Sagar Narhari Agnihotri
Postdoktor vid Institutionen för materialvetenskap; Medicinsk teknik
- E-post:
- sagar.agnihotri@angstrom.uu.se
- Besöksadress:
- Ångströmlaboratoriet, Lägerhyddsvägen 1
- Postadress:
- Box 35
751 03 UPPSALA
Gästforskare vid Institutionen för medicinsk biokemi och mikrobiologi; Infektioner och Immunitet; Dan I Andersson
- E-post:
- sagar.agnihotri@imbim.uu.se
- Besöksadress:
- BMC
Husargatan 3
752 37 UPPSALA - Postadress:
- Box 582
751 23 UPPSALA
Mer information visas för dig som medarbetare om du loggar in.
Kort presentation
Nyckelord
- acoustofluidics
- antimicrobial resistance
- computational fluid dynamics
- droplet microfluidics
- lab-on-chip diagnostics
- microfabrication
- microfluidics
Biografi
Denna text finns inte på svenska, därför visas den engelska versionen.
Dr. Sagar N. Agnihotri is a post-doctoral researcher at Uppsala University, Sweden, specializing in microfluidics for healthcare and point-of-care diagnostics. His research focuses on microfluidics, microfabrication, computational fluid dynamics, and innovative product development using advanced techniques such as 3D printing. With prior post-doctoral experience at Northeastern University, USA, he has contributed significantly to areas like immunotherapy applications, single-cell analysis, and two-phase flow systems. Dr. Agnihotri completed his Ph.D. at IIT Bombay in collaboration with Monash University, where he investigated droplet breakup in microfluidic systems. He holds an M.Tech in Thermal and Fluid Engineering and a B.Tech in Mechanical Engineering from GCE, Amravati.
Forskning
Denna text finns inte på svenska, därför visas den engelska versionen.
Antibiotic resistance is a serious medical challenge that puts patients at risk of untreatable bacterial infections and threatens major advances in modern medicine that rely on antibiotics. To tackle this problem, innovative diagnostic tools are required to quickly identify resistances and choose the correct antibiotic for treatment. A challenge with identifying if the cells are susceptible or resistant to the antibiotics prescribed is that a population of bacterial cells can show heterogeneity and transient changes in terms of their susceptibility to the antibiotic. This can lead to an erroneous antibiotic choice and a resulting treatment failure. Droplet microfluidics offers unique advantages like lower fluid and associated costs, reagent consumption, and higher throughput. Hence droplet-based microfluidics can offer a faster, more efficient, and low-cost method with the ability to detect even single bacteria for antibiotic resistance compared to the agar plate-based methods.
Publikationer
Senaste publikationer
- Droplet Acoustofluidics and Pico-injection for Long-term Cell Culture (2022)
- Environment-friendly oils and surfactants for droplet microfluidics – the need to find replacements for PFAS-based chemicals
- Long-term droplet cell culture enabled by droplet acoustofluidics
- Microfluidic system with integrated nanocellulose cell culture substrate to study alignment of human umbilical vein endothelial cells in relation to external physical cues
Alla publikationer
Artiklar
- Environment-friendly oils and surfactants for droplet microfluidics – the need to find replacements for PFAS-based chemicals
- Long-term droplet cell culture enabled by droplet acoustofluidics
- Microfluidic system with integrated nanocellulose cell culture substrate to study alignment of human umbilical vein endothelial cells in relation to external physical cues