectiveness, acceptability, and completeness and quality of intervention reporting of psychological interventions for people with dementia or mild cognitive impairment: protocol for a mixed-methods systematic review
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High Self‐Reported Levels of Pain 1 Year After a Myocardial Infarction Are Related to Long‐Term All‐Cause Mortality: A SWEDEHEART Study Including 18 376 Patients

Vixner, Linda; Hambraeus, Kristina; Äng, Björn; Berglund, Lars

Ingår i Journal of the American Heart Association, 2023

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• DOI för High Self‐Reported Levels of Pain 1 Year After a Myocardial Infarction Are Related to Long‐Term All‐Cause Mortality: A SWEDEHEART Study Including 18 376 Patients
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Longitudinal Effects of Herpesviruses on Multiple Cognitive Outcomes in Healthy Elderly Adults

Weidung, Bodil; Josefsson, Maria; Lyttkens, Peter; Olsson, Jan et al.

Ingår i Journal of Alzheimer's Disease, s. 751-762, 2023

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• DOI för Longitudinal Effects of Herpesviruses on Multiple Cognitive Outcomes in Healthy Elderly Adults
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Temporal Dementia and Cognitive Impairment Trends in the Very Old in the 21st Century

Weidung, Bodil; Lovheim, Hugo; Littbrand, Hakan; Wahlin, Johanna et al.

Ingår i Journal of Alzheimer's Disease, s. 61-74, 2023

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• DOI för Temporal Dementia and Cognitive Impairment Trends in the Very Old in the 21st Century
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Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake

Williamson, Alice; Norris, Dougall M; Yin, Xianyong; Broadaway, K Alaine et al.

Ingår i Nature Genetics, s. 973-983, 2023

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• DOI för Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake

Plasma proteomic signatures of a direct measure of insulin sensitivity in two population cohorts

Zanetti, Daniela; Stell, Laurel; Gustafsson, Stefan; Abbasi, Fahim et al.

Ingår i Diabetologia, s. 1643-1654, 2023

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• DOI för Plasma proteomic signatures of a direct measure of insulin sensitivity in two population cohorts
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Dual-Task Interference of Gait Parameters During Different Conditions of the Timed Up-and-Go Test Performed by Community-Dwelling Older Adults

Åberg, Anna Cristina; Larsson, Liss Elin; Giedraitis, Vilmantas; Berglund, Lars et al.

Ingår i Journal of Aging and Physical Activity, s. 823-832, 2023

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• DOI för Dual-Task Interference of Gait Parameters During Different Conditions of the Timed Up-and-Go Test Performed by Community-Dwelling Older Adults
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Prediction of conversion to dementia disorders based on timed up and go dual-task test verbal and motor outcomes: a five-year prospective memory-clinic-based study

Åberg, Anna Cristina; Petersson, Johanna R.; Giedraitis, Vilmantas; Mckee, Kevin J. et al.

Ingår i BMC Geriatrics, 2023

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• DOI för Prediction of conversion to dementia disorders based on timed up and go dual-task test verbal and motor outcomes: a five-year prospective memory-clinic-based study
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New insights into the genetic etiology of Alzheimer's disease and related dementias

Bellenguez, Celine; Giedraitis, Vilmantas; Ingelsson, Martin; Lambert, Jean-Charles

Ingår i Nature Genetics, s. 412-436, 2022

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• DOI för New insights into the genetic etiology of Alzheimer's disease and related dementias
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Follicular fluid and blood levels of persistent organic pollutants and reproductive outcomes among women undergoing assisted reproductive technologies

Bjorvang, Richelle D.; Hallberg, Ida; Pikki, Anne; Berglund, Lars et al.

Ingår i Environmental Research, 2022

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• DOI för Follicular fluid and blood levels of persistent organic pollutants and reproductive outcomes among women undergoing assisted reproductive technologies
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Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies

Gorski, Mathias; Rasheed, Humaira; Teumer, Alexander; Thomas, Laurent F. et al.

Ingår i Kidney International, s. 624-639, 2022

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• DOI för Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies
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CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease PSEN1 M146L mutation

Konstantinidis, Evangelos; Molisak, Agnieszka; Perrin, Florian; Streubel-Gallasch, Linn et al.

Ingår i Molecular Therapy Nucleic Acids, s. 450-461, 2022

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• DOI för CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease PSEN1 M146L mutation
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Mixed Pathologies in a Subject with a Novel PSEN1 G206R Mutation

Libard, Sylwia; Giedraitis, Vilmantas; Kilander, Lena; Ingelsson, Martin et al.

Ingår i Journal of Alzheimer's Disease, s. 1601-1614, 2022

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• DOI för Mixed Pathologies in a Subject with a Novel PSEN1 G206R Mutation
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Association of Gonadotropin-Releasing Hormone Agonists for Prostate Cancer With Cardiovascular Disease Risk and Hypertension in Men With Diabetes

Lin, E.; Garmo, Hans; Van Hemelrijck, Mieke; Zethelius, Björn et al.

Ingår i JAMA Network Open, 2022

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• DOI för Association of Gonadotropin-Releasing Hormone Agonists for Prostate Cancer With Cardiovascular Disease Risk and Hypertension in Men With Diabetes
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Self-reported physical activity and different cardiovascular diseases-Results from updated measurements over 40 years

Lind, Lars; Zethelius, Björn; Byberg, Liisa

Ingår i PLOS ONE, 2022

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• DOI för Self-reported physical activity and different cardiovascular diseases-Results from updated measurements over 40 years
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