Lena Friberg
Professor vid Institutionen för farmaci; Farmakokinetik och Farmakodynamik
- Mobiltelefon:
- 070-425 02 03
- E-post:
- lena.friberg@farmaci.uu.se
- Besöksadress:
- Biomedicinskt Centrum BMC, Husargatan 3
- Postadress:
- Box 580
751 23 UPPSALA
- Akademiska meriter:
- FarmD, Docent (PhD Associate professor)
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Kort presentation
Lena Friberg was promoted to Professor of Pharmacometrics in 2014 and is since 2021 employed as Professor of Pharmacokinetics and Pharmacodynamics. Her research focuses on translation and dose optimization within oncology and infectious diseases, by advancing concepts for interpretation and integration of in vitro, in vivo and clinical data through PKPD-modelling. Developed methodology facilitates transition between drug development stages while considering both desired and adverse effects.
Nyckelord
- antibiotic resistance
- antibiotics
- anticancer therapy
- bacterial infections
- cancer
- drug development
- drug usage
- immune system
- modeling and simulation
- non-linear mixed effects modelling
- pharmacodynamics
- pharmacokinetics
- pharmacometrics
- preclinical
- translational medicine
- translational research
- vaccines
Biografi
Lena is since 2021 employed as Professor of Pharmacokinetics and Pharmacodynamics (Professor of Pharmacometrics 2014-2021). She obtained her PhD in 2003 and in 2007 she became Docent (Associate professor). During 2003-2008 she was supported by a personal grant from Knut & Alice Wallenberg foundation for a postdoc at the University of Queensland, Australia, and as a researcher at Uppsala University.
The research focuses on developing approaches for predictive translation of effects from preclinical data to patients, both for desired outcomes and adverse events. Important achievements include frameworks to be applied for optimized dosing strategies of new and available drugs in the areas of oncology and infection.
Lena has published >190 peer-reviewed research articles and has an h-index of 56. She has been main (co) supervisor of 12 (10) students to PhD degree and is currently supervising 9 (4) PhD students, in addition to mentoring Postdocs and early researchers. She holds competitive grants from Swedish Research Council, Swedish Cancer Society, Swedish Childhood Cancer Fund, Innovative Medicines Initiative (EU-IMI2) and Marie Skłodowska-Curie Innovative Training Networks (ITN). Lena has received the Giorgio Segré Prize from EUFEPS for “distinct research in the Pharmacokinetic-Pharmacodynamic area”, the Innovation award from ISoP and been appointed ISoP fellow and Key Scientist" by Vinnova/BioSweden. She is since 2023 the Head of Department of Pharmacy.
Publikationer
Urval av publikationer
- A PK/PD Analysis of Circulating Biomarkers and Their Relationship to Tumor Response in Atezolizumab-Treated non-small Cell Lung Cancer Patients (2019)
- Model-Based Drug Development in Pulmonary Delivery (2019)
- Population pharmacokinetics of piperacillin in febrile children receiving cancer chemotherapy (2019)
- A Whole-Body Physiologically Based Pharmacokinetic Model for Colistin and Colistin Methanesulfonate in Rat (2018)
- Semi-mechanistic pharmacokinetic-pharmacodynamic modelling of antibiotic drug combinations (2018)
- Predicting mutant selection in competition experiments with ciprofloxacin-exposed Escherichia coli (2018)
- The risk of febrile neutropenia in breast cancer patients following adjuvant chemotherapy is predicted by the time course of interleukin-6 and C-reactive protein by modelling. (2018)
- A whole-body physiologically based pharmacokinetic (WB-PBPK) model of ciprofloxacin (2017)
- PK-PD Modeling of Individual Lesion FDG-PET Response to Predict Overall Survival in Patients With Sunitinib-treated Gastrointestinal Stromal Tumor (2016)
- Models for change in tumour size, appearance of new lesions and survival probability in patients with advanced epithelial ovarian cancer (2016)
- Population pharmacokinetic pharmacodynamic modelling in oncology (2015)
Senaste publikationer
- Integration of individual preclinical and clinical anti-infective PKPD data to predict clinical study outcomes (2024)
- Bridging responses to a human telomerase reverse transcriptase-based peptide cancer vaccine candidate in a mechanism-based model (2024)
- Impact of continuous-infusion meropenem degradation and infusion bag changes on bacterial killing of Pseudomonas aeruginosa based on model-informed translation (2024)
- Multistate modeling for survival analysis in critically ill patients treated with meropenem (2024)
- Quantitative modeling of tumor dynamics and development of drug resistance in non-small cell lung cancer patients treated with erlotinib (2024)
Alla publikationer
Artiklar
- Integration of individual preclinical and clinical anti-infective PKPD data to predict clinical study outcomes (2024)
- Bridging responses to a human telomerase reverse transcriptase-based peptide cancer vaccine candidate in a mechanism-based model (2024)
- Impact of continuous-infusion meropenem degradation and infusion bag changes on bacterial killing of Pseudomonas aeruginosa based on model-informed translation (2024)
- Multistate modeling for survival analysis in critically ill patients treated with meropenem (2024)
- Quantitative modeling of tumor dynamics and development of drug resistance in non-small cell lung cancer patients treated with erlotinib (2024)
- Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model (2024)
- Predicting cytokine kinetics during sepsis; a modelling framework from a porcine sepsis model with live Escherichia coli (2023)
- Optimization of blood pressure measurement practices for pharmacodynamic analyses of tyrosine-kinase inhibitors (2023)
- Assessment of ibrutinib scheduling on leukocyte, lymph node size and blood pressure dynamics in chronic lymphocytic leukemia through pharmacokinetic-pharmacodynamic models (2023)
- Prevalence and Clinical Consequences of Colistin Heteroresistance and Evolution into Full Resistance in Carbapenem-Resistant Acinetobacter baumannii (2023)
- A multistate modeling and simulation framework to learn dose-response of oncology drugs (2023)
- Multistate Pharmacometric Model to Define the Impact of Second-Line Immunotherapies on the Survival Outcome of the IMpower131 Study (2023)
- Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time-kill experiments (2023)
- Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time-kill experiments: high agreement with in silico predictions (2023)
- Rituximab pharmacokinetic and pharmacokinetic-pharmacodynamic evaluation based on a study in diffuse large B-cell lymphoma (2023)
- A model‐based approach leveraging in vitro data to support dose selection from the outset (2023)
- Model‐based assessment of neutrophil‐mediated phagocytosis and digestion of bacteria across in vitro and in vivo studies (2023)
- Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia (2022)
- Expert workshop summary (2022)
- Variability of murine bacterial pneumonia models used to evaluate antimicrobial agents (2022)
- Research priorities towards precision antibiotic therapy to improve patient care (2022)
- Large-scale WGS of carbapenem-resistant Acinetobacter baumannii isolates reveals patterns of dissemination of ST clades associated with antibiotic resistance (2022)
- Pulmonary and systemic pharmacokinetics of colistin methanesulfonate (CMS) and formed colistin following nebulisation of CMS among patients with ventilator-associated pneumonia (2022)
- Model-Based Characterization of the Bidirectional Interaction Between Pharmacokinetics and Tumor Growth Dynamics in Patients with Metastatic Merkel Cell Carcinoma Treated with Avelumab (2022)
- Bayesian forecasting of tumor size metrics and overall survival (2022)
- Pharmacokinetic/pharmacodynamic models for time courses of antibiotic effects (2022)
- Model-Informed Translation of In Vitro Effects of Short-, Prolonged- and Continuous-Infusion Meropenem against Pseudomonas aeruginosa to Clinical Settings (2022)
- In vivo fitness of carbapenem-resistant Acinetobacter baumannii strains in murine infection is associated with treatment failure in human infections (2022)
- Preclinical InVivo Data Integrated in a Modeling Network Informs a Refined Clinical Strategy for a CD3 T-Cell Bispecific in Combination with Anti-PD-L1 (2022)
- Anti-cancer treatment schedule optimization based on tumor dynamics modelling incorporating evolving resistance (2022)
- Population pharmacokinetics of apramycin from first-in-human plasma and urine data to support prediction of efficacious dose (2022)
- Population Pharmacokinetics of Flucloxacillin In Bone and Soft Tissue (2022)
- Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice (2021)
- Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis (2021)
- Excluded versus included patients in a randomized controlled trial of infections caused by carbapenem-resistant Gram-negative bacteria (2021)
- Pivotal Role of Translation in Anti-Infective Development (2021)
- Multistate model for pharmacometric analyses of overall survival in HER2-negative breast cancer patients treated with docetaxel (2021)
- Tumor growth inhibition modeling of individual lesion dynamics and interorgan variability in HER2-negative breast cancer patients treated with docetaxel (2021)
- Continuous infusion of piperacillin‐tazobactam significantly improves target attainment in children with cancer and fever (2021)
- Model-Informed Drug Development for Anti-Infectives (2021)
- CPT (2021)
- Dr. Hartmut Derendorf, PhD, a world-renowned expert in pharmacokinetics and pharmacometrics (1953–2020) (2021)
- Model-Informed Drug Development for Antimicrobials (2021)
- Effect of Scalp Cooling on the Pharmacokinetics of Paclitaxel (2021)
- Tissue Type Differences in ABCB1 Expression and Paclitaxel Tissue Pharmacokinetics in Patients With Esophageal Cancer (2021)
- From Therapeutic Drug Monitoring to Model-Informed Precision Dosing for Antibiotic (2021)
- Population pharmacokinetics of piperacillin in plasma and subcutaneous tissue in patients on continuous renal replacement therapy (2020)
- Model-Based Biomarker Selection for Dose Individualization of Tyrosine-Kinase Inhibitors (2020)
- Model-based Dose Individualization of Sunitinib in Gastrointestinal Stromal Tumors (2020)
- Acinetobacter Infections (2020)
- Colistin Resistance Development Following Colistin-Meropenem Combination Therapy Versus Colistin Monotherapy in Patients With Infections Caused by Carbapenem-Resistant Organisms (2020)
- Considerations for the optimal management of antibiotic therapy in elderly patients (2020)
- Acute bacterial or viral infection-What's the difference? (2020)
- Population Pharmacokinetics of Piperacillin following Continuous Infusion in Critically Ill Patients and Impact of Renal Function on Target Attainment (2020)
- Population pharmacokinetics of colistin and the relation to survival in critically ill patients infected with colistin susceptible and carbapenem-resistant bacteria (2020)
- Pharmacometrics and Systems Pharmacology 2030 (2020)
- The tumor time-course predicts overall survival in non-small cell lung cancer patients treated with atezolizumab (2020)
- Comparing Circulating Tumor Cell Counts with Dynamic Tumor Size Changes as Predictor of Overall Survival (2020)
- Colistin plus meropenem for carbapenem-resistant Gram-negative infections (2020)
- Efficacy of Antibiotic Combinations against Multidrug-Resistant Pseudomonas aeruginosa in Automated Time-Lapse Microscopy and Static Time-Kill Experiments (2020)
- Model-Informed Drug Development in Pulmonary Delivery (2020)
- Pharmacodynamics of immune response biomarkers of interest for evaluation of treatment effects in bacterial infections (2020)
- Extension of Pharmacokinetic/Pharmacodynamic Time-Kill Studies To Include Lipopolysaccharide/Endotoxin Release from Escherichia coli Exposed to Cefuroxime. (2020)
- How preclinical infection models help define antibiotic doses in the clinic (2020)
- Evaluation of polymyxin B in combination with 13 other antibiotics against carbapenemase-producing Klebsiella pneumoniae in time-lapse microscopy and time-kill experiments (2020)
- Combination of polymyxin B and minocycline against multidrug-resistant Klebsiella pneumoniae (2020)
- Treatment Outcomes of Colistin- and Carbapenem-resistant Acinetobacter baumannii Infections (2019)
- Effects of cladribine tablets on heart rate, atrio-ventricular conduction and cardiac repolarization in patients with relapsing multiple sclerosis (2019)
- Piperacillin pharmacokinetics and target attainment in children with cancer and fever (2019)
- A PK/PD Analysis of Circulating Biomarkers and Their Relationship to Tumor Response in Atezolizumab-Treated non-small Cell Lung Cancer Patients (2019)
- Model-Based Drug Development in Pulmonary Delivery (2019)
- A non-linear mixed effect model for innate immune response (2019)
- Population pharmacokinetics of piperacillin in febrile children receiving cancer chemotherapy (2019)
- Association between Paclitaxel Clearance and Tumor Response in Patients with Esophageal Cancer (2019)
- Population Pharmacokinetics of Piperacillin in Sepsis Patients (2018)
- A Whole-Body Physiologically Based Pharmacokinetic Model for Colistin and Colistin Methanesulfonate in Rat (2018)
- Semi-mechanistic pharmacokinetic-pharmacodynamic modelling of antibiotic drug combinations (2018)
- Population Pharmacokinetics of Meropenem in Plasma and Subcutis from Patients on Extracorporeal Membrane Oxygenation Treatment (2018)
- Reply to Prim et al., "Is Colistin Susceptibility Testing Finally on the Right Track?" (2018)
- Predicting mutant selection in competition experiments with ciprofloxacin-exposed Escherichia coli (2018)
- The risk of febrile neutropenia in breast cancer patients following adjuvant chemotherapy is predicted by the time course of interleukin-6 and C-reactive protein by modelling. (2018)
- Colistin alone versus colistin plus meropenem for treatment of severe infections caused by carbapenem-resistant Gram-negative bacteria (2018)
- Model-Based Adaptive Optimal Design (MBAOD) Improves Combination Dose Finding Designs (2018)
- A pharmacometric analysis of patient-reported outcomes in breast cancer patients through item response theory (2018)
- Colistin is Extensively Lost during Standard in Vitro Experimental Conditions (2017)
- Item Response Theory to Quantify Longitudinal Placebo and Paliperidone Effects on PANSS Scores in Schizophrenia (2017)
- Advanced Methods for Dose and Regimen Finding During Drug Development (2017)
- A PKPD analysis of circulating biomarkers and their relationship to the tumor size time-course in atezolizumab treated non-small cell lung cancer patients (2017)
- Model-based prediction of myelosuppression and recovery based on frequent neutrophil monitoring (2017)
- Can a pharmacokinetic/pharmacodynamic (PKPD) model be predictive across bacterial densities and strains? (2017)
- A whole-body physiologically based pharmacokinetic (WB-PBPK) model of ciprofloxacin (2017)
- A Pharmacometric Framework for Axitinib Exposure, Efficacy, and Safety in Metastatic Renal Cell Carcinoma Patients (2017)
- Pharmacometric Modeling of Liver Metastases' Diameter, Volume, and Density and Their Relation to Clinical Outcome in Imatinib-Treated Patients With Gastrointestinal Stromal Tumors (2017)
- Population Pharmacokinetic Modeling as a Tool To Characterize the Decrease in Ciprofloxacin Free Interstitial Levels Caused by Pseudomonas aeruginosa Biofilm Lung Infection in Wistar Rats (2017)
- Assessment of early combination effects of colistin and meropenem against Pseudomonas aeruginosa and Acinetobacter baumannii in dynamic time-kill experiments (2017)
- The role of infection models and PK/PD modelling for optimising care of critically ill patients with severe infections (2017)
- Multicentre open-label randomised controlled trial to compare colistin alone with colistin plus meropenem for the treatment of severe infections caused by carbapenem-resistant Gram-negative infections (AIDA) (2016)
- Challenge for higher colistin dosage in critically ill patients receiving continuous venovenous haemodiafiltration (2016)
- A pharmacokinetic-pharmacodynamic (PKPD) model based on in vitro time-kill data predicts the in vivo PK/PD index of colistin (2016)
- Simulation-Based Evaluation of PK/PD Indices for Meropenem Across Patient Groups and Experimental Designs (2016)
- Dynamic interaction of colistin and meropenem on a WT and a resistant strain of Pseudomonas aeruginosa as quantified in a PK/PD model (2016)
- PK-PD Modeling of Individual Lesion FDG-PET Response to Predict Overall Survival in Patients With Sunitinib-treated Gastrointestinal Stromal Tumor (2016)
- Models for change in tumour size, appearance of new lesions and survival probability in patients with advanced epithelial ovarian cancer (2016)
- Population pharmacokinetic pharmacodynamic modelling in oncology (2015)
- Performance of Nonlinear Mixed Effects Models in the Presence of Informative Dropout (2015)
- Colistin Population Pharmacokinetics after Application of a Loading Dose of 9 MU Colistin Methanesulfonate in Critically Ill Patients (2015)
- A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants (2015)
- Inter occasion variability in individual optimal design (2015)
- A pharmacokinetic binding model for bevacizumab and VEGF(165) in colorectal cancer patients (2015)
- Analyzing Patient-Reported Outcomes in Breast Cancer throughItem-Response Theory Pharmacometric Modeling (2015)
- Optimizing Oncology Therapeutics Through Quantitative Translational and Clinical Pharmacology (2015)
- A Mechanistic Pharmacokinetic Model Elucidating the Disposition of Trastuzumab Emtansine (T-DM1), an Antibody-Drug Conjugate (ADC) for Treatment of Metastatic Breast Cancer (2014)
- Simultaneous Exposure-Response Modeling of ACR20, ACR50, and ACR70 Improvement Scores in Rheumatoid Arthritis Patients With Certolizumab Pegol (2014)
- A pharmacokinetic/pharmacodynamic model developed for the effect of colistin on Pseudomonas aeruginosa in vitro with evaluation of population pharmacokinetic variability on simulated bacterial killing (2014)
- Characterization of Endogenous G-CSF and the Inverse Correlation to Chemotherapy-Induced Neutropenia in Patients with Breast Cancer Using Population Modeling (2014)
- A review of mixed-effects models of tumor growth and effects of anticancer drug treatment used in population analysis (2014)
- CPT (2014)
- Whole Body Physiologically-Based Pharmacokinetic Model for Colistin and Colistimethate Sodium (CMS) in Six Different Species (2013)
- A Pharmacogenetic Predictive Model for Paclitaxel Clearance Based on the DMET Platform (2013)
- CYP3A4*22 Genotype and Systemic Exposure Affect Paclitaxel-Induced Neurotoxicity (2013)
- Tutorials on the foundations of pharmacometrics and systems pharmacology (2013)
- Warfarin dose prediction in children using pharmacometric bridging (2013)
- Characterising variability in warfarin dose requirements in children using modelling and simulation (2013)
- PKPD Modeling of VEGF, sVEGFR-2, sVEGFR-3, and sKIT as Predictors of Tumor Dynamics and Overall Survival Following Sunitinib Treatment in GIST (2013)
- PKPD Modeling of Predictors for Adverse Effects and Overall Survival in Sunitinib-Treated Patients With GIST (2013)
- Colistin methanesulfonate and colistin pharmacokinetics in critically ill patients receiving continuous venovenous hemodiafiltration (2013)
- PK/PD Index Versus Mechanism-Based PKPD Modeling to Describe Antibacterial Efficacy of Ciprofloxacin and Colistin (2013)
- Handling of Inter Occasion Variability (IOV) in Individual Optimal Design (OD) of a Colistin PK Sampling Schedule (2013)
- Longitudinal infusion of a complex of insulin-like growth factor-I and IGF-binding protein-3 in five preterm infants (2013)
- Pharmacokinetic-Pharmacodynamic Modeling of Antibacterial Drugs (2013)
- Predictions of In Vivo Prolactin Levels from In Vitro K (i) Values of D-2 Receptor Antagonists Using an Agonist-Antagonist Interaction Model (2013)
- Pharmacometrics and Systems Pharmacology Software Tutorials and Use (2013)
- Systematic Review and Meta-Analysis of In Vitro Synergy of Polymyxins and Carbapenems (2013)
- A population pharmacokinetic/pharmacodynamic model of thrombocytopenia characterizing the effect of trastuzumab emtansine (T-DM1) on platelet counts in patients with HER2-positive metastatic breast cancer (2012)
- Influence of drug exposure and genetic variation on paclitaxel-induced neurotoxicity (2012)
- Influence of Polymorphic OATP1B-Type Carriers on the Disposition of Docetaxel (2012)
- Influence of Smoking on the Pharmacokinetics and Toxicity Profiles of Taxane Therapy (2012)
- A long-term prospective population pharmacokinetic study on imatinib plasma concentrations in GIST patients (2012)
- Integrated Population Pharmacokinetic Analysis of Voriconazole in Children, Adolescents, and Adults (2012)
- The shape of the myelosuppression time profile is related to the probability of developing neutropenic fever in patients with docetaxel-induced grade IV neutropenia (2012)
- Population pharmacokinetics of cytarabine, etoposide, and daunorubicin in the treatment for acute myeloid leukemia (2012)
- Evaluation of IPPSE, an alternative method for sequential population PKPD analysis (2012)
- Pharmacokinetic-pharmacodynamic model for gentamicin and its adaptive resistance with predictions of dosing schedules in newborn infants (2012)
- Application of a Loading Dose of Colistin Methanesulfonate in Critically Ill Patients (2012)
- Increased Clearance of Docetaxel in Androgen Deprived Prostate Cancer Patients (2012)
- A simultaneous analysis of the time-course of leukocytes and neutrophils following docetaxel administration using a semi-mechanistic myelosuppression model (2012)
- Impact of CYP2C8*3 on paclitaxel clearance (2011)
- Influence of Cremophor EL and Genetic Polymorphisms on the Pharmacokinetics of Paclitaxel and Its Metabolites Using a Mechanism-Based Model (2011)
- Predicting in vitro antibacterial efficacy across experimental designs with a semimechanistic pharmacokinetic-pharmacodynamic model (2011)
- Pharmacokinetic/Pharmacodynamic (PK/PD) indices of antibiotics predicted by a semi-mechanistic PKPD model (2011)
- Predictive ability of a semi-mechanistic model for neutropenia in the development of novel anti-cancer agents (2011)
- Scaling the time-course of myelosuppression from rats to patients with a semi-physiological model (2010)
- A Semi-Mechanistic Model of CP-690,550-Induced Reduction in Neutrophil Counts in Patients With Rheumatoid Arthritis (2010)
- Limited inter-occasion variability in relation to inter-individual variability in chemotherapy-induced myelosuppression (2010)
- Comparison of the agonist-antagonist interaction model and the pool model for the effect of remoxipride on prolactin (2010)
- Transforming parts of a differential equations system to difference equations as a method for run-time savings in NONMEM (2010)
- Modelling the genesis and treatment of cancer (2010)
- A CYP3A4 Phenotype-Based Dosing Algorithm for Individualized Treatment of Irinotecan (2010)
- Model-Based Neutrophil-Guided Dose Adaptation in Chemotherapy (2010)
- An agonist-antagonist interaction model for prolactin release following risperidone and paliperidone treatment (2009)
- Modeling and Simulation of the Time Course of Asenapine Exposure Response and Dropout Patterns in Acute Schizophrenia (2009)
- Quantitative analysis of colistin A and colistin B in plasma and culture medium using a simple precipitation step followed by LC/MS/MS (2009)
- The effect of decontamination procedures on the pharmacokinetics of venlafaxine in overdose (2009)
- A pharmacodynamic Markov mixed-effects model for determining the effect of exposure to certolizumab pegol on the ACR20 score in patients with rheumatoid arthritis (2009)
- A Pharmacodynamic Markov Mixed-Effects Model for Determining the Effect of Exposure to Certolizumab Pegol on the ACR20 Score in Patients With Rheumatoid Arthritis (2009)
- Dose response of whole-grain biomarkers (2009)
- A Pharmacokinetic and Dosing Study of Intravenous Insulin-Like Growth Factor-I and IGF-Binding Protein-3 Complex to Preterm Infants (2009)
- Developmental Pharmacokinetics of Gentamicin in Preterm and Term Neonates (2009)
- Population pharmacokinetic analysis of colistin methanesulfonate and colistin after intravenous administration in critically ill patients with infections caused by gram-negative bacteria (2009)
- A tool for neutrophil guided dose adaptation in chemotherapy (2009)
- Population pharmacokinetics of tacrolimus in paediatric haematopoietic stem cell transplant recipients (2009)
- Irinotecan-induced diarrhea (2007)
- Pharmacokinetics of quetiapine in overdose and the effect of activated charcoal (2007)
- Application of pharmacokinetic-pharmacodynamic modeling in management of QT abnormalities after citalopram overdose. Reply to A. Manini (2007)
- Reply to Dr. Megarbane et al. regarding "Pharmacokinetic/pharmacodynamic modelling of cardiac toxicity in venlafaxine overdose" (2007)
- Activated charcoal decreases the risk of QT prolongation after citalopram overdose (2007)
- Human methyl parathion poisoning (2007)
- Cigarette smoking and irinotecan treatment (2007)
- Population pharmacokinetics of itraconazole and its active metabolite hydroxy-itraconazole in paediatric cystic fibrosis and bone marrow transplant patients (2006)
- Pharmacokinetic-pharmacodynamic modelling of the schedule-dependent effect of the anti-cancer agent CHS 828 in a rat hollow fibre model. (2005)
- Pharmacokinetic-Pharmacodynamic modelling of the schedule-dependent effect of the anti-cancer agent CHS 828 in a rat hollow fibre model (2005)
- Pharmacokinetic/pharmacodynamic modelling in oncological drug development. (2005)
- Pharmacodynamic differences between species exemplified by the novel anticancer agent CHS 828 (2004)
- Mechanistic models for myelosuppression (2003)
- Model of Chemotherapy-Induced Myelosuppression With Parameter Consistency Across Drugs (2002)
- Model of chemotherapy-induced myelosuppression with parameter consistency across drugs (2002)
- Determination of drug effect on tumour cells, host animal toxicity and drug pharmacokinetics in a hollow-fibre model in rats (2000)
- New population modeling approaches for tumor response and survival analysis: an extension of the TGI-TTE framework using docetaxel and paclitaxel data
- Comparative Analysis of Pharmacoeconomic and Pharmacometric Modeling in the Cost-Effectiveness Evaluation of Sunitinib Therapy with Therapeutic Drug Monitoring for Gastrointestinal Stromal Tumors
- Pharmacokinetic-pharmacodynamic modeling of the schedule-dependent effect of CHS 828 in a rat hollow fiber model
- Predicting the relative importance of genetic, clinical and demographic factors on warfarin dose in children using pharmacometric modelling
- The influence of second-line immuno-therapies on the survival outcome of first-line non-small cell lung cancer atezolizumab IMpower131 study: An application of multistate modeling
- Model-based assessment of neutrophil-mediated phagocytosis and digeston of bacteria across in vitro and in vivo studies
- Endotoxin challenge models: Model-based translation from piglets to healthy volunteers
- Physiological response to endotoxin: Linking hemodynamic and respiratory longitudinal changes through modelling
- Translational PKPD modelling and simulation framework to explore the combined effect of polymyxin B and minocycline against Klebsiella pneumoniae