Jing Cen

The Welander TIA1 mutation dedifferentiates insulin-producing cells: Reversal by a GLP-1 receptor agonist

Zhao, Tongjian; Cen, Jing; Wang, Xuan; Yang, Mingyu et al.

Ingår i Journal of Biological Chemistry, 2026

• DOI för The Welander TIA1 mutation dedifferentiates insulin-producing cells: Reversal by a GLP-1 receptor agonist
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Bri2 BRICHOS domain inhibits IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress

Cen, Jing; Ivis, Anja; Vasylovska, Svitlana; Adjieva, Kina et al.

Ingår i Diabetologia, s. 436-450, 2026

• DOI för Bri2 BRICHOS domain inhibits IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress
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GDF15 Protects Insulin-Producing Beta Cells against Pro-Inflammatory Cytokines and Metabolic Stress via Increased Deamination of Intracellular Adenosine

Ngamjariyawat, Anongnad; Cen, Jing; Wang, Xuan; Welsh, Nils

Ingår i International Journal of Molecular Sciences, 2024

• DOI för GDF15 Protects Insulin-Producing Beta Cells against Pro-Inflammatory Cytokines and Metabolic Stress via Increased Deamination of Intracellular Adenosine
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CLEC11A improves insulin secretion and promotes cell proliferation in human beta-cells

Shi, Ruifeng; Cen, Jing; Westermark, Gunilla; Zhao, Sheng et al.

Ingår i Journal of Molecular Endocrinology, 2023

• DOI för CLEC11A improves insulin secretion and promotes cell proliferation in human beta-cells
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Metabolic stress-induced human beta-cell death is mediated by increased intracellular levels of adenosine

Ngamjariyawat, Anongnad; Cen, Jing; Said, Romain; Incedal, Ceren et al.

Ingår i Frontiers in Endocrinology, 2023

• DOI för Metabolic stress-induced human beta-cell death is mediated by increased intracellular levels of adenosine
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The Welander TIA1 mutation dedifferentiates insulin-producing cells: Reversal by a GLP-1 receptor agonist

Zhao, Tongjian; Cen, Jing; Wang, Xuan; Yang, Mingyu et al.

Ingår i Journal of Biological Chemistry, 2026

• DOI för The Welander TIA1 mutation dedifferentiates insulin-producing cells: Reversal by a GLP-1 receptor agonist
• Ladda ner fulltext (pdf) av The Welander TIA1 mutation dedifferentiates insulin-producing cells: Reversal by a GLP-1 receptor agonist

Bri2 BRICHOS domain inhibits IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress

Cen, Jing; Ivis, Anja; Vasylovska, Svitlana; Adjieva, Kina et al.

Ingår i Diabetologia, s. 436-450, 2026

• DOI för Bri2 BRICHOS domain inhibits IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress
• Ladda ner fulltext (pdf) av Bri2 BRICHOS domain inhibits IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress

GDF15 Protects Insulin-Producing Beta Cells against Pro-Inflammatory Cytokines and Metabolic Stress via Increased Deamination of Intracellular Adenosine

Ngamjariyawat, Anongnad; Cen, Jing; Wang, Xuan; Welsh, Nils

Ingår i International Journal of Molecular Sciences, 2024

• DOI för GDF15 Protects Insulin-Producing Beta Cells against Pro-Inflammatory Cytokines and Metabolic Stress via Increased Deamination of Intracellular Adenosine
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CLEC11A improves insulin secretion and promotes cell proliferation in human beta-cells

Shi, Ruifeng; Cen, Jing; Westermark, Gunilla; Zhao, Sheng et al.

Ingår i Journal of Molecular Endocrinology, 2023

• DOI för CLEC11A improves insulin secretion and promotes cell proliferation in human beta-cells
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Metabolic stress-induced human beta-cell death is mediated by increased intracellular levels of adenosine

Ngamjariyawat, Anongnad; Cen, Jing; Said, Romain; Incedal, Ceren et al.

Ingår i Frontiers in Endocrinology, 2023

• DOI för Metabolic stress-induced human beta-cell death is mediated by increased intracellular levels of adenosine
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Altered mitochondrial metabolism in peripheral blood cells from patients with inborn errors of β-oxidation

Stenlid, Rasmus; Olsson, David; Cen, Jing; Manell, Hannes et al.

Ingår i Clinical and Translational Science, s. 182-194, 2022

• DOI för Altered mitochondrial metabolism in peripheral blood cells from patients with inborn errors of β-oxidation
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The endoplasmic reticulum-plasma membrane tethering protein TMEM24 is a regulator of cellular Ca2+ homeostasis

Xie, Beichen; Panagiotou, Styliani; Cen, Jing; Gilon, Patrick et al.

Ingår i Journal of Cell Science, 2022

• DOI för The endoplasmic reticulum-plasma membrane tethering protein TMEM24 is a regulator of cellular Ca2+ homeostasis
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Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK

Elksnis, Andris; Schiffer, Tomas A.; Palm, Fredrik; Wang, Yun et al.

Ingår i Clinical Science, s. 2243-2263, 2021

• DOI för Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK

Impaired HMG-CoA reductase activity caused by genetic variants or statin exposure: impact on human adipose tissue, β-cells and metabolome

Sarsenbayeva, Assel; Jui Nandi, Bipasha; Fanni, Giovanni; Barbosa, Pedro et al.

Ingår i Metabolites, 2021

• DOI för Impaired HMG-CoA reductase activity caused by genetic variants or statin exposure: impact on human adipose tissue, β-cells and metabolome
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Novel AQP2 Mutations and Clinical Characteristics in Seven Chinese Families With Congenital Nephrogenic Diabetes Insipidus

Li, Qian; Tian, Dan; Cen, Jing; Duan, Lian et al.

Ingår i Frontiers in Endocrinology, 2021

• DOI för Novel AQP2 Mutations and Clinical Characteristics in Seven Chinese Families With Congenital Nephrogenic Diabetes Insipidus
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Pharmacological Inhibition of NOX4 Improves Mitochondrial Function and Survival in Human Beta-Cells

Elksnis, Andris; Cen, Jing; Wikström, Per; Carlsson, Per-Ola et al.

Ingår i Biomedicines, 2021

• DOI för Pharmacological Inhibition of NOX4 Improves Mitochondrial Function and Survival in Human Beta-Cells
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ZBED6 counteracts high-fat diet-induced glucose intolerance by maintaining beta cell area and reducing excess mitochondrial activation

Wang, Xuan; Younis, Shady; Cen, Jing; Wang, Yun et al.

Ingår i Diabetologia, s. 2292-2305, 2021

• DOI för ZBED6 counteracts high-fat diet-induced glucose intolerance by maintaining beta cell area and reducing excess mitochondrial activation
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Novel AVPR2 mutations and clinical characteristics in 28 Chinese families with congenital nephrogenic diabetes insipidus

Li, Q.; Tian, D.; Cen, Jing; Duan, L. et al.

Ingår i Journal of Endocrinological Investigation, s. 2777-2783, 2021

• DOI för Novel AVPR2 mutations and clinical characteristics in 28 Chinese families with congenital nephrogenic diabetes insipidus

Identification of early biological changes in palmitate-treated isolated human islets.

Sargsyan, Ernest; Cen, Jing; Roomp, Kirsten; Schneider, Reinhard et al.

Ingår i BMC Genomics, 2018

• DOI för Identification of early biological changes in palmitate-treated isolated human islets.
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Mechanisms of beneficial effects of metformin on fatty acid-treated human islets

Cen, Jing; Sargsyan, Ernest; Forslund, Anders; Bergsten, Peter

Ingår i Journal of Molecular Endocrinology, s. 91-99, 2018

• DOI för Mechanisms of beneficial effects of metformin on fatty acid-treated human islets

Palmitate-Induced Insulin Hypersecretion and Later Secretory Decline Associated with Changes in Protein Expression Patterns in Human Pancreatic Islets

Groebe, Karlfried; Cen, Jing; Schvartz, Domitille; Sargsyan, Ernest et al.

Ingår i Journal of Proteome Research, s. 3824-3836, 2018

• DOI för Palmitate-Induced Insulin Hypersecretion and Later Secretory Decline Associated with Changes in Protein Expression Patterns in Human Pancreatic Islets

Metformin restores insulin secretion from palmitate-treated human islets by normalising mitochondrial metabolism and reducing ER stress and apoptosis

Cen, Jing; Sargsyan, Ernest; Bergsten, Peter

Ingår i Diabetologia, 2017

Pancreatic Fat Is Associated With Metabolic Syndrome and Visceral Fat but Not Beta-Cell Function or Body Mass Index in Pediatric Obesity

Staaf, Johan; Labmayr, Viktor; Paulmichl, Katharina; Manell, Hannes et al.

Ingår i Pancreas, s. 358-365, 2017

• DOI för Pancreatic Fat Is Associated With Metabolic Syndrome and Visceral Fat but Not Beta-Cell Function or Body Mass Index in Pediatric Obesity
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Fatty acids stimulate insulin secretion from human pancreatic islets at fasting glucose concentrations via mitochondria-dependent and -independent mechanisms

Cen, Jing; Sargsyan, Ernest; Bergsten, Peter

Ingår i Nutrition & Metabolism, 2016

• DOI för Fatty acids stimulate insulin secretion from human pancreatic islets at fasting glucose concentrations via mitochondria-dependent and -independent mechanisms
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Altered Plasma Levels of Glucagon, GLP-1 and Glicentin During OGTT in Adolescents With Obesity and Type 2 Diabetes

Manell, Hannes; Staaf, Johan; Manukyan, Levon; Kristinsson, Hjalti et al.

Ingår i Journal of Clinical Endocrinology and Metabolism, s. 1181-1189, 2016

• DOI för Altered Plasma Levels of Glucagon, GLP-1 and Glicentin During OGTT in Adolescents With Obesity and Type 2 Diabetes

Role of the AMP kinase in cytokine-induced human EndoC-beta H1 cell death

Fred, Rikard G.; Kappe, Camilla; Ameur, Adam; Cen, Jing et al.

Ingår i Molecular and Cellular Endocrinology, s. 53-63, 2015

• DOI för Role of the AMP kinase in cytokine-induced human EndoC-beta H1 cell death
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Pancreatic Fat is Associated with Metabolic Syndrome and Visceral Adipose Tissue but not Beta-Cell Function or Body Mass Index in Paediatric Obesity

Staaf, Johan; Labmayr, V.; Paulmichl, K.; Ohlsson, H. et al.

Ingår i Acta Paediatrica, s. 2-2, 2015

Free fatty acids and insulin hypersecretion studied in human islets

Cen, Jing

2018

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Sorcin counteracts lipotoxicity in palmitate-exposed human beta-cells

Cen, Jing; Sargsyan, Ernest; Bergsten, Peter