Xiaonan Zhang

Identification of a small molecule targeting EPLIN as a novel strategy for the treatment of pediatric neuroblastoma and medulloblastoma

Lindell, Emma; Guo, Jing; Zhao, Miao; Rameika, Natallia et al.

Part of Cell Death and Disease, 2025

• DOI for Identification of a small molecule targeting EPLIN as a novel strategy for the treatment of pediatric neuroblastoma and medulloblastoma
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Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib

Zhang, Xiaonan; Rameika, Natallia; Zhong, Lei; Veanes, Margus et al.

Part of EBioMedicine, 2024

• DOI for Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib
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Genetic differences between primary and metastatic cancer: a pan-cancer whole-genome comparison study

Zhong, Lei; Zhao, Zhipeng; Zhang, Xiaonan

Part of Signal Transduction and Targeted Therapy, 2023

• DOI for Genetic differences between primary and metastatic cancer: a pan-cancer whole-genome comparison study
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Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells

Lu, Xi; Zhong, Lei; Lindell, Emma; Veanes, Margus et al.

Part of Cell Death and Disease, 2023

• DOI for Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells
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Quiescent Cancer Cells: A Potential Therapeutic Target to Overcome Tumor Resistance and Relapse

Lindell, Emma; Zhong, Lei; Zhang, Xiaonan

Part of International Journal of Molecular Sciences, 2023

• DOI for Quiescent Cancer Cells: A Potential Therapeutic Target to Overcome Tumor Resistance and Relapse
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Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions

Westergren Jakobsson, Amanda; Kundu, Snehangshu; Guo, Jing; Chowdhury, Azazul Islam et al.

Part of Cancers, 2022

• DOI for Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions
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Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the Ovaries

Zhang, Xiaonan; Shetty, Mihir; Clemente, Valentino; Linder, Stig et al.

Part of International Journal of Molecular Sciences, 2021

• DOI for Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the Ovaries
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Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics

Zhang, Xiaonan; De Milito, Angelo; Demiroglu-Zergeroglu, Asuman; Gullbo, Joachim et al.

Part of Trends in Cancer, p. 657-663, 2016

• DOI for Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics

Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors

Zhang, Xiaonan; de Milito, Angelo; Olofsson, Maria Hagg; Gullbo, Joachim et al.

Part of International Journal of Molecular Sciences, p. 27313-27326, 2015

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Zhang, Xiaonan; Fryknäs, Mårten; Hernlund, Emma; Fayad, Walid et al.

Part of Nature Communications, p. 3295, 2014

Albacarcin V adds EPLIN as a novel and promising target for the treatment of female cancers and pediatric medulloblastoma

Krahulcova, Lucia; Lindell, Emma; Lu, Xi; Conejeros Monsalve, Jessica Javiera et al.

Part of Biochemical Pharmacology, 2026

• DOI for Albacarcin V adds EPLIN as a novel and promising target for the treatment of female cancers and pediatric medulloblastoma
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NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors

Rameika, Natallia; Tsiara, Ioanna; Zhang, Xiaonan; Haberek, Wawrzyniec et al.

Part of Biochimica et Biophysica Acta - Molecular Basis of Disease, 2025

• DOI for NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors
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Identification of a small molecule targeting EPLIN as a novel strategy for the treatment of pediatric neuroblastoma and medulloblastoma

Lindell, Emma; Guo, Jing; Zhao, Miao; Rameika, Natallia et al.

Part of Cell Death and Disease, 2025

• DOI for Identification of a small molecule targeting EPLIN as a novel strategy for the treatment of pediatric neuroblastoma and medulloblastoma
• Download full text (pdf) of Identification of a small molecule targeting EPLIN as a novel strategy for the treatment of pediatric neuroblastoma and medulloblastoma

Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib

Zhang, Xiaonan; Rameika, Natallia; Zhong, Lei; Veanes, Margus et al.

Part of EBioMedicine, 2024

• DOI for Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib
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Red blood cell derived nanocarrier drug delivery system: A promising strategy for tumor therapy

Wang, Xin; Mao, Kuirong; Zhang, Xiaonan; Zhang, Yuning et al.

Part of Interdisciplinary Medicine, 2024

• DOI for Red blood cell derived nanocarrier drug delivery system: A promising strategy for tumor therapy
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Albacarcin V adds EPLIN as a novel and promising target for the treatment of female cancers and pediatric medulloblastoma

Krahulcova, Lucia; Lindell, Emma; Lu, Xi; Conejeros Monsalve, Jessica Javiera et al.

Part of Biochemical Pharmacology, 2026

• DOI for Albacarcin V adds EPLIN as a novel and promising target for the treatment of female cancers and pediatric medulloblastoma
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NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors

Rameika, Natallia; Tsiara, Ioanna; Zhang, Xiaonan; Haberek, Wawrzyniec et al.

Part of Biochimica et Biophysica Acta - Molecular Basis of Disease, 2025

• DOI for NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors
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Identification of a small molecule targeting EPLIN as a novel strategy for the treatment of pediatric neuroblastoma and medulloblastoma

Lindell, Emma; Guo, Jing; Zhao, Miao; Rameika, Natallia et al.

Part of Cell Death and Disease, 2025

• DOI for Identification of a small molecule targeting EPLIN as a novel strategy for the treatment of pediatric neuroblastoma and medulloblastoma
• Download full text (pdf) of Identification of a small molecule targeting EPLIN as a novel strategy for the treatment of pediatric neuroblastoma and medulloblastoma

Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib

Zhang, Xiaonan; Rameika, Natallia; Zhong, Lei; Veanes, Margus et al.

Part of EBioMedicine, 2024

• DOI for Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib
• Download full text (pdf) of Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib

Genetic differences between primary and metastatic cancer: a pan-cancer whole-genome comparison study

Zhong, Lei; Zhao, Zhipeng; Zhang, Xiaonan

Part of Signal Transduction and Targeted Therapy, 2023

• DOI for Genetic differences between primary and metastatic cancer: a pan-cancer whole-genome comparison study
• Download full text (pdf) of Genetic differences between primary and metastatic cancer: a pan-cancer whole-genome comparison study

Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells

Lu, Xi; Zhong, Lei; Lindell, Emma; Veanes, Margus et al.

Part of Cell Death and Disease, 2023

• DOI for Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells
• Download full text (pdf) of Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells

Emetine, a small molecule natural product, displays potent anti-gastric cancer activity via regulation of multiple signaling pathways

Peng, Xuerun; Shi, Jianyou; Zhao, Zhipeng; Tong, Rongsheng et al.

Part of Cancer Chemotherapy and Pharmacology, p. 303-315, 2023

• DOI for Emetine, a small molecule natural product, displays potent anti-gastric cancer activity via regulation of multiple signaling pathways

Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity

Zhang, Xiaonan; Akcan, Ece; Correia, Mario S. P.; Rameika, Natallia et al.

Part of Biochemical Pharmacology, 2022

• DOI for Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity
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Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions

Westergren Jakobsson, Amanda; Kundu, Snehangshu; Guo, Jing; Chowdhury, Azazul Islam et al.

Part of Cancers, 2022

• DOI for Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions
• Download full text (pdf) of Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions

Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the Ovaries

Zhang, Xiaonan; Shetty, Mihir; Clemente, Valentino; Linder, Stig et al.

Part of International Journal of Molecular Sciences, 2021

• DOI for Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the Ovaries
• Download full text (pdf) of Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the Ovaries

UNC-45A Breaks MT Lattice Independent of its Effect on Non-Muscle Myosin II

Habicht, Juri; Mooneyham, Ashley; Hoshino, Asumi; Shetty, Mihir et al.

Part of Journal of Cell Science, 2020

• DOI for UNC-45A Breaks MT Lattice Independent of its Effect on Non-Muscle Myosin II

Induction of ER Stress in Acute Lymphoblastic Leukemia Cells by the Deubiquitinase Inhibitor VLX1570

Pellegrini, Paola; Selvaraju, Karthik; Faustini, Elena; Mofers, Arjan et al.

Part of International Journal of Molecular Sciences, 2020

• DOI for Induction of ER Stress in Acute Lymphoblastic Leukemia Cells by the Deubiquitinase Inhibitor VLX1570
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UNC-45A is preferentially expressed in epithelial cells and binds to and co-localizes with interphase MTs

Habicht, Juri; Mooneyham, Ashley; Shetty, Mihir; Zhang, Xiaonan et al.

Part of Cancer Biology & Therapy, p. 1304-1313, 2019

• DOI for UNC-45A is preferentially expressed in epithelial cells and binds to and co-localizes with interphase MTs

Proteasome inhibitor b-AP15 induces enhanced proteotoxicity by inhibiting cytoprotective aggresome formation

Hillert, Ellin-Kristina; Brnjic, Slavica; Zhang, Xiaonan; Mazurkiewicz, Magdalena et al.

Part of Cancer Letters, p. 70-83, 2019

• DOI for Proteasome inhibitor b-AP15 induces enhanced proteotoxicity by inhibiting cytoprotective aggresome formation

Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug

Zhang, Xiaonan; Selvaraju, Karthik; Saei, Amir Ata; D'Arcy, Padraig et al.

Part of Biochimie, p. 46-54, 2019

• DOI for Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug

Oxidative Stress Induced by the Deubiquitinase Inhibitor b-AP15 Is Associated with Mitochondrial Impairment

Zhang, Xiaonan; Espinosa, Belén; Saei, Amir Ata; D'Arcy, Padraig et al.

Part of Oxidative Medicine and Cellular Longevity, p. 1-11, 2019

• DOI for Oxidative Stress Induced by the Deubiquitinase Inhibitor b-AP15 Is Associated with Mitochondrial Impairment

The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage

Zhang, Xiaonan; Pellegrini, Paola; Saei, Amir Ata; Hillert, Ellin-Kristina et al.

Part of Biochemical Pharmacology, p. 291-301, 2018

• DOI for The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage

Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy

Stafford, William C.; Peng, Xiaoxiao; Olofsson, Maria Hägg; Zhang, Xiaonan et al.

Part of Science Translational Medicine, 2018

• DOI for Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy

MYC is downregulated by a mitochondrial checkpoint mechanism

Zhang, Xiaonan; Mofers, Arjan; Hydbring, Per; Olofsson, Maria Hägg et al.

Part of Oncotarget, p. 90225-90237, 2017

• DOI for MYC is downregulated by a mitochondrial checkpoint mechanism

Estrogen Receptor β as a Therapeutic Target in Breast Cancer Stem Cells

Ma, Ran; Karthik, Govindasamy-Muralidharan; Lövrot, John; Haglund, Felix et al.

Part of Journal of the National Cancer Institute, 2017

• DOI for Estrogen Receptor β as a Therapeutic Target in Breast Cancer Stem Cells

IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells

Mao, Yumeng; van Hoef, Vincent; Zhang, Xiaonan; Wennerberg, Erik et al.

Part of Blood, p. 1475-1489, 2016

• DOI for IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells

Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

Senkowski, Wojciech; Zhang, Xiaonan; Olofsson, Maria Hagg; Isacson, Ruben et al.

Part of Molecular Cancer Therapeutics, p. 1504-1516, 2015

• DOI for Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

The anticancer activity of the DUB inhibitor b-AP15 is associated with accumulation of proteasome bound ubiquitin and oxidative stress

Mazurkiewicz, Magdalena; Brnjic, Slavica; Fryknas, Marten; Sun, Chao et al.

Part of Cancer Research, 2015

• DOI for The anticancer activity of the DUB inhibitor b-AP15 is associated with accumulation of proteasome bound ubiquitin and oxidative stress

Spheroid-based high throughput screening for identification of molecules targeting different tumor microenvironment characteristics

Senkowski, Wojciech; Zhang, Xiaonan; Nygren, Peter; Olofsson, Maria Hagg et al.

Part of Cancer Research, 2015

• DOI for Spheroid-based high throughput screening for identification of molecules targeting different tumor microenvironment characteristics

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Zhang, Xiaonan; Fryknäs, Mårten; Hernlund, Emma; Fayad, Walid et al.

Part of Nature Communications, p. 3295, 2014

Label-free detection and dynamic monitoring of drug-induced intracellular vesicle formation enabled using a 2-dimensional matched filter

Aftab, Obaid; Fryknäs, Mårten; Zhang, Xiaonan; De Milito, Angelo et al.

Part of Autophagy, p. 57-69, 2014

• DOI for Label-free detection and dynamic monitoring of drug-induced intracellular vesicle formation enabled using a 2-dimensional matched filter

The 19S Deubiquitinase Inhibitor b-AP15 Is Enriched in Cells and Elicits Rapid Commitment to Cell Death

Wang, Xin; Stafford, William; Mazurkiewicz, Magdalena; Fryknäs, Mårten et al.

Part of Molecular Pharmacology, p. 932-945, 2014

• DOI for The 19S Deubiquitinase Inhibitor b-AP15 Is Enriched in Cells and Elicits Rapid Commitment to Cell Death

Induction of Tumor Cell Apoptosis by a Proteasome Deubiquitinase Inhibitor Is Associated with Oxidative Stress

Brnjic, Slavica; Mazurkiewicz, Magdalena; Fryknäs, Mårten; Sun, Chao et al.

Part of Antioxidants and Redox Signaling, p. 2271-2285, 2014

• DOI for Induction of Tumor Cell Apoptosis by a Proteasome Deubiquitinase Inhibitor Is Associated with Oxidative Stress

A spheroid-based screen identifies mitochondrial targeting as a promising strategy for cancer treatment and drug repositioning

Senkowski, Wojciech; Zhang, Xiaonan; Olofsson, Maria Hagg; Linder, Stig et al.

Part of Cancer Research, 2014

• DOI for A spheroid-based screen identifies mitochondrial targeting as a promising strategy for cancer treatment and drug repositioning

Autophagy Is a Protective Mechanism for Human Melanoma Cells under Acidic Stress

Marino, Maria Lucia; Pellegrini, Paola; Di Lernia, Giuseppe; Djavaheri-Mergny, Mojgan et al.

Part of Journal of Biological Chemistry, p. 30664-30676, 2012

• DOI for Autophagy Is a Protective Mechanism for Human Melanoma Cells under Acidic Stress

The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy

Hernlund, Emma; Olofsson, Maria Hägg; Fayad, Walid; Fryknäs, Mårten et al.

Part of European Journal of Cancer, p. 396-406, 2012

• DOI for The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy

Red blood cell derived nanocarrier drug delivery system: A promising strategy for tumor therapy

Wang, Xin; Mao, Kuirong; Zhang, Xiaonan; Zhang, Yuning et al.

Part of Interdisciplinary Medicine, 2024

• DOI for Red blood cell derived nanocarrier drug delivery system: A promising strategy for tumor therapy
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Exploring the Enigma: The Role of the Epithelial Protein Lost in Neoplasm in Normal Physiology and Cancer Pathogenesis

Lindell, Emma; Zhang, Xiaonan

Part of International Journal of Molecular Sciences, 2024

• DOI for Exploring the Enigma: The Role of the Epithelial Protein Lost in Neoplasm in Normal Physiology and Cancer Pathogenesis
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Quiescent Cancer Cells: A Potential Therapeutic Target to Overcome Tumor Resistance and Relapse

Lindell, Emma; Zhong, Lei; Zhang, Xiaonan

Part of International Journal of Molecular Sciences, 2023

• DOI for Quiescent Cancer Cells: A Potential Therapeutic Target to Overcome Tumor Resistance and Relapse
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Targeting Loss of Heterozygosity: A Novel Paradigm for Cancer Therapy

Zhang, Xiaonan; Sjöblom, Tobias

Part of Pharmaceuticals, 2021

• DOI for Targeting Loss of Heterozygosity: A Novel Paradigm for Cancer Therapy
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Drug Development Targeting the Ubiquitin-Proteasome System (UPS) for the Treatment of Human Cancers

Zhang, Xiaonan; Linder, Stig; Bazzaro, Martina

Part of Cancers, 2020

• DOI for Drug Development Targeting the Ubiquitin-Proteasome System (UPS) for the Treatment of Human Cancers
• Download full text (pdf) of Drug Development Targeting the Ubiquitin-Proteasome System (UPS) for the Treatment of Human Cancers

Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics

Zhang, Xiaonan; De Milito, Angelo; Demiroglu-Zergeroglu, Asuman; Gullbo, Joachim et al.

Part of Trends in Cancer, p. 657-663, 2016

• DOI for Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics

Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors

Zhang, Xiaonan; de Milito, Angelo; Olofsson, Maria Hagg; Gullbo, Joachim et al.

Part of International Journal of Molecular Sciences, p. 27313-27326, 2015

Novel anti-cancer agents targeting NAT2 loss in colorectal cancer

Rameika, Natallia; Tsiara, Ioanna; Haberek, Wawrzyniec; Akcan, Ece et al.