Eva Brittebo
Professor emer. i farmaceutisk toxikologi vid Institutionen för farmaceutisk biovetenskap; Forskning; Toxikologi och läkemedelssäkerhet
- E-post:
- eva.brittebo@uu.se
- Besöksadress:
- Uppsala biomedicinska centrum BMC, Husarg. 3
- Postadress:
- Box 591
751 24 UPPSALA
- Akademiska meriter:
- FarmD
- ORCID:
- 0000-0002-7644-1967
Kort presentation
Eva Brittebo är professor i farmaceutisk toxikologi. Tidigare var hon prefekt för Institutionen för farmaceutisk biovetenskap och rektorsråd för forskarutbildningen vid Uppsala universitet. Hennes forskning berör mekanismer för kemikalie-inducerad toxicitet i olika experimentella system in vivo och in vitro. Hon har utvecklat nya on-line kurser i läkemedelssäkerhet och farmakovigilans.
Nyckelord
- environmental pollutants
- toxicology
- pharmaceuticals
- pharmacovigilance
- drug safety
- autoradiography
- intranasal administration
- neurotoxicity

Publikationer
Senaste publikationer
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Ingår i Antioxidants, 2023
- DOI för Long-Term Effects of Perinatal Exposure to a Glyphosate-Based Herbicide on Melatonin Levels and Oxidative Brain Damage in Adult Male Rats
- Ladda ner fulltext (pdf) av Long-Term Effects of Perinatal Exposure to a Glyphosate-Based Herbicide on Melatonin Levels and Oxidative Brain Damage in Adult Male Rats
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Ingår i Neurotoxicity research, s. 81-106, 2021
- DOI för Is Exposure to BMAA a Risk Factor for Neurodegenerative Diseases?: A Response to a Critical Review of the BMAA Hypothesis
- Ladda ner fulltext (pdf) av Is Exposure to BMAA a Risk Factor for Neurodegenerative Diseases?: A Response to a Critical Review of the BMAA Hypothesis
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Ingår i Toxicology, 2021
- DOI för Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats
- Ladda ner fulltext (pdf) av Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats
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The cyanobacterial neurotoxinbeta-N-methylamino-L-alanine (BMAA) targets the olfactory bulb region
Ingår i Archives of Toxicology, s. 2799-2808, 2020
- DOI för The cyanobacterial neurotoxinbeta-N-methylamino-L-alanine (BMAA) targets the olfactory bulb region
- Ladda ner fulltext (pdf) av The cyanobacterial neurotoxinbeta-N-methylamino-L-alanine (BMAA) targets the olfactory bulb region
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Ingår i Amino Acids, s. 905-919, 2017
- DOI för β-N-Methylamino-L-alanine (BMAA) perturbs alanine, aspartate and glutamate metabolism pathways in human neuroblastoma cells as determined by metabolic profiling
- Ladda ner fulltext (pdf) av β-N-Methylamino-L-alanine (BMAA) perturbs alanine, aspartate and glutamate metabolism pathways in human neuroblastoma cells as determined by metabolic profiling
Alla publikationer
Artiklar i tidskrift
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Ingår i Antioxidants, 2023
- DOI för Long-Term Effects of Perinatal Exposure to a Glyphosate-Based Herbicide on Melatonin Levels and Oxidative Brain Damage in Adult Male Rats
- Ladda ner fulltext (pdf) av Long-Term Effects of Perinatal Exposure to a Glyphosate-Based Herbicide on Melatonin Levels and Oxidative Brain Damage in Adult Male Rats
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Ingår i Toxicology, 2021
- DOI för Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats
- Ladda ner fulltext (pdf) av Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats
-
The cyanobacterial neurotoxinbeta-N-methylamino-L-alanine (BMAA) targets the olfactory bulb region
Ingår i Archives of Toxicology, s. 2799-2808, 2020
- DOI för The cyanobacterial neurotoxinbeta-N-methylamino-L-alanine (BMAA) targets the olfactory bulb region
- Ladda ner fulltext (pdf) av The cyanobacterial neurotoxinbeta-N-methylamino-L-alanine (BMAA) targets the olfactory bulb region
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Ingår i Amino Acids, s. 905-919, 2017
- DOI för β-N-Methylamino-L-alanine (BMAA) perturbs alanine, aspartate and glutamate metabolism pathways in human neuroblastoma cells as determined by metabolic profiling
- Ladda ner fulltext (pdf) av β-N-Methylamino-L-alanine (BMAA) perturbs alanine, aspartate and glutamate metabolism pathways in human neuroblastoma cells as determined by metabolic profiling
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Ingår i Upsala Journal of Medical Sciences, s. 20-27, 2017
- DOI för Low-dose exposure to bisphenol A in combination with fructose increases expression of genes regulating angiogenesis and vascular tone in juvenile Fischer 344 rat cardiac tissue
- Ladda ner fulltext (pdf) av Low-dose exposure to bisphenol A in combination with fructose increases expression of genes regulating angiogenesis and vascular tone in juvenile Fischer 344 rat cardiac tissue
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Ingår i Scientific Reports, 2015
- DOI för Environmental neurotoxin interaction with proteins: Dose-dependent increase of free and protein-associated BMAA (beta-N-methylamino-L-alanine) in neonatal rat brain
- Ladda ner fulltext (pdf) av Environmental neurotoxin interaction with proteins: Dose-dependent increase of free and protein-associated BMAA (beta-N-methylamino-L-alanine) in neonatal rat brain
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Ingår i Archives of Toxicology, s. 423-436, 2015
- DOI för Intracellular fibril formation, calcification, and enrichment of chaperones, cytoskeletal, and intermediate filament proteins in the adult hippocampus CA1 following neonatal exposure to the nonprotein amino acid BMAA
- Ladda ner fulltext (pdf) av Intracellular fibril formation, calcification, and enrichment of chaperones, cytoskeletal, and intermediate filament proteins in the adult hippocampus CA1 following neonatal exposure to the nonprotein amino acid BMAA
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Ingår i ACS Chemical Neuroscience, s. 568-575, 2014
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Ingår i Immunology, s. 431-441, 2014
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Ingår i Surface and Interface Analysis, s. 375-378, 2014
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Ingår i Toxicology Letters, s. 1-5, 2014
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Ingår i PLOS ONE, 2013
- DOI för Maternal Transfer of the Cyanobacterial Neurotoxin beta-N-Methylamino-L-Alanine (BMAA) via Milk to Suckling Offspring
- Ladda ner fulltext (pdf) av Maternal Transfer of the Cyanobacterial Neurotoxin beta-N-Methylamino-L-Alanine (BMAA) via Milk to Suckling Offspring
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Ingår i Amino Acids, s. 905-919, 2013
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Neurotoxin-Induced Neuropeptide Perturbations in Striatum of Neonatal Rats
Ingår i Journal of Proteome Research, s. 1678-1690, 2013
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CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery
Ingår i Journal of Neuroinflammation, s. 112, 2012
- DOI för CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery
- Ladda ner fulltext (pdf) av CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery
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Ingår i Toxicological Sciences, s. 391-404, 2012
- DOI för Neonatal Exposure to the Cyanobacterial Toxin BMAA Induces Changes in Protein Expression and Neurodegeneration in Adult Hippocampus
- Ladda ner fulltext (pdf) av Neonatal Exposure to the Cyanobacterial Toxin BMAA Induces Changes in Protein Expression and Neurodegeneration in Adult Hippocampus
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Ingår i Archives of Toxicology, s. 465-474, 2012
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Neurotoxin-induced fibril formation and protein changes in rodents
Ingår i Toxicology Letters, 2012
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Ingår i American Journal of Pathology, s. 2527-2535, 2012
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Ingår i Toxicology, s. 46-56, 2011
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Ingår i Behavioural Brain Research, s. 310-320, 2011
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Genetically Engineered Cells Target CNS and Cure Experimental Autoimmune Encephalomyelitis
Ingår i Human Gene Therapy, s. 1381-1381, 2010
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Combination Effects of 17 beta-Estradiol and PCB 126 on Human Endothelial Cells
Ingår i Arteriosclerosis, Thrombosis and Vascular Biology, 2010
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Tamoxifen-Induced Adduct Formation and Cell Stress in Human Endometrial Glands
Ingår i Drug Metabolism And Disposition, s. 200-207, 2010
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Ingår i Toxicology, s. 57-64, 2009
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Ingår i Pigment cell & melanoma research, s. 120-130, 2009
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Ingår i Toxicological Sciences, s. 286-295, 2009
- DOI för Selective Brain Uptake and Behavioral Effects of the Cyanobacterial Toxin BMAA (β-N-Methylamino-L-alanine) following Neonatal Administration to Rodents
- Ladda ner fulltext (pdf) av Selective Brain Uptake and Behavioral Effects of the Cyanobacterial Toxin BMAA (β-N-Methylamino-L-alanine) following Neonatal Administration to Rodents
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Long-term cognitive impairments in adult rats treated neonatally with beta-N-Methylamino-L-Alanine
Ingår i Toxicological Sciences, s. 185-195, 2009
- DOI för Long-term cognitive impairments in adult rats treated neonatally with beta-N-Methylamino-L-Alanine
- Ladda ner fulltext (pdf) av Long-term cognitive impairments in adult rats treated neonatally with beta-N-Methylamino-L-Alanine
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Differential effects of dopamine melanin on norharman-induced toxicity in PC12 cells
Ingår i Journal of neural transmission, s. 909-918, 2007
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Ingår i Drug Metabolism And Disposition, s. 61-68, 2006
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Ingår i Journal of neural transmission, s. 313-329, 2006
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Ingår i J Neural Transm, s. 313-29, 2006
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Ingår i Drug Metab Dispos, s. 61-8, 2006
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Dopamine melanin-loaded PC12 cells: A model for studies on pigmented neurons of substantia nigra
Ingår i Pigment Cell Research, s. 306-314, 2005
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Dopamine melanin-loaded PC12 cells: a model for studies on pigmented neurons.
Ingår i Pigment Cell Research, s. 306-14, 2005
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Toxicant-induced ER-stress and Caspase Activation in the Olfactory Mucosa
Ingår i Archives of Toxicology, s. 561-570, 2005
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Ingår i European Journal of Pharmaceutical Sciences, s. 565-573, 2005
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Long-term retention of β-carbolines in brain neuromelanin
Ingår i Journal of neural transmission, s. 141-157, 2004
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Isomer-specific Bioactivation and Toxicity of Dichlorophenyl Methylsulphone in Rat Olfactory Mucosa
Ingår i Toxicologic pathology (Print), s. 364-372, 2003
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Cell-specific Expression of CYP2A5 in the Mouse Respiratory Tract: Effects of Olfactory Toxicants
Ingår i Journal of Histochemistry and Cytochemistry, s. 1545-1555, 2003
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Ingår i Drug Metabolism And Disposition, s. 259-265, 2003
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Long-term retention of neurotoxic ß-carbolines in brain neuromelanin
Ingår i Journal of neural transmission, s. 141-157, 2003
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Ingår i Drug Metabolism And Disposition, s. 259-265, 2003
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Cell specific expression of CYP2A5 in the mouse respiratory tract: Effects of olfactory toxicants
Ingår i Journal of Histochemistry and Cytochemistry, s. 1545-1555, 2003
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Cell-specific expression of CYP2A5 in the mouse respiratory tract: effects of olfactory toxicants.
Ingår i Journal of Histochemistry and Cytochemistry, s. 1545-1555, 2003
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Ingår i Toxicol Pathol, s. 379-87, 2003
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Ingår i Drug Met. Disp., s. 259, 2003
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Effects of lactic acid bacteria on the distribution of Trp-p-2 in mice.
Ingår i Scandinavian Journal of Gastroenterology, s. 215, 2002
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Drug targeting to the brain: Transfer of picolinic acid along the olfactory pathways
Ingår i J Drug Target, s. 469, 2002
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Differential effects of olfactory toxicants on olfactory regeneration.
Ingår i Arch Toxicol, s. 104, 2002
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Transfer of dopamine in the olfactory pathway following nasal administration in mice
Ingår i Pharmaceutical research, s. 737-742, 2000
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Ingår i Toxicology and Applied Pharmacology, s. 94-101, 2000
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Ingår i Toxicology and Applied Pharmacology, s. 49-59, 2000
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Ingår i Toxicology Applied Pharmacology, s. 94, 2000
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Transfer of dopamine in the olfactory pathway following nasal administration in mice
Ingår i Pharm Res, s. 737, 2000
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Ingår i Mutation Research, s. 145, 2000
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Ingår i Arch. Toxicol., s. 335, 2000
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Basal and induced EROD activity in the chorioallantoic membrane during chicken embryo development
Ingår i Environmental Toxicology and Pharmacology, s. 49-52, 1999
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Ingår i Toxicological Sciences, s. 116-123, 1999
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Basal and induced EROD activity in the chorioallantoic membrane during chicken embryo development
Ingår i ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, s. 49, 1999
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Transfer of some carboxylic acids in the olfactory system following intranasal administration
Ingår i J DRUG TARGETING, s. 131, 1999
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Ingår i TOXICOLOGY, s. 153, 1999
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Ingår i TOXICOLOGY AND APPLIED PHARMACOLOGY, s. 190, 1999
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Ingår i Archives of Toxicology, s. 402-410, 1998
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Ingår i TOXICOLOGY, s. 145, 1998
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Metabolism-dependent activation and toxicity of chemicals in nasal glands
Ingår i Mutation research, s. 61-75, 1997
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Ingår i TOXICOLOGY IN VITRO, s. 417, 1997
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Ingår i TOXICOLOGIC PATHOLOGY, s. 186, 1997
Artiklar, forskningsöversikt
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Ingår i Neurotoxicity research, s. 81-106, 2021
- DOI för Is Exposure to BMAA a Risk Factor for Neurodegenerative Diseases?: A Response to a Critical Review of the BMAA Hypothesis
- Ladda ner fulltext (pdf) av Is Exposure to BMAA a Risk Factor for Neurodegenerative Diseases?: A Response to a Critical Review of the BMAA Hypothesis
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Ingår i ATLA (Alternatives to Laboratory Animals), s. 421-439, 2007
Kapitel i böcker, delar av antologi
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Toxicity in the respiratory system
Ingår i Pharmaceutical Toxicology, 2006
Konferensbidrag
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Ingår i Organohalogen compound database (http://www.dioxin20xx.org/ohc_database_search.htm), 2012
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Ingår i , 2012
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Effects of olfactory toxicants on the expression of CYP2A2
Ingår i Toxicology Letters 144, Suppl 1,, s. 153, 2003
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Long-term effects in the olfactory mucosa and bulb following systemic exposure to chemicals
Ingår i Toxicology Letters 135, Suppl 1, s. 139, 2002