Marika Nestor

Evaluation of CD44v6-targeted radionuclide therapy on bone marrow, skin and esophageal epithelium using a novel internal dosimetry model

Hemmingsson, Jens; Nestor, Marika; Lundgren Mortensen, Anja; Frejd, Fredrik et al.

Ingår i Physics in Medicine and Biology, 2025

• DOI för Evaluation of CD44v6-targeted radionuclide therapy on bone marrow, skin and esophageal epithelium using a novel internal dosimetry model
• Ladda ner fulltext (pdf) av Evaluation of CD44v6-targeted radionuclide therapy on bone marrow, skin and esophageal epithelium using a novel internal dosimetry model

Dual targeting of G9a and DNMTs induces antitumor effects in multiple myeloma

Nylund, Patrick; Garrido-Zabala, Berta; Tziola, Stefania Iliana; Mohajershojai, Tabassom et al.

Ingår i Blood Advances, s. 4825-4841, 2025

• DOI för Dual targeting of G9a and DNMTs induces antitumor effects in multiple myeloma
• Ladda ner fulltext (pdf) av Dual targeting of G9a and DNMTs induces antitumor effects in multiple myeloma

CD44v6 expression in non-anaplastic thyroid carcinoma: characterization of candidates for targeted therapy

Stenman, Adam; Nilsson, Joachim N.; Condello, Vincenzo; Mortensen, Anja C. L. et al.

Ingår i Thyroid Research, 2025

• DOI för CD44v6 expression in non-anaplastic thyroid carcinoma: characterization of candidates for targeted therapy
• Ladda ner fulltext (pdf) av CD44v6 expression in non-anaplastic thyroid carcinoma: characterization of candidates for targeted therapy

Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts

Mortensen, Anja; Berglund, Hanna; Jha, Preeti; Stenman, Adam et al.

Ingår i Molecular Cancer Therapeutics, s. 753-762, 2025

• DOI för Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts
• Ladda ner fulltext (pdf) av Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts

Affinity maturation and optimization of CD44v6-targeting antibodies for molecular radiotherapy

Lundgren Mortensen, Anja Charlotte; Hofström, Camilla; Persson, Helena; Dahllund, Leif et al.

Ingår i Nuclear Medicine and Biology, 2025

• DOI för Affinity maturation and optimization of CD44v6-targeting antibodies for molecular radiotherapy
• Ladda ner fulltext (pdf) av Affinity maturation and optimization of CD44v6-targeting antibodies for molecular radiotherapy

Evaluation of CD44v6-targeted radionuclide therapy on bone marrow, skin and esophageal epithelium using a novel internal dosimetry model

Hemmingsson, Jens; Nestor, Marika; Lundgren Mortensen, Anja; Frejd, Fredrik et al.

Ingår i Physics in Medicine and Biology, 2025

• DOI för Evaluation of CD44v6-targeted radionuclide therapy on bone marrow, skin and esophageal epithelium using a novel internal dosimetry model
• Ladda ner fulltext (pdf) av Evaluation of CD44v6-targeted radionuclide therapy on bone marrow, skin and esophageal epithelium using a novel internal dosimetry model

Dual targeting of G9a and DNMTs induces antitumor effects in multiple myeloma

Nylund, Patrick; Garrido-Zabala, Berta; Tziola, Stefania Iliana; Mohajershojai, Tabassom et al.

Ingår i Blood Advances, s. 4825-4841, 2025

• DOI för Dual targeting of G9a and DNMTs induces antitumor effects in multiple myeloma
• Ladda ner fulltext (pdf) av Dual targeting of G9a and DNMTs induces antitumor effects in multiple myeloma

CD44v6 expression in non-anaplastic thyroid carcinoma: characterization of candidates for targeted therapy

Stenman, Adam; Nilsson, Joachim N.; Condello, Vincenzo; Mortensen, Anja C. L. et al.

Ingår i Thyroid Research, 2025

• DOI för CD44v6 expression in non-anaplastic thyroid carcinoma: characterization of candidates for targeted therapy
• Ladda ner fulltext (pdf) av CD44v6 expression in non-anaplastic thyroid carcinoma: characterization of candidates for targeted therapy

Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts

Mortensen, Anja; Berglund, Hanna; Jha, Preeti; Stenman, Adam et al.

Ingår i Molecular Cancer Therapeutics, s. 753-762, 2025

• DOI för Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts
• Ladda ner fulltext (pdf) av Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts

Affinity maturation and optimization of CD44v6-targeting antibodies for molecular radiotherapy

Lundgren Mortensen, Anja Charlotte; Hofström, Camilla; Persson, Helena; Dahllund, Leif et al.

Ingår i Nuclear Medicine and Biology, 2025

• DOI för Affinity maturation and optimization of CD44v6-targeting antibodies for molecular radiotherapy
• Ladda ner fulltext (pdf) av Affinity maturation and optimization of CD44v6-targeting antibodies for molecular radiotherapy

Targeting mutant p53: Evaluation of novel anti-p53^R175H monoclonal antibodies as diagnostic tools

Spiegelberg, Diana; Hwang, Le-Ann; Pua, Khian Hong; Kumar, Sashwini Chandra et al.

Ingår i Scientific Reports, 2025

• DOI för Targeting mutant p53: Evaluation of novel anti-p53^R175H monoclonal antibodies as diagnostic tools
• Ladda ner fulltext (pdf) av Targeting mutant p53: Evaluation of novel anti-p53^R175H monoclonal antibodies as diagnostic tools

MDM2/MDMX inhibition by Sulanemadlin synergizes with anti-Programmed Death 1 immunotherapy in wild-type p53 tumors

Ingelshed, Katrine; Melssen, Marit M.; Kannan, Pavitra; Chandramohan, Arun et al.

Ingår i iScience, 2024

• DOI för MDM2/MDMX inhibition by Sulanemadlin synergizes with anti-Programmed Death 1 immunotherapy in wild-type p53 tumors
• Ladda ner fulltext (pdf) av MDM2/MDMX inhibition by Sulanemadlin synergizes with anti-Programmed Death 1 immunotherapy in wild-type p53 tumors

Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists

Chandramohan, Arun; Josien, Hubert; Yuen, Tsz Ying; Duggal, Ruchia et al.

Ingår i Nature Communications, 2024

• DOI för Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists
• Ladda ner fulltext (pdf) av Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists

Selection, characterization and in vivo evaluation of novel CD44v6-targeting antibodies for targeted molecular radiotherapy

Mortensen, Anja; Berglund, Hanna; Segerström, Lova; Walle, M. et al.

Ingår i Scientific Reports, 2023

• DOI för Selection, characterization and in vivo evaluation of novel CD44v6-targeting antibodies for targeted molecular radiotherapy
• Ladda ner fulltext (pdf) av Selection, characterization and in vivo evaluation of novel CD44v6-targeting antibodies for targeted molecular radiotherapy

p53 stabilisation potentiates [¹⁷⁷Lu]Lu-DOTATATE treatment in neuroblastoma xenografts

Berglund, Hanna; Lundsten Salomonsson, Sara; Mohajershojai, Tabassom; Ferrer Gago, Fernando Jose et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2023

• DOI för p53 stabilisation potentiates [¹⁷⁷Lu]Lu-DOTATATE treatment in neuroblastoma xenografts
• Ladda ner fulltext (pdf) av p53 stabilisation potentiates [¹⁷⁷Lu]Lu-DOTATATE treatment in neuroblastoma xenografts

Enhanced Therapeutic Effects of ¹⁷⁷Lu-DOTA-M5A in Combination with Heat Shock Protein 90 Inhibitor Onalespib in Colorectal Cancer Xenografts

Mohajershojai, Tabassom; Spangler, Douglas; Chopra, Saloni; Frejd, Fredrik Y. et al.

Ingår i Cancers, 2023

• DOI för Enhanced Therapeutic Effects of ¹⁷⁷Lu-DOTA-M5A in Combination with Heat Shock Protein 90 Inhibitor Onalespib in Colorectal Cancer Xenografts
• Ladda ner fulltext (pdf) av Enhanced Therapeutic Effects of ¹⁷⁷Lu-DOTA-M5A in Combination with Heat Shock Protein 90 Inhibitor Onalespib in Colorectal Cancer Xenografts

Utilizing CD44v6 and V600EBRAF-mutation for in vitro targeted combination therapy of thyroid carcinomas

Mortensen, Anja; Imgenberg-Kreuz, Juliana; Spiegelberg, Diana; Botling, J. et al.

Ingår i Heliyon, 2023

• DOI för Utilizing CD44v6 and V600EBRAF-mutation for in vitro targeted combination therapy of thyroid carcinomas
• Ladda ner fulltext (pdf) av Utilizing CD44v6 and V600EBRAF-mutation for in vitro targeted combination therapy of thyroid carcinomas

Complementarity-determining region clustering may cause CAR-T cell dysfunction

Sarén, Tina; Saronio, Giulia; Marti Torrell, Paula; Zhu, Xu et al.

Ingår i Nature Communications, 2023

• DOI för Complementarity-determining region clustering may cause CAR-T cell dysfunction
• Ladda ner fulltext (pdf) av Complementarity-determining region clustering may cause CAR-T cell dysfunction

Photoactive immunoconjugates for targeted photodynamic therapy of cancer

Fernandes, Sara R.G.; Mohajershojai, Tabassom; Lundsten, Sara; Sarmento, Bruno et al.

Ingår i Journal of Photochemistry and Photobiology. B, 2023

• DOI för Photoactive immunoconjugates for targeted photodynamic therapy of cancer

In Vitro Characterization of Lu-177-DOTA-M5A Anti-Carcinoembryonic Antigen Humanized Antibody and HSP90 Inhibition for Potentiated Radioimmunotherapy of Colorectal Cancer

Mohajershojai, Tabassom; Jha, Preeti; Bostroem, Anna; Frejd, Fredrik Y. et al.

Ingår i Frontiers in Oncology, 2022

• DOI för In Vitro Characterization of Lu-177-DOTA-M5A Anti-Carcinoembryonic Antigen Humanized Antibody and HSP90 Inhibition for Potentiated Radioimmunotherapy of Colorectal Cancer
• Ladda ner fulltext (pdf) av In Vitro Characterization of Lu-177-DOTA-M5A Anti-Carcinoembryonic Antigen Humanized Antibody and HSP90 Inhibition for Potentiated Radioimmunotherapy of Colorectal Cancer

Conformation specific antagonistic high affinity antibodies to the RON receptor kinase for imaging and therapy

Yu Koh, Xin; Koh, Xiao Hui; Spiegelberg, Diana; Jha, Preeti et al.

Ingår i Scientific Reports, 2022

• DOI för Conformation specific antagonistic high affinity antibodies to the RON receptor kinase for imaging and therapy
• Ladda ner fulltext (pdf) av Conformation specific antagonistic high affinity antibodies to the RON receptor kinase for imaging and therapy

The MDM2 Inhibitor Navtemadlin Arrests Mouse Melanoma Growth In Vivo and Potentiates Radiotherapy

Ingelshed, Katrine; Spiegelberg, Diana; Kannan, Pavitra; Påvénius, Linnéa et al.

Ingår i Cancer Research Communications, s. 1075-1088, 2022

• DOI för The MDM2 Inhibitor Navtemadlin Arrests Mouse Melanoma Growth In Vivo and Potentiates Radiotherapy
• Ladda ner fulltext (pdf) av The MDM2 Inhibitor Navtemadlin Arrests Mouse Melanoma Growth In Vivo and Potentiates Radiotherapy

p53-Mediated Radiosensitization of ¹⁷⁷Lu-DOTATATE in Neuroblastoma Tumor Spheroids

Lundsten, Sara; Berglund, Hanna; Jha, Preeti; Krona, Cecilia et al.

Ingår i Biomolecules, 2021

• DOI för p53-Mediated Radiosensitization of ¹⁷⁷Lu-DOTATATE in Neuroblastoma Tumor Spheroids
• Ladda ner fulltext (pdf) av p53-Mediated Radiosensitization of ¹⁷⁷Lu-DOTATATE in Neuroblastoma Tumor Spheroids

Improved sensitivity in hydrophilic interaction liquid chromatography-electrospray-mass spectrometry after removal of sodium and potassium ions from biological samples

Erngren, Ida; Nestor, Marika; Pettersson, Curt; Hedeland, Mikael

Ingår i Metabolites, 2021

• DOI för Improved sensitivity in hydrophilic interaction liquid chromatography-electrospray-mass spectrometry after removal of sodium and potassium ions from biological samples
• Ladda ner fulltext (pdf) av Improved sensitivity in hydrophilic interaction liquid chromatography-electrospray-mass spectrometry after removal of sodium and potassium ions from biological samples

Polymeric micelles targeted against CD44v6 receptor increase niclosamide efficacy against colorectal cancer stem cells and reduce circulating tumor cells in vivo

Andrade, Fernanda; Rafael, Diana; Vilar-Hernandez, Mireia; Montero, Sara et al.

Ingår i Journal of Controlled Release, s. 198-212, 2021

• DOI för Polymeric micelles targeted against CD44v6 receptor increase niclosamide efficacy against colorectal cancer stem cells and reduce circulating tumor cells in vivo

A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma

Johansson, Patrik; Krona, Cecilia; Kundu, Soumi; Doroszko, Milena et al.

Ingår i Cell Reports, 2020

• DOI för A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma
• Ladda ner fulltext (pdf) av A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma

The Novel Anti-cMet Antibody seeMet 12 Potentiates Sorafenib Therapy and Radiotherapy in a Colorectal Cancer Model

Spiegelberg, Diana; Lundgren Mortensen, Anja Charlotte; Palupi, Kartika Dyah; Micke, Patrick et al.

Ingår i Frontiers in Oncology, 2020

• DOI för The Novel Anti-cMet Antibody seeMet 12 Potentiates Sorafenib Therapy and Radiotherapy in a Colorectal Cancer Model
• Ladda ner fulltext (pdf) av The Novel Anti-cMet Antibody seeMet 12 Potentiates Sorafenib Therapy and Radiotherapy in a Colorectal Cancer Model

The HSP90 inhibitor Onalespib exerts synergistic anti-cancer effects when combined with radiotherapy: an in vitro and in vivo approach

Spiegelberg, Diana; Abramenkovs, Andris; Mortensen, Anja; Lundsten, Sara et al.

Ingår i Scientific Reports, 2020

• DOI för The HSP90 inhibitor Onalespib exerts synergistic anti-cancer effects when combined with radiotherapy: an in vitro and in vivo approach
• Ladda ner fulltext (pdf) av The HSP90 inhibitor Onalespib exerts synergistic anti-cancer effects when combined with radiotherapy: an in vitro and in vivo approach

Enhancing the therapeutic effects of in vitro targeted radionuclide therapy of 3D multicellular tumor spheroids using the novel stapled MDM2/X-p53 antagonist PM2

Mortensen, Anja; Morin, Eric; Brown, Christopher J.; Lane, David P. et al.

Ingår i EJNMMI Research, 2020

• DOI för Enhancing the therapeutic effects of in vitro targeted radionuclide therapy of 3D multicellular tumor spheroids using the novel stapled MDM2/X-p53 antagonist PM2
• Ladda ner fulltext (pdf) av Enhancing the therapeutic effects of in vitro targeted radionuclide therapy of 3D multicellular tumor spheroids using the novel stapled MDM2/X-p53 antagonist PM2

Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks

Lundsten, Sara; Hernandez, Victor Agmo; Gedda, Lars; Sarén, Tina et al.

Ingår i Nanomaterials, 2020

• DOI för Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks
• Ladda ner fulltext (pdf) av Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks

The radiosensitizer Onalespib increases complete remission in Lu-177-DOTATATE-treated mice bearing neuroendocrine tumor xenografts

Lundsten, Sara; Spiegelberg, Diana; Raval, Nakul; Nestor, Marika

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 980-990, 2020

• DOI för The radiosensitizer Onalespib increases complete remission in Lu-177-DOTATATE-treated mice bearing neuroendocrine tumor xenografts
• Ladda ner fulltext (pdf) av The radiosensitizer Onalespib increases complete remission in Lu-177-DOTATATE-treated mice bearing neuroendocrine tumor xenografts

Bivalent binding on cells varies between anti-CD20 antibodies and is dose-dependent

Bondza, Sina; ten Broeke, Toine; Nestor, Marika; Leusen, Jeanette H. W. et al.

Ingår i mAbs, 2020

• DOI för Bivalent binding on cells varies between anti-CD20 antibodies and is dose-dependent

Exploring Radiation Response in Two Head and Neck Squamous Carcinoma Cell Lines Through Metabolic Profiling

Lindell Jonsson, Eva; Erngren, Ida; Engskog, Mikael; Haglöf, Jakob et al.

Ingår i Frontiers in Oncology, 2019

• DOI för Exploring Radiation Response in Two Head and Neck Squamous Carcinoma Cell Lines Through Metabolic Profiling
• Ladda ner fulltext (pdf) av Exploring Radiation Response in Two Head and Neck Squamous Carcinoma Cell Lines Through Metabolic Profiling

The Stapled Peptide PM2 Stabilizes p53 Levels and Radiosensitizes Wild-Type p53 Cancer Cells

Lundgren Mortensen, Anja; Spiegelberg, Diana; Brown, Christopher John; Lane, David Philip et al.

Ingår i Frontiers in Oncology, 2019

• DOI för The Stapled Peptide PM2 Stabilizes p53 Levels and Radiosensitizes Wild-Type p53 Cancer Cells
• Ladda ner fulltext (pdf) av The Stapled Peptide PM2 Stabilizes p53 Levels and Radiosensitizes Wild-Type p53 Cancer Cells

The HSP90 inhibitor onalespib potentiates Lu-177-DOTATATE therapy in neuroendocrine tumor cells

Lundsten, Sara; Spiegelberg, Diana; Stenerlöw, Bo; Nestor, Marika

Ingår i International Journal of Oncology, s. 1287-1295, 2019

• DOI för The HSP90 inhibitor onalespib potentiates Lu-177-DOTATATE therapy in neuroendocrine tumor cells
• Ladda ner fulltext (pdf) av The HSP90 inhibitor onalespib potentiates Lu-177-DOTATATE therapy in neuroendocrine tumor cells

Adduct formation in electrospray ionisation-mass spectrometry with hydrophilic interaction liquid chromatography is strongly affected by the inorganic ion concentration of the samples

Erngren, Ida; Haglöf, Jakob; Engskog, Mikael K R; Nestor, Marika et al.

Ingår i Journal of Chromatography A, s. 174-182, 2019

• DOI för Adduct formation in electrospray ionisation-mass spectrometry with hydrophilic interaction liquid chromatography is strongly affected by the inorganic ion concentration of the samples

Preclinical evaluation of a novel engineered recombinant human anti-CD44v6 antibody for potential use in radio-immunotherapy

Mortensen, Anja; Spiegelberg, Diana; Haylock, Anna-Karin; Lundqvist, Hans et al.

Ingår i International Journal of Oncology, s. 1875-1885, 2018

• DOI för Preclinical evaluation of a novel engineered recombinant human anti-CD44v6 antibody for potential use in radio-immunotherapy
• Ladda ner fulltext (pdf) av Preclinical evaluation of a novel engineered recombinant human anti-CD44v6 antibody for potential use in radio-immunotherapy

First in vivo study of the MDM2/MDMX-p53 antagonist PM2 as potentiator of external radiotherapy in wt p53 cancer

Spiegelberg, Diana; Mortensen, Anja C.; Lundsten, Sara; Brown, C. J. et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2018

• DOI för First in vivo study of the MDM2/MDMX-p53 antagonist PM2 as potentiator of external radiotherapy in wt p53 cancer

Potentiating Lu-177-DOTATATE Therapy By HSP90 Inhibition - First In Vivo Study

Lundsten, Sara; Spiegelberg, Diana; Raval, Nakul; Stenerlöw, Bo et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2018

Fab-conjugated PLGA nanoparticles effectively target cancer cells expressing human CD44v6

Kennedy, Patrick J.; Sousa, Flavia; Ferreira, Daniel; Pereira, Carla et al.

Ingår i Acta Biomaterialia, s. 208-218, 2018

• DOI för Fab-conjugated PLGA nanoparticles effectively target cancer cells expressing human CD44v6

The MDM2/MDMX-p53 Antagonist PM2 Radiosensitizes Wild-Type p53 Tumors

Spiegelberg, Diana; Mortensen, Anja; Lundsten, Sara; Brown, Christopher J. et al.

Ingår i Cancer Research, s. 5084-5093, 2018

• DOI för The MDM2/MDMX-p53 Antagonist PM2 Radiosensitizes Wild-Type p53 Tumors

Method selectivity evaluation using the co-feature ratio in LC/MS metabolomics: Comparison of HILIC stationary phase performance for the analysis of plasma, urine and cell extracts.

Elmsjö, Albert; Haglöf, Jakob; Engskog, Mikael K R; Erngren, Ida et al.

Ingår i Journal of Chromatography A, s. 49-56, 2018

• DOI för Method selectivity evaluation using the co-feature ratio in LC/MS metabolomics: Comparison of HILIC stationary phase performance for the analysis of plasma, urine and cell extracts.

Impact of surfactants on the target recognition of Fab-conjugated PLGA nanoparticles

Kennedy, Patrick J.; Perreira, Ines; Ferreira, Daniel; Nestor, Marika et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 366-370, 2018

• DOI för Impact of surfactants on the target recognition of Fab-conjugated PLGA nanoparticles

Analysis of radiation effects in two irradiated tumor spheroid models

Al-Ramadan, Afkar; Mortensen, Anja; Carlsson, Jörgen; Nestor, Marika V.

Ingår i Oncology Letters, s. 3008-3016, 2018

• DOI för Analysis of radiation effects in two irradiated tumor spheroid models

Different functions of AKT1 and AKT2 in molecular pathways, cell migration and metabolism in colon cancer cells

Häggblad Sahlberg, Sara; Mortensen, Anja C.; Haglöf, Jakob; Engskog, Mikael K. R. et al.

Ingår i International Journal of Oncology, s. 5-14, 2017

• DOI för Different functions of AKT1 and AKT2 in molecular pathways, cell migration and metabolism in colon cancer cells
• Ladda ner fulltext (pdf) av Different functions of AKT1 and AKT2 in molecular pathways, cell migration and metabolism in colon cancer cells

Generation and evaluation of antibody agents for molecular imaging of CD44v6-expressing cancers

Haylock, Anna-Karin; Nilvebrant, Johan; Mortensen, Anja; Velikyan, Irina et al.

Ingår i Oncotarget, s. 65152-65170, 2017

• DOI för Generation and evaluation of antibody agents for molecular imaging of CD44v6-expressing cancers
• Ladda ner fulltext (pdf) av Generation and evaluation of antibody agents for molecular imaging of CD44v6-expressing cancers

Radioiodination Of Small Stapled Peptides For p53 Therapy

Lundsten, Sara; Spiegelberg, Diana; Agmo Hernández, Víctor; Brown, C. et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2017

Novel Real-Time Proximity Assay for Characterizing Multiple Receptor Interactions on Living Cells

Bondza, Sina; Björkelund, Hanna; Nestor, Marika; Andersson, Karl et al.

Ingår i Analytical Chemistry, s. 13212-13218, 2017

• DOI för Novel Real-Time Proximity Assay for Characterizing Multiple Receptor Interactions on Living Cells

The Novel, Stapled HDM2/HDMX-p53 Antagonist PM2 Has Potent Antitumorigenic Activities and Enhances the Effects of External Radiotherapy

Mortensen, Anja C.; Spiegelberg, Diana; Brown, C.; Lane, D. P. et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2017

In Vivo Assessment of p53 Therapy as a Way of Enhancing Therapeutic Effects of Radiation

Mortensen, Anja C.; Spiegelberg, Diana; Lundsten, Sara; Brown, C. et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2017

The HSP90-inhibitor Onalespib Potentiates Lu-177-Dotatate Treatment of Neuroendocrine Tumors

Lundsten, Sara; Mortensen, Anja; Makiniemi, A.; Spiegelberg, Diana et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2017

In Vitro and In Vivo Growth Inhibitory and Radiosensitizing Effects of the Anti-HSP90 agent Onalespib

Spiegelberg, Diana; Lundsten, Sara; Mortensen, Anja C.; Abramenkovs, Andris et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2017

The co-feature ratio, a novel method for the measurement of chromatographic and signal selectivity in LC-MS-based metabolomics.

Elmsjö, Albert; Haglöf, Jakob; Engskog, Mikael K. R.; Nestor, Marika et al.

Ingår i Analytica Chimica Acta, s. 40-47, 2017

• DOI för The co-feature ratio, a novel method for the measurement of chromatographic and signal selectivity in LC-MS-based metabolomics.

A real-time in vitro assay as a potential predictor of in vivo tumor imaging properties

Spiegelberg, Diana; Stenberg, Jonas; Haylock, Anna-Karin; Nestor, Marika

Ingår i Nuclear Medicine and Biology, s. 12-18, 2016

• DOI för A real-time in vitro assay as a potential predictor of in vivo tumor imaging properties

Evaluation of a novel type of imaging probe based on a recombinant bivalent mini-antibody construct for detection of CD44v6-expressing squamous cell carcinoma

Haylock, Anna-Karin; Spiegelberg, Diana; Mortensen, Anja C.; Selvaraju, Ram K. et al.

Ingår i International journal of oncology, s. 461-470, 2016

• DOI för Evaluation of a novel type of imaging probe based on a recombinant bivalent mini-antibody construct for detection of CD44v6-expressing squamous cell carcinoma
• Ladda ner fulltext (pdf) av Evaluation of a novel type of imaging probe based on a recombinant bivalent mini-antibody construct for detection of CD44v6-expressing squamous cell carcinoma

Molecular imaging of EGFR and CD44v6 for prediction and response monitoring of HSP90 inhibition in an in vivo squamous cell carcinoma model.

Spiegelberg, Diana; Mortensen, Anja C; Selvaraju, Ram K; Eriksson, Olof et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 974-982, 2016

• DOI för Molecular imaging of EGFR and CD44v6 for prediction and response monitoring of HSP90 inhibition in an in vivo squamous cell carcinoma model.
• Ladda ner fulltext (pdf) av Molecular imaging of EGFR and CD44v6 for prediction and response monitoring of HSP90 inhibition in an in vivo squamous cell carcinoma model.

The novel HSP90 inhibitor AT13387 potentiates radiation effects in squamous cell carcinoma and adenocarcinoma cells

Spiegelberg, Diana; Dascalu, Adrian; Mortensen, Anja; Abramenkovs, Andris et al.

Ingår i Oncotarget, s. 35652-35666, 2015

• DOI för The novel HSP90 inhibitor AT13387 potentiates radiation effects in squamous cell carcinoma and adenocarcinoma cells
• Ladda ner fulltext (pdf) av The novel HSP90 inhibitor AT13387 potentiates radiation effects in squamous cell carcinoma and adenocarcinoma cells

Molecular imaging of EGFR and EGFRvIII for prediction and response monitoring of HSP90 inhibition in an in vivo squamous cell carcinoma model

Spiegelberg, Diana; Mortensen, Anja C.; Selvaraju, Ram Kumar; Eriksson, Olof et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2015

A real-time in vitro assay as a potential predictor of in vivo tumour imaging properties

Spiegelberg, Diana; Stenberg, J.; Haylock, Anna-Karin; Nestor, Marika

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2015

Improving EGFR imaging by use of an anti-EGFRvIII monoclonal antibody: characterizations in an in vivo squamous cell carcinoma model

Spiegelberg, Diana; Mortensen, Anja C.; Selvaraju, Ram Kumar; Stenberg, J. et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2015

Enhancing the effect of radiotherapy in cultured tumour cells using p53 therapy

Mortensen, Anja C.; Spiegelberg, Diana; Scott, A. M.; Lane, D. P. et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2015

In vivo characterization of the novel CD44v6-targeting Fab fragment AbD15179 for molecular imaging of squamous cell carcinoma: a dual-isotope study

Haylock, Anna-Karin; Spiegelberg, Diana; Nilvebrant, Johan; Sandström, Karl et al.

Ingår i EJNMMI Research, 2014

• DOI för In vivo characterization of the novel CD44v6-targeting Fab fragment AbD15179 for molecular imaging of squamous cell carcinoma: a dual-isotope study
• Ladda ner fulltext (pdf) av In vivo characterization of the novel CD44v6-targeting Fab fragment AbD15179 for molecular imaging of squamous cell carcinoma: a dual-isotope study

Impact of Conjugation of Antibodies and Antibody Fragments on Their Interaction With Target Antigens on Living Cells

Stenberg, Jonas; Bondza, Sina; Spiegelberg, Diana; Björkelund, Hanna et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2014

Evaluation of cancer stem cell markers CD133, CD44, CD24: association with AKT isoforms and radiation resistance in colon cancer cells.

Häggblad Sahlberg, Sara; Spiegelberg, Diana; Glimelius, Bengt; Stenerlöw, Bo et al.

Ingår i PLOS ONE, 2014

• DOI för Evaluation of cancer stem cell markers CD133, CD44, CD24: association with AKT isoforms and radiation resistance in colon cancer cells.
• Ladda ner fulltext (pdf) av Evaluation of cancer stem cell markers CD133, CD44, CD24: association with AKT isoforms and radiation resistance in colon cancer cells.

Characterization of CD44 variant expression in head and neck squamous cell carcinomas

Spiegelberg, Diana; Kuku, Gamze; Selvaraju, Ram; Nestor, Marika

Ingår i Tumor Biology, s. 2053-2062, 2014

• DOI för Characterization of CD44 variant expression in head and neck squamous cell carcinomas
• Ladda ner fulltext (pdf) av Characterization of CD44 variant expression in head and neck squamous cell carcinomas

Conjugation Effects on Antibody-Drug Conjugates: Evaluation of Interaction Kinetics in Real Time on Living Cells

Bondza, Sina; Stenberg, Jonas; Nestor, Marika; Andersson, Karl et al.

Ingår i Molecular Pharmaceutics, s. 4154-4163, 2014

• DOI för Conjugation Effects on Antibody-Drug Conjugates: Evaluation of Interaction Kinetics in Real Time on Living Cells

Choice of labeling and cell line influences interactions between the Fab fragment AbD15179 and its target antigen CD44v6

Stenberg, Jonas; Spiegelberg, Diana; Karlsson, Hampus; Nestor, Marika

Ingår i Nuclear Medicine and Biology, s. 140-147, 2014

• DOI för Choice of labeling and cell line influences interactions between the Fab fragment AbD15179 and its target antigen CD44v6

Evaluation of biomarkers for imaging and radio-immunotherapy in combination with HSP90 inhibition in squamous cell carcinomas

Spiegelberg, Diana; Mortensen, Anja C.; Haylock, Anna-Karin; Selvaraju, Ram Kumar et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2014

In vivo characterization of a novel engineered CD44v6-targeting bivalent antibody fragment AbD19384 for molecular imaging of squamous cell carcinoma

Mortensen, Anja C.; Spegelberg, Diana; Haylock, Anna-Karin; Selvaraju, Ram Kumar et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2014

In vivo characterization of CD44v6-targeting Fab fragments for molecular imaging of squamous cell carcinoma: a dual isotope study

Spiegelberg, Diana; Haylock, Anna-Karin; Nestor, Marika

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2013

A novel CD44v6 targeting antibody fragment with improved tumor-to-blood ratio

Sandström, Karl; Haylock, Anna-Karin; Spiegelberg, Diana; Qvarnström, Fredrik et al.

Ingår i International Journal of Oncology, s. 1525-1532, 2012

• DOI för A novel CD44v6 targeting antibody fragment with improved tumor-to-blood ratio

Targeted therapy in head and neck cancer

Kundu, S K; Nestor, Marika

Ingår i Tumor Biology, s. 707-721, 2012

• DOI för Targeted therapy in head and neck cancer

Selection and in vitro characterization of human CD44v6-binding antibody fragments

Nilvebrant, Johan; Kuku, Gamze; Björkelund, Hanna; Nestor, Marika

Ingår i Biotechnology and applied biochemistry, s. 367-380, 2012

• DOI för Selection and in vitro characterization of human CD44v6-binding antibody fragments

Characterization of CD44 Variant Expression in Cultured Head & Neck Squamous Cell Carcinomas for Possible Use in Radio-Immunotargeting

Spiegelberg, Diana; Nestor, Marika

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2012

Selection and characterisation of human CD44v6-binding antibody fragments for specific targeting of head and neck squamous cell carcinoma

Nilvebrant, J.; Kuku, G.; Björkelund, Hanna; Nestor, Marika

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2012

Improved Tumor-to-Organ Ratios of a Novel ⁶⁷Ga-Human Epidermal Growth Factor Radionuclide Conjugate with Preadministered Antiepidermal Growth Factor Receptor Affibody Molecules

Sandström, Karl; Haylock, Anna-Karin; Velikyan, Irina; Spiegelberg, Diana et al.

Ingår i Cancer Biotherapy and Radiopharmaceuticals, s. 593-601, 2011

• DOI för Improved Tumor-to-Organ Ratios of a Novel ⁶⁷Ga-Human Epidermal Growth Factor Radionuclide Conjugate with Preadministered Antiepidermal Growth Factor Receptor Affibody Molecules

Effect of cetuximab in combination with alpha-radioimmunotherapy in cultured squamous cell carcinomas

Nestor, Marika; Sundström, Magnus; Anniko, Matti; Tolmachev, Vladimir

Ingår i Nuclear Medicine and Biology, s. 103-112, 2011

• DOI för Effect of cetuximab in combination with alpha-radioimmunotherapy in cultured squamous cell carcinomas

Blocking EGFR in the liver improves the tumor-to-liver uptake ratio of radiolabeled EGF

Kareem, Heewa; Sandström, Karl; Elia, Ronny; Gedda, Lars et al.

Ingår i Tumor Biology, s. 79-87, 2010

• DOI för Blocking EGFR in the liver improves the tumor-to-liver uptake ratio of radiolabeled EGF

Effect of cetuximab treatment in squamous cell carcinomas

Nestor, Marika

Ingår i Tumor Biology, s. 141-147, 2010

• DOI för Effect of cetuximab treatment in squamous cell carcinomas

The use of closo-dodecaborate-containing linker improves targeting of HNSCC xenografts with radioiodinated chimeric monoclonal antibody U36

Cheng, Junping; Engström, Mats; Ekberg, Tomas; Nestor, Marika et al.

Ingår i Molecular Medicine Reports, s. 155-160, 2010

• DOI för The use of closo-dodecaborate-containing linker improves targeting of HNSCC xenografts with radioiodinated chimeric monoclonal antibody U36

Characterization of In-111 and Lu-177-labeled antibodies binding to CD44v6 using a novel automated radioimmunoassay

Nestor, Marika; Andersson, Karl; Lundqvist, Hans

Ingår i Journal of Molecular Recognition, s. 179-183, 2008

• DOI för Characterization of In-111 and Lu-177-labeled antibodies binding to CD44v6 using a novel automated radioimmunoassay

Targeting CD44v6 expressed in head and neck squamous cell carcinoma: preclinical characterization of an 111In-labeled monoclonal antibody

Sandström, Karl; Nestor, Marika; Ekberg, Tomas; Engström, Mats et al.

Ingår i Tumor Biology, s. 137-144, 2008

• DOI för Targeting CD44v6 expressed in head and neck squamous cell carcinoma: preclinical characterization of an 111In-labeled monoclonal antibody

Quantification of CD44v6 and EGFR expression in head and neck squamous cell carcinomas using a single-dose radioimmunoassay

Nestor, Marika; Ekberg, Tomas; Dring, John; van Dongen, Guus et al.

Ingår i Tumor Biology, s. 253-263, 2007

• DOI för Quantification of CD44v6 and EGFR expression in head and neck squamous cell carcinomas using a single-dose radioimmunoassay

Immuno-PET of undifferentiated thyroid carcinoma with radioiodine-labelled antibody cMAb U36: application to antibody tumour uptake studies

Fortin, Marc-André; Salnikov, Alexei V.; Nestor, Marika; Heldin, Nils-Erik et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 1376-1387, 2007

• DOI för Immuno-PET of undifferentiated thyroid carcinoma with radioiodine-labelled antibody cMAb U36: application to antibody tumour uptake studies

Radioimmunotherapy with astatine-211 using chimeric monoclonal antibody U36 in head and neck squamous cell carcinoma

Cheng, Junping; Ekberg, Tomas; Engström, Mats; Nestor, Marika et al.

Ingår i The Laryngoscope, s. 1013-1018, 2007

• DOI för Radioimmunotherapy with astatine-211 using chimeric monoclonal antibody U36 in head and neck squamous cell carcinoma

Expression of EGFR, HER2, HER3, and HER4 in metastatic squamous cell carcinomas of the oral cavity and base of tongue

Ekberg, Thomas; Nestor, Marika; Engström, Mats; Nordgren, Hans et al.

Ingår i International Journal of Oncology, s. 1177-85, 2005

In vitro evaluation of the astatinated chimeric monoclonal antibody U36, a potential candidate for treatment of head and neck squamous cell carcinoma

Nestor, Marika; Persson, Mikael; van Dongen, Guus A.; Jensen, Holger J. et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 1296-304, 2005

• DOI för In vitro evaluation of the astatinated chimeric monoclonal antibody U36, a potential candidate for treatment of head and neck squamous cell carcinoma

Tumor-cell targeted EGF liposomes loaded with boronated acridine: Uptake and processing

Kullberg, Erika Bohl; Nestor, Marika; Gedda, Lars

Ingår i Pharmaceutical research, s. 229-236, 2003

• DOI för Tumor-cell targeted EGF liposomes loaded with boronated acridine: Uptake and processing

Biodistribution of the chimeric monoclonal antibody U36 radioiodinated with a closo-dodecaborate-containing linker: Comparison with other radioiodination methods

Nestor, Marika; Persson, Mikael; Cheng, Junping; Tolmachev, Vladimir et al.

Ingår i Bioconjugate chemistry, s. 805-10, 2003

• DOI för Biodistribution of the chimeric monoclonal antibody U36 radioiodinated with a closo-dodecaborate-containing linker: Comparison with other radioiodination methods

Targeted radionuclide therapy in head and neck cancer

Nestor, Marika V.

Ingår i Head and Neck, s. 666-678, 2010

• DOI för Targeted radionuclide therapy in head and neck cancer

Conjugated Therapy: Cancer of the Head and Neck

Nestor, Marika

Ingår i Targeted Radionuclide Therapy, Lippincott Williams & Wilkins, 2010

Selectivity evaluation using the co-feature ratio in LC/MS metabolomics: comparison of HILIC stationary phases’ performance for the analysis of plasma, urine and cell extracts.

Elmsjö, Albert; Haglöf, Jakob; Engskog, Mikael; Erngren, Ida et al.

Enhancing therapeutic effects of radio-immunotherapy using the novel stapled MDM2/X-p53 antagonist PM2

Mortensen, Anja C.; Morin, Eric; Brown, Christopher J; Claesson-Welsh, Lena et al.

Bivalent Binding on Cells varies between CD20 Antibodies and is Dose-dependent

Bondza, Sina; ten Broeke, Toine; Nestor, Marika; Leusen, Jeanette et al.

PD-1 blockade enhances therapeutic effects of ¹⁷⁷Lu-DOTA-M5A in colorectal cancer CEA-transgenic mice

Mohajershojai, Tabassom; Bengtsson, Emil; Vallin, Ingrid; Spangler, Douglas et al.

Therapeutic combination of HSP90 inhibition and radiation therapy reduces tumor growth in a syngeneic neuroblastoma mouse model.

Berglund, Hanna; Pereira, Beatriz; Nestor, Marika; Spiegelberg, Diana

Exploring real-time interaction analysis to monitor CD44 expression modulation in cancer cells by inhibiting Musashi-1 interactions with RNA

Pérez-Ropero, Guillermo; Ortstad, Nathalie; Nestor, Marika; Danielson, Helena et al.