Panagiotis Kanellopoulos

Preclinical Evaluation of a ¹⁷⁷Lu-Labeled Gastrin-Releasing Peptide Receptor Antagonist and Prostate Cancer Treatment with Monotherapy and in Combination with Everolimus

Kumar, Naveen; Bilinska, Adrianna; Menéndez, Elena; Läppchen, Tilman et al.

Ingår i ACS Pharmacology & Translational Science, s. 59-68, 2026

• DOI för Preclinical Evaluation of a ¹⁷⁷Lu-Labeled Gastrin-Releasing Peptide Receptor Antagonist and Prostate Cancer Treatment with Monotherapy and in Combination with Everolimus
• Ladda ner fulltext (pdf) av Preclinical Evaluation of a ¹⁷⁷Lu-Labeled Gastrin-Releasing Peptide Receptor Antagonist and Prostate Cancer Treatment with Monotherapy and in Combination with Everolimus

Exploring the theranostic potential of two metabolically stable GRPR-targeting peptides labelled with Ga-68 for PET imaging

Obeid, Karim; Bezverkhniaia, Ekaterina; Tolmachev, Vladimir M.; Orlova, Anna et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2026

• DOI för Exploring the theranostic potential of two metabolically stable GRPR-targeting peptides labelled with Ga-68 for PET imaging
• Ladda ner fulltext (pdf) av Exploring the theranostic potential of two metabolically stable GRPR-targeting peptides labelled with Ga-68 for PET imaging

Linker modifications in radiolabeled RM26-based antagonists to gastrin-releasing peptide receptor (GRPR) improved tracers' pharmacokinetics

Bezverkhniaia, Ekaterina; Abouzayed, Ayman; Kanellopoulos, Panagiotis; Tolmachev, Vladimir M. et al.

Ingår i European Journal of Pharmaceutical Sciences, 2025

• DOI för Linker modifications in radiolabeled RM26-based antagonists to gastrin-releasing peptide receptor (GRPR) improved tracers' pharmacokinetics
• Ladda ner fulltext (pdf) av Linker modifications in radiolabeled RM26-based antagonists to gastrin-releasing peptide receptor (GRPR) improved tracers' pharmacokinetics

Reduction of negative charge in mercaptoacetyl-based chelators influences the biodistribution of prostate-specific membrane antigen-targeting pseudopeptides labeled with technetium-99m

Bezverkhniaia, Ekaterina; Kanellopoulos, Panagiotis; Rosenström, Ulrika; Tolmachev, Vladimir M. et al.

Ingår i ACS Pharmacology & Translational Science, s. 3600-3612, 2025

• DOI för Reduction of negative charge in mercaptoacetyl-based chelators influences the biodistribution of prostate-specific membrane antigen-targeting pseudopeptides labeled with technetium-99m
• Ladda ner fulltext (pdf) av Reduction of negative charge in mercaptoacetyl-based chelators influences the biodistribution of prostate-specific membrane antigen-targeting pseudopeptides labeled with technetium-99m

Improving GRPR-targeting peptides for radiotheranostics application: insights from chelator modifications and α-methyl-L tryptophan substitution.

Obeid, Karim; Bezverkhniaia, Ekaterina; Tolmachev, Vladimir M.; Orlova, Anna et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2025

• DOI för Improving GRPR-targeting peptides for radiotheranostics application: insights from chelator modifications and α-methyl-L tryptophan substitution.
• Ladda ner fulltext (pdf) av Improving GRPR-targeting peptides for radiotheranostics application: insights from chelator modifications and α-methyl-L tryptophan substitution.

Preclinical Evaluation of a ¹⁷⁷Lu-Labeled Gastrin-Releasing Peptide Receptor Antagonist and Prostate Cancer Treatment with Monotherapy and in Combination with Everolimus

Kumar, Naveen; Bilinska, Adrianna; Menéndez, Elena; Läppchen, Tilman et al.

Ingår i ACS Pharmacology & Translational Science, s. 59-68, 2026

• DOI för Preclinical Evaluation of a ¹⁷⁷Lu-Labeled Gastrin-Releasing Peptide Receptor Antagonist and Prostate Cancer Treatment with Monotherapy and in Combination with Everolimus
• Ladda ner fulltext (pdf) av Preclinical Evaluation of a ¹⁷⁷Lu-Labeled Gastrin-Releasing Peptide Receptor Antagonist and Prostate Cancer Treatment with Monotherapy and in Combination with Everolimus

Exploring the theranostic potential of two metabolically stable GRPR-targeting peptides labelled with Ga-68 for PET imaging

Obeid, Karim; Bezverkhniaia, Ekaterina; Tolmachev, Vladimir M.; Orlova, Anna et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2026

• DOI för Exploring the theranostic potential of two metabolically stable GRPR-targeting peptides labelled with Ga-68 for PET imaging
• Ladda ner fulltext (pdf) av Exploring the theranostic potential of two metabolically stable GRPR-targeting peptides labelled with Ga-68 for PET imaging

Linker modifications in radiolabeled RM26-based antagonists to gastrin-releasing peptide receptor (GRPR) improved tracers' pharmacokinetics

Bezverkhniaia, Ekaterina; Abouzayed, Ayman; Kanellopoulos, Panagiotis; Tolmachev, Vladimir M. et al.

Ingår i European Journal of Pharmaceutical Sciences, 2025

• DOI för Linker modifications in radiolabeled RM26-based antagonists to gastrin-releasing peptide receptor (GRPR) improved tracers' pharmacokinetics
• Ladda ner fulltext (pdf) av Linker modifications in radiolabeled RM26-based antagonists to gastrin-releasing peptide receptor (GRPR) improved tracers' pharmacokinetics

Reduction of negative charge in mercaptoacetyl-based chelators influences the biodistribution of prostate-specific membrane antigen-targeting pseudopeptides labeled with technetium-99m

Bezverkhniaia, Ekaterina; Kanellopoulos, Panagiotis; Rosenström, Ulrika; Tolmachev, Vladimir M. et al.

Ingår i ACS Pharmacology & Translational Science, s. 3600-3612, 2025

• DOI för Reduction of negative charge in mercaptoacetyl-based chelators influences the biodistribution of prostate-specific membrane antigen-targeting pseudopeptides labeled with technetium-99m
• Ladda ner fulltext (pdf) av Reduction of negative charge in mercaptoacetyl-based chelators influences the biodistribution of prostate-specific membrane antigen-targeting pseudopeptides labeled with technetium-99m

Improving GRPR-targeting peptides for radiotheranostics application: insights from chelator modifications and α-methyl-L tryptophan substitution.

Obeid, Karim; Bezverkhniaia, Ekaterina; Tolmachev, Vladimir M.; Orlova, Anna et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2025

• DOI för Improving GRPR-targeting peptides for radiotheranostics application: insights from chelator modifications and α-methyl-L tryptophan substitution.
• Ladda ner fulltext (pdf) av Improving GRPR-targeting peptides for radiotheranostics application: insights from chelator modifications and α-methyl-L tryptophan substitution.

Phase I Clinical Study with the GRPR-Antagonist [^99mTc]Tc-DB8 for SPECT Imaging of Prostate Cancer: Does the Injected Peptide Mass Make a Difference?

Orlova, Anna; Rybina, Anastasia; Medvedeva, Anna; Zelchan, Roman et al.

Ingår i Pharmaceutics, 2025

• DOI för Phase I Clinical Study with the GRPR-Antagonist [^99mTc]Tc-DB8 for SPECT Imaging of Prostate Cancer: Does the Injected Peptide Mass Make a Difference?
• Ladda ner fulltext (pdf) av Phase I Clinical Study with the GRPR-Antagonist [^99mTc]Tc-DB8 for SPECT Imaging of Prostate Cancer: Does the Injected Peptide Mass Make a Difference?

The Impact of the Injected Mass of the Gastrin-Releasing Peptide Receptor Antagonist on Uptake in Breast Cancer: Lessons from a Phase I Trial of [99mTc]Tc-DB8

Bragina, Olga; Chernov, Vladimir; Larkina, Mariia; Varvashenya, Ruslan et al.

Ingår i Pharmaceutics, 2025

• DOI för The Impact of the Injected Mass of the Gastrin-Releasing Peptide Receptor Antagonist on Uptake in Breast Cancer: Lessons from a Phase I Trial of [99mTc]Tc-DB8
• Ladda ner fulltext (pdf) av The Impact of the Injected Mass of the Gastrin-Releasing Peptide Receptor Antagonist on Uptake in Breast Cancer: Lessons from a Phase I Trial of [99mTc]Tc-DB8

A preclinical study on the influence of linkers in [⁶⁸Ga]Ga-NOTA-X-RM26 radiotracers for PET imaging of GRPR expression

Olaniran Håkansson, Esther; Zelepukin, Ivan V.; Obeid, Karim; Bitzios, Athanasios et al.

Ingår i EJNMMI Research, 2025

• DOI för A preclinical study on the influence of linkers in [⁶⁸Ga]Ga-NOTA-X-RM26 radiotracers for PET imaging of GRPR expression
• Ladda ner fulltext (pdf) av A preclinical study on the influence of linkers in [⁶⁸Ga]Ga-NOTA-X-RM26 radiotracers for PET imaging of GRPR expression

RM2 and DB15 analogues bearing [¹⁷⁷Lu]Lu-DOTAGA via different linkers, as radiotherapeutics: a head-to-head comparative study

Kanellopoulos, Panagiotis; Bitzios, Athanasios; Zelepukin, Ivan; Bezverkhniaia, Ekaterina et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2025

• DOI för RM2 and DB15 analogues bearing [¹⁷⁷Lu]Lu-DOTAGA via different linkers, as radiotherapeutics: a head-to-head comparative study
• Ladda ner fulltext (pdf) av RM2 and DB15 analogues bearing [¹⁷⁷Lu]Lu-DOTAGA via different linkers, as radiotherapeutics: a head-to-head comparative study

Synthesis and preclinical evaluation of gastrin releasing peptide receptor antagonist [¹⁸F]MeTz-PEG2-RM26 for positron emission tomography

Kanellopoulos, Panagiotis; Lundmark, Fanny; Abouzayed, Ayman; Balestri, Lorenzo Jacopo Ilic et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2025

• DOI för Synthesis and preclinical evaluation of gastrin releasing peptide receptor antagonist [¹⁸F]MeTz-PEG2-RM26 for positron emission tomography
• Ladda ner fulltext (pdf) av Synthesis and preclinical evaluation of gastrin releasing peptide receptor antagonist [¹⁸F]MeTz-PEG2-RM26 for positron emission tomography

Evaluation of maSSS/maSES-PEG2-RM26 for their potential therapeutic use after labeling with Re-188. Could their [^99mTc]Tc-labeled counterparts be used to estimate dosimetry?

Kanellopoulos, Panagiotis; Yu, Quanyi; Abouzayed, Abouzayed; Bezverkhniaia, Ekaterina et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2025

• DOI för Evaluation of maSSS/maSES-PEG2-RM26 for their potential therapeutic use after labeling with Re-188. Could their [^99mTc]Tc-labeled counterparts be used to estimate dosimetry?
• Ladda ner fulltext (pdf) av Evaluation of maSSS/maSES-PEG2-RM26 for their potential therapeutic use after labeling with Re-188. Could their [^99mTc]Tc-labeled counterparts be used to estimate dosimetry?

Evaluation of ABD-Linked RM26 Conjugates for GRPR-Targeted Drug Delivery

Nagy, Abel; Abouzayed, Ayman; Kanellopoulos, Panagiotis; Landmark, Fredrika et al.

Ingår i ACS Omega, s. 36122-36133, 2024

• DOI för Evaluation of ABD-Linked RM26 Conjugates for GRPR-Targeted Drug Delivery
• Ladda ner fulltext (pdf) av Evaluation of ABD-Linked RM26 Conjugates for GRPR-Targeted Drug Delivery

GRPR-Antagonists Carrying DOTAGA-Chelator via Positively Charged Linkers: Perspectives for Prostate Cancer Theranostics

Obeid, Karim; Kanellopoulos, Panagiotis; Abouzayed, Ayman; Mattsson, Adam et al.

Ingår i Pharmaceutics, 2024

• DOI för GRPR-Antagonists Carrying DOTAGA-Chelator via Positively Charged Linkers: Perspectives for Prostate Cancer Theranostics
• Ladda ner fulltext (pdf) av GRPR-Antagonists Carrying DOTAGA-Chelator via Positively Charged Linkers: Perspectives for Prostate Cancer Theranostics

Two Novel [⁶⁸Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar¹¹]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer

Kanellopoulos, Panagiotis; Bezverkhniaia, Ekaterina; Abouzayed, Ayman; Rosenström, Ulrika et al.

Ingår i ACS Omega, s. 18608-18616, 2024

• DOI för Two Novel [⁶⁸Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar¹¹]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer
• Ladda ner fulltext (pdf) av Two Novel [⁶⁸Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar¹¹]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer

Influence of Molecular Design on the Tumor Targeting and Biodistribution of PSMA-Binding Tracers Labeled with Technetium-99m

Bezverkhniaia, Ekaterina; Kanellopoulos, Panagiotis; Rosenström, Ulrika; Tolmachev, Vladimir et al.

Ingår i International Journal of Molecular Sciences, 2024

• DOI för Influence of Molecular Design on the Tumor Targeting and Biodistribution of PSMA-Binding Tracers Labeled with Technetium-99m
• Ladda ner fulltext (pdf) av Influence of Molecular Design on the Tumor Targeting and Biodistribution of PSMA-Binding Tracers Labeled with Technetium-99m

Preclinical evaluation of new GRPR-antagonists with improved metabolic stability for radiotheranostic use in oncology

Kanellopoulos, Panagiotis; Mattsson, Adam; Abouzayed, Ayman; Obeid, Karim et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2024

• DOI för Preclinical evaluation of new GRPR-antagonists with improved metabolic stability for radiotheranostic use in oncology
• Ladda ner fulltext (pdf) av Preclinical evaluation of new GRPR-antagonists with improved metabolic stability for radiotheranostic use in oncology

Preclinical Characterization of a Stabilized Gastrin-Releasing Peptide Receptor Antagonist for Targeted Cancer Theranostics

Abouzayed, Ayman; Kanellopoulos, Panagiotis; Gorislav, Alisa; Tolmachev, Vladimir et al.

Ingår i Biomolecules, 2023

• DOI för Preclinical Characterization of a Stabilized Gastrin-Releasing Peptide Receptor Antagonist for Targeted Cancer Theranostics
• Ladda ner fulltext (pdf) av Preclinical Characterization of a Stabilized Gastrin-Releasing Peptide Receptor Antagonist for Targeted Cancer Theranostics

Preclinical Evaluation of a Novel High-Affinity Radioligand [^99mTc]Tc-BQ0413 Targeting Prostate-Specific Membrane Antigen (PSMA)

Bezverkhniaia, Ekaterina; Kanellopoulos, Panagiotis; Abouzayed, Ayman; Larkina, Mariia et al.

Ingår i International Journal of Molecular Sciences, 2023

• DOI för Preclinical Evaluation of a Novel High-Affinity Radioligand [^99mTc]Tc-BQ0413 Targeting Prostate-Specific Membrane Antigen (PSMA)
• Ladda ner fulltext (pdf) av Preclinical Evaluation of a Novel High-Affinity Radioligand [^99mTc]Tc-BQ0413 Targeting Prostate-Specific Membrane Antigen (PSMA)

Synthesis and Preclinical Evaluation of GRPR Antagonist [¹⁸F]-MeTz-PEG₂-RM26 for Position Emission Tomography

Lundmark, Fanny; Abouzayed, Ayman; Kanellopoulos, Panagiotis; Tolmachev, Vladimir et al.