Femke Heindryckx

Prevalence of gastrointestinal side effects in hepatocellular carcinoma patients receiving sorafenib: a meta-analysis of 136 studies and 14,416 patients

Arendt, Nathalie; Payo-Serafin, Tania; Kolosenko, Anna; Kopsida, Maria et al.

Ingår i Therapeutic Advances in Medical Oncology, 2026

• DOI för Prevalence of gastrointestinal side effects in hepatocellular carcinoma patients receiving sorafenib: a meta-analysis of 136 studies and 14,416 patients
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CombiCTx: screening diffusion gradients of anti-cancer drug combinations

Stelzl, Christina; Clavero, Ada Lerma; Camenisch, Selina; Simon, Benoit et al.

Ingår i Lab on a Chip, s. 695-710, 2026

• DOI för CombiCTx: screening diffusion gradients of anti-cancer drug combinations
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A comparative study of idarubicin and doxorubicin in a chemically-induced in vivo mouse model for hepatocellular carcinoma

Lerma-Clavero, Ada; Kopsida, Maria; Arendt, Nathalie; Lennernäs, Hans et al.

Ingår i Biomedicine and Pharmacotherapy, 2025

• DOI för A comparative study of idarubicin and doxorubicin in a chemically-induced in vivo mouse model for hepatocellular carcinoma
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Gastrointestinal side effects in hepatocellular carcinoma patients receiving transarterial chemoembolization: a meta-analysis of 81 studies and 9495 patients

Arendt, Nathalie; Kopsida, Maria; Khaled, Jaafar; Sjöblom, Markus et al.

Ingår i Therapeutic Advances in Medical Oncology, s. 1-30, 2025

• DOI för Gastrointestinal side effects in hepatocellular carcinoma patients receiving transarterial chemoembolization: a meta-analysis of 81 studies and 9495 patients
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Statin-mediated protection in chemotherapy-induced intestinal and cardiac toxicity: current perspectives

Arendt, Nathalie; Kopsida, Maria; Lennernäs, Hans; Sjöblom, Markus et al.

Ingår i European Journal of Pharmacology, 2025

• DOI för Statin-mediated protection in chemotherapy-induced intestinal and cardiac toxicity: current perspectives
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Prevalence of gastrointestinal side effects in hepatocellular carcinoma patients receiving sorafenib: a meta-analysis of 136 studies and 14,416 patients

Arendt, Nathalie; Payo-Serafin, Tania; Kolosenko, Anna; Kopsida, Maria et al.

Ingår i Therapeutic Advances in Medical Oncology, 2026

• DOI för Prevalence of gastrointestinal side effects in hepatocellular carcinoma patients receiving sorafenib: a meta-analysis of 136 studies and 14,416 patients
• Ladda ner fulltext (pdf) av Prevalence of gastrointestinal side effects in hepatocellular carcinoma patients receiving sorafenib: a meta-analysis of 136 studies and 14,416 patients

CombiCTx: screening diffusion gradients of anti-cancer drug combinations

Stelzl, Christina; Clavero, Ada Lerma; Camenisch, Selina; Simon, Benoit et al.

Ingår i Lab on a Chip, s. 695-710, 2026

• DOI för CombiCTx: screening diffusion gradients of anti-cancer drug combinations
• Ladda ner fulltext (pdf) av CombiCTx: screening diffusion gradients of anti-cancer drug combinations

A comparative study of idarubicin and doxorubicin in a chemically-induced in vivo mouse model for hepatocellular carcinoma

Lerma-Clavero, Ada; Kopsida, Maria; Arendt, Nathalie; Lennernäs, Hans et al.

Ingår i Biomedicine and Pharmacotherapy, 2025

• DOI för A comparative study of idarubicin and doxorubicin in a chemically-induced in vivo mouse model for hepatocellular carcinoma
• Ladda ner fulltext (pdf) av A comparative study of idarubicin and doxorubicin in a chemically-induced in vivo mouse model for hepatocellular carcinoma

Gastrointestinal side effects in hepatocellular carcinoma patients receiving transarterial chemoembolization: a meta-analysis of 81 studies and 9495 patients

Arendt, Nathalie; Kopsida, Maria; Khaled, Jaafar; Sjöblom, Markus et al.

Ingår i Therapeutic Advances in Medical Oncology, s. 1-30, 2025

• DOI för Gastrointestinal side effects in hepatocellular carcinoma patients receiving transarterial chemoembolization: a meta-analysis of 81 studies and 9495 patients
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Statin-mediated protection in chemotherapy-induced intestinal and cardiac toxicity: current perspectives

Arendt, Nathalie; Kopsida, Maria; Lennernäs, Hans; Sjöblom, Markus et al.

Ingår i European Journal of Pharmacology, 2025

• DOI för Statin-mediated protection in chemotherapy-induced intestinal and cardiac toxicity: current perspectives
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Mapping the polar metabolome in Huh-7 liver cancer cells reveal the role of atorvastatin in enhancing chemotherapeutic efficacy of doxorubicin.

Kopsida, Maria; Regtop, Lotta; Lennernäs, Hans; Hedeland, Mikael et al.

Ingår i Journal of Pharmaceutical and Biomedical Analysis, s. 117012, 2025

• DOI för Mapping the polar metabolome in Huh-7 liver cancer cells reveal the role of atorvastatin in enhancing chemotherapeutic efficacy of doxorubicin.
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Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells

Kopsida, Maria; Clavero, Ada Lerma; Khaled, Jaafar; Balgoma, David et al.

Ingår i Molecular Metabolism, 2024

• DOI för Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells
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Melatonin mitigates chemotherapy-induced small intestinal atrophy in rats and reduces cytotoxicity in murine intestinal organoids

Peters, Karsten; Clavero, Ada Lerma; Kullenberg, Fredrik; Kopsida, Maria et al.

Ingår i PLOS ONE, 2024

• DOI för Melatonin mitigates chemotherapy-induced small intestinal atrophy in rats and reduces cytotoxicity in murine intestinal organoids
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Ammonium bicarbonate buffers combined with hybrid surface technology columns improve the peak shape of strongly tailing lipids

Nilsson, Jenny M.; Balgoma, David; Pettersson, Curt; Lennernäs, Hans et al.

Ingår i Analytica Chimica Acta, 2024

• DOI för Ammonium bicarbonate buffers combined with hybrid surface technology columns improve the peak shape of strongly tailing lipids
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Quantitative imaging of doxorubicin diffusion and cellular uptake in biomimetic gels with human liver tumor cells

Degerstedt, Oliver; O'Callaghan, Paul; Clavero, Ada Lerma; Gråsjö, Johan et al.

Ingår i Drug Delivery and Translational Research, s. 970-983, 2023

• DOI för Quantitative imaging of doxorubicin diffusion and cellular uptake in biomimetic gels with human liver tumor cells
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Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma

Calitz, Carlemi; Rosenquist, Jenny; Degerstedt, Oliver; Khaled, Jaafar et al.

Ingår i Scientific Reports, 2023

• DOI för Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma
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The progression of doxorubicin-induced intestinal mucositis in rats

Kullenberg, Fredrik; Peters, Karsten; Luna-Marco, C.; Salomonsson, A. et al.

Ingår i Naunyn-Schmiedeberg's Archives of Pharmacology, s. 247-260, 2023

• DOI för The progression of doxorubicin-induced intestinal mucositis in rats
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Anakinra and dexamethasone treatment of idarubicin-induced mucositis and diarrhoea in rats

Kullenberg, Fredrik; Peters, Karsten; Sjöblom, Markus; Heindryckx, Femke et al.

Ingår i Basic & Clinical Pharmacology & Toxicology, s. 507-516, 2023

• DOI för Anakinra and dexamethasone treatment of idarubicin-induced mucositis and diarrhoea in rats
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Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival

Sennefelt Nyman, Sofi; Ahlström, Håkan; Dimopoulou, Angeliki; Dahlgren, David et al.

Ingår i BMJ Open, 2022

• DOI för Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival
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Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma

Khaled, Jaafar; Kopsida, Maria; Lennernäs, Hans; Heindryckx, Femke

Ingår i Cells, 2022

• DOI för Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma
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Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding

Balgoma, David; Kullenberg, Fredrik; Peters, Karsten; Dahlgren, David et al.

Ingår i Metabolites, 2022

• DOI för Orthogonality in Principal Component Analysis Allows the Discovery of Lipids in the Jejunum That Are Independent of Ad Libitum Feeding
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Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death

Balgoma, David; Kullenberg, Fredrik; Calitz, Carlemi; Kopsida, Maria et al.

Ingår i Cells, 2021

• DOI för Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death
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In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma

Kullenberg, Fredrik; Degerstedt, Oliver; Calitz, Carlemi; Pavlovic, Natasa et al.

Ingår i Cells, 2021

• DOI för In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma
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Exploring the Role of Endoplasmic Reticulum Stress in Hepatocellular Carcinoma through mining of the Human Protein Atlas

Pavlovic, Natasa; Heindryckx, Femke

Ingår i Biology, 2021

• DOI för Exploring the Role of Endoplasmic Reticulum Stress in Hepatocellular Carcinoma through mining of the Human Protein Atlas
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Activated platelets contribute to the progression of hepatocellular carcinoma by altering the tumor environment

Pavlovic, Natasa; Kopsida, Maria; Gerwins, Pär; Heindryckx, Femke

Ingår i Life Sciences, 2021

• DOI för Activated platelets contribute to the progression of hepatocellular carcinoma by altering the tumor environment
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A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

Calitz, Carlemi; Pavlovic, Natasa; Rosenquist, Jenny; Zagami, Claudia et al.

Ingår i Journal of Visualized Experiments, 2020

• DOI för A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

Inhibiting P2Y12 in Macrophages Induces Endoplasmic Reticulum Stress and Promotes an Anti-Tumoral Phenotype

Pavlović, Natasa; Kopsida, Maria; Gerwins, Pär; Heindryckx, Femke

Ingår i International Journal of Molecular Sciences, 2020

• DOI för Inhibiting P2Y12 in Macrophages Induces Endoplasmic Reticulum Stress and Promotes an Anti-Tumoral Phenotype
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Inhibiting IRE1α-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma

Pavlovic, Natasa; Calitz, Carlemi; Thanapirom, Kess; Mazza, Guiseppe et al.

Ingår i eLIFE, 2020

• DOI för Inhibiting IRE1α-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma
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Fibrin fragment E potentiates TGF-beta-induced myofibroblast activation and recruitment

Öhman Fuchs, Peder; Calitz, Carlemi; Pavlovic, Natasa; Binet, Francois et al.

Ingår i Cellular Signalling, 2020

• DOI för Fibrin fragment E potentiates TGF-beta-induced myofibroblast activation and recruitment
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Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile

Dubbelboer, Ilse R; Pavlovic, Natasa; Heindryckx, Femke; Sjögren, Erik et al.

Ingår i Cancers, 2019

• DOI för Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile
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Macrophage Depletion Attenuates Extracellular Matrix Deposition and Ductular Reaction in a Mouse Model of Chronic Cholangiopathies

Best, Jan; Verhulst, Stefaan; Syn, Wing-Kin; Lagaisse, Kimberly et al.

Ingår i PLOS ONE, 2016

• DOI för Macrophage Depletion Attenuates Extracellular Matrix Deposition and Ductular Reaction in a Mouse Model of Chronic Cholangiopathies
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Endoplasmic reticulum stress enhances fibrosis through IRE1α-mediated degradation of miR-150 and XBP-1 splicing

Heindryckx, Femke; Binet, Francois; Ponticos, Markella; Rombouts, Krista et al.

Ingår i EMBO Molecular Medicine, s. 729-744, 2016

• DOI för Endoplasmic reticulum stress enhances fibrosis through IRE1α-mediated degradation of miR-150 and XBP-1 splicing
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Targeting the tumor stroma in hepatocellular carcinoma

Heindryckx, Femke; Gerwins, Pär

Ingår i World Journal of Hepatology, s. 165-176, 2015

• DOI för Targeting the tumor stroma in hepatocellular carcinoma

ER Stress Enhances Liver Fibrosis Through MIR-150 Degradation and XBP-1 Splicing

Heindryckx, Femke; Binet, F.; Kreuger, Johan; Gerwins, Pär

Ingår i Journal of Hepatology, 2015

Effect Of Extracellular Matrix On Cancer Stem Cells

Heindryckx, Femke; Rauer, D.; Bogaerts, E.; Gerwins, Pär et al.

Ingår i Journal of Hepatology, 2015

Time-Dependent Effect of Hypoxia on Tumor Progression and Liver Progenitor Cell Markers in Primary Liver Tumors

Bogaerts, Eliene; Heindryckx, Femke; Devisscher, Lindsey; Paridaens, Annelies et al.

Ingår i PLOS ONE, 2015

• DOI för Time-Dependent Effect of Hypoxia on Tumor Progression and Liver Progenitor Cell Markers in Primary Liver Tumors
• Ladda ner fulltext (pdf) av Time-Dependent Effect of Hypoxia on Tumor Progression and Liver Progenitor Cell Markers in Primary Liver Tumors

The need for transparency and good practices in the qPCR literature

Bustin, Stephen A.; Benes, Vladimir; Garson, Jeremy; Hellemans, Jan et al.

Ingår i Nature Methods, s. 1063-1067, 2013

• DOI för The need for transparency and good practices in the qPCR literature

MicroRNA-24 Suppression of N-Deacetylase/N-Sulfotransferase-1 (NDST1) Reduces Endothelial Cell Responsiveness to Vascular Endothelial Growth Factor A (VEGFA)

Kasza, Zsolt; Fredlund Fuchs, Peder; Tamm, Christoffer; Eriksson, Anna S. et al.

Ingår i Journal of Biological Chemistry, s. 25956-25963, 2013

• DOI för MicroRNA-24 Suppression of N-Deacetylase/N-Sulfotransferase-1 (NDST1) Reduces Endothelial Cell Responsiveness to Vascular Endothelial Growth Factor A (VEGFA)

Endoplasmic reticulum stress in the pathogenesis of chemotherapy-induced mucositis: Physiological mechanisms and therapeutic implications

Heindryckx, Femke; Sjöblom, Markus

Ingår i Acta Physiologica, 2024

• DOI för Endoplasmic reticulum stress in the pathogenesis of chemotherapy-induced mucositis: Physiological mechanisms and therapeutic implications
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Endoplasmic Reticulum Stress and Metabolism in Hepatocellular Carcinoma

Luna-Marco, Clara; Ubink, Anna; Kopsida, Maria; Heindryckx, Femke

Ingår i American Journal of Pathology, s. 1377-1388, 2023

• DOI för Endoplasmic Reticulum Stress and Metabolism in Hepatocellular Carcinoma

Targeting ER stress in the hepatic tumor microenvironment

Pavlović, Natasa; Heindryckx, Femke

Ingår i The FEBS Journal, s. 7163-7176, 2022

• DOI för Targeting ER stress in the hepatic tumor microenvironment
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Limitations and Possibilities of Transarterial Chemotherapeutic Treatment of Hepatocellular Carcinoma

Ebeling Barbier, Charlotte; Heindryckx, Femke; Lennernäs, Hans

Ingår i International Journal of Molecular Sciences, 2021

• DOI för Limitations and Possibilities of Transarterial Chemotherapeutic Treatment of Hepatocellular Carcinoma
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Platelets as Key Factors in Hepatocellular Carcinoma

Pavlovic, Natasa; Rani, Bhavna; Gerwins, Pär; Heindryckx, Femke

Ingår i Cancers, 2019

• DOI för Platelets as Key Factors in Hepatocellular Carcinoma
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Role of proteoglycans in neuro-inflammation and central nervous system fibrosis

Heindryckx, Femke; Li, Jin-Ping

Ingår i Matrix Biology, s. 589-601, 2018

• DOI för Role of proteoglycans in neuro-inflammation and central nervous system fibrosis

Hepatitis mouse models: from acute-to-chronic autoimmune hepatitis

Yuksel, Muhammed; Laukens, Debby; Heindryckx, Femke; Van Vlierberghe, Hans et al.

Ingår i International journal of experimental pathology (Print), s. 309-320, 2014

• DOI för Hepatitis mouse models: from acute-to-chronic autoimmune hepatitis

The roles of transforming growth factor- similar to, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours ( Review)

Bogaerts, Eliene; Heindryckx, Femke; Vandewynckel, Yves-Paul; Van Grunsven, Leo A. et al.

Ingår i International Journal of Oncology, s. 1015-1022, 2014

• DOI för The roles of transforming growth factor- similar to, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours ( Review)

The Paradox of the Unfolded Protein Response in Cancer

Vandewyncicel, Yves-Paul; Laukens, Debby; Geerts, Anja; Bogaerts, Eliene et al.

Ingår i Anticancer Research, s. 4683-4694, 2013

Pharmacological inhibition of PERK during early carcinogenesis restrains tumor progression and remodels the tumor microenvironment in hepatocellular carcinoma

Khaled, Jaafar; Kopsida, Maria; Payo Serafín, Tania; Sennefelt Nyman, Sofi et al.

Treatment with tauroursodeoxycholic acid reduces tumor burden during early hepatocarcinogenesis in a mouse model for HCC

Khaled, Jaafar; Kopsida, Maria; Heindryckx, Femke

Characterization of hepatocellular carcinoma patient-derived organoids receiving transarterial chemoembolization as a preclinical model for drug response assessment

Khaled, Jaafar; Sennefelt Nyman, Sofi; Rorsman, Fredrik; Lennernäs, Hans et al.