Joëlle Rüegg
Affilierad Professor vid Institutet för framtidsinriktad och tvärgående forskning (UUniFI); Institutet för forskning om målkonflikter i hållbar samhällsomställning, UUniCORN
- E-post:
- joelle.ruegg@ebc.uu.se
- Besöksadress:
- Segerstedthuset, Dag Hammarskjölds v 7
751 05 Uppsala - Postadress:
- Box 256
751 05 Uppsala
Prefekt vid Institutionen för organismbiologi
- Telefon:
- 018-471 61 64
- E-post:
- joelle.ruegg@ebc.uu.se
- Besöksadress:
- Evolutionsbiologiskt Centrum EBC
Norbyvägen 18 A - Postadress:
- Norbyvägen 18 A
752 36 Uppsala
Ladda ned kontaktuppgifter för Joëlle Rüegg vid Institutionen för organismbiologi
Professor vid Institutionen för organismbiologi; Fysiologi och miljötoxikologi
- Telefon:
- 073-712 15 92, 018-471 61 64
- E-post:
- joelle.ruegg@ebc.uu.se
- Besöksadress:
- Evolutionsbiologiskt Centrum EBC
Norbyvägen 18 A - Postadress:
- Norbyvägen 18 A
752 36 Uppsala
- ORCID:
- 0000-0002-6580-9201
Kort presentation
Min forskning fokuserar på hur hormonstörande ämnen, dvs. kemikalier som interfererar med vårt hormonsystem, påverkar hjärnutvecklingen. Jag samverkar i multidisciplinära projekt för att kunna förstå ämnens hela komplexitet genom att länka molekylära mekanismer med human hälsa, och för att ta vetenskapliga insikter vidare till regulatoriska och politiska beslut. Jag är koordinator av ett sådant projekt, Horizon 2020-finanisierade ENDpoiNTs. Läs mer om min forskning här.
Nyckelord
- epigenetics
- blood brain barrier
- neurodevelopmental disorders
- endocrine disruptors
- molecular toxicology
- chemical mixtures
Forskning
My research focusses on the question how early life exposure to endocrine disrupting chemicals (EDCs) affects human (neuro)development via epigenetic changes, i.e. long-lasting changes in gene regulation that do not involve alteration in the DNA sequence. In the Molecular Toxicology and Epigenetics group, we are working on four main projects:
- ENDpoiNTs, a H2020-funded research and innovation action including 16 participants, that aims at developing novel testing methods and strategies to identify chemicals that affect neurodevelopment via endocrine disrupting mechanisms.
- RACH-Mix, a Formas-funded project where we identify epigenetic changes induced by chemical mixtures and address their value as early markers for human exposure-linked disease risk.
- The Formas-funded BBB project, in which we investigate the effect of EDCs on the human blood-brain barrier using advanced in vitro models, and link our results to epidemiological findings.
Publikationer
Senaste publikationer
Ingår i Molecular Psychiatry, s. 4736-4748, 2025
- DOI för Differentially expressed transcripts associated with depressive symptoms during pregnancy and postpartum
- Ladda ner fulltext (pdf) av Differentially expressed transcripts associated with depressive symptoms during pregnancy and postpartum
Ingår i Environmental Sciences Europe, 2025
- DOI för Developmental exposure to environmentally relevant PFOS and PFBS disrupts adult behaviour, reproductive fitness, and lipid metabolism in Zebrafish
- Ladda ner fulltext (pdf) av Developmental exposure to environmentally relevant PFOS and PFBS disrupts adult behaviour, reproductive fitness, and lipid metabolism in Zebrafish
Ingår i Environmental Research, 2025
- DOI för Long-term exposure to air pollution and road traffic noise in relation to dispensed antidepressant medications: A Swedish cohort study
- Ladda ner fulltext (pdf) av Long-term exposure to air pollution and road traffic noise in relation to dispensed antidepressant medications: A Swedish cohort study
Ingår i Psychiatry Research, 2025
- DOI för Associations between autism, gender dysphoria and gender incongruence: insights from the Swedish Gender Dysphoria Study (SKDS)
- Ladda ner fulltext (pdf) av Associations between autism, gender dysphoria and gender incongruence: insights from the Swedish Gender Dysphoria Study (SKDS)
State of the Science on Assessing Developmental Neurotoxicity Using New Approach Methods
Ingår i Altex, s. 121-144, 2025
- DOI för State of the Science on Assessing Developmental Neurotoxicity Using New Approach Methods
- Ladda ner fulltext (pdf) av State of the Science on Assessing Developmental Neurotoxicity Using New Approach Methods
Alla publikationer
Artiklar i tidskrift
Ingår i Molecular Psychiatry, s. 4736-4748, 2025
- DOI för Differentially expressed transcripts associated with depressive symptoms during pregnancy and postpartum
- Ladda ner fulltext (pdf) av Differentially expressed transcripts associated with depressive symptoms during pregnancy and postpartum
Ingår i Environmental Sciences Europe, 2025
- DOI för Developmental exposure to environmentally relevant PFOS and PFBS disrupts adult behaviour, reproductive fitness, and lipid metabolism in Zebrafish
- Ladda ner fulltext (pdf) av Developmental exposure to environmentally relevant PFOS and PFBS disrupts adult behaviour, reproductive fitness, and lipid metabolism in Zebrafish
Ingår i Environmental Research, 2025
- DOI för Long-term exposure to air pollution and road traffic noise in relation to dispensed antidepressant medications: A Swedish cohort study
- Ladda ner fulltext (pdf) av Long-term exposure to air pollution and road traffic noise in relation to dispensed antidepressant medications: A Swedish cohort study
Ingår i Psychiatry Research, 2025
- DOI för Associations between autism, gender dysphoria and gender incongruence: insights from the Swedish Gender Dysphoria Study (SKDS)
- Ladda ner fulltext (pdf) av Associations between autism, gender dysphoria and gender incongruence: insights from the Swedish Gender Dysphoria Study (SKDS)
State of the Science on Assessing Developmental Neurotoxicity Using New Approach Methods
Ingår i Altex, s. 121-144, 2025
- DOI för State of the Science on Assessing Developmental Neurotoxicity Using New Approach Methods
- Ladda ner fulltext (pdf) av State of the Science on Assessing Developmental Neurotoxicity Using New Approach Methods
Ingår i Altex, s. 91-110, 2025
- DOI för Characterization of the C17.2 Cell Line as Test System for Endocrine Disruption-Induced Developmental Neurotoxicity
- Ladda ner fulltext (pdf) av Characterization of the C17.2 Cell Line as Test System for Endocrine Disruption-Induced Developmental Neurotoxicity
Ingår i PLOS ONE, 2024
- DOI för Gender-specific play behavior in relation to autistic traits and behavioral difficulties at the age of seven in the SELMA study
- Ladda ner fulltext (pdf) av Gender-specific play behavior in relation to autistic traits and behavioral difficulties at the age of seven in the SELMA study
Ingår i International Journal of Molecular Sciences, 2024
- DOI för Prenatal Exposure to a Human Relevant Mixture of Endocrine-Disrupting Chemicals Affects Mandibular Development in Mice
- Ladda ner fulltext (pdf) av Prenatal Exposure to a Human Relevant Mixture of Endocrine-Disrupting Chemicals Affects Mandibular Development in Mice
Ingår i Microorganisms, 2024
- DOI för Retrospective Detection of Ophidiomyces ophidiicola from Snake Moults Collected in Bieszczady Mountains, Poland
- Ladda ner fulltext (pdf) av Retrospective Detection of Ophidiomyces ophidiicola from Snake Moults Collected in Bieszczady Mountains, Poland
Ingår i Frontiers in Toxicology, 2024
- DOI för New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project
- Ladda ner fulltext (pdf) av New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project
DNA methylation at DLGAP2 and risk for relapse in alcohol dependence during acamprosate treatment
Ingår i Drug And Alcohol Dependence, 2024
- DOI för DNA methylation at DLGAP2 and risk for relapse in alcohol dependence during acamprosate treatment
- Ladda ner fulltext (pdf) av DNA methylation at DLGAP2 and risk for relapse in alcohol dependence during acamprosate treatment
Ingår i Environment International, 2023
- DOI för Prenatal exposure to phthalates and gender-specific play behavior at seven years of age in the SELMA study
- Ladda ner fulltext (pdf) av Prenatal exposure to phthalates and gender-specific play behavior at seven years of age in the SELMA study
Ingår i Neurotoxicology, s. 34-46, 2023
Ingår i Chemosphere, 2023
- DOI för A human-relevant mixture of endocrine disrupting chemicals induces changes in hippocampal DNA methylation correlating with hyperactive behavior in male mice
- Ladda ner fulltext (pdf) av A human-relevant mixture of endocrine disrupting chemicals induces changes in hippocampal DNA methylation correlating with hyperactive behavior in male mice
Ingår i Neuroendocrinology, s. 1193-1214, 2023
Ingår i Toxics, 2023
- DOI för From Cohort to Cohort: A Similar Mixture Approach (SMACH) to Evaluate Exposures to a Mixture Leading to Thyroid-Mediated Neurodevelopmental Effects Using NHANES Data
- Ladda ner fulltext (pdf) av From Cohort to Cohort: A Similar Mixture Approach (SMACH) to Evaluate Exposures to a Mixture Leading to Thyroid-Mediated Neurodevelopmental Effects Using NHANES Data
Pilot survey reveals ophidiomycosis in dice snakes Natrix tessellata from Lake Garda, Italy
Ingår i Veterinary research communications, s. 1707-1719, 2023
- DOI för Pilot survey reveals ophidiomycosis in dice snakes Natrix tessellata from Lake Garda, Italy
- Ladda ner fulltext (pdf) av Pilot survey reveals ophidiomycosis in dice snakes Natrix tessellata from Lake Garda, Italy
Ingår i Reproductive Toxicology, s. 19-30, 2022
- DOI för Bovine oocyte exposure to perfluorohexane sulfonate (PFHxS) induces phenotypic, transcriptomic, and DNA methylation changes in resulting embryos in vitro
- Ladda ner fulltext (pdf) av Bovine oocyte exposure to perfluorohexane sulfonate (PFHxS) induces phenotypic, transcriptomic, and DNA methylation changes in resulting embryos in vitro
Methylmercury-induced DNA methylation-From epidemiological observations to experimental evidence
Ingår i Frontiers in Genetics, 2022
- DOI för Methylmercury-induced DNA methylation-From epidemiological observations to experimental evidence
- Ladda ner fulltext (pdf) av Methylmercury-induced DNA methylation-From epidemiological observations to experimental evidence
Ingår i International Journal of Molecular Sciences, 2022
- DOI för A Mixture of Endocrine Disrupting Chemicals Associated with Lower Birth Weight in Children Induces Adipogenesis and DNA Methylation Changes in Human Mesenchymal Stem Cells
- Ladda ner fulltext (pdf) av A Mixture of Endocrine Disrupting Chemicals Associated with Lower Birth Weight in Children Induces Adipogenesis and DNA Methylation Changes in Human Mesenchymal Stem Cells
Ingår i EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM, s. 131-141, 2022
- DOI för Impact of endocrine disrupting chemicals on neurodevelopment: the need for better testing strategies for endocrine disruption-induced developmental neurotoxicity
- Ladda ner fulltext (pdf) av Impact of endocrine disrupting chemicals on neurodevelopment: the need for better testing strategies for endocrine disruption-induced developmental neurotoxicity
From cohorts to molecules: Adverse impacts of endocrine disrupting mixtures
Ingår i Science, 2022
Zeitotox: Toxicology and the Rhythms of Life
Ingår i Environmental Science and Technology, s. 11100-11102, 2022
- DOI för Zeitotox: Toxicology and the Rhythms of Life
- Ladda ner fulltext (pdf) av Zeitotox: Toxicology and the Rhythms of Life
Ingår i Toxicology, 2021
- DOI för Perfluorooctane sulfonate (PFOS) exposure of bovine oocytes affects early embryonic development at human-relevant levels in an in vitro model
- Ladda ner fulltext (pdf) av Perfluorooctane sulfonate (PFOS) exposure of bovine oocytes affects early embryonic development at human-relevant levels in an in vitro model
Ingår i Environment International, 2021
- DOI för Prenatal methylmercury exposure and DNA methylation in seven-year-old children in the Seychelles Child Development Study
- Ladda ner fulltext (pdf) av Prenatal methylmercury exposure and DNA methylation in seven-year-old children in the Seychelles Child Development Study
Ingår i Science of the Total Environment, 2021
Ingår i Environment International, 2021
- DOI för Prenatal exposure to bisphenols and cognitive function in children at 7 years of age in the Swedish SELMA study
- Ladda ner fulltext (pdf) av Prenatal exposure to bisphenols and cognitive function in children at 7 years of age in the Swedish SELMA study
Ingår i Environment International, 2021
- DOI för DNA methylation at GRIN2B partially mediates the association between prenatal bisphenol F exposure and cognitive functions in 7-year-old children in the SELMA study
- Ladda ner fulltext (pdf) av DNA methylation at GRIN2B partially mediates the association between prenatal bisphenol F exposure and cognitive functions in 7-year-old children in the SELMA study
Ingår i International Journal of Molecular Sciences, 2021
- DOI för Bisphenol A Inhibits the Transporter Function of the Blood-Brain Barrier by Directly Interacting with the ABC Transporter Breast Cancer Resistance Protein (BCRP)
- Ladda ner fulltext (pdf) av Bisphenol A Inhibits the Transporter Function of the Blood-Brain Barrier by Directly Interacting with the ABC Transporter Breast Cancer Resistance Protein (BCRP)
Childhood adversity increases methylation in the GRIN2B gene
Ingår i Journal of Psychiatric Research, s. 38-43, 2021
- DOI för Childhood adversity increases methylation in the GRIN2B gene
- Ladda ner fulltext (pdf) av Childhood adversity increases methylation in the GRIN2B gene
Ingår i International Journal of Molecular Sciences, 2020
- DOI för The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity
- Ladda ner fulltext (pdf) av The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity
Ingår i Scientific Reports, 2020
- DOI för Long term transcriptional and behavioral effects in mice developmentally exposed to a mixture of endocrine disruptors associated with delayed human neurodevelopment
- Ladda ner fulltext (pdf) av Long term transcriptional and behavioral effects in mice developmentally exposed to a mixture of endocrine disruptors associated with delayed human neurodevelopment
Ingår i Brain, behavior, and immunity, s. 9-19, 2020
- DOI för Effects of a synbiotic on symptoms, and daily functioning in attention deficit hyperactivity disorder - A double-blind randomized controlled
- Ladda ner fulltext (pdf) av Effects of a synbiotic on symptoms, and daily functioning in attention deficit hyperactivity disorder - A double-blind randomized controlled
Ingår i Environment International, 2020
- DOI för Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment
- Ladda ner fulltext (pdf) av Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment
Ingår i Altex, s. 682-699, 2019
- DOI för Template for the Description of Cell-Based Toxicological Test Methods to Allow Evaluation and Regulatory Use of the Data
- Ladda ner fulltext (pdf) av Template for the Description of Cell-Based Toxicological Test Methods to Allow Evaluation and Regulatory Use of the Data
Artiklar, forskningsöversikt
Present and future challenges for the investigation of transgenerational epigenetic inheritance
Ingår i Environment International, 2023
- DOI för Present and future challenges for the investigation of transgenerational epigenetic inheritance
- Ladda ner fulltext (pdf) av Present and future challenges for the investigation of transgenerational epigenetic inheritance
Innovative tools and methods for toxicity testing within PARC work package 5 on hazard assessment
Ingår i Frontiers in Toxicology, 2023
- DOI för Innovative tools and methods for toxicity testing within PARC work package 5 on hazard assessment
- Ladda ner fulltext (pdf) av Innovative tools and methods for toxicity testing within PARC work package 5 on hazard assessment
Kapitel i böcker, delar av antologi
Prenatal Exposure to Endocrine Disrupting Chemicals and Their Effect on Health Later in Life
Ingår i Beyond Our Genes, s. 53-77, Springer Nature, 2020