Eva Brittebo
Professor emer. i farmaceutisk toxikologi vid Institutionen för farmaceutisk biovetenskap; Forskning; Toxikologi och läkemedelssäkerhet
- E-post:
- eva.brittebo@uu.se
- Besöksadress:
- Uppsala biomedicinska centrum BMC, Husarg. 3
- Postadress:
- Box 591
751 24 UPPSALA
- Akademiska meriter:
- FarmD
- ORCID:
- 0000-0002-7644-1967
Kort presentation
Eva Brittebo är professor i farmaceutisk toxikologi. Tidigare var hon prefekt för Institutionen för farmaceutisk biovetenskap och rektorsråd för forskarutbildningen vid Uppsala universitet. Hennes forskning berör mekanismer för kemikalie-inducerad toxicitet i olika experimentella system in vivo och in vitro. Hon har utvecklat nya on-line kurser i läkemedelssäkerhet och farmakovigilans.
Nyckelord
- environmental pollutants
- toxicology
- pharmaceuticals
- pharmacovigilance
- drug safety
- autoradiography
- intranasal administration
- neurotoxicity

Publikationer
Senaste publikationer
Ingår i Antioxidants, 2023
- DOI för Long-Term Effects of Perinatal Exposure to a Glyphosate-Based Herbicide on Melatonin Levels and Oxidative Brain Damage in Adult Male Rats
- Ladda ner fulltext (pdf) av Long-Term Effects of Perinatal Exposure to a Glyphosate-Based Herbicide on Melatonin Levels and Oxidative Brain Damage in Adult Male Rats
Ingår i Neurotoxicity research, s. 81-106, 2021
- DOI för Is Exposure to BMAA a Risk Factor for Neurodegenerative Diseases?: A Response to a Critical Review of the BMAA Hypothesis
- Ladda ner fulltext (pdf) av Is Exposure to BMAA a Risk Factor for Neurodegenerative Diseases?: A Response to a Critical Review of the BMAA Hypothesis
Ingår i Toxicology, 2021
- DOI för Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats
- Ladda ner fulltext (pdf) av Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats
The cyanobacterial neurotoxinbeta-N-methylamino-L-alanine (BMAA) targets the olfactory bulb region
Ingår i Archives of Toxicology, s. 2799-2808, 2020
- DOI för The cyanobacterial neurotoxinbeta-N-methylamino-L-alanine (BMAA) targets the olfactory bulb region
- Ladda ner fulltext (pdf) av The cyanobacterial neurotoxinbeta-N-methylamino-L-alanine (BMAA) targets the olfactory bulb region
Ingår i Amino Acids, s. 905-919, 2017
- DOI för β-N-Methylamino-L-alanine (BMAA) perturbs alanine, aspartate and glutamate metabolism pathways in human neuroblastoma cells as determined by metabolic profiling
- Ladda ner fulltext (pdf) av β-N-Methylamino-L-alanine (BMAA) perturbs alanine, aspartate and glutamate metabolism pathways in human neuroblastoma cells as determined by metabolic profiling
Alla publikationer
Artiklar i tidskrift
Ingår i Antioxidants, 2023
- DOI för Long-Term Effects of Perinatal Exposure to a Glyphosate-Based Herbicide on Melatonin Levels and Oxidative Brain Damage in Adult Male Rats
- Ladda ner fulltext (pdf) av Long-Term Effects of Perinatal Exposure to a Glyphosate-Based Herbicide on Melatonin Levels and Oxidative Brain Damage in Adult Male Rats
Ingår i Toxicology, 2021
- DOI för Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats
- Ladda ner fulltext (pdf) av Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats
The cyanobacterial neurotoxinbeta-N-methylamino-L-alanine (BMAA) targets the olfactory bulb region
Ingår i Archives of Toxicology, s. 2799-2808, 2020
- DOI för The cyanobacterial neurotoxinbeta-N-methylamino-L-alanine (BMAA) targets the olfactory bulb region
- Ladda ner fulltext (pdf) av The cyanobacterial neurotoxinbeta-N-methylamino-L-alanine (BMAA) targets the olfactory bulb region
Ingår i Amino Acids, s. 905-919, 2017
- DOI för β-N-Methylamino-L-alanine (BMAA) perturbs alanine, aspartate and glutamate metabolism pathways in human neuroblastoma cells as determined by metabolic profiling
- Ladda ner fulltext (pdf) av β-N-Methylamino-L-alanine (BMAA) perturbs alanine, aspartate and glutamate metabolism pathways in human neuroblastoma cells as determined by metabolic profiling
Ingår i Upsala Journal of Medical Sciences, s. 20-27, 2017
- DOI för Low-dose exposure to bisphenol A in combination with fructose increases expression of genes regulating angiogenesis and vascular tone in juvenile Fischer 344 rat cardiac tissue
- Ladda ner fulltext (pdf) av Low-dose exposure to bisphenol A in combination with fructose increases expression of genes regulating angiogenesis and vascular tone in juvenile Fischer 344 rat cardiac tissue
Ingår i Scientific Reports, 2015
- DOI för Environmental neurotoxin interaction with proteins: Dose-dependent increase of free and protein-associated BMAA (beta-N-methylamino-L-alanine) in neonatal rat brain
- Ladda ner fulltext (pdf) av Environmental neurotoxin interaction with proteins: Dose-dependent increase of free and protein-associated BMAA (beta-N-methylamino-L-alanine) in neonatal rat brain
Ingår i Archives of Toxicology, s. 423-436, 2015
- DOI för Intracellular fibril formation, calcification, and enrichment of chaperones, cytoskeletal, and intermediate filament proteins in the adult hippocampus CA1 following neonatal exposure to the nonprotein amino acid BMAA
- Ladda ner fulltext (pdf) av Intracellular fibril formation, calcification, and enrichment of chaperones, cytoskeletal, and intermediate filament proteins in the adult hippocampus CA1 following neonatal exposure to the nonprotein amino acid BMAA
Ingår i ACS Chemical Neuroscience, s. 568-575, 2014
Ingår i Immunology, s. 431-441, 2014
Ingår i Surface and Interface Analysis, s. 375-378, 2014
Ingår i Toxicology Letters, s. 1-5, 2014
Ingår i PLOS ONE, 2013
- DOI för Maternal Transfer of the Cyanobacterial Neurotoxin beta-N-Methylamino-L-Alanine (BMAA) via Milk to Suckling Offspring
- Ladda ner fulltext (pdf) av Maternal Transfer of the Cyanobacterial Neurotoxin beta-N-Methylamino-L-Alanine (BMAA) via Milk to Suckling Offspring
Ingår i Amino Acids, s. 905-919, 2013
Neurotoxin-Induced Neuropeptide Perturbations in Striatum of Neonatal Rats
Ingår i Journal of Proteome Research, s. 1678-1690, 2013
CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery
Ingår i Journal of Neuroinflammation, s. 112, 2012
- DOI för CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery
- Ladda ner fulltext (pdf) av CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery
Ingår i Toxicological Sciences, s. 391-404, 2012
- DOI för Neonatal Exposure to the Cyanobacterial Toxin BMAA Induces Changes in Protein Expression and Neurodegeneration in Adult Hippocampus
- Ladda ner fulltext (pdf) av Neonatal Exposure to the Cyanobacterial Toxin BMAA Induces Changes in Protein Expression and Neurodegeneration in Adult Hippocampus
Ingår i Archives of Toxicology, s. 465-474, 2012
Neurotoxin-induced fibril formation and protein changes in rodents
Ingår i Toxicology Letters, 2012
Ingår i American Journal of Pathology, s. 2527-2535, 2012
Ingår i Toxicology, s. 46-56, 2011
Ingår i Behavioural Brain Research, s. 310-320, 2011
Genetically Engineered Cells Target CNS and Cure Experimental Autoimmune Encephalomyelitis
Ingår i Human Gene Therapy, s. 1381-1381, 2010
Combination Effects of 17 beta-Estradiol and PCB 126 on Human Endothelial Cells
Ingår i Arteriosclerosis, Thrombosis and Vascular Biology, 2010
Tamoxifen-Induced Adduct Formation and Cell Stress in Human Endometrial Glands
Ingår i Drug Metabolism And Disposition, s. 200-207, 2010
Ingår i Toxicology, s. 57-64, 2009
Ingår i Pigment cell & melanoma research, s. 120-130, 2009
Ingår i Toxicological Sciences, s. 286-295, 2009
- DOI för Selective Brain Uptake and Behavioral Effects of the Cyanobacterial Toxin BMAA (β-N-Methylamino-L-alanine) following Neonatal Administration to Rodents
- Ladda ner fulltext (pdf) av Selective Brain Uptake and Behavioral Effects of the Cyanobacterial Toxin BMAA (β-N-Methylamino-L-alanine) following Neonatal Administration to Rodents
Long-term cognitive impairments in adult rats treated neonatally with beta-N-Methylamino-L-Alanine
Ingår i Toxicological Sciences, s. 185-195, 2009
- DOI för Long-term cognitive impairments in adult rats treated neonatally with beta-N-Methylamino-L-Alanine
- Ladda ner fulltext (pdf) av Long-term cognitive impairments in adult rats treated neonatally with beta-N-Methylamino-L-Alanine
Differential effects of dopamine melanin on norharman-induced toxicity in PC12 cells
Ingår i Journal of neural transmission, s. 909-918, 2007
Ingår i Drug Metabolism And Disposition, s. 61-68, 2006
Ingår i Journal of neural transmission, s. 313-329, 2006
Ingår i J Neural Transm, s. 313-29, 2006
Ingår i Drug Metab Dispos, s. 61-8, 2006
Dopamine melanin-loaded PC12 cells: A model for studies on pigmented neurons of substantia nigra
Ingår i Pigment Cell Research, s. 306-314, 2005
Dopamine melanin-loaded PC12 cells: a model for studies on pigmented neurons.
Ingår i Pigment Cell Research, s. 306-14, 2005
Toxicant-induced ER-stress and Caspase Activation in the Olfactory Mucosa
Ingår i Archives of Toxicology, s. 561-570, 2005
Ingår i European Journal of Pharmaceutical Sciences, s. 565-573, 2005
Long-term retention of β-carbolines in brain neuromelanin
Ingår i Journal of neural transmission, s. 141-157, 2004
Isomer-specific Bioactivation and Toxicity of Dichlorophenyl Methylsulphone in Rat Olfactory Mucosa
Ingår i Toxicologic pathology (Print), s. 364-372, 2003
Cell-specific Expression of CYP2A5 in the Mouse Respiratory Tract: Effects of Olfactory Toxicants
Ingår i Journal of Histochemistry and Cytochemistry, s. 1545-1555, 2003
Ingår i Drug Metabolism And Disposition, s. 259-265, 2003
Long-term retention of neurotoxic ß-carbolines in brain neuromelanin
Ingår i Journal of neural transmission, s. 141-157, 2003
Ingår i Drug Metabolism And Disposition, s. 259-265, 2003
Cell specific expression of CYP2A5 in the mouse respiratory tract: Effects of olfactory toxicants
Ingår i Journal of Histochemistry and Cytochemistry, s. 1545-1555, 2003
Cell-specific expression of CYP2A5 in the mouse respiratory tract: effects of olfactory toxicants.
Ingår i Journal of Histochemistry and Cytochemistry, s. 1545-1555, 2003
Ingår i Toxicol Pathol, s. 379-87, 2003
Ingår i Drug Met. Disp., s. 259, 2003
Effects of lactic acid bacteria on the distribution of Trp-p-2 in mice.
Ingår i Scandinavian Journal of Gastroenterology, s. 215, 2002
Drug targeting to the brain: Transfer of picolinic acid along the olfactory pathways
Ingår i J Drug Target, s. 469, 2002
Differential effects of olfactory toxicants on olfactory regeneration.
Ingår i Arch Toxicol, s. 104, 2002
Transfer of dopamine in the olfactory pathway following nasal administration in mice
Ingår i Pharmaceutical research, s. 737-742, 2000
Ingår i Toxicology and Applied Pharmacology, s. 94-101, 2000
Ingår i Toxicology and Applied Pharmacology, s. 49-59, 2000
Ingår i Toxicology Applied Pharmacology, s. 94, 2000
Transfer of dopamine in the olfactory pathway following nasal administration in mice
Ingår i Pharm Res, s. 737, 2000
Ingår i Mutation Research, s. 145, 2000
Ingår i Arch. Toxicol., s. 335, 2000
Basal and induced EROD activity in the chorioallantoic membrane during chicken embryo development
Ingår i Environmental Toxicology and Pharmacology, s. 49-52, 1999
Ingår i Toxicological Sciences, s. 116-123, 1999
Basal and induced EROD activity in the chorioallantoic membrane during chicken embryo development
Ingår i ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, s. 49, 1999
Transfer of some carboxylic acids in the olfactory system following intranasal administration
Ingår i J DRUG TARGETING, s. 131, 1999
Ingår i TOXICOLOGY, s. 153, 1999
Ingår i TOXICOLOGY AND APPLIED PHARMACOLOGY, s. 190, 1999
Ingår i Archives of Toxicology, s. 402-410, 1998
Ingår i TOXICOLOGY, s. 145, 1998
Metabolism-dependent activation and toxicity of chemicals in nasal glands
Ingår i Mutation research, s. 61-75, 1997
Ingår i TOXICOLOGY IN VITRO, s. 417, 1997
Ingår i TOXICOLOGIC PATHOLOGY, s. 186, 1997
Artiklar, forskningsöversikt
Ingår i Neurotoxicity research, s. 81-106, 2021
- DOI för Is Exposure to BMAA a Risk Factor for Neurodegenerative Diseases?: A Response to a Critical Review of the BMAA Hypothesis
- Ladda ner fulltext (pdf) av Is Exposure to BMAA a Risk Factor for Neurodegenerative Diseases?: A Response to a Critical Review of the BMAA Hypothesis
Ingår i ATLA (Alternatives to Laboratory Animals), s. 421-439, 2007
Kapitel i böcker, delar av antologi
Toxicity in the respiratory system
Ingår i Pharmaceutical Toxicology, 2006
Konferensbidrag
Ingår i Organohalogen compound database (http://www.dioxin20xx.org/ohc_database_search.htm), 2012
Ingår i , 2012
Effects of olfactory toxicants on the expression of CYP2A2
Ingår i Toxicology Letters 144, Suppl 1,, s. 153, 2003
Long-term effects in the olfactory mucosa and bulb following systemic exposure to chemicals
Ingår i Toxicology Letters 135, Suppl 1, s. 139, 2002