Anja Mortensen

Preclinical evaluation of an antibody-based companion diagnostic for CD44v6 expressing cancer

Oroujeni, Maryam; Selvaraju, Ram Kumar; Persson, Helena; Dahllund, Leif et al.

Ingår i Nuclear medicine communications, s. 401-410, 2026

• DOI för Preclinical evaluation of an antibody-based companion diagnostic for CD44v6 expressing cancer
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Preclinical Validation of [¹⁷⁷Lu]Lu-AKIR001, a CD44v6-Targeted Radiotherapeutic Entering First-in-Human Trials

Mortensen, Anja C. L.; Mohajershojai, Tabassom; Gustafsson, Amanda; Berglund, Hanna et al.

Ingår i Journal of Nuclear Medicine, s. 269-275, 2026

• DOI för Preclinical Validation of [¹⁷⁷Lu]Lu-AKIR001, a CD44v6-Targeted Radiotherapeutic Entering First-in-Human Trials
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Evaluation of CD44v6-targeted radionuclide therapy on bone marrow, skin and esophageal epithelium using a novel internal dosimetry model

Hemmingsson, Jens; Nestor, Marika; Lundgren Mortensen, Anja; Frejd, Fredrik et al.

Ingår i Physics in Medicine and Biology, 2025

• DOI för Evaluation of CD44v6-targeted radionuclide therapy on bone marrow, skin and esophageal epithelium using a novel internal dosimetry model
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Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts

Mortensen, Anja; Berglund, Hanna; Jha, Preeti; Stenman, Adam et al.

Ingår i Molecular Cancer Therapeutics, s. 753-762, 2025

• DOI för Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts
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Affinity maturation and optimization of CD44v6-targeting antibodies for molecular radiotherapy

Lundgren Mortensen, Anja Charlotte; Hofström, Camilla; Persson, Helena; Dahllund, Leif et al.

Ingår i Nuclear Medicine and Biology, 2025

• DOI för Affinity maturation and optimization of CD44v6-targeting antibodies for molecular radiotherapy
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Preclinical evaluation of an antibody-based companion diagnostic for CD44v6 expressing cancer

Oroujeni, Maryam; Selvaraju, Ram Kumar; Persson, Helena; Dahllund, Leif et al.

Ingår i Nuclear medicine communications, s. 401-410, 2026

• DOI för Preclinical evaluation of an antibody-based companion diagnostic for CD44v6 expressing cancer
• Ladda ner fulltext (pdf) av Preclinical evaluation of an antibody-based companion diagnostic for CD44v6 expressing cancer

Preclinical Validation of [¹⁷⁷Lu]Lu-AKIR001, a CD44v6-Targeted Radiotherapeutic Entering First-in-Human Trials

Mortensen, Anja C. L.; Mohajershojai, Tabassom; Gustafsson, Amanda; Berglund, Hanna et al.

Ingår i Journal of Nuclear Medicine, s. 269-275, 2026

• DOI för Preclinical Validation of [¹⁷⁷Lu]Lu-AKIR001, a CD44v6-Targeted Radiotherapeutic Entering First-in-Human Trials
• Ladda ner fulltext (pdf) av Preclinical Validation of [¹⁷⁷Lu]Lu-AKIR001, a CD44v6-Targeted Radiotherapeutic Entering First-in-Human Trials

Evaluation of CD44v6-targeted radionuclide therapy on bone marrow, skin and esophageal epithelium using a novel internal dosimetry model

Hemmingsson, Jens; Nestor, Marika; Lundgren Mortensen, Anja; Frejd, Fredrik et al.

Ingår i Physics in Medicine and Biology, 2025

• DOI för Evaluation of CD44v6-targeted radionuclide therapy on bone marrow, skin and esophageal epithelium using a novel internal dosimetry model
• Ladda ner fulltext (pdf) av Evaluation of CD44v6-targeted radionuclide therapy on bone marrow, skin and esophageal epithelium using a novel internal dosimetry model

Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts

Mortensen, Anja; Berglund, Hanna; Jha, Preeti; Stenman, Adam et al.

Ingår i Molecular Cancer Therapeutics, s. 753-762, 2025

• DOI för Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts
• Ladda ner fulltext (pdf) av Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts

Affinity maturation and optimization of CD44v6-targeting antibodies for molecular radiotherapy

Lundgren Mortensen, Anja Charlotte; Hofström, Camilla; Persson, Helena; Dahllund, Leif et al.

Ingår i Nuclear Medicine and Biology, 2025

• DOI för Affinity maturation and optimization of CD44v6-targeting antibodies for molecular radiotherapy
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Selection, characterization and in vivo evaluation of novel CD44v6-targeting antibodies for targeted molecular radiotherapy

Mortensen, Anja; Berglund, Hanna; Segerström, Lova; Walle, M. et al.

Ingår i Scientific Reports, 2023

• DOI för Selection, characterization and in vivo evaluation of novel CD44v6-targeting antibodies for targeted molecular radiotherapy
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Utilizing CD44v6 and V600EBRAF-mutation for in vitro targeted combination therapy of thyroid carcinomas

Mortensen, Anja; Imgenberg-Kreuz, Juliana; Spiegelberg, Diana; Botling, J. et al.

Ingår i Heliyon, 2023

• DOI för Utilizing CD44v6 and V600EBRAF-mutation for in vitro targeted combination therapy of thyroid carcinomas
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Combination therapy of tyrosine kinase inhibitor sorafenib with the HSP90 inhibitor onalespib as a novel treatment regimen for thyroid cancer

Lundgren Mortensen, Anja Charlotte; Berglund, Hanna; Hariri, Mehran; Papalanis, Eleftherios et al.

Ingår i Scientific Reports, 2023

• DOI för Combination therapy of tyrosine kinase inhibitor sorafenib with the HSP90 inhibitor onalespib as a novel treatment regimen for thyroid cancer
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Overcoming Limitations of Cisplatin Therapy by Additional Treatment With the HSP90 Inhibitor Onalespib

Mortensen, Anja; Mohajershojai, Tabassom; Hariri, Mehran; Pettersson, Marika et al.

Ingår i Frontiers in Oncology, 2020

• DOI för Overcoming Limitations of Cisplatin Therapy by Additional Treatment With the HSP90 Inhibitor Onalespib
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The Novel Anti-cMet Antibody seeMet 12 Potentiates Sorafenib Therapy and Radiotherapy in a Colorectal Cancer Model

Spiegelberg, Diana; Lundgren Mortensen, Anja Charlotte; Palupi, Kartika Dyah; Micke, Patrick et al.

Ingår i Frontiers in Oncology, 2020

• DOI för The Novel Anti-cMet Antibody seeMet 12 Potentiates Sorafenib Therapy and Radiotherapy in a Colorectal Cancer Model
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The HSP90 inhibitor Onalespib exerts synergistic anti-cancer effects when combined with radiotherapy: an in vitro and in vivo approach

Spiegelberg, Diana; Abramenkovs, Andris; Mortensen, Anja; Lundsten, Sara et al.

Ingår i Scientific Reports, 2020

• DOI för The HSP90 inhibitor Onalespib exerts synergistic anti-cancer effects when combined with radiotherapy: an in vitro and in vivo approach
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Enhancing the therapeutic effects of in vitro targeted radionuclide therapy of 3D multicellular tumor spheroids using the novel stapled MDM2/X-p53 antagonist PM2

Mortensen, Anja; Morin, Eric; Brown, Christopher J.; Lane, David P. et al.

Ingår i EJNMMI Research, 2020

• DOI för Enhancing the therapeutic effects of in vitro targeted radionuclide therapy of 3D multicellular tumor spheroids using the novel stapled MDM2/X-p53 antagonist PM2
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The Stapled Peptide PM2 Stabilizes p53 Levels and Radiosensitizes Wild-Type p53 Cancer Cells

Lundgren Mortensen, Anja; Spiegelberg, Diana; Brown, Christopher John; Lane, David Philip et al.

Ingår i Frontiers in Oncology, 2019

• DOI för The Stapled Peptide PM2 Stabilizes p53 Levels and Radiosensitizes Wild-Type p53 Cancer Cells
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Preclinical evaluation of a novel engineered recombinant human anti-CD44v6 antibody for potential use in radio-immunotherapy

Mortensen, Anja; Spiegelberg, Diana; Haylock, Anna-Karin; Lundqvist, Hans et al.

Ingår i International Journal of Oncology, s. 1875-1885, 2018

• DOI för Preclinical evaluation of a novel engineered recombinant human anti-CD44v6 antibody for potential use in radio-immunotherapy
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First in vivo study of the MDM2/MDMX-p53 antagonist PM2 as potentiator of external radiotherapy in wt p53 cancer

Spiegelberg, Diana; Mortensen, Anja C.; Lundsten, Sara; Brown, C. J. et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2018

• DOI för First in vivo study of the MDM2/MDMX-p53 antagonist PM2 as potentiator of external radiotherapy in wt p53 cancer

The MDM2/MDMX-p53 Antagonist PM2 Radiosensitizes Wild-Type p53 Tumors

Spiegelberg, Diana; Mortensen, Anja; Lundsten, Sara; Brown, Christopher J. et al.

Ingår i Cancer Research, s. 5084-5093, 2018

• DOI för The MDM2/MDMX-p53 Antagonist PM2 Radiosensitizes Wild-Type p53 Tumors

Analysis of radiation effects in two irradiated tumor spheroid models

Al-Ramadan, Afkar; Mortensen, Anja; Carlsson, Jörgen; Nestor, Marika V.

Ingår i Oncology Letters, s. 3008-3016, 2018

• DOI för Analysis of radiation effects in two irradiated tumor spheroid models

Different functions of AKT1 and AKT2 in molecular pathways, cell migration and metabolism in colon cancer cells

Häggblad Sahlberg, Sara; Mortensen, Anja C.; Haglöf, Jakob; Engskog, Mikael K. R. et al.

Ingår i International Journal of Oncology, s. 5-14, 2017

• DOI för Different functions of AKT1 and AKT2 in molecular pathways, cell migration and metabolism in colon cancer cells
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Generation and evaluation of antibody agents for molecular imaging of CD44v6-expressing cancers

Haylock, Anna-Karin; Nilvebrant, Johan; Mortensen, Anja; Velikyan, Irina et al.

Ingår i Oncotarget, s. 65152-65170, 2017

• DOI för Generation and evaluation of antibody agents for molecular imaging of CD44v6-expressing cancers
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The Novel, Stapled HDM2/HDMX-p53 Antagonist PM2 Has Potent Antitumorigenic Activities and Enhances the Effects of External Radiotherapy

Mortensen, Anja C.; Spiegelberg, Diana; Brown, C.; Lane, D. P. et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2017

In Vivo Assessment of p53 Therapy as a Way of Enhancing Therapeutic Effects of Radiation

Mortensen, Anja C.; Spiegelberg, Diana; Lundsten, Sara; Brown, C. et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2017

The HSP90-inhibitor Onalespib Potentiates Lu-177-Dotatate Treatment of Neuroendocrine Tumors

Lundsten, Sara; Mortensen, Anja; Makiniemi, A.; Spiegelberg, Diana et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2017

In Vitro and In Vivo Growth Inhibitory and Radiosensitizing Effects of the Anti-HSP90 agent Onalespib

Spiegelberg, Diana; Lundsten, Sara; Mortensen, Anja C.; Abramenkovs, Andris et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2017

Evaluation of a novel type of imaging probe based on a recombinant bivalent mini-antibody construct for detection of CD44v6-expressing squamous cell carcinoma

Haylock, Anna-Karin; Spiegelberg, Diana; Mortensen, Anja C.; Selvaraju, Ram K. et al.

Ingår i International journal of oncology, s. 461-470, 2016

• DOI för Evaluation of a novel type of imaging probe based on a recombinant bivalent mini-antibody construct for detection of CD44v6-expressing squamous cell carcinoma
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Molecular imaging of EGFR and CD44v6 for prediction and response monitoring of HSP90 inhibition in an in vivo squamous cell carcinoma model.

Spiegelberg, Diana; Mortensen, Anja C; Selvaraju, Ram K; Eriksson, Olof et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 974-982, 2016

• DOI för Molecular imaging of EGFR and CD44v6 for prediction and response monitoring of HSP90 inhibition in an in vivo squamous cell carcinoma model.
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The novel HSP90 inhibitor AT13387 potentiates radiation effects in squamous cell carcinoma and adenocarcinoma cells

Spiegelberg, Diana; Dascalu, Adrian; Mortensen, Anja; Abramenkovs, Andris et al.

Ingår i Oncotarget, s. 35652-35666, 2015

• DOI för The novel HSP90 inhibitor AT13387 potentiates radiation effects in squamous cell carcinoma and adenocarcinoma cells
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Enhancing the effect of radiotherapy in cultured tumour cells using p53 therapy

Mortensen, Anja C.; Spiegelberg, Diana; Scott, A. M.; Lane, D. P. et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2015

Improving EGFR imaging by use of an anti-EGFRvIII monoclonal antibody: characterizations in an in vivo squamous cell carcinoma model

Spiegelberg, Diana; Mortensen, Anja C.; Selvaraju, Ram Kumar; Stenberg, J. et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2015

Molecular imaging of EGFR and EGFRvIII for prediction and response monitoring of HSP90 inhibition in an in vivo squamous cell carcinoma model

Spiegelberg, Diana; Mortensen, Anja C.; Selvaraju, Ram Kumar; Eriksson, Olof et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2015

In vivo characterization of a novel engineered CD44v6-targeting bivalent antibody fragment AbD19384 for molecular imaging of squamous cell carcinoma

Mortensen, Anja C.; Spegelberg, Diana; Haylock, Anna-Karin; Selvaraju, Ram Kumar et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2014

Evaluation of biomarkers for imaging and radio-immunotherapy in combination with HSP90 inhibition in squamous cell carcinomas

Spiegelberg, Diana; Mortensen, Anja C.; Haylock, Anna-Karin; Selvaraju, Ram Kumar et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2014

Precision medicine and targeted therapy: Turning the tables on cancer

Mortensen, Anja

2018

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Enhancing therapeutic effects of radio-immunotherapy using the novel stapled MDM2/X-p53 antagonist PM2

Mortensen, Anja C.; Morin, Eric; Brown, Christopher J; Claesson-Welsh, Lena et al.