Joëlle Rüegg
Professor vid Institutionen för organismbiologi; Fysiologi och miljötoxikologi
- Telefon:
- 073-712 15 92
- E-post:
- joelle.ruegg@ebc.uu.se
- Besöksadress:
- Evolutionsbiologiskt Centrum EBC
Norbyvägen 18 A - Postadress:
- Norbyvägen 18 A
752 36 Uppsala
Prefekt vid Institutionen för organismbiologi
- Besöksadress:
- Evolutionsbiologiskt Centrum EBC
Norbyvägen 18 A - Postadress:
- Norbyvägen 18 A
752 36 Uppsala
Ladda ned kontaktuppgifter för Joëlle Rüegg vid Institutionen för organismbiologi
- ORCID:
- 0000-0002-6580-9201
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Kort presentation
Min forskning fokuserar på hur hormonstörande ämnen, dvs. kemikalier som interfererar med vårt hormonsystem, påverkar hjärnutvecklingen. Jag samverkar i multidisciplinära projekt för att kunna förstå ämnens hela komplexitet genom att länka molekylära mekanismer med human hälsa, och för att ta vetenskapliga insikter vidare till regulatoriska och politiska beslut. Jag är koordinator av ett sådant projekt, Horizon 2020-finanisierade ENDpoiNTs. Läs mer om min forskning här.
Nyckelord
- blood brain barrier
- chemical mixtures
- endocrine disruptors
- epigenetics
- molecular toxicology
- neurodevelopmental disorders
Biografi
Denna text finns inte på svenska, därför visas den engelska versionen.
Diploma in Biochemistry, University of Zürich (1994-1999)
MSc in Neuroscience, University of Edinburgh (1999-2000)
PhD Ludwig Maximilian University München, (2000-2004)
Docent in Toxicology, Karolinska Institutet 2018
Professor in Environmental Toxicology, Uppsala University 2019Forskning
My research focusses on the question how early life exposure to endocrine disrupting chemicals (EDCs) affects human (neuro)development via epigenetic changes, i.e. long-lasting changes in gene regulation that do not involve alteration in the DNA sequence. In the Molecular Toxicology and Epigenetics group, we are working on four main projects:
- ENDpoiNTs, a H2020-funded research and innovation action including 16 participants, that aims at developing novel testing methods and strategies to identify chemicals that affect neurodevelopment via endocrine disrupting mechanisms.
- RACH-Mix, a Formas-funded project where we identify epigenetic changes induced by chemical mixtures and address their value as early markers for human exposure-linked disease risk.
- The Formas-funded BBB project, in which we investigate the effect of EDCs on the human blood-brain barrier using advanced in vitro models, and link our results to epidemiological findings.
Publikationer
Senaste publikationer
- Retrospective Detection of Ophidiomyces ophidiicola from Snake Moults Collected in Bieszczady Mountains, Poland (2024)
- New approach methods to assess developmental and adult neurotoxicity for regulatory use (2024)
- DNA methylation at DLGAP2 and risk for relapse in alcohol dependence during acamprosate treatment (2024)
- Gender-specific play behavior in relation to autistic traits and behavioral difficulties at the age of seven in the SELMA study (2024)
- Epigenetics of methylmercury (2023)
Alla publikationer
Artiklar
- Retrospective Detection of Ophidiomyces ophidiicola from Snake Moults Collected in Bieszczady Mountains, Poland (2024)
- New approach methods to assess developmental and adult neurotoxicity for regulatory use (2024)
- DNA methylation at DLGAP2 and risk for relapse in alcohol dependence during acamprosate treatment (2024)
- Gender-specific play behavior in relation to autistic traits and behavioral difficulties at the age of seven in the SELMA study (2024)
- Epigenetics of methylmercury (2023)
- Innovative tools and methods for toxicity testing within PARC work package 5 on hazard assessment (2023)
- A human-relevant mixture of endocrine disrupting chemicals induces changes in hippocampal DNA methylation correlating with hyperactive behavior in male mice (2023)
- Present and future challenges for the investigation of transgenerational epigenetic inheritance (2023)
- Endocrine Disrupting Chemicals and Hippocampal Development (2023)
- Pilot survey reveals ophidiomycosis in dice snakes Natrix tessellata from Lake Garda, Italy (2023)
- From Cohort to Cohort (2023)
- Prenatal exposure to phthalates and gender-specific play behavior at seven years of age in the SELMA study (2023)
- From cohorts to molecules (2022)
- Impact of endocrine disrupting chemicals on neurodevelopment (2022)
- Methylmercury-induced DNA methylation-From epidemiological observations to experimental evidence (2022)
- Bovine oocyte exposure to perfluorohexane sulfonate (PFHxS) induces phenotypic, transcriptomic, and DNA methylation changes in resulting embryos in vitro (2022)
- A Mixture of Endocrine Disrupting Chemicals Associated with Lower Birth Weight in Children Induces Adipogenesis and DNA Methylation Changes in Human Mesenchymal Stem Cells (2022)
- Zeitotox (2022)
- The insecticide permethrin induces transgenerational behavioral changes linked to transcriptomic and epigenetic alterations in zebrafish (Danio rerio) (2021)
- Prenatal exposure to bisphenols and cognitive function in children at 7 years of age in the Swedish SELMA study (2021)
- Prenatal methylmercury exposure and DNA methylation in seven-year-old children in the Seychelles Child Development Study (2021)
- Childhood adversity increases methylation in the GRIN2B gene (2021)
- DNA methylation at GRIN2B partially mediates the association between prenatal bisphenol F exposure and cognitive functions in 7-year-old children in the SELMA study (2021)
- Bisphenol A Inhibits the Transporter Function of the Blood-Brain Barrier by Directly Interacting with the ABC Transporter Breast Cancer Resistance Protein (BCRP) (2021)
- Perfluorooctane sulfonate (PFOS) exposure of bovine oocytes affects early embryonic development at human-relevant levels in an in vitro model (2021)
- Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment (2020)
- The ENDpoiNTs Project (2020)
- Long term transcriptional and behavioral effects in mice developmentally exposed to a mixture of endocrine disruptors associated with delayed human neurodevelopment (2020)
- Effects of a synbiotic on symptoms, and daily functioning in attention deficit hyperactivity disorder - A double-blind randomized controlled (2020)
- Template for the Description of Cell-Based Toxicological Test Methods to Allow Evaluation and Regulatory Use of the Data (2019)
- The C17.2 cell line as testing system for endocrine disruption-induced developmental neurotoxicity
- The pesticides endosulfan and cypermethrin affect neuronal differentiation via retinoic and peroxisome proliferator receptor activity