Eva Brittebo
Professor emer. i farmaceutisk toxikologi vid Institutionen för farmaceutisk biovetenskap; Forskning; Toxikologi och läkemedelssäkerhet
- E-post:
- eva.brittebo@uu.se
- Besöksadress:
- Uppsala biomedicinska centrum BMC, Husarg. 3
- Postadress:
- Box 591
751 24 UPPSALA
- Akademiska meriter:
- FarmD
- ORCID:
- 0000-0002-7644-1967
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Kort presentation
Eva Brittebo är professor i farmaceutisk toxikologi. Tidigare var hon prefekt för Institutionen för farmaceutisk biovetenskap och rektorsråd för forskarutbildningen vid Uppsala universitet. Hennes forskning berör mekanismer för kemikalie-inducerad toxicitet i olika experimentella system in vivo och in vitro. Hon har utvecklat nya on-line kurser i läkemedelssäkerhet och farmakovigilans.
Nyckelord
- autoradiography
- drug safety
- environmental pollutants
- intranasal administration
- neurotoxicity
- pharmaceuticals
- pharmacovigilance
- toxicology
Forskning
Denna text finns inte på svenska, därför visas den engelska versionen.
The main research interest has been to study mechanisms of harmful effects of environmental pollutants, herbicides, carcinogens, and pharmaceuticals in various experimental systems in vivo and in vitro. For instance, she has examined cytochrome P450-catalyzed bioactivation of pharmaceuticals and toxicants and identified some novel potent toxicants in the upper respiratory tract. The studies have been based on both imaging techniques (histopathology, immunohistochemistry, autoradiography) and various in vitro-methods.
Presently she is studying
- neurodegenerative changes in the adult brain following early life exposure to toxicants
- effects of toxicants in cultured neuronal cells
- intranasal administration of therapeutic agents to the brain
Publikationer
Senaste publikationer
- Long-Term Effects of Perinatal Exposure to a Glyphosate-Based Herbicide on Melatonin Levels and Oxidative Brain Damage in Adult Male Rats (2023)
- Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats (2021)
- Is Exposure to BMAA a Risk Factor for Neurodegenerative Diseases? (2021)
- The cyanobacterial neurotoxinbeta-N-methylamino-L-alanine (BMAA) targets the olfactory bulb region (2020)
- β-N-Methylamino-L-alanine (BMAA) perturbs alanine, aspartate and glutamate metabolism pathways in human neuroblastoma cells as determined by metabolic profiling (2017)
Alla publikationer
Artiklar
- Long-Term Effects of Perinatal Exposure to a Glyphosate-Based Herbicide on Melatonin Levels and Oxidative Brain Damage in Adult Male Rats (2023)
- Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats (2021)
- Is Exposure to BMAA a Risk Factor for Neurodegenerative Diseases? (2021)
- The cyanobacterial neurotoxinbeta-N-methylamino-L-alanine (BMAA) targets the olfactory bulb region (2020)
- β-N-Methylamino-L-alanine (BMAA) perturbs alanine, aspartate and glutamate metabolism pathways in human neuroblastoma cells as determined by metabolic profiling (2017)
- Low-dose exposure to bisphenol A in combination with fructose increases expression of genes regulating angiogenesis and vascular tone in juvenile Fischer 344 rat cardiac tissue (2017)
- Intracellular fibril formation, calcification, and enrichment of chaperones, cytoskeletal, and intermediate filament proteins in the adult hippocampus CA1 following neonatal exposure to the nonprotein amino acid BMAA (2015)
- Environmental neurotoxin interaction with proteins (2015)
- Intranasal Delivery of CNS-Retargeted Human Mesenchymal Stromal Cells Prolongs Treatment Efficacy of Experimental Autoimmune Encephalomyelitis (2014)
- Probing the lipid chemistry of neurotoxin-induced hippocampal lesions using multimodal imaging mass spectrometry (2014)
- High resolution metabolite imaging in the hippocampus following neonatal exposure to the environmental toxin BMAA using ToF-SIMS (2014)
- Protein association of the neurotoxin and non-protein amino acid BMAA (beta-N-methylamino-L-alanine) in the liver and brain following neonatal administration in rats (2014)
- Maternal Transfer of the Cyanobacterial Neurotoxin beta-N-Methylamino-L-Alanine (BMAA) via Milk to Suckling Offspring (2013)
- The cyanobacterial amino acid beta-N-methylamino-L-alanine perturbs the intermediary metabolism in neonatal rats (2013)
- Neurotoxin-Induced Neuropeptide Perturbations in Striatum of Neonatal Rats (2013)
- Proangiogenic Effects of Environmentally Relevant Levels of Bisphenol A in Human Primary Endothelial Cells (2012)
- Neurotoxin-induced fibril formation and protein changes in rodents (2012)
- CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery (2012)
- Tamoxifen Modulates Cell Migration and Expression of Angiogenesis-Related Genes in Human Endometrial Endothelial Cells (2012)
- Neonatal Exposure to the Cyanobacterial Toxin BMAA Induces Changes in Protein Expression and Neurodegeneration in Adult Hippocampus (2012)
- Effects of PCB126 and 17 beta-oestradiol on endothelium-derived vasoactive factors in human endothelial cells (2011)
- Early hippocampal cell death, and late learning and memory deficits in rats exposed to the environmental toxin BMAA (β-N-methylamino-l-alanine) during the neonatal period (2011)
- Combination Effects of 17 beta-Estradiol and PCB 126 on Human Endothelial Cells (2010)
- Tamoxifen-Induced Adduct Formation and Cell Stress in Human Endometrial Glands (2010)
- Genetically Engineered Cells Target CNS and Cure Experimental Autoimmune Encephalomyelitis (2010)
- Low levels of the air pollutant 1-nitropyrene induce DNA damage, increased levels of reactive oxygen species and endoplasmic reticulum stress in human endothelial cells (2009)
- Retention of the cyanobacterial neurotoxin beta-N-methylamino-l-alanine in melanin and neuromelanin-containing cells (2009)
- Selective Brain Uptake and Behavioral Effects of the Cyanobacterial Toxin BMAA (β-N-Methylamino-L-alanine) following Neonatal Administration to Rodents (2009)
- Long-term cognitive impairments in adult rats treated neonatally with beta-N-Methylamino-L-Alanine (2009)
- In vitro tests for detecting chemicals affecting the embryo implantation process (2007)
- Differential effects of dopamine melanin on norharman-induced toxicity in PC12 cells (2007)
- CYP2A5-mediated activation and early ultrastructural changes in the olfactory mucosa (2006)
- CYP2A5-mediated activation and early ultrastructural changes in the olfactory mucosa (2006)
- Norharman-induced motoric impairment in mice (2006)
- Norharman-induced motoric impairment in mice: Neurodegeneration and glial activation in substantia nigra (2006)
- Toxicant-induced ER-stress and Caspase Activation in the Olfactory Mucosa (2005)
- Dopamine melanin-loaded PC12 cells (2005)
- Transfer of morphine along the olfactory pathway to the central nervous system after nasal administration to rodents (2005)
- Dopamine melanin-loaded PC12 cells (2005)
- Long-term retention of β-carbolines in brain neuromelanin (2004)
- Methimazole-induced damage in the olfactory mucosa (2003)
- Isomer-specific Bioactivation and Toxicity of Dichlorophenyl Methylsulphone in Rat Olfactory Mucosa (2003)
- CYP1A1 and CYP1B1 in blood-brain interfaces: CYP1A1-dependent bioactivation of 7,12 dimethylbenz(a)anthracene (DMBA) in endothelial cells (2003)
- CYP1A1 and CYP1B1 in blood-brain interfaces (2003)
- CYP1A1 and CYP1B1 in blood-brain interfaces: (2003)
- Cell specific expression of CYP2A5 in the mouse respiratory tract: Effects of olfactory toxicants (2003)
- Cell-specific Expression of CYP2A5 in the Mouse Respiratory Tract (2003)
- Cell-specific expression of CYP2A5 in the mouse respiratory tract (2003)
- Long-term retention of neurotoxic ß-carbolines in brain neuromelanin (2003)
- Differential effects of olfactory toxicants on olfactory regeneration. (2002)
- Drug targeting to the brain: Transfer of picolinic acid along the olfactory pathways (2002)
- Effects of lactic acid bacteria on the distribution of Trp-p-2 in mice. (2002)
- Evaluation of benzo(a)pyrene-inducedDNA damage in human endotehlial cells using alkaline single cellelectrophoresis. (2000)
- CYP1A-dependent activation ofxenobiotics in endothelial linings of the chorioallantoic membrane (CAM)in birds. (2000)
- Differential response of cultured human umbilical vein and artery endothelial cells to Ah receptor agonist treatment (2000)
- Differential response of cultured human umbilical vein and artery endothelial cells to Ah receptor agonist treatment:CYP-dependent activation of food and environmental mutagens. (2000)
- Persistent Olfactory Mucosal Metaplasia and Increased Olfactory Bulb Glial Fibrillary Acidic Protein Levels Following a Single Dose of Methylsulfonyl-dichlorobenzene in Mice: Comparison of the 2,5- and 2,6-Dichlorinated Isomers (2000)
- Transfer of dopamine in the olfactory pathway following nasal administration in mice (2000)
- Transfer of dopamine in the olfactory pathway following nasal administration in mice (2000)
- Basal and induced EROD activity in the chorioallantoic membrane during chicken embryo development (1999)
- Basal and induced EROD activity in the chorioallantoic membrane during chicken embryo development (1999)
- Localization and comparative toxicity of methylsulfonyl-2,5-and 2,6-dichlorobenzene in the olfactory mucosa of mice (1999)
- Methimazole toxicity in rodents: Covalent binding in the olfactory mucosa and detection of glial fibrillary acidic protein in the olfactory bulb (1999)
- Transfer of some carboxylic acids in the olfactory system following intranasal administration (1999)
- Binding of the potent allergen hexahydrophthalic anhydride in the mucosa of the upper respiratory and alimentary tract following single inhalation exposures in guinea pigs and rats (1999)
- Localization of cytochrome P4501A1 and covalent binding of a mutagenic heterocyclic amine in blood vessel endothelia of rodents (1998)
- Induction of ethoxyresorufin O-deethylase (EROD) and endothelial activation of the heterocyclic amine Trp-P-1 in bird embryo hearts (1998)
- Cell- and tissue-specific metabolic activation of chemicals as determined by autoradiography: In vitro in vivo correlations (1997)
- Metabolism-dependent activation and toxicity of chemicals in nasal glands (1997)
- Effects of dichlobenil on ultrastructural morphology and cell replication in the mouse olfactory mucosa (1997)
- Human Mesenchymal stromal cells expressing a CNS-targeting receptor can be administrated intra nasally and cure expersimental autoimmune enchphlomyelitis
- Engineered T regulatory cells target CNS and suppress active EAE upon intra nasal delivery
- LONG-TERM MORPHOLOGICAL AND PROTEIN CHANGES IN THE BRAIN OF ADULT RATS NEONATALLY TREATED WITH THE ENVIRONMENTAL TOXIN β-N-METHYLAMINO-L-ALANINE (BMAA)
Kapitel
Konferenser
- Experimental studies of bisphenol A in cardiovascular cells and tissues (2012)
- Bioactivation and effects of environmental pollutants in human and rodent blood vessel endothelial cells (2012)
- Effects of olfactory toxicants on the expression of CYP2A2 (2003)
- Long-term effects in the olfactory mucosa and bulb following systemic exposure to chemicals (2002)
