Irena Loryan

Unbound Brain-to-Plasma Partition Coefficient, K-p,K-uu,K-brain-a Game Changing Parameter for CNS Drug Discovery and Development

Loryan, Irena; Reichel, Andreas; Feng, Bo; Bundgaard, Christoffer et al.

Ingår i Pharmaceutical research, s. 1321-1341, 2022

• DOI för Unbound Brain-to-Plasma Partition Coefficient, K-p,K-uu,K-brain-a Game Changing Parameter for CNS Drug Discovery and Development
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Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood-brain barrier.

Luptáková, Dominika; Vallianatou, Theodosia; Nilsson, Anna; Shariatgorji, Reza et al.

Ingår i Molecular Psychiatry, s. 7732-7745, 2021

• DOI för Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood-brain barrier.
• Ladda ner fulltext (pdf) av Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood-brain barrier.

Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development

Gustafsson, Sofia; Sehlin, Dag; Lampa, Erik; Hammarlund-Udenaes, Margareta et al.

Ingår i Scientific Reports, 2019

• DOI för Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development
• Ladda ner fulltext (pdf) av Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development

In-depth neuropharmacokinetic analysis of antipsychotics based on a novel approach to estimate unbound target-site concentration in CNS regions: link to spatial receptor occupancy

Loryan, Irena; Melander, Erik; Svensson, M.; Payan, M. et al.

Ingår i Molecular Psychiatry, s. 1527-1536, 2016

• DOI för In-depth neuropharmacokinetic analysis of antipsychotics based on a novel approach to estimate unbound target-site concentration in CNS regions: link to spatial receptor occupancy

Molecular properties determining unbound intracellular and extracellular brain exposure of CNS drug candidates

Loryan, Irena; Sinha, Vikash; Mackie, Claire; van Peer, Achiel et al.

Ingår i Molecular Pharmaceutics, s. 520-532, 2015

• DOI för Molecular properties determining unbound intracellular and extracellular brain exposure of CNS drug candidates

Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery

Loryan, Irena; Vikash, Sinha; Claire, Mackie; Van Peer, Achiel et al.

Ingår i Pharmaceutical research, s. 2203-2219, 2014

• DOI för Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery

The brain slice method for studying drug distribution in the CNS

Loryan, Irena; Friden, Markus; Hammarlund-Udenaes, Margareta

Ingår i Fluids and Barriers of the CNS, s. 6, 2013

• DOI för The brain slice method for studying drug distribution in the CNS
• Ladda ner fulltext (pdf) av The brain slice method for studying drug distribution in the CNS

Assessing central nervous system drug delivery

Hammarlund-Udenaes, Margareta; Loryan, Irena

Ingår i Expert Opinion on Drug Delivery, s. 421-439, 2025

• DOI för Assessing central nervous system drug delivery
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Ceftazidime-avibactam (CAZ-AVI) pharmacokinetics in critically ill patients undergoing continuous venovenous hemodiafiltration (CVVHDF)

O'Jeanson, Amaury; Ioannidis, Konstantinos; Nielsen, Elisabet I.; Galani, Lamprini et al.

Ingår i International Journal of Antimicrobial Agents, 2025

• DOI för Ceftazidime-avibactam (CAZ-AVI) pharmacokinetics in critically ill patients undergoing continuous venovenous hemodiafiltration (CVVHDF)
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The challenge to identify sensitive safety biomarkers of peripheral neurotoxicity in the rat: A collaborative effort across industry and academia (IMI NeuroDeRisk project)

Micheli, Laura; Balayssac, David; Busserolles, Jérôme; Dalbos, Cristelle et al.

Ingår i Toxicology, 2025

• DOI för The challenge to identify sensitive safety biomarkers of peripheral neurotoxicity in the rat: A collaborative effort across industry and academia (IMI NeuroDeRisk project)
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Reduced oxycodone brain delivery in rats due to lipopolysaccharide-induced inflammation: microdialysis insights into brain disposition and sex-specific pharmacokinetics

Bällgren, Frida; Hammarlund-Udenaes, Margareta; Loryan, Irena

Ingår i Fluids and Barriers of the CNS, 2024

• DOI för Reduced oxycodone brain delivery in rats due to lipopolysaccharide-induced inflammation: microdialysis insights into brain disposition and sex-specific pharmacokinetics
• Ladda ner fulltext (pdf) av Reduced oxycodone brain delivery in rats due to lipopolysaccharide-induced inflammation: microdialysis insights into brain disposition and sex-specific pharmacokinetics

Formulation-dependent differences in paclitaxel distribution to anatomical sites relevant to chemotherapy-induced peripheral neuropathy

Girdenytė, Milda; Hu, Yang; Ginosyan, Aghavni; Hammarlund-Udenaes, Margareta et al.

Ingår i Frontiers in Pharmacology, 2024

• DOI för Formulation-dependent differences in paclitaxel distribution to anatomical sites relevant to chemotherapy-induced peripheral neuropathy
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Ceftazidime-avibactam (CAZ-AVI) pharmacokinetics in critically ill patients undergoing continuous venovenous hemodiafiltration (CVVHDF)

O'Jeanson, Amaury; Ioannidis, Konstantinos; Nielsen, Elisabet I.; Galani, Lamprini et al.

Ingår i International Journal of Antimicrobial Agents, 2025

• DOI för Ceftazidime-avibactam (CAZ-AVI) pharmacokinetics in critically ill patients undergoing continuous venovenous hemodiafiltration (CVVHDF)
• Ladda ner fulltext (pdf) av Ceftazidime-avibactam (CAZ-AVI) pharmacokinetics in critically ill patients undergoing continuous venovenous hemodiafiltration (CVVHDF)

The challenge to identify sensitive safety biomarkers of peripheral neurotoxicity in the rat: A collaborative effort across industry and academia (IMI NeuroDeRisk project)

Micheli, Laura; Balayssac, David; Busserolles, Jérôme; Dalbos, Cristelle et al.

Ingår i Toxicology, 2025

• DOI för The challenge to identify sensitive safety biomarkers of peripheral neurotoxicity in the rat: A collaborative effort across industry and academia (IMI NeuroDeRisk project)
• Ladda ner fulltext (pdf) av The challenge to identify sensitive safety biomarkers of peripheral neurotoxicity in the rat: A collaborative effort across industry and academia (IMI NeuroDeRisk project)

Reduced oxycodone brain delivery in rats due to lipopolysaccharide-induced inflammation: microdialysis insights into brain disposition and sex-specific pharmacokinetics

Bällgren, Frida; Hammarlund-Udenaes, Margareta; Loryan, Irena

Ingår i Fluids and Barriers of the CNS, 2024

• DOI för Reduced oxycodone brain delivery in rats due to lipopolysaccharide-induced inflammation: microdialysis insights into brain disposition and sex-specific pharmacokinetics
• Ladda ner fulltext (pdf) av Reduced oxycodone brain delivery in rats due to lipopolysaccharide-induced inflammation: microdialysis insights into brain disposition and sex-specific pharmacokinetics

Formulation-dependent differences in paclitaxel distribution to anatomical sites relevant to chemotherapy-induced peripheral neuropathy

Girdenytė, Milda; Hu, Yang; Ginosyan, Aghavni; Hammarlund-Udenaes, Margareta et al.

Ingår i Frontiers in Pharmacology, 2024

• DOI för Formulation-dependent differences in paclitaxel distribution to anatomical sites relevant to chemotherapy-induced peripheral neuropathy
• Ladda ner fulltext (pdf) av Formulation-dependent differences in paclitaxel distribution to anatomical sites relevant to chemotherapy-induced peripheral neuropathy

Active CNS delivery of oxycodone in healthy and endotoxemic pigs

Bällgren, Frida; Bergfast, Tilda; Ginosyan, Aghavni; Mahajan, Jessica et al.

Ingår i Fluids and Barriers of the CNS, 2024

• DOI för Active CNS delivery of oxycodone in healthy and endotoxemic pigs
• Ladda ner fulltext (pdf) av Active CNS delivery of oxycodone in healthy and endotoxemic pigs

Region-independent active CNS net uptake of marketed H⁺/ OC antiporter system substrates

Bällgren, Frida; Hu, Yang; Li, Shannuo; van de Beek, Lara et al.

Ingår i Frontiers in Cellular Neuroscience, 2024

• DOI för Region-independent active CNS net uptake of marketed H⁺/ OC antiporter system substrates
• Ladda ner fulltext (pdf) av Region-independent active CNS net uptake of marketed H⁺/ OC antiporter system substrates

Regional distribution of unbound eletriptan and sumatriptan in the CNS and PNS in rats: implications for a potential central action

Svane, Nana; Bällgren, Frida; Ginosyan, Aghavni; Kristensen, Mie et al.

Ingår i Journal of Headache and Pain, 2024

• DOI för Regional distribution of unbound eletriptan and sumatriptan in the CNS and PNS in rats: implications for a potential central action
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The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier

Kurtyka, Magdalena; Wessely, Frank; Bau, Sarah; Ifie, Eseoghene et al.

Ingår i European Journal of Cell Biology, 2024

• DOI för The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier
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Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy

Hu, Yang; Girdenyte, Milda; Roest, Lieke; Liukkonen, Iida et al.

Ingår i Fluids and Barriers of the CNS, 2024

• DOI för Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy
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Differential Blood-Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro

Melander, Erik; Eriksson, Camilla; Wellens, Sara; Hosseini, Kimia et al.

Ingår i Pharmaceutics, 2023

• DOI för Differential Blood-Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro
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Active Uptake of Oxycodone at Both the Blood-Cerebrospinal Fluid Barrier and The Blood-Brain Barrier without Sex Differences: A Rat Microdialysis Study

Bällgren, Frida; Hammarlund-Udenaes, Margareta; Loryan, Irena

Ingår i Pharmaceutical research, s. 2715-2730, 2023

• DOI för Active Uptake of Oxycodone at Both the Blood-Cerebrospinal Fluid Barrier and The Blood-Brain Barrier without Sex Differences: A Rat Microdialysis Study
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Pharmacokinetics of Novel Dopamine Transporter Inhibitor CE-123 and Modafinil with a Focus on Central Nervous System Distribution

Spreitzer, Iva; Keife, Josefin; Strasser, Tobias; Kalaba, Predrag et al.

Ingår i International Journal of Molecular Sciences, 2023

• DOI för Pharmacokinetics of Novel Dopamine Transporter Inhibitor CE-123 and Modafinil with a Focus on Central Nervous System Distribution
• Ladda ner fulltext (pdf) av Pharmacokinetics of Novel Dopamine Transporter Inhibitor CE-123 and Modafinil with a Focus on Central Nervous System Distribution

Neurofilament light chain in plasma as a sensitive diagnostic biomarker of peripheral neurotoxicity: In Vivo mouse studies with oxaliplatin and paclitaxel - NeuroDeRisk project

Balayssac, David; Busserolles, Jérôme; Broto, Catherine; Dalbos, Cristelle et al.

Ingår i Biomedicine and Pharmacotherapy, 2023

• DOI för Neurofilament light chain in plasma as a sensitive diagnostic biomarker of peripheral neurotoxicity: In Vivo mouse studies with oxaliplatin and paclitaxel - NeuroDeRisk project
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Brain barriers virtual: an interim solution or future opportunity?

Holder, Brianna M.; Tolan, Shaina E.; Heinrich, Kaleb K.; Miller, Kaitlin C. et al.

Ingår i Fluids and Barriers of the CNS, 2022

• DOI för Brain barriers virtual: an interim solution or future opportunity?
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Unbound Brain-to-Plasma Partition Coefficient, K-p,K-uu,K-brain-a Game Changing Parameter for CNS Drug Discovery and Development

Loryan, Irena; Reichel, Andreas; Feng, Bo; Bundgaard, Christoffer et al.

Ingår i Pharmaceutical research, s. 1321-1341, 2022

• DOI för Unbound Brain-to-Plasma Partition Coefficient, K-p,K-uu,K-brain-a Game Changing Parameter for CNS Drug Discovery and Development
• Ladda ner fulltext (pdf) av Unbound Brain-to-Plasma Partition Coefficient, K-p,K-uu,K-brain-a Game Changing Parameter for CNS Drug Discovery and Development

Professor Margareta Hammarlund-Udenaes - Humbled Scientist Shaping Modern Neuropharmacokinetics

Loryan, Irena; Smith, David E.; Artursson, Per; Breimer, Douwe et al.

Ingår i Pharmaceutical research, s. 1283-1289, 2022

• DOI för Professor Margareta Hammarlund-Udenaes - Humbled Scientist Shaping Modern Neuropharmacokinetics

Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood-brain barrier.

Luptáková, Dominika; Vallianatou, Theodosia; Nilsson, Anna; Shariatgorji, Reza et al.

Ingår i Molecular Psychiatry, s. 7732-7745, 2021

• DOI för Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood-brain barrier.
• Ladda ner fulltext (pdf) av Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood-brain barrier.

Molecular basis of mood and cognitive adverse events elucidated via a combination of pharmacovigilance data mining and functional enrichment analysis

Andronis, Christos; Silva, João Pedro; Lekka, Eftychia; Virvilis, Vassilis et al.

Ingår i Archives of Toxicology, s. 2829-2845, 2020

• DOI för Molecular basis of mood and cognitive adverse events elucidated via a combination of pharmacovigilance data mining and functional enrichment analysis
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Amorphisation of Free Acid Ibuprofen and Other Profens in Mixtures with Nanocellulose: Dry Powder Formulation Strategy for Enhanced Solubility

Mantas, Athanasios; Labbe, Valentine; Loryan, Irena; Mihranyan, Albert

Ingår i Pharmaceutics, 2019

• DOI för Amorphisation of Free Acid Ibuprofen and Other Profens in Mixtures with Nanocellulose: Dry Powder Formulation Strategy for Enhanced Solubility
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Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development

Gustafsson, Sofia; Sehlin, Dag; Lampa, Erik; Hammarlund-Udenaes, Margareta et al.

Ingår i Scientific Reports, 2019

• DOI för Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development
• Ladda ner fulltext (pdf) av Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development

Rate and extent of mitragynine and 7-hydroxymitragynine blood-brain barrier transport and their intra-brain distribution: the missing link in pharmacodynamic studies

Yusof, Siti R; Mohd Uzid, Mahathir; Teh, Eng-Huat; Hanapi, Nur Aziah et al.

Ingår i Addiction Biology, s. 935-945, 2019

• DOI för Rate and extent of mitragynine and 7-hydroxymitragynine blood-brain barrier transport and their intra-brain distribution: the missing link in pharmacodynamic studies

Mechanistic Study on the Use of the L-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets

Puris, Elena; Gynther, Mikko; de Lange, Elizabeth C. M.; Auriola, Seppo et al.

Ingår i Molecular Pharmaceutics, s. 3261-3274, 2019

• DOI för Mechanistic Study on the Use of the L-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets

Quantitative Assessment of Drug Delivery to Tissues and Association with Phospholipidosis: A Case Study with Two Structurally Related Diamines in Development

Loryan, Irena; Hoppe, Edmund; Hansen, Klaus; Held, Felix et al.

Ingår i Molecular Pharmaceutics, s. 4362-4373, 2017

• DOI för Quantitative Assessment of Drug Delivery to Tissues and Association with Phospholipidosis: A Case Study with Two Structurally Related Diamines in Development

In-depth neuropharmacokinetic analysis of antipsychotics based on a novel approach to estimate unbound target-site concentration in CNS regions: link to spatial receptor occupancy

Loryan, Irena; Melander, Erik; Svensson, M.; Payan, M. et al.

Ingår i Molecular Psychiatry, s. 1527-1536, 2016

• DOI för In-depth neuropharmacokinetic analysis of antipsychotics based on a novel approach to estimate unbound target-site concentration in CNS regions: link to spatial receptor occupancy

Molecular properties determining unbound intracellular and extracellular brain exposure of CNS drug candidates

Loryan, Irena; Sinha, Vikash; Mackie, Claire; van Peer, Achiel et al.

Ingår i Molecular Pharmaceutics, s. 520-532, 2015

• DOI för Molecular properties determining unbound intracellular and extracellular brain exposure of CNS drug candidates

Effect of transporter inhibition on the distribution of cefadroxil in rat brain

Chen, Xiaomei; Loryan, Irena; Payan, Maryam; Keep, Richard et al.

Ingår i Fluids and Barriers of the CNS, 2014

• DOI för Effect of transporter inhibition on the distribution of cefadroxil in rat brain
• Ladda ner fulltext (pdf) av Effect of transporter inhibition on the distribution of cefadroxil in rat brain

Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery

Loryan, Irena; Vikash, Sinha; Claire, Mackie; Van Peer, Achiel et al.

Ingår i Pharmaceutical research, s. 2203-2219, 2014

• DOI för Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery

The brain slice method for studying drug distribution in the CNS

Loryan, Irena; Friden, Markus; Hammarlund-Udenaes, Margareta

Ingår i Fluids and Barriers of the CNS, s. 6, 2013

• DOI för The brain slice method for studying drug distribution in the CNS
• Ladda ner fulltext (pdf) av The brain slice method for studying drug distribution in the CNS

Sex difference in formation of propofol metabolites: a replication study

Choong, Eva; Loryan, Irena; Lindqvist, Marja; Nordling, Åsa et al.

Ingår i Basic & Clinical Pharmacology & Toxicology, s. 126-131, 2013

• DOI för Sex difference in formation of propofol metabolites: a replication study

UGT1A4*3 encodes significantly increased glucuronidation of olanzapine in patients on maintenance treatment and in recombinant systems

Haslemo, T; Loryan, Irena; Ueda, N; Mannheimer, B et al.

Ingår i Clinical Pharmacology and Therapeutics, s. 221-227, 2012

• DOI för UGT1A4*3 encodes significantly increased glucuronidation of olanzapine in patients on maintenance treatment and in recombinant systems

Influence of sex on propofol metabolism, a pilot study: implications for propofol anesthesia

Loryan, Irena; Lindqvist, Marja; Johansson, Inger; Hiratsuka, Masahiro et al.

Ingår i European Journal of Clinical Pharmacology, s. 397-406, 2012

• DOI för Influence of sex on propofol metabolism, a pilot study: implications for propofol anesthesia

Assessing central nervous system drug delivery

Hammarlund-Udenaes, Margareta; Loryan, Irena

Ingår i Expert Opinion on Drug Delivery, s. 421-439, 2025

• DOI för Assessing central nervous system drug delivery
• Ladda ner fulltext (pdf) av Assessing central nervous system drug delivery

Brain Distribution of Drugs: Pharmacokinetic Considerations

Loryan, Irena; Hammarlund-Udenaes, Margareta; Syvänen, Stina

Ingår i Handbook of Experimental Pharmacology, Springer Berlin/Heidelberg, 2020

• DOI för Brain Distribution of Drugs: Pharmacokinetic Considerations

Drug Discovery Methods for Studying Brain Drug Delivery and Distribution

Loryan, Irena; Margareta, Hammarlund-Udenaes

Ingår i Drug Delivery to the Brain, Springer, 2014

Drug discovery methods for studying brain drug delivery and distribution

Loryan, Irena; Hammarlund-Udenaes, Margareta

Ingår i Drug delivery to the brain, s. 271-316, Springer, 2014

• DOI för Drug discovery methods for studying brain drug delivery and distribution

Dual behavior of cyclic peptides at the blood-brain barrier vs brain cellular uptake: Importance for CNS drug development

Melander, Erik; Eriksson, Camilla; Wellens, Sara; Culot, Maxime et al.

Cellular uptake and intra-brain distribution of cyclic cell penetrating peptides: why tissue and cell type matters

Melander, Erik; Hosseini, Kimia; Eriksson, Camilla; Fredriksson, Robert et al.

Pharmacokinetic-pharmacodynamic modelling to evaluate the relative impact of immune response and meropenem on bacterial killing in vivo

Saporta, Raphaël; Tassi, Natália; Biordi, Veronica; Ticha, Olga et al.