Tianqi Xu

[¹⁶¹Tb]Tb-DOTATATE as a potential treatment option for neuroblastoma

Chopra, Saloni; Xu, Tianqi; Berglund, Hanna; Gustafsson, Amanda et al.

Ingår i EJNMMI Research, 2026

• DOI för [¹⁶¹Tb]Tb-DOTATATE as a potential treatment option for neuroblastoma
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Engineering a conditionally active cetuximab prodrug via affibody-based paratope masking

Mestre Borras, Anna; Mehari, Hanna; Bitzios, Athanasios; Zelepukin, Ivan et al.

Ingår i Journal of Biological Engineering, 2026

• DOI för Engineering a conditionally active cetuximab prodrug via affibody-based paratope masking
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Half-life extension via ABD-fusion leads to higher tumor uptake of an affibody-drug conjugate compared to PAS- and XTENylation.

Zhang, Jie; Bodenko, Vitalina; Larkina, Maria; Bezverkhniaia, Ekaterina et al.

Ingår i Journal of Controlled Release, s. 468-478, 2024

• DOI för Half-life extension via ABD-fusion leads to higher tumor uptake of an affibody-drug conjugate compared to PAS- and XTENylation.
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Scaffold Protein-based Theranostics of HER2-overexpressing Ovarian Cancer: Imaging-guided Therapy

Xu, Tianqi

2024

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Reduction of renal activity retention of radiolabeled albumin binding domain-derived affinity proteins using a non-residualizing label strategy compared with a cleavable glycine-leucine-glycine-lysine-linker

Lundmark, Fanny; Vorobyeva, Anzhelika; Liu, Yongsheng; Lindbo, Sarah et al.

Ingår i Molecular Medicine Reports, 2024

• DOI för Reduction of renal activity retention of radiolabeled albumin binding domain-derived affinity proteins using a non-residualizing label strategy compared with a cleavable glycine-leucine-glycine-lysine-linker
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[¹⁶¹Tb]Tb-DOTATATE as a potential treatment option for neuroblastoma

Chopra, Saloni; Xu, Tianqi; Berglund, Hanna; Gustafsson, Amanda et al.

Ingår i EJNMMI Research, 2026

• DOI för [¹⁶¹Tb]Tb-DOTATATE as a potential treatment option for neuroblastoma
• Ladda ner fulltext (pdf) av [¹⁶¹Tb]Tb-DOTATATE as a potential treatment option for neuroblastoma

Engineering a conditionally active cetuximab prodrug via affibody-based paratope masking

Mestre Borras, Anna; Mehari, Hanna; Bitzios, Athanasios; Zelepukin, Ivan et al.

Ingår i Journal of Biological Engineering, 2026

• DOI för Engineering a conditionally active cetuximab prodrug via affibody-based paratope masking
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Half-life extension via ABD-fusion leads to higher tumor uptake of an affibody-drug conjugate compared to PAS- and XTENylation.

Zhang, Jie; Bodenko, Vitalina; Larkina, Maria; Bezverkhniaia, Ekaterina et al.

Ingår i Journal of Controlled Release, s. 468-478, 2024

• DOI för Half-life extension via ABD-fusion leads to higher tumor uptake of an affibody-drug conjugate compared to PAS- and XTENylation.
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Reduction of renal activity retention of radiolabeled albumin binding domain-derived affinity proteins using a non-residualizing label strategy compared with a cleavable glycine-leucine-glycine-lysine-linker

Lundmark, Fanny; Vorobyeva, Anzhelika; Liu, Yongsheng; Lindbo, Sarah et al.

Ingår i Molecular Medicine Reports, 2024

• DOI för Reduction of renal activity retention of radiolabeled albumin binding domain-derived affinity proteins using a non-residualizing label strategy compared with a cleavable glycine-leucine-glycine-lysine-linker
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Radionuclide Therapy of HER2-Expressing Xenografts Using [Lu-177]Lu-ABY-027 Affibody Molecule Alone and in Combination with Trastuzumab

Liu, Yongsheng; Xu, Tianqi; Vorobyeva, Anzhelika; Loftenius, Annika et al.

Ingår i Cancers, 2023

• DOI för Radionuclide Therapy of HER2-Expressing Xenografts Using [Lu-177]Lu-ABY-027 Affibody Molecule Alone and in Combination with Trastuzumab
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Comparison of HER2-targeted affibody conjugates loaded with auristatin-and maytansine-derived drugs

Yin, Wen; Xu, Tianqi; Ding, Haozhong; Zhang, Jie et al.

Ingår i Journal of Controlled Release, s. 515-527, 2023

• DOI för Comparison of HER2-targeted affibody conjugates loaded with auristatin-and maytansine-derived drugs

Conditionally activated affibody-based prodrug targeting EGFR demonstrates improved tumour selectivity

Leitao, Charles Dahlsson; Borras, Anna Mestre; Xu, Tianqi; Oroujeni, Maryam et al.

Ingår i Journal of Controlled Release, s. 185-195, 2023

• DOI för Conditionally activated affibody-based prodrug targeting EGFR demonstrates improved tumour selectivity

Evaluation of affinity matured Affibody molecules for imaging of the immune checkpoint protein B7-H3

Oroujeni, Maryam; Bezverkhniaia, Ekaterina A.; Xu, Tianqi; Liu, Yongsheng et al.

Ingår i Nuclear Medicine and Biology, 2023

• DOI för Evaluation of affinity matured Affibody molecules for imaging of the immune checkpoint protein B7-H3
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Feasibility of Co-Targeting HER3 and EpCAM Using Seribantumab and DARPin-Toxin Fusion in a Pancreatic Cancer Xenograft Model

Xu, Tianqi; Schulga, Alexey; Konovalova, Elena; Rinne, Sara S. et al.

Ingår i International Journal of Molecular Sciences, 2023

• DOI för Feasibility of Co-Targeting HER3 and EpCAM Using Seribantumab and DARPin-Toxin Fusion in a Pancreatic Cancer Xenograft Model
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Epithelial cell adhesion molecule-targeting designed ankyrin repeat protein-toxin fusion Ec1-LoPE exhibits potent cytotoxic action in prostate cancer cells

Xu, Tianqi; Liu, Yongsheng; Schulga, Alexey; Konovalova, Elena et al.

Ingår i Oncology Reports, 2022

• DOI för Epithelial cell adhesion molecule-targeting designed ankyrin repeat protein-toxin fusion Ec1-LoPE exhibits potent cytotoxic action in prostate cancer cells
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Experimental Therapy of HER2-Expressing Xenografts Using the Second-Generation HER2-Targeting Affibody Molecule ¹⁸⁸Re-ZHER2:41071

Liu, Yongsheng; Vorobyeva, Anzhelika; Orlova, Anna; Konijnenberg, Mark W. et al.

Ingår i Pharmaceutics, 2022

• DOI för Experimental Therapy of HER2-Expressing Xenografts Using the Second-Generation HER2-Targeting Affibody Molecule ¹⁸⁸Re-ZHER2:41071
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Effect of Inter-Domain Linker Composition on Biodistribution of ABD-Fused Affibody-Drug Conjugates Targeting HER2

Xu, Tianqi; Zhang, Jie; Oroujeni, Maryam; Tretyakova, Maria S. et al.

Ingår i Pharmaceutics, 2022

• DOI för Effect of Inter-Domain Linker Composition on Biodistribution of ABD-Fused Affibody-Drug Conjugates Targeting HER2
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Evaluation of an Affibody-Based Binder for Imaging of Immune Check-Point Molecule B7-H3

Oroujeni, Maryam; Bezverkhniaia, Ekaterina A.; Xu, Tianqi; Liu, Yongsheng et al.

Ingår i Pharmaceutics, 2022

• DOI för Evaluation of an Affibody-Based Binder for Imaging of Immune Check-Point Molecule B7-H3
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Preclinical Evaluation of a New Format of Ga-68- and In-111-Labeled Affibody Molecule Z(IGF-1R:4551) for the Visualization of IGF-1R Expression in Malignant Tumors Using PET and SPECT

Liu, Yongsheng; Yu, Shengze; Xu, Tianqi; Bodenko, Vitalina et al.

Ingår i Pharmaceutics, 2022

• DOI för Preclinical Evaluation of a New Format of Ga-68- and In-111-Labeled Affibody Molecule Z(IGF-1R:4551) for the Visualization of IGF-1R Expression in Malignant Tumors Using PET and SPECT
• Ladda ner fulltext (pdf) av Preclinical Evaluation of a New Format of Ga-68- and In-111-Labeled Affibody Molecule Z(IGF-1R:4551) for the Visualization of IGF-1R Expression in Malignant Tumors Using PET and SPECT

Experimental HER2-Targeted Therapy Using ADAPT6-ABD-mcDM1 in Mice Bearing SKOV3 Ovarian Cancer Xenografts: Efficacy and Selection of Companion Imaging Counterpart

Garousi, Javad; Xu, Tianqi; Liu, Yongsheng; Vorontsova, Olga et al.

Ingår i Pharmaceutics, 2022

• DOI för Experimental HER2-Targeted Therapy Using ADAPT6-ABD-mcDM1 in Mice Bearing SKOV3 Ovarian Cancer Xenografts: Efficacy and Selection of Companion Imaging Counterpart
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Affibody-Mediated PNA-Based Pretargeted Cotreatment Improves Survival of Trastuzumab-Treated Mice Bearing HER2-Expressing Xenografts

Oroujeni, Maryam; Tano, Hanna; Vorobyeva, Anzhelika; Liu, Yongsheng et al.

Ingår i Journal of Nuclear Medicine, s. 1046-1051, 2022

• DOI för Affibody-Mediated PNA-Based Pretargeted Cotreatment Improves Survival of Trastuzumab-Treated Mice Bearing HER2-Expressing Xenografts

Comparative Preclinical Evaluation of HER2-Targeting ABD-Fused Affibody^® Molecules ¹⁷⁷Lu-ABY-271 and ¹⁷⁷Lu-ABY-027: Impact of DOTA Position on ABD Domain

Liu, Yongsheng; Vorobyeva, Anzhelika; Xu, Tianqi; Orlova, Anna et al.

Ingår i Pharmaceutics, 2021

• DOI för Comparative Preclinical Evaluation of HER2-Targeting ABD-Fused Affibody^® Molecules ¹⁷⁷Lu-ABY-271 and ¹⁷⁷Lu-ABY-027: Impact of DOTA Position on ABD Domain
• Ladda ner fulltext (pdf) av Comparative Preclinical Evaluation of HER2-Targeting ABD-Fused Affibody^® Molecules ¹⁷⁷Lu-ABY-271 and ¹⁷⁷Lu-ABY-027: Impact of DOTA Position on ABD Domain

Targeting HER2 Expressing Tumors with a Potent Drug Conjugate Based on an Albumin Binding Domain-Derived Affinity Protein

Garousi, Javad; Ding, Haozhong; von Witting, Emma; Xu, Tianqi et al.

Ingår i Pharmaceutics, 2021

• DOI för Targeting HER2 Expressing Tumors with a Potent Drug Conjugate Based on an Albumin Binding Domain-Derived Affinity Protein
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Drug Conjugates Based on a Monovalent Affibody Targeting Vector Can Efficiently Eradicate HER2 Positive Human Tumors in an Experimental Mouse Model

Xu, Tianqi; Ding, Haozhong; Vorobyeva, Anzhelika; Oroujeni, Maryam et al.

Ingår i Cancers, 2021

• DOI för Drug Conjugates Based on a Monovalent Affibody Targeting Vector Can Efficiently Eradicate HER2 Positive Human Tumors in an Experimental Mouse Model
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Affibody-Derived Drug Conjugates Targeting HER2: Effect of Drug Load on Cytotoxicity and Biodistribution

Ding, Haozhong; Xu, Tianqi; Zhang, Jie; Tolmachev, Vladimir et al.

Ingår i Pharmaceutics, 2021

• DOI för Affibody-Derived Drug Conjugates Targeting HER2: Effect of Drug Load on Cytotoxicity and Biodistribution
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The Influence of Domain Permutations of an Albumin-Binding Domain-Fused HER2-Targeting Affibody-Based Drug Conjugate on Tumor Cell Proliferation and Therapy Efficacy

Yin, Wen; Xu, Tianqi; Altai, Mohamed; Oroujeni, Maryam et al.

Ingår i Pharmaceutics, 2021

• DOI för The Influence of Domain Permutations of an Albumin-Binding Domain-Fused HER2-Targeting Affibody-Based Drug Conjugate on Tumor Cell Proliferation and Therapy Efficacy
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The Use of a Non-Conventional Long-Lived Gallium Radioisotope ⁶⁶Ga Improves Imaging Contrast of EGFR Expression in Malignant Tumours Using DFO-ZEGFR: 2377 Affibody Molecule

Oroujeni, Maryam; Xu, Tianqi; Gagnon, Katherine; Rinne, Sara S. et al.

Ingår i Pharmaceutics, 2021

• DOI för The Use of a Non-Conventional Long-Lived Gallium Radioisotope ⁶⁶Ga Improves Imaging Contrast of EGFR Expression in Malignant Tumours Using DFO-ZEGFR: 2377 Affibody Molecule
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Influence of the Position and Composition of Radiometals and Radioiodine Labels on Imaging of Epcam Expression in Prostate Cancer Model Using the DARPin Ec1

Deyev, Sergey M.; Xu, Tianqi; Liu, Yongsheng; Schulga, Alexey et al.

Ingår i Cancers, 2021

• DOI för Influence of the Position and Composition of Radiometals and Radioiodine Labels on Imaging of Epcam Expression in Prostate Cancer Model Using the DARPin Ec1
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Imaging-Guided Therapy Simultaneously Targeting HER2 and EpCAM with Trastuzumab and EpCAM-Directed Toxin Provides Additive Effect in Ovarian Cancer Model

Xu, Tianqi; Vorobyeva, Anzhelika; Schulga, Alexey; Konovalova, Elena et al.

Ingår i Cancers, 2021

• DOI för Imaging-Guided Therapy Simultaneously Targeting HER2 and EpCAM with Trastuzumab and EpCAM-Directed Toxin Provides Additive Effect in Ovarian Cancer Model
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Comparative Evaluation of Novel Lu-177-Labeled PNA Probes for Affibody-Mediated PNA-Based Pretargeting

Tano, Hanna; Oroujeni, Maryam; Vorobyeva, Anzhelika; Westerlund, Kristina et al.

Ingår i Cancers, 2021

• DOI för Comparative Evaluation of Novel Lu-177-Labeled PNA Probes for Affibody-Mediated PNA-Based Pretargeting
• Ladda ner fulltext (pdf) av Comparative Evaluation of Novel Lu-177-Labeled PNA Probes for Affibody-Mediated PNA-Based Pretargeting

HER2-Specific Pseudomonas Exotoxin A PE25 Based Fusions: Influence of Targeting Domain on Target Binding, Toxicity, and In Vivo Biodistribution

Ding, Haozhong; Altai, Mohamed; Yin, Wen; Lindbo, Sarah et al.

Ingår i Pharmaceutics, 2020

• DOI för HER2-Specific Pseudomonas Exotoxin A PE25 Based Fusions: Influence of Targeting Domain on Target Binding, Toxicity, and In Vivo Biodistribution
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Influence of Residualizing Properties of the Radiolabel on Radionuclide Molecular Imaging of HER3 Using Affibody Molecules

Rinne, Sara S.; Xu, Tianqi; Leitao, Charles Dahlsson; Stahl, Stefan et al.

Ingår i International Journal of Molecular Sciences, 2020

• DOI för Influence of Residualizing Properties of the Radiolabel on Radionuclide Molecular Imaging of HER3 Using Affibody Molecules
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Investigation of a Pharmacological Approach for Reduction of Renal Uptake of Radiolabeled ADAPT Scaffold Protein

Vorobyeva, Anzhelika; Oroujeni, Maryam; Lindbo, Sarah; Hober, Sophia et al.

Ingår i Molecules, 2020

• DOI för Investigation of a Pharmacological Approach for Reduction of Renal Uptake of Radiolabeled ADAPT Scaffold Protein
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Feasibility of Imaging EpCAM Expression in Ovarian Cancer Using Radiolabeled DARPin Ec1

Vorobyeva, Anzhelika; Konovalova, Elena; Xu, Tianqi; Schulga, Alexey et al.

Ingår i International Journal of Molecular Sciences, 2020

• DOI för Feasibility of Imaging EpCAM Expression in Ovarian Cancer Using Radiolabeled DARPin Ec1
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Scaffold Protein-based Theranostics of HER2-overexpressing Ovarian Cancer: Imaging-guided Therapy

Xu, Tianqi

2024

• Ladda ner fulltext (pdf) av Scaffold Protein-based Theranostics of HER2-overexpressing Ovarian Cancer: Imaging-guided Therapy