Entry requirements

120 credits in Science including 60 credits Chemistry, or equivalent.

Learning outcomes

The successful participant of this course will have the ability to:

• Apply of retrosynthetic analysis.
• Discuss advanced methods in organic synthesis.
• Describe and plan DOS (diversity-oriented synthesis)
• Devise strategies in combinatorial and parallel synthesis.
• Plan chemical synthesis of peptide and non-peptide libraries.
• Discuss, plan and execute construction and evaluation of a small-molecular-weight compound library.

Content

Fundamental as well as advanced methods in organic synthesis. Understanding the use of DOS (diversity-oriented synthesis) for efficient creation of broad representations of compounds in chemistry space. Development of pathways leading to the efficient (3-5 step) synthesis of collections of small molecules having rich skeletal and stereochemical diversity and the potential to attach appendages to several attachment sites. The basis of chemical genetics, where small molecules are used to probe biological systems in a systematic way.

The development of efficient, high-throughput synthesis methods, spanning from solid-supported synthesis to solution-phase multicomponent reactions. Analysis and monitoring of chemical libraries.

During the laborative part of the course, the student will plan, execute the synthesis of, analyse, and evaluate a small library of organic molecules.

Instruction

Lectures, exercises, laboratory work and discussions. Training in oral and written reports

Assessment

Written exam at the end of the course. The laboratory exercises as well as the theoretical work must be passed in order for the student to pass the whole course. Division of points: Written exam 10 credits, mandatory exercises, laboratory work and their reports 5 credits.