Xiaonan Zhang

Exploring the Enigma: The Role of the Epithelial Protein Lost in Neoplasm in Normal Physiology and Cancer Pathogenesis

Lindell, Emma; Zhang, Xiaonan

Ingår i International Journal of Molecular Sciences, 2024

• DOI för Exploring the Enigma: The Role of the Epithelial Protein Lost in Neoplasm in Normal Physiology and Cancer Pathogenesis
• Ladda ner fulltext (pdf) av Exploring the Enigma: The Role of the Epithelial Protein Lost in Neoplasm in Normal Physiology and Cancer Pathogenesis

Genetic differences between primary and metastatic cancer: a pan-cancer whole-genome comparison study

Zhong, Lei; Zhao, Zhipeng; Zhang, Xiaonan

Ingår i Signal Transduction and targeted Therapy, 2023

• DOI för Genetic differences between primary and metastatic cancer: a pan-cancer whole-genome comparison study
• Ladda ner fulltext (pdf) av Genetic differences between primary and metastatic cancer: a pan-cancer whole-genome comparison study

Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells

Lu, Xi; Zhong, Lei; Lindell, Emma; Veanes, Margus et al.

Ingår i Cell Death and Disease, 2023

• DOI för Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells
• Ladda ner fulltext (pdf) av Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells

Quiescent Cancer Cells: A Potential Therapeutic Target to Overcome Tumor Resistance and Relapse

Lindell, Emma; Zhong, Lei; Zhang, Xiaonan

Ingår i International Journal of Molecular Sciences, 2023

• DOI för Quiescent Cancer Cells: A Potential Therapeutic Target to Overcome Tumor Resistance and Relapse
• Ladda ner fulltext (pdf) av Quiescent Cancer Cells: A Potential Therapeutic Target to Overcome Tumor Resistance and Relapse

Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity

Zhang, Xiaonan; Akcan, Ece; Correia, Mario S. P.; Rameika, Natallia et al.

Ingår i Biochemical Pharmacology, 2022

• DOI för Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity
• Ladda ner fulltext (pdf) av Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity

Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions

Westergren Jakobsson, Amanda; Kundu, Snehangshu; Guo, Jing; Chowdhury, Azazul Islam et al.

Ingår i Cancers, 2022

• DOI för Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions
• Ladda ner fulltext (pdf) av Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions

Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the Ovaries

Zhang, Xiaonan; Shetty, Mihir; Clemente, Valentino; Linder, Stig et al.

Ingår i International Journal of Molecular Sciences, 2021

• DOI för Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the Ovaries
• Ladda ner fulltext (pdf) av Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the Ovaries

Oxidative Stress Induced by the Deubiquitinase Inhibitor b-AP15 Is Associated with Mitochondrial Impairment

Zhang, Xiaonan; Espinosa, Belén; Saei, Amir Ata; D'Arcy, Padraig et al.

Ingår i Oxidative Medicine and Cellular Longevity, s. 1-11, 2019

• DOI för Oxidative Stress Induced by the Deubiquitinase Inhibitor b-AP15 Is Associated with Mitochondrial Impairment

The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage

Zhang, Xiaonan; Pellegrini, Paola; Saei, Amir Ata; Hillert, Ellin-Kristina et al.

Ingår i Biochemical Pharmacology, s. 291-301, 2018

• DOI för The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage

Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics

Zhang, Xiaonan; De Milito, Angelo; Demiroglu-Zergeroglu, Asuman; Gullbo, Joachim et al.

Ingår i Trends in Cancer, s. 657-663, 2016

• DOI för Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Zhang, Xiaonan; Fryknäs, Mårten; Hernlund, Emma; Fayad, Walid et al.

Ingår i Nature Communications, s. 3295, 2014

NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors

Rameika, Natallia; Tsiara, Ioanna; Zhang, Xiaonan; Haberek, Wawrzyniec et al.

Ingår i Biochimica et Biophysica Acta - Molecular Basis of Disease, 2025

• DOI för NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors
• Ladda ner fulltext (pdf) av NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors

Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib

Zhang, Xiaonan; Rameika, Natallia; Zhong, Lei; Veanes, Margus et al.

Ingår i EBioMedicine, 2024

• DOI för Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib
• Ladda ner fulltext (pdf) av Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib

Red blood cell derived nanocarrier drug delivery system: A promising strategy for tumor therapy

Wang, Xin; Mao, Kuirong; Zhang, Xiaonan; Zhang, Yuning et al.

Ingår i Interdisciplinary Medicine, 2024

• DOI för Red blood cell derived nanocarrier drug delivery system: A promising strategy for tumor therapy
• Ladda ner fulltext (pdf) av Red blood cell derived nanocarrier drug delivery system: A promising strategy for tumor therapy

Exploring the Enigma: The Role of the Epithelial Protein Lost in Neoplasm in Normal Physiology and Cancer Pathogenesis

Lindell, Emma; Zhang, Xiaonan

Ingår i International Journal of Molecular Sciences, 2024

• DOI för Exploring the Enigma: The Role of the Epithelial Protein Lost in Neoplasm in Normal Physiology and Cancer Pathogenesis
• Ladda ner fulltext (pdf) av Exploring the Enigma: The Role of the Epithelial Protein Lost in Neoplasm in Normal Physiology and Cancer Pathogenesis

Genetic differences between primary and metastatic cancer: a pan-cancer whole-genome comparison study

Zhong, Lei; Zhao, Zhipeng; Zhang, Xiaonan

Ingår i Signal Transduction and targeted Therapy, 2023

• DOI för Genetic differences between primary and metastatic cancer: a pan-cancer whole-genome comparison study
• Ladda ner fulltext (pdf) av Genetic differences between primary and metastatic cancer: a pan-cancer whole-genome comparison study

NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors

Rameika, Natallia; Tsiara, Ioanna; Zhang, Xiaonan; Haberek, Wawrzyniec et al.

Ingår i Biochimica et Biophysica Acta - Molecular Basis of Disease, 2025

• DOI för NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors
• Ladda ner fulltext (pdf) av NAT2 activity increases cytotoxicity of anthracycline antibiotics and HDAC inhibitors

Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib

Zhang, Xiaonan; Rameika, Natallia; Zhong, Lei; Veanes, Margus et al.

Ingår i EBioMedicine, 2024

• DOI för Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib
• Ladda ner fulltext (pdf) av Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib

Genetic differences between primary and metastatic cancer: a pan-cancer whole-genome comparison study

Zhong, Lei; Zhao, Zhipeng; Zhang, Xiaonan

Ingår i Signal Transduction and targeted Therapy, 2023

• DOI för Genetic differences between primary and metastatic cancer: a pan-cancer whole-genome comparison study
• Ladda ner fulltext (pdf) av Genetic differences between primary and metastatic cancer: a pan-cancer whole-genome comparison study

Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells

Lu, Xi; Zhong, Lei; Lindell, Emma; Veanes, Margus et al.

Ingår i Cell Death and Disease, 2023

• DOI för Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells
• Ladda ner fulltext (pdf) av Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells

Emetine, a small molecule natural product, displays potent anti-gastric cancer activity via regulation of multiple signaling pathways

Peng, Xuerun; Shi, Jianyou; Zhao, Zhipeng; Tong, Rongsheng et al.

Ingår i Cancer Chemotherapy and Pharmacology, s. 303-315, 2023

• DOI för Emetine, a small molecule natural product, displays potent anti-gastric cancer activity via regulation of multiple signaling pathways

Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity

Zhang, Xiaonan; Akcan, Ece; Correia, Mario S. P.; Rameika, Natallia et al.

Ingår i Biochemical Pharmacology, 2022

• DOI för Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity
• Ladda ner fulltext (pdf) av Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity

Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions

Westergren Jakobsson, Amanda; Kundu, Snehangshu; Guo, Jing; Chowdhury, Azazul Islam et al.

Ingår i Cancers, 2022

• DOI för Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions
• Ladda ner fulltext (pdf) av Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions

Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the Ovaries

Zhang, Xiaonan; Shetty, Mihir; Clemente, Valentino; Linder, Stig et al.

Ingår i International Journal of Molecular Sciences, 2021

• DOI för Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the Ovaries
• Ladda ner fulltext (pdf) av Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the Ovaries

UNC-45A Breaks MT Lattice Independent of its Effect on Non-Muscle Myosin II

Habicht, Juri; Mooneyham, Ashley; Hoshino, Asumi; Shetty, Mihir et al.

Ingår i Journal of Cell Science, 2020

• DOI för UNC-45A Breaks MT Lattice Independent of its Effect on Non-Muscle Myosin II

Induction of ER Stress in Acute Lymphoblastic Leukemia Cells by the Deubiquitinase Inhibitor VLX1570

Pellegrini, Paola; Selvaraju, Karthik; Faustini, Elena; Mofers, Arjan et al.

Ingår i International Journal of Molecular Sciences, 2020

• DOI för Induction of ER Stress in Acute Lymphoblastic Leukemia Cells by the Deubiquitinase Inhibitor VLX1570
• Ladda ner fulltext (pdf) av Induction of ER Stress in Acute Lymphoblastic Leukemia Cells by the Deubiquitinase Inhibitor VLX1570

Proteasome inhibitor b-AP15 induces enhanced proteotoxicity by inhibiting cytoprotective aggresome formation

Hillert, Ellin-Kristina; Brnjic, Slavica; Zhang, Xiaonan; Mazurkiewicz, Magdalena et al.

Ingår i Cancer Letters, s. 70-83, 2019

• DOI för Proteasome inhibitor b-AP15 induces enhanced proteotoxicity by inhibiting cytoprotective aggresome formation

Oxidative Stress Induced by the Deubiquitinase Inhibitor b-AP15 Is Associated with Mitochondrial Impairment

Zhang, Xiaonan; Espinosa, Belén; Saei, Amir Ata; D'Arcy, Padraig et al.

Ingår i Oxidative Medicine and Cellular Longevity, s. 1-11, 2019

• DOI för Oxidative Stress Induced by the Deubiquitinase Inhibitor b-AP15 Is Associated with Mitochondrial Impairment

Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug

Zhang, Xiaonan; Selvaraju, Karthik; Saei, Amir Ata; D'Arcy, Padraig et al.

Ingår i Biochimie, s. 46-54, 2019

• DOI för Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug

UNC-45A is preferentially expressed in epithelial cells and binds to and co-localizes with interphase MTs

Habicht, Juri; Mooneyham, Ashley; Shetty, Mihir; Zhang, Xiaonan et al.

Ingår i Cancer Biology & Therapy, s. 1304-1313, 2019

• DOI för UNC-45A is preferentially expressed in epithelial cells and binds to and co-localizes with interphase MTs

The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage

Zhang, Xiaonan; Pellegrini, Paola; Saei, Amir Ata; Hillert, Ellin-Kristina et al.

Ingår i Biochemical Pharmacology, s. 291-301, 2018

• DOI för The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage

Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy

Stafford, William C.; Peng, Xiaoxiao; Olofsson, Maria Hägg; Zhang, Xiaonan et al.

Ingår i Science Translational Medicine, 2018

• DOI för Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy

MYC is downregulated by a mitochondrial checkpoint mechanism

Zhang, Xiaonan; Mofers, Arjan; Hydbring, Per; Olofsson, Maria Hägg et al.

Ingår i Oncotarget, s. 90225-90237, 2017

• DOI för MYC is downregulated by a mitochondrial checkpoint mechanism

Estrogen Receptor β as a Therapeutic Target in Breast Cancer Stem Cells

Ma, Ran; Karthik, Govindasamy-Muralidharan; Lövrot, John; Haglund, Felix et al.

Ingår i Journal of the National Cancer Institute, 2017

• DOI för Estrogen Receptor β as a Therapeutic Target in Breast Cancer Stem Cells

IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells

Mao, Yumeng; van Hoef, Vincent; Zhang, Xiaonan; Wennerberg, Erik et al.

Ingår i Blood, s. 1475-1489, 2016

• DOI för IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells

Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

Senkowski, Wojciech; Zhang, Xiaonan; Olofsson, Maria Hagg; Isacson, Ruben et al.

Ingår i Molecular Cancer Therapeutics, s. 1504-1516, 2015

• DOI för Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

The anticancer activity of the DUB inhibitor b-AP15 is associated with accumulation of proteasome bound ubiquitin and oxidative stress

Mazurkiewicz, Magdalena; Brnjic, Slavica; Fryknas, Marten; Sun, Chao et al.

Ingår i Cancer Research, 2015

• DOI för The anticancer activity of the DUB inhibitor b-AP15 is associated with accumulation of proteasome bound ubiquitin and oxidative stress

Spheroid-based high throughput screening for identification of molecules targeting different tumor microenvironment characteristics

Senkowski, Wojciech; Zhang, Xiaonan; Nygren, Peter; Olofsson, Maria Hagg et al.

Ingår i Cancer Research, 2015

• DOI för Spheroid-based high throughput screening for identification of molecules targeting different tumor microenvironment characteristics

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Zhang, Xiaonan; Fryknäs, Mårten; Hernlund, Emma; Fayad, Walid et al.

Ingår i Nature Communications, s. 3295, 2014

Label-free detection and dynamic monitoring of drug-induced intracellular vesicle formation enabled using a 2-dimensional matched filter

Aftab, Obaid; Fryknäs, Mårten; Zhang, Xiaonan; De Milito, Angelo et al.

Ingår i Autophagy, s. 57-69, 2014

• DOI för Label-free detection and dynamic monitoring of drug-induced intracellular vesicle formation enabled using a 2-dimensional matched filter

The 19S Deubiquitinase Inhibitor b-AP15 Is Enriched in Cells and Elicits Rapid Commitment to Cell Death

Wang, Xin; Stafford, William; Mazurkiewicz, Magdalena; Fryknäs, Mårten et al.

Ingår i Molecular Pharmacology, s. 932-945, 2014

• DOI för The 19S Deubiquitinase Inhibitor b-AP15 Is Enriched in Cells and Elicits Rapid Commitment to Cell Death

Induction of Tumor Cell Apoptosis by a Proteasome Deubiquitinase Inhibitor Is Associated with Oxidative Stress

Brnjic, Slavica; Mazurkiewicz, Magdalena; Fryknäs, Mårten; Sun, Chao et al.

Ingår i Antioxidants and Redox Signaling, s. 2271-2285, 2014

• DOI för Induction of Tumor Cell Apoptosis by a Proteasome Deubiquitinase Inhibitor Is Associated with Oxidative Stress

A spheroid-based screen identifies mitochondrial targeting as a promising strategy for cancer treatment and drug repositioning

Senkowski, Wojciech; Zhang, Xiaonan; Olofsson, Maria Hagg; Linder, Stig et al.

Ingår i Cancer Research, 2014

• DOI för A spheroid-based screen identifies mitochondrial targeting as a promising strategy for cancer treatment and drug repositioning

Autophagy Is a Protective Mechanism for Human Melanoma Cells under Acidic Stress

Marino, Maria Lucia; Pellegrini, Paola; Di Lernia, Giuseppe; Djavaheri-Mergny, Mojgan et al.

Ingår i Journal of Biological Chemistry, s. 30664-30676, 2012

• DOI för Autophagy Is a Protective Mechanism for Human Melanoma Cells under Acidic Stress

The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy

Hernlund, Emma; Olofsson, Maria Hägg; Fayad, Walid; Fryknäs, Mårten et al.

Ingår i European Journal of Cancer, s. 396-406, 2012

• DOI för The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy

Red blood cell derived nanocarrier drug delivery system: A promising strategy for tumor therapy

Wang, Xin; Mao, Kuirong; Zhang, Xiaonan; Zhang, Yuning et al.

Ingår i Interdisciplinary Medicine, 2024

• DOI för Red blood cell derived nanocarrier drug delivery system: A promising strategy for tumor therapy
• Ladda ner fulltext (pdf) av Red blood cell derived nanocarrier drug delivery system: A promising strategy for tumor therapy

Exploring the Enigma: The Role of the Epithelial Protein Lost in Neoplasm in Normal Physiology and Cancer Pathogenesis

Lindell, Emma; Zhang, Xiaonan

Ingår i International Journal of Molecular Sciences, 2024

• DOI för Exploring the Enigma: The Role of the Epithelial Protein Lost in Neoplasm in Normal Physiology and Cancer Pathogenesis
• Ladda ner fulltext (pdf) av Exploring the Enigma: The Role of the Epithelial Protein Lost in Neoplasm in Normal Physiology and Cancer Pathogenesis

Quiescent Cancer Cells: A Potential Therapeutic Target to Overcome Tumor Resistance and Relapse

Lindell, Emma; Zhong, Lei; Zhang, Xiaonan

Ingår i International Journal of Molecular Sciences, 2023

• DOI för Quiescent Cancer Cells: A Potential Therapeutic Target to Overcome Tumor Resistance and Relapse
• Ladda ner fulltext (pdf) av Quiescent Cancer Cells: A Potential Therapeutic Target to Overcome Tumor Resistance and Relapse

Targeting Loss of Heterozygosity: A Novel Paradigm for Cancer Therapy

Zhang, Xiaonan; Sjöblom, Tobias

Ingår i Pharmaceuticals, 2021

• DOI för Targeting Loss of Heterozygosity: A Novel Paradigm for Cancer Therapy
• Ladda ner fulltext (pdf) av Targeting Loss of Heterozygosity: A Novel Paradigm for Cancer Therapy

Drug Development Targeting the Ubiquitin-Proteasome System (UPS) for the Treatment of Human Cancers

Zhang, Xiaonan; Linder, Stig; Bazzaro, Martina

Ingår i Cancers, 2020

• DOI för Drug Development Targeting the Ubiquitin-Proteasome System (UPS) for the Treatment of Human Cancers
• Ladda ner fulltext (pdf) av Drug Development Targeting the Ubiquitin-Proteasome System (UPS) for the Treatment of Human Cancers

Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics

Zhang, Xiaonan; De Milito, Angelo; Demiroglu-Zergeroglu, Asuman; Gullbo, Joachim et al.

Ingår i Trends in Cancer, s. 657-663, 2016

• DOI för Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics

Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors

Zhang, Xiaonan; de Milito, Angelo; Olofsson, Maria Hagg; Gullbo, Joachim et al.

Ingår i International Journal of Molecular Sciences, s. 27313-27326, 2015

Novel anti-cancer agents targeting NAT2 loss in colorectal cancer

Rameika, Natallia; Tsiara, Ioanna; Haberek, Wawrzyniec; Akcan, Ece et al.