Lionel Guy
Universitetslektor vid Institutionen för medicinsk biokemi och mikrobiologi; Infektioner och Immunitet; Lionel Guy
- Telefon:
- 018-471 42 46
- E-post:
- lionel.guy@imbim.uu.se
- Besöksadress:
- BMC
Husargatan 3
752 37 UPPSALA - Postadress:
- Box 582
751 23 UPPSALA
- ORCID:
- 0000-0001-8354-2398
Kort presentation
I'm an Associate Professor/Senior Lecturer at the Department of Medical Biochemistry and Microbiology. My research explores how microorganisms, particularly bacteria, adapt to hosts, and how their relationships evolve over time.
Link to my website: https://www.uu.se/en/department/medical-biochemistry-and-microbiology/research/guy-lionel
Photo credit: Chaiko & Markstedt Photography, 2022

Publikationer
Senaste publikationer
High-efficiency transfection of Acanthamoeba castellanii using a cationic polymer
Ingår i Cell Reports Methods, s. 101269-101269, 2026
Origin and evolution of key enzymes in the anammox pathway revisited
Ingår i Genome Biology and Evolution, 2026
- DOI för Origin and evolution of key enzymes in the anammox pathway revisited
- Ladda ner fulltext (pdf) av Origin and evolution of key enzymes in the anammox pathway revisited
Origin and Evolution of Key Enzymes in the Anammox Pathway Revisited
Ingår i Genome Biology and Evolution, 2025
Host-Specific Adaptation of Legionella pneumophila to Single and Multiple Hosts
Ingår i Molecular biology and evolution, 2025
- DOI för Host-Specific Adaptation of Legionella pneumophila to Single and Multiple Hosts
- Ladda ner fulltext (pdf) av Host-Specific Adaptation of Legionella pneumophila to Single and Multiple Hosts
Machine learning detection of heteroresistance in Escherichia coli
Ingår i EBioMedicine, 2025
- DOI för Machine learning detection of heteroresistance in Escherichia coli
- Ladda ner fulltext (pdf) av Machine learning detection of heteroresistance in Escherichia coli
Alla publikationer
Artiklar i tidskrift
High-efficiency transfection of Acanthamoeba castellanii using a cationic polymer
Ingår i Cell Reports Methods, s. 101269-101269, 2026
Origin and evolution of key enzymes in the anammox pathway revisited
Ingår i Genome Biology and Evolution, 2026
- DOI för Origin and evolution of key enzymes in the anammox pathway revisited
- Ladda ner fulltext (pdf) av Origin and evolution of key enzymes in the anammox pathway revisited
Origin and Evolution of Key Enzymes in the Anammox Pathway Revisited
Ingår i Genome Biology and Evolution, 2025
Host-Specific Adaptation of Legionella pneumophila to Single and Multiple Hosts
Ingår i Molecular biology and evolution, 2025
- DOI för Host-Specific Adaptation of Legionella pneumophila to Single and Multiple Hosts
- Ladda ner fulltext (pdf) av Host-Specific Adaptation of Legionella pneumophila to Single and Multiple Hosts
Machine learning detection of heteroresistance in Escherichia coli
Ingår i EBioMedicine, 2025
- DOI för Machine learning detection of heteroresistance in Escherichia coli
- Ladda ner fulltext (pdf) av Machine learning detection of heteroresistance in Escherichia coli
Ingår i Genome Biology and Evolution, 2024
- DOI för Phylogeny and Expansion of Serine/Threonine Kinases in Phagocytotic Bacteria in the Phylum Planctomycetota
- Ladda ner fulltext (pdf) av Phylogeny and Expansion of Serine/Threonine Kinases in Phagocytotic Bacteria in the Phylum Planctomycetota
The evolution of intramitochondriality in Midichloria bacteria
Ingår i Environmental Microbiology, s. 2102-2117, 2023
TADA: Taxonomy-Aware Dataset Aggregator
Ingår i Bioinformatics, 2023
- DOI för TADA: Taxonomy-Aware Dataset Aggregator
- Ladda ner fulltext (pdf) av TADA: Taxonomy-Aware Dataset Aggregator
Rapid adaptations of Legionella pneumophila to the human host
Ingår i Microbial Genomics, 2023
- DOI för Rapid adaptations of Legionella pneumophila to the human host
- Ladda ner fulltext (pdf) av Rapid adaptations of Legionella pneumophila to the human host
Host Adaptation in Legionellales Is 1.9 Ga, Coincident with Eukaryogenesis
Ingår i Molecular biology and evolution, 2022
- DOI för Host Adaptation in Legionellales Is 1.9 Ga, Coincident with Eukaryogenesis
- Ladda ner fulltext (pdf) av Host Adaptation in Legionellales Is 1.9 Ga, Coincident with Eukaryogenesis
Phylogenetic affiliation of mitochondria with Alpha-II and Rickettsiales is an artefact
Ingår i Nature Ecology & Evolution, s. 1829-1831, 2022
Early divergence of translation initiation and elongation factors
Ingår i Protein Science, 2022
- DOI för Early divergence of translation initiation and elongation factors
- Ladda ner fulltext (pdf) av Early divergence of translation initiation and elongation factors
Ingår i Frontiers in Microbiology, 2021
- DOI för Molecular Characterization of Multidrug-Resistant Yersinia enterocolitica From Foodborne Outbreaks in Sweden
- Ladda ner fulltext (pdf) av Molecular Characterization of Multidrug-Resistant Yersinia enterocolitica From Foodborne Outbreaks in Sweden
Chromosomal Location Determines the Rate of Intrachromosomal Homologous Recombination in Salmonella
Ingår i mBio, 2021
- DOI för Chromosomal Location Determines the Rate of Intrachromosomal Homologous Recombination in Salmonella
- Ladda ner fulltext (pdf) av Chromosomal Location Determines the Rate of Intrachromosomal Homologous Recombination in Salmonella
Heimdallarchaea encodes profilin with eukaryotic-like actin regulation and polyproline binding
Ingår i Communications Biology, 2021
- DOI för Heimdallarchaea encodes profilin with eukaryotic-like actin regulation and polyproline binding
- Ladda ner fulltext (pdf) av Heimdallarchaea encodes profilin with eukaryotic-like actin regulation and polyproline binding
Expression of the qepA1 gene is induced under antibiotic exposure
Ingår i Journal of Antimicrobial Chemotherapy, s. 1433-1440, 2021
- DOI för Expression of the qepA1 gene is induced under antibiotic exposure
- Ladda ner fulltext (pdf) av Expression of the qepA1 gene is induced under antibiotic exposure
Paralogization and New Protein Architectures in Planctomycetes Bacteria with Complex Cell Structures
Ingår i Molecular biology and evolution, s. 1020-1040, 2020
Ingår i Microbes and infection, s. 356-359, 2020
- DOI för Chlamydia psittaci in Fulmars on The Faroe Islands: A Causative Link to South American Psittacines Eight Decades After a Severe Epidemic
- Ladda ner fulltext (pdf) av Chlamydia psittaci in Fulmars on The Faroe Islands: A Causative Link to South American Psittacines Eight Decades After a Severe Epidemic
miComplete: weighted quality evaluation of assembled microbial genomes
Ingår i Bioinformatics, s. 936-937, 2020
- DOI för miComplete: weighted quality evaluation of assembled microbial genomes
- Ladda ner fulltext (pdf) av miComplete: weighted quality evaluation of assembled microbial genomes
Asgard archaea are the closest prokaryotic relatives of eukaryotes
Ingår i PLOS Genetics, 2018
- DOI för Asgard archaea are the closest prokaryotic relatives of eukaryotes
- Ladda ner fulltext (pdf) av Asgard archaea are the closest prokaryotic relatives of eukaryotes
Deep mitochondrial origin outside the sampled alphaproteobacteria
Ingår i Nature, s. 101-105, 2018
Ingår i FEMS Microbiology Ecology, 2018
- DOI för The all-intracellular order Legionellales is unexpectedly diverse, globally distributed and lowly abundant.
- Ladda ner fulltext (pdf) av The all-intracellular order Legionellales is unexpectedly diverse, globally distributed and lowly abundant.
Origin and evolution of the Bartonella Gene Transfer Agent
Ingår i Molecular biology and evolution, s. 451-464, 2018
- DOI för Origin and evolution of the Bartonella Gene Transfer Agent
- Ladda ner fulltext (pdf) av Origin and evolution of the Bartonella Gene Transfer Agent
Genomes of two archaeal endosymbionts show convergent adaptations to an intracellular lifestyle.
Ingår i The ISME Journal, s. 2655-2667, 2018
Ingår i Environmental Research, s. 638-646, 2018
Ingår i Molecular biology and evolution, s. 704-718, 2018
- DOI för Experimental Determination and Prediction of the Fitness Effects of Random Point Mutations in the Biosynthetic Enzyme HisA
- Ladda ner fulltext (pdf) av Experimental Determination and Prediction of the Fitness Effects of Random Point Mutations in the Biosynthetic Enzyme HisA
phyloSkeleton: taxon selection, data retrieval and marker identification for phylogenomics
Ingår i Bioinformatics, s. 1230-1232, 2017
- DOI för phyloSkeleton: taxon selection, data retrieval and marker identification for phylogenomics
- Ladda ner fulltext (pdf) av phyloSkeleton: taxon selection, data retrieval and marker identification for phylogenomics
Resurrecting ancestral genes in bacteria to interpret ancient biosignatures
Ingår i Philosophical Transactions. Series A, 2017
- DOI för Resurrecting ancestral genes in bacteria to interpret ancient biosignatures
- Ladda ner fulltext (pdf) av Resurrecting ancestral genes in bacteria to interpret ancient biosignatures
Ingår i Scientific Reports, s. 1-11, 2016
- DOI för The genome of Rhizobiales bacteria in predatory ants reveals urease gene functions but no genes for nitrogen fixation
- Ladda ner fulltext (pdf) av The genome of Rhizobiales bacteria in predatory ants reveals urease gene functions but no genes for nitrogen fixation
Proposal of Coetzeea brasiliensis gen. nov. sp. nov. isolated from larvae of Anopheles darlingi
Ingår i International Journal of Systematic and Evolutionary Microbiology, s. 5211-5217, 2016
Ingår i International Journal of Systematic and Evolutionary Microbiology, s. 444-451, 2015
Exploring microbial dark matter to resolve the deep archaeal ancestry of eukaryotes
Ingår i Philosophical Transactions of the Royal Society of London. Biological Sciences, 2015
Complex archaea that bridge the gap between prokaryotes and eukaryotes
Ingår i Nature, s. 173-179, 2015
Ingår i The ISME Journal, s. 2373-2385, 2015
The Archaeal Legacy of Eukaryotes: A Phylogenomic Perspective
Ingår i Cold Spring Harbor Perspectives in Biology, 2014
Ingår i The ISME Journal, s. 1353-1357, 2014
Ingår i PLOS ONE, 2013
- DOI för Adaptive Mutations and Replacements of Virulence Traits in the Escherichia coli O104:H4 Outbreak Population
- Ladda ner fulltext (pdf) av Adaptive Mutations and Replacements of Virulence Traits in the Escherichia coli O104:H4 Outbreak Population
Community-wide plasmid gene mobilization and selection
Ingår i The ISME Journal, s. 1173-1186, 2013
- DOI för Community-wide plasmid gene mobilization and selection
- Ladda ner fulltext (pdf) av Community-wide plasmid gene mobilization and selection
Ingår i PLOS Genetics, 2013
- DOI för A Gene Transfer Agent and a Dynamic Repertoire of Secretion Systems Hold the Keys to the Explosive Radiation of the Emerging Pathogen Bartonella
- Ladda ner fulltext (pdf) av A Gene Transfer Agent and a Dynamic Repertoire of Secretion Systems Hold the Keys to the Explosive Radiation of the Emerging Pathogen Bartonella
A genome-wide study of recombination rate variation in Bartonella henselae
Ingår i BMC Evolutionary Biology, s. 65, 2012
- DOI för A genome-wide study of recombination rate variation in Bartonella henselae
- Ladda ner fulltext (pdf) av A genome-wide study of recombination rate variation in Bartonella henselae
Genomic diversity of the 2011 European outbreaks of Escherichia coli O104:H4
Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2012
genoPlotR: comparative gene and genome visualization in R
Ingår i Bioinformatics, s. 2334-2335, 2010
- DOI för genoPlotR: comparative gene and genome visualization in R
- Ladda ner fulltext (pdf) av genoPlotR: comparative gene and genome visualization in R
Ingår i BMC Genomics, 2009
- DOI för M-protein and other intrinsic virulence factors of Streptococcus pyogenes are encoded on an ancient pathogenicity island
- Ladda ner fulltext (pdf) av M-protein and other intrinsic virulence factors of Streptococcus pyogenes are encoded on an ancient pathogenicity island
Genomic insights into two independent events of archaeal endosymbiosis
Artiklar, forskningsöversikt
Ingår i FEMS Microbiology Reviews, 2024
- DOI för Host–bacteria interactions: ecological and evolutionary insights from ancient, professional endosymbionts
- Ladda ner fulltext (pdf) av Host–bacteria interactions: ecological and evolutionary insights from ancient, professional endosymbionts
Close Encounters of the Third Domain: The Emerging Genomic View of Archaeal Diversity and Evolution
Ingår i Archaea, s. 202358, 2013
The archaeal ‘TACK’ superphylum and the origin of eukaryotes
Ingår i Trends in Microbiology, s. 580-587, 2011
Manuskript (preprint)
Rapid, in-patient adaptations of Legionella pneumophila to the human host
- DOI för Rapid, in-patient adaptations of Legionella pneumophila to the human host
- Ladda ner fulltext (pdf) av Rapid, in-patient adaptations of Legionella pneumophila to the human host
High-efficiency transfection of Acanthamoeba castellanii using a cationic polymer