Stina Syvänen

PET imaging of TREM2 in amyloid-beta induced neuroinflammation

Dahlén, Amelia; Roshanbin, Sahar; Aguilar, Ximena; Bucher, Nadja et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 4320-4333, 2025

• DOI för PET imaging of TREM2 in amyloid-beta induced neuroinflammation
• Ladda ner fulltext (pdf) av PET imaging of TREM2 in amyloid-beta induced neuroinflammation

Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine

Lopes van den Broek, Sara; Eriksson, Jonas; Yang, Qiaojun; Bucher, Nadja M. et al.

Ingår i Translational Neurodegeneration, 2025

• DOI för Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine
• Ladda ner fulltext (pdf) av Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine

Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease

Sehlin, Dag; Hultqvist, Greta; Michno, Wojciech; Aguilar, Ximena et al.

Ingår i The Journal of Prevention of Alzheimer's Disease, 2025

• DOI för Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease
• Ladda ner fulltext (pdf) av Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease

The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo

Bonvicini, Gillian; Singh, Sunitha; Sandersjoo, Lisa; Sehlin, Dag et al.

Ingår i Fluids and Barriers of the CNS, 2025

• DOI för The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo
• Ladda ner fulltext (pdf) av The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo

Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody

Faresjö, Rebecca; Sehlin, Dag; Syvänen, Stina

Ingår i Fluids and Barriers of the CNS, 2023

• DOI för Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody
• Ladda ner fulltext (pdf) av Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody

Brain pharmacokinetics of mono- and bispecific amyloid-beta antibodies in wild-type and Alzheimer's disease mice measured by high cut-off microdialysis

Julku, Ulrika; Xiong, Mengfei; Wik, Elin; Roshanbin, Sahar et al.

Ingår i Fluids and Barriers of the CNS, 2022

• DOI för Brain pharmacokinetics of mono- and bispecific amyloid-beta antibodies in wild-type and Alzheimer's disease mice measured by high cut-off microdialysis
• Ladda ner fulltext (pdf) av Brain pharmacokinetics of mono- and bispecific amyloid-beta antibodies in wild-type and Alzheimer's disease mice measured by high cut-off microdialysis

¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention

Meier, Silvio R.; Sehlin, Dag; Roshanbin, Sahar; Lim Falk, Victoria et al.

Ingår i Journal of Nuclear Medicine, s. 302-309, 2022

• DOI för ¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention
• Ladda ner fulltext (pdf) av ¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention

Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease

Sehlin, Dag; Fang, Xiaotian T.; Cato, Linda; Antoni, Gunnar et al.

Ingår i Nature Communications, 2016

• DOI för Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease
• Ladda ner fulltext (pdf) av Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease

Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport

Syvänen, Stina; Lindhe, Örjan; Palner, Mikael; Kornum, Birgitte R et al.

Ingår i Drug Metabolism And Disposition, s. 635-643, 2009

• DOI för Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport

On the rate and extent of drug delivery to the brain

Hammarlund-Udenaes, Margareta; Fridén, Markus; Syvänen, Stina; Gupta, Anubha

Ingår i Pharmaceutical research, s. 1737-1750, 2008

• DOI för On the rate and extent of drug delivery to the brain

Evaluating the impact of age and treatment on neuroinflammation-related proteins in mouse models of proteinopathies

Dahlén, Amelia; Roshanbin, Sahar; Bucher, Nadja M.; Sehlin, Dag et al.

Ingår i Experimental Neurology, 2026

• DOI för Evaluating the impact of age and treatment on neuroinflammation-related proteins in mouse models of proteinopathies
• Ladda ner fulltext (pdf) av Evaluating the impact of age and treatment on neuroinflammation-related proteins in mouse models of proteinopathies

Somatostatin therapy, neprilysin activation, and amyloid beta reduction: A novel approach for Alzheimer's treatment

Metzendorf, Nicole G.; Godec, Ana; Petrovic, Alex; Chourlia, Aikaterini et al.

Ingår i Biomedicine and Pharmacotherapy, 2025

• DOI för Somatostatin therapy, neprilysin activation, and amyloid beta reduction: A novel approach for Alzheimer's treatment
• Ladda ner fulltext (pdf) av Somatostatin therapy, neprilysin activation, and amyloid beta reduction: A novel approach for Alzheimer's treatment

PET imaging of TREM2 in amyloid-beta induced neuroinflammation

Dahlén, Amelia; Roshanbin, Sahar; Aguilar, Ximena; Bucher, Nadja et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 4320-4333, 2025

• DOI för PET imaging of TREM2 in amyloid-beta induced neuroinflammation
• Ladda ner fulltext (pdf) av PET imaging of TREM2 in amyloid-beta induced neuroinflammation

Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine

Lopes van den Broek, Sara; Eriksson, Jonas; Yang, Qiaojun; Bucher, Nadja M. et al.

Ingår i Translational Neurodegeneration, 2025

• DOI för Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine
• Ladda ner fulltext (pdf) av Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine

Cryo-EM studies of amyloid-β fibrils from human and murine brains carrying the Uppsala APP mutation (Δ690-695)

Zielinski, Mara; Peralta Reyes, Fernanda S.; Gremer, Lothar; Sommerhage, Simon et al.

Ingår i Acta neuropathologica communications, 2025

• DOI för Cryo-EM studies of amyloid-β fibrils from human and murine brains carrying the Uppsala APP mutation (Δ690-695)
• Ladda ner fulltext (pdf) av Cryo-EM studies of amyloid-β fibrils from human and murine brains carrying the Uppsala APP mutation (Δ690-695)

Evaluating the impact of age and treatment on neuroinflammation-related proteins in mouse models of proteinopathies

Dahlén, Amelia; Roshanbin, Sahar; Bucher, Nadja M.; Sehlin, Dag et al.

Ingår i Experimental Neurology, 2026

• DOI för Evaluating the impact of age and treatment on neuroinflammation-related proteins in mouse models of proteinopathies
• Ladda ner fulltext (pdf) av Evaluating the impact of age and treatment on neuroinflammation-related proteins in mouse models of proteinopathies

Somatostatin therapy, neprilysin activation, and amyloid beta reduction: A novel approach for Alzheimer's treatment

Metzendorf, Nicole G.; Godec, Ana; Petrovic, Alex; Chourlia, Aikaterini et al.

Ingår i Biomedicine and Pharmacotherapy, 2025

• DOI för Somatostatin therapy, neprilysin activation, and amyloid beta reduction: A novel approach for Alzheimer's treatment
• Ladda ner fulltext (pdf) av Somatostatin therapy, neprilysin activation, and amyloid beta reduction: A novel approach for Alzheimer's treatment

PET imaging of TREM2 in amyloid-beta induced neuroinflammation

Dahlén, Amelia; Roshanbin, Sahar; Aguilar, Ximena; Bucher, Nadja et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 4320-4333, 2025

• DOI för PET imaging of TREM2 in amyloid-beta induced neuroinflammation
• Ladda ner fulltext (pdf) av PET imaging of TREM2 in amyloid-beta induced neuroinflammation

Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine

Lopes van den Broek, Sara; Eriksson, Jonas; Yang, Qiaojun; Bucher, Nadja M. et al.

Ingår i Translational Neurodegeneration, 2025

• DOI för Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine
• Ladda ner fulltext (pdf) av Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine

Cryo-EM studies of amyloid-β fibrils from human and murine brains carrying the Uppsala APP mutation (Δ690-695)

Zielinski, Mara; Peralta Reyes, Fernanda S.; Gremer, Lothar; Sommerhage, Simon et al.

Ingår i Acta neuropathologica communications, 2025

• DOI för Cryo-EM studies of amyloid-β fibrils from human and murine brains carrying the Uppsala APP mutation (Δ690-695)
• Ladda ner fulltext (pdf) av Cryo-EM studies of amyloid-β fibrils from human and murine brains carrying the Uppsala APP mutation (Δ690-695)

Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease

Sehlin, Dag; Hultqvist, Greta; Michno, Wojciech; Aguilar, Ximena et al.

Ingår i The Journal of Prevention of Alzheimer's Disease, 2025

• DOI för Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease
• Ladda ner fulltext (pdf) av Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease

Brain-penetrating peptide and antibody radioligands for proof-of-concept PET imaging of fibrin in Alzheimer's disease

Sehlin, Dag; Aguilar, Ximena; Cortes-Canteli, Marta; Syvänen, Stina et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2025

• DOI för Brain-penetrating peptide and antibody radioligands for proof-of-concept PET imaging of fibrin in Alzheimer's disease
• Ladda ner fulltext (pdf) av Brain-penetrating peptide and antibody radioligands for proof-of-concept PET imaging of fibrin in Alzheimer's disease

Fluorine-18 ImmunoPET Imaging of Antibody Brain Kinetics and Amyloid-Beta Pathology

Schlein, Eva; Lopes van den Broek, Sara; Dallas, Tiffany; Andersson, Ken G. et al.

Ingår i ACS Pharmacology & Translational Science, s. 2804-2813, 2025

• DOI för Fluorine-18 ImmunoPET Imaging of Antibody Brain Kinetics and Amyloid-Beta Pathology
• Ladda ner fulltext (pdf) av Fluorine-18 ImmunoPET Imaging of Antibody Brain Kinetics and Amyloid-Beta Pathology

High-affinity transferrin receptor binding improves brain delivery of bispecific antibodies at tracer dose

Bonvicini, Gillian; Singh, Sunitha; Sandersjoo, Lisa; Dallas, Tiffany et al.

Ingår i Fluids and Barriers of the CNS, 2025

• DOI för High-affinity transferrin receptor binding improves brain delivery of bispecific antibodies at tracer dose
• Ladda ner fulltext (pdf) av High-affinity transferrin receptor binding improves brain delivery of bispecific antibodies at tracer dose

Development of a toxin-selective immunotracer for in vivo detection of Clostridioides difficile infection by immunoPET

Gonzalez-Arjona, Mario; Cusso, Lorena; Alcala, Luis; Gonzalez, Maria Isabel et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2025

• DOI för Development of a toxin-selective immunotracer for in vivo detection of Clostridioides difficile infection by immunoPET
• Ladda ner fulltext (pdf) av Development of a toxin-selective immunotracer for in vivo detection of Clostridioides difficile infection by immunoPET

A brain-penetrant bispecific antibody lowers oligomeric alpha-synuclein and activates microglia in a mouse model of alpha-synuclein pathology

Sehlin, Dag; Roshanbin, Sahar; Zachrisson, Olof; Ingelsson, Martin et al.

Ingår i Neurotherapeutics, 2025

• DOI för A brain-penetrant bispecific antibody lowers oligomeric alpha-synuclein and activates microglia in a mouse model of alpha-synuclein pathology
• Ladda ner fulltext (pdf) av A brain-penetrant bispecific antibody lowers oligomeric alpha-synuclein and activates microglia in a mouse model of alpha-synuclein pathology

Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, N-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues

Lee, Yea-Rin; Kaya, Ibrahim; Wik, Elin; Baijnath, Sooraj et al.

Ingår i Analytical Chemistry, s. 1338-1346, 2025

• DOI för Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, N-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues
• Ladda ner fulltext (pdf) av Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, N-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues

The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo

Bonvicini, Gillian; Singh, Sunitha; Sandersjoo, Lisa; Sehlin, Dag et al.

Ingår i Fluids and Barriers of the CNS, 2025

• DOI för The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo
• Ladda ner fulltext (pdf) av The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo

Dual-ligand fluorescence microscopy enables chronological and spatial histological assignment of distinct amyloid-β deposits

Klingstedt, Therése; Shirani, Hamid; Parvin, Farjana; Nyström, Sofie et al.

Ingår i Journal of Biological Chemistry, 2025

• DOI för Dual-ligand fluorescence microscopy enables chronological and spatial histological assignment of distinct amyloid-β deposits
• Ladda ner fulltext (pdf) av Dual-ligand fluorescence microscopy enables chronological and spatial histological assignment of distinct amyloid-β deposits

Comparing in vitro affinity measurements of antibodies to TfR1: Surface plasmon resonance versus on-cell affinity

Bonvicini, Gillian; Singh, Sunitha; Nygren, Patrik; Xiong, Mengfei et al.

Ingår i Analytical Biochemistry, 2024

• DOI för Comparing in vitro affinity measurements of antibodies to TfR1: Surface plasmon resonance versus on-cell affinity
• Ladda ner fulltext (pdf) av Comparing in vitro affinity measurements of antibodies to TfR1: Surface plasmon resonance versus on-cell affinity

Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody

Schlein, Eva; Andersson, Ken G.; Dallas, Tiffany; Syvänen, Stina et al.

Ingår i mAbs, 2024

• DOI för Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody
• Ladda ner fulltext (pdf) av Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody

Antibody engagement with amyloid‐beta does not inhibit [¹¹C]PiB binding for PET imaging

Xiong, Mengfei; Dahlén, Amelia; Roshanbin, Sahar; Wik, Elin et al.

Ingår i Journal of Neurochemistry, s. 2601-2610, 2024

• DOI för Antibody engagement with amyloid‐beta does not inhibit [¹¹C]PiB binding for PET imaging
• Ladda ner fulltext (pdf) av Antibody engagement with amyloid‐beta does not inhibit [¹¹C]PiB binding for PET imaging

Active CNS delivery of oxycodone in healthy and endotoxemic pigs

Bällgren, Frida; Bergfast, Tilda; Ginosyan, Aghavni; Mahajan, Jessica et al.

Ingår i Fluids and Barriers of the CNS, 2024

• DOI för Active CNS delivery of oxycodone in healthy and endotoxemic pigs
• Ladda ner fulltext (pdf) av Active CNS delivery of oxycodone in healthy and endotoxemic pigs

Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β

Faresjö, Rebecca; Sjöström, Elisabet O.; Dallas, Tiffany; Berglund, Magnus M. et al.

Ingår i mAbs, 2024

• DOI för Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β
• Ladda ner fulltext (pdf) av Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β

Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging

Gustavsson, Tobias; Herth, Matthias M.; Sehlin, Dag; Syvänen, Stina

Ingår i Upsala Journal of Medical Sciences, 2024

• DOI för Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging
• Ladda ner fulltext (pdf) av Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging

Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET

Schlein, Eva; Rokka, Johanna; Odell, Luke R.; Lopes van den Broek, Sara et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2024

• DOI för Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET
• Ladda ner fulltext (pdf) av Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET

Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion

Pagnon de la Vega, María; Syvänen, Stina; Giedraitis, Vilmantas; Hooley, Monique et al.

Ingår i Acta neuropathologica communications, 2024

• DOI för Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion
• Ladda ner fulltext (pdf) av Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion

Development of brain-penetrable antibody radioligands for in vivo PET imaging of amyloid-β and tau

Banka, Vinay; Kelleher, Andrew; Sehlin, Dag; Hultqvist, Greta et al.

Ingår i Frontiers in Nuclear Medicine, 2023

• DOI för Development of brain-penetrable antibody radioligands for in vivo PET imaging of amyloid-β and tau
• Ladda ner fulltext (pdf) av Development of brain-penetrable antibody radioligands for in vivo PET imaging of amyloid-β and tau

Synaptic density in aging mice measured by [18F]SynVesT-1 PET

Xiong, Mengfei; Roshanbin, Sahar; Sehlin, Dag; Hansen, Hanne D. et al.

Ingår i NeuroImage, 2023

• DOI för Synaptic density in aging mice measured by [18F]SynVesT-1 PET
• Ladda ner fulltext (pdf) av Synaptic density in aging mice measured by [18F]SynVesT-1 PET

Cryo-EM of Aβ fibrils from mouse models find tg-APP_ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease

Zielinski, Mara; Peralta Reyes, Fernanda S; Gremer, Lothar; Schemmert, Sarah et al.

Ingår i Nature Neuroscience, s. 2073-2080, 2023

• DOI för Cryo-EM of Aβ fibrils from mouse models find tg-APP_ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease
• Ladda ner fulltext (pdf) av Cryo-EM of Aβ fibrils from mouse models find tg-APP_ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease

Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease

Gustavsson, Tobias; Metzendorf, Nicole G.; Wik, Elin; Roshanbin, Sahar et al.

Ingår i Alzheimer's Research & Therapy, 2023

• DOI för Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease
• Ladda ner fulltext (pdf) av Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease

Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody

Faresjö, Rebecca; Sehlin, Dag; Syvänen, Stina

Ingår i Fluids and Barriers of the CNS, 2023

• DOI för Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody
• Ladda ner fulltext (pdf) av Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody

Pretargeted imaging beyond the blood-brain barrier

Shalgunov, Vladimir; van den Broek, Sara Lopes; Andersen, Ida Vang; Vazquez, Rocio Garcia et al.

Ingår i RSC Medicinal Chemistry, s. 444-453, 2023

• DOI för Pretargeted imaging beyond the blood-brain barrier
• Ladda ner fulltext (pdf) av Pretargeted imaging beyond the blood-brain barrier

A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice

Rofo, Fadi; Meier, Silvio R.; Metzendorf, Nicole G.; Morrison, Jamie et al.

Ingår i Neurotherapeutics, s. 1588-1602, 2022

• DOI för A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice
• Ladda ner fulltext (pdf) av A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice

The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier

van den Broek, Sara Lopes; Sehlin, Dag; Andersen, Jens V.; Aldana, Blanca I. et al.

Ingår i Frontiers in Nuclear Medicine, 2022

• DOI för The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier
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Development of the First Tritiated Tetrazine: Facilitating Tritiation of Proteins

Bidesi, Natasha Shalina Radjani; Battisti, Umberto Maria; van de Broek, Sara Lopes; Shalgunov, Vladimir et al.

Ingår i ChemBioChem, 2022

• DOI för Development of the First Tritiated Tetrazine: Facilitating Tritiation of Proteins
• Ladda ner fulltext (pdf) av Development of the First Tritiated Tetrazine: Facilitating Tritiation of Proteins

Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-A beta-Affibodies

Faresjö, Rebecca; Lindberg, Hanna; Stahl, Stefan; Lofblom, John et al.

Ingår i Pharmaceutical research, s. 1509-1521, 2022

• DOI för Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-A beta-Affibodies
• Ladda ner fulltext (pdf) av Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-A beta-Affibodies

Brain pharmacokinetics of mono- and bispecific amyloid-beta antibodies in wild-type and Alzheimer's disease mice measured by high cut-off microdialysis

Julku, Ulrika; Xiong, Mengfei; Wik, Elin; Roshanbin, Sahar et al.

Ingår i Fluids and Barriers of the CNS, 2022

• DOI för Brain pharmacokinetics of mono- and bispecific amyloid-beta antibodies in wild-type and Alzheimer's disease mice measured by high cut-off microdialysis
• Ladda ner fulltext (pdf) av Brain pharmacokinetics of mono- and bispecific amyloid-beta antibodies in wild-type and Alzheimer's disease mice measured by high cut-off microdialysis

Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

Roshanbin, Sahar; Julku, Ulrika; Xiong, Mengfei; Eriksson, Jonas et al.

Ingår i Pharmaceutics, 2022

• DOI för Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody
• Ladda ner fulltext (pdf) av Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

In vivo imaging of alpha-synuclein with antibody-based PET

Roshanbin, Sahar; Xiong, Mengfei; Hultqvist, Greta; Soderberg, Linda et al.

Ingår i Neuropharmacology, 2022

• DOI för In vivo imaging of alpha-synuclein with antibody-based PET
• Ladda ner fulltext (pdf) av In vivo imaging of alpha-synuclein with antibody-based PET

Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3

de la Rosa, Andres; Metzendorf, Nicole G.; Morrison, Jamie; Faresjö, Rebecca et al.

Ingår i Scientific Reports, 2022

• DOI för Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3
• Ladda ner fulltext (pdf) av Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3

ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer's disease with a bispecific, brain-penetrating fusion protein

Bonvicini, Gillian; Syvänen, Stina; Andersson, Ken G. G.; Haaparanta-Solin, Merja et al.

Ingår i Translational Neurodegeneration, 2022

• DOI för ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer's disease with a bispecific, brain-penetrating fusion protein
• Ladda ner fulltext (pdf) av ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer's disease with a bispecific, brain-penetrating fusion protein

Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging

Schlein, Eva; Syvänen, Stina; Rokka, Johanna; Gustavsson, Tobias et al.

Ingår i Molecular Pharmaceutics, s. 4111-4122, 2022

• DOI för Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging
• Ladda ner fulltext (pdf) av Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging

Passive and receptor mediated brain delivery of an anti-GFAP nanobody

Meier, Silvio R.; Sehlin, Dag; Syvänen, Stina

Ingår i Nuclear Medicine and Biology, s. 128-134, 2022

• DOI för Passive and receptor mediated brain delivery of an anti-GFAP nanobody
• Ladda ner fulltext (pdf) av Passive and receptor mediated brain delivery of an anti-GFAP nanobody

Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease

Rofo, Fadi; Metzendorf, Nicole; Saubi, Cristina; Suominen, Laura et al.

Ingår i Alzheimer's Research & Therapy, 2022

• DOI för Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease
• Ladda ner fulltext (pdf) av Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease

Pretargeted Imaging beyond the Blood-Brain Barrier-Utopia or Feasible?

van den Broek, Sara Lopes; Shalgunov, Vladimir; Vazquez, Rocio Garcia; Beschorner, Natalie et al.

Ingår i Pharmaceuticals, 2022

• DOI för Pretargeted Imaging beyond the Blood-Brain Barrier-Utopia or Feasible?
• Ladda ner fulltext (pdf) av Pretargeted Imaging beyond the Blood-Brain Barrier-Utopia or Feasible?

Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's A beta amyloidosis

Jiang, Richeng; Smailovic, Una; Haytural, Hazal; Tijms, Betty M. et al.

Ingår i Acta neuropathologica communications, 2022

• DOI för Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's A beta amyloidosis
• Ladda ner fulltext (pdf) av Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's A beta amyloidosis

Professor Margareta Hammarlund-Udenaes: a Modern and Visionary Mentor

Syvänen, Stina; Fridén, Markus

Ingår i Pharmaceutical research, s. 1291-1296, 2022

• DOI för Professor Margareta Hammarlund-Udenaes: a Modern and Visionary Mentor

¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention

Meier, Silvio R.; Sehlin, Dag; Roshanbin, Sahar; Lim Falk, Victoria et al.

Ingår i Journal of Nuclear Medicine, s. 302-309, 2022

• DOI för ¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention
• Ladda ner fulltext (pdf) av ¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention

Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain

Rofo, Fadi; Yilmaz, Canan Ugur; Metzendorf, Nicole G.; Gustavsson, Tobias et al.

Ingår i Theranostics, s. 789-804, 2021

• DOI för Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain
• Ladda ner fulltext (pdf) av Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain

Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide

Rofo, Fadi; Sandbaumhüter, Friederike A.; Chourlia, Aikaterini; Metzendorf, Nicole G. et al.

Ingår i ACS Chemical Neuroscience, s. 2529-2541, 2021

• DOI för Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide
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Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

Faresjö, Rebecca; Bonvicini, Gillian; Fang, Xiaotian T.; Aguilar, Ximena et al.

Ingår i Fluids and Barriers of the CNS, 2021

• DOI för Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size
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In vivo imaging of synaptic density with [C-11]UCB-J PET in two mouse models of neurodegenerative disease

Xiong, Mengfei; Roshanbin, Sahar; Rokka, Johanna; Schlein, Eva et al.

Ingår i NeuroImage, 2021

• DOI för In vivo imaging of synaptic density with [C-11]UCB-J PET in two mouse models of neurodegenerative disease
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Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer's Disease

Meier, Silvio R.; Sehlin, Dag; Hultqvist, Greta; Syvänen, Stina

Ingår i Molecular Imaging and Biology, s. 665-675, 2021

• DOI för Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer's Disease
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Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain

Syvänen, Stina; Fang, Xiaotian T.; Faresjö, Rebecca; Rokka, Johanna et al.

Ingår i ACS Chemical Neuroscience, s. 4460-4468, 2020

• DOI för Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain
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Blocking of efflux transporters in rats improves translational validation of brain radioligands

Shalgunov, Vladimir; Xiong, Mengfei; L'Estrade, Elina T.; Raval, Nakul R. et al.

Ingår i EJNMMI Research, 2020

• DOI för Blocking of efflux transporters in rats improves translational validation of brain radioligands
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SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-beta antibody in a mouse model of Alzheimer's disease

Gustavsson, Tobias; Syvänen, Stina; O'Callaghan, Paul; Sehlin, Dag

Ingår i Translational Neurodegeneration, 2020

• DOI för SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-beta antibody in a mouse model of Alzheimer's disease
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Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle.

Sehlin, Dag; Stocki, Pawel; Gustavsson, Tobias; Hultqvist, Greta et al.

Ingår i The FASEB Journal, s. 13272-13283, 2020

• DOI för Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle.
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Chemical imaging of evolving amyloid plaque pathology and associated A β peptide aggregation in a transgenic mouse model of Alzheimer's disease

Michno, Wojciech; Wehrli, Patrick; Meier, Silvio R.; Sehlin, Dag et al.

Ingår i Journal of Neurochemistry, s. 602-616, 2020

• DOI för Chemical imaging of evolving amyloid plaque pathology and associated A β peptide aggregation in a transgenic mouse model of Alzheimer's disease

Long-Term Effects of Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease

Zysk, Marlena; Clausen, Fredrik; Aguilar, Ximena; Sehlin, Dag et al.

Ingår i Journal of Alzheimer's Disease, s. 161-180, 2019

• DOI för Long-Term Effects of Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease
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Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology

Michno, Wojciech; Nyström, Sofie; Wehrli, Patrick; Lashley, Tammaryn et al.

Ingår i Journal of Biological Chemistry, s. 6719-6732, 2019

• DOI för Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology
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High detection sensitivity with antibody-based PET radioligand for amyloid beta in brain

Fang, Xiaotian T.; Hultqvist, Greta; Meier, Silvio R.; Antoni, Gunnar et al.

Ingår i NeuroImage, s. 881-888, 2019

• DOI för High detection sensitivity with antibody-based PET radioligand for amyloid beta in brain

Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([¹⁸F]4FIMPTC) as a novel PET tracer of P-glycoprotein expression

Verbeek, Joost; Eriksson, Jonas; Syvänen, Stina; Huisman, Marc et al.

Ingår i EJNMMI Radiopharmacy and Chemistry, 2018

• DOI för Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([¹⁸F]4FIMPTC) as a novel PET tracer of P-glycoprotein expression
• Ladda ner fulltext (pdf) av Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([¹⁸F]4FIMPTC) as a novel PET tracer of P-glycoprotein expression

Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy

Gustafsson, Sofia; Gustavsson, Tobias; Roshanbin, Sahar; Hultqvist, Greta et al.

Ingår i Neuropharmacology, s. 1-9, 2018

• DOI för Blood-Brain Barrier Integrity in a Mouse Model of Alzheimer’s Disease With or Without Acute 3D6 Immunotherapy
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Intact blood-brain barrier transport of small molecular drugs in animal models of amyloid beta and alpha-synuclein pathology

Gustafsson, Sofia; Lindström, Veronica; Ingelsson, Martin; Hammarlund-Udenaes, Margareta et al.

Ingår i Neuropharmacology, s. 482-491, 2018

• DOI för Intact blood-brain barrier transport of small molecular drugs in animal models of amyloid beta and alpha-synuclein pathology
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Antibody-Based In Vivo PET Imaging Detects Amyloid-beta Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition

Meier, Silvio R.; Syvänen, Stina; Hultqvist, Greta; Fang, Xiaotian T. et al.

Ingår i Journal of Nuclear Medicine, s. 1885-1891, 2018

• DOI för Antibody-Based In Vivo PET Imaging Detects Amyloid-beta Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition
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Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody

Syvänen, Stina; Hultqvist, Greta; Gustavsson, Tobias; Gumucio, Astrid et al.

Ingår i Alzheimer's Research & Therapy, 2018

• DOI för Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody
• Ladda ner fulltext (pdf) av Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody

[F-18]Tetrazine-trans-cyclooctene mediated labelling of antibodies for PET imaging of amyloid-beta

Eriksson, Jonas; Fang, Xiaotian T.; Hultqvist, Greta; Olberg, D. E. et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2018

P-glycoprotein protein expression versus functionality at the blood-brain barrier using immunohistochemistry, microdialysis and mathematical modeling

De Lange, E. C. M.; van der Berg, D. J.; Bellanti, F.; Voskuyl, R. A. et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 61-70, 2018

• DOI för P-glycoprotein protein expression versus functionality at the blood-brain barrier using immunohistochemistry, microdialysis and mathematical modeling
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Astroglial Responses to Amyloid-Beta Progression in a Mouse Model of Alzheimer's Disease

Olsen, Malin; Aguilar, Ximena; Sehlin, Dag; Fang, Xiaotian T. et al.

Ingår i Molecular Imaging and Biology, s. 605-614, 2018

• DOI för Astroglial Responses to Amyloid-Beta Progression in a Mouse Model of Alzheimer's Disease
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Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells

Fang, Xiaotian T.; Sehlin, Dag; Lannfelt, Lars; Syvänen, Stina et al.

Ingår i Biological Procedures Online, 2017

• DOI för Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells
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Efficient clearance of Amyloid-beta protofibrils in APP-transgenic mice treated with a brain penetrating bifunctional antibody

Sehlin, Dag; Hultqvist, Greta; Gumucio, Astrid; Laudon, H. et al.

Ingår i Journal of Cerebral Blood Flow and Metabolism, s. 415-416, 2017

Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor

Hultqvist, Greta; Syvänen, Stina; Fang, Xiaotian T.; Lannfelt, Lars et al.

Ingår i Theranostics, s. 308-318, 2017

• DOI för Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor
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Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer's Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry

Kaya, Ibrahim; Brinet, Dimitri; Michno, Wojciech; Syvänen, Stina et al.

Ingår i ACS Chemical Neuroscience, s. 347-355, 2017

• DOI för Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer's Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry
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Pharmacokinetics, biodistribution and brain retention of a bispecific antibody-based PET radioligand for imaging of amyloid-beta

Sehlin, Dag; Fang, Xiaotian T.; Meier, Silvio R.; Jansson, Malin et al.

Ingår i Scientific Reports, 2017

• DOI för Pharmacokinetics, biodistribution and brain retention of a bispecific antibody-based PET radioligand for imaging of amyloid-beta
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Combined PET and microdialysis for in vivo estimation of drug blood-brain barrier transport and brain unbound concentrations

Gustafsson, Sofia; Eriksson, Jonas; Syvänen, Stina; Eriksson, Olof et al.

Ingår i NeuroImage, s. 177-186, 2017

• DOI för Combined PET and microdialysis for in vivo estimation of drug blood-brain barrier transport and brain unbound concentrations

Cationization increases brain distribution of an amyloid-beta protofibril selective F(ab')₂ fragment

Syvänen, Stina; Edén, Desireé; Sehlin, Dag

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 120-125, 2017

• DOI för Cationization increases brain distribution of an amyloid-beta protofibril selective F(ab')₂ fragment
• Ladda ner fulltext (pdf) av Cationization increases brain distribution of an amyloid-beta protofibril selective F(ab')₂ fragment

Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting

Fang, Xiaotian T.; Eriksson, Jonas; Antoni, Gunnar; Yngve, Ulrika et al.

Ingår i Neuropharmacology, s. 293-300, 2017

• DOI för Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting

Antibody-based PET radioligands for imaging of amyloid-beta protofibrils

Syvänen, Stina; Fang, Xiaotian T.; Hultqvist, Greta; Falting, J. et al.

Ingår i Journal of Cerebral Blood Flow and Metabolism, s. 84-84, 2017

A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging

Syvänen, Stina; Fang, Xiaotian T.; Hultqvist, Greta; Meier, Silvio R. et al.

Ingår i NeuroImage, s. 55-63, 2017

• DOI för A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging
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Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease

Sehlin, Dag; Fang, Xiaotian T.; Cato, Linda; Antoni, Gunnar et al.

Ingår i Nature Communications, 2016

• DOI för Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease
• Ladda ner fulltext (pdf) av Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease

Probing amyloid-β pathology in transgenic Alzheimer's disease (tgArcSwe) mice using MALDI imaging mass spectrometry

Carlred, Louise; Michno, Wojciech; Kaya, Ibrahim; Sjövall, Peter et al.

Ingår i Journal of Neurochemistry, s. 469-478, 2016

• DOI för Probing amyloid-β pathology in transgenic Alzheimer's disease (tgArcSwe) mice using MALDI imaging mass spectrometry

(R)-[(11)C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: Evaluation in a rat epilepsy model

Bogdanović, Renée Marie; Syvänen, Stina; Michler, Christina; Russmann, Vera et al.

Ingår i Neuropharmacology, s. 104-112, 2014

• DOI för (R)-[(11)C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: Evaluation in a rat epilepsy model

Molecular Imaging of Inflammation Reveals Differences Between Drug-Resistant and Drug-Sensitive Animals in a Chronic Model of Temporal Lobe Epilepsy

Potschka, H.; Bogdanovic, R. M.; Syvänen, Stina; Michler, C. et al.

Ingår i Epilepsia, s. 32-32, 2014

• DOI för Molecular Imaging of Inflammation Reveals Differences Between Drug-Resistant and Drug-Sensitive Animals in a Chronic Model of Temporal Lobe Epilepsy

Mechanism-Based Evaluation of Codeine Toxicity in Children

Gaitonde, P.; Trame, M. N.; Syvanen, Stina; Lesko, L. J. et al.

Ingår i Clinical Pharmacology and Therapeutics, 2014

Specific Uptake of an Amyloid-beta Protofibril-Binding Antibody-Tracer in A beta PP Transgenic Mouse Brain

Magnusson, Kristina; Sehlin, Dag; Syvänen, Stina; Svedberg, Marie M. et al.

Ingår i Journal of Alzheimer's Disease, s. 29-40, 2013

• DOI för Specific Uptake of an Amyloid-beta Protofibril-Binding Antibody-Tracer in A beta PP Transgenic Mouse Brain

[C-11]quinidine and [C-11]laniquidar PET imaging in a chronic rodent epilepsy model: Impact of epilepsy and drug-responsiveness

Syvänen, Stina; Russmann, Vera; Verbeek, Joost; Eriksson, Jonas et al.

Ingår i Nuclear Medicine and Biology, s. 764-775, 2013

• DOI för [C-11]quinidine and [C-11]laniquidar PET imaging in a chronic rodent epilepsy model: Impact of epilepsy and drug-responsiveness

Alteration in P-glycoprotein functionality affects intrabrain distribution of quinidine more than brain entry-a study in rats subjected to status epilepticus by kainate.

Syvänen, Stina; Schenke, Maarten; van den Berg, Dirk-Jan; Voskuyl, Rob A et al.

Ingår i AAPS Journal, s. 87-96, 2012

• DOI för Alteration in P-glycoprotein functionality affects intrabrain distribution of quinidine more than brain entry-a study in rats subjected to status epilepticus by kainate.

Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood--brain barriers studied with (R)-[11C]verapamil positron emission tomography.

Müllauer, Julia; Kuntner, Claudia; Bauer, Martin; Bankstahl, Jens P et al.

Ingår i EJNMMI Research, 2012

• DOI för Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood--brain barriers studied with (R)-[11C]verapamil positron emission tomography.
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[11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in rats.

Verbeek, Joost; Eriksson, Jonas; Syvänen, Stina; Labots, Maaike et al.

Ingår i EJNMMI Research, s. 36, 2012

• DOI för [11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in rats.

[11C]Flumazenil brain uptake is influenced by the blood-brain barrier efflux transporter P-glycoprotein.

Froklage, Femke E; Syvänen, Stina; Hendrikse, N Harry; Huisman, Marc C et al.

Ingår i EJNMMI Research, s. 12, 2012

• DOI för [11C]Flumazenil brain uptake is influenced by the blood-brain barrier efflux transporter P-glycoprotein.

Altered GABAA Receptor Density and Unaltered Blood-Brain Barrier Transport in a Kainate Model of Epilepsy: An In Vivo Study Using 11C-Flumazenil and PET.

Syvänen, Stina; Labots, Maaike; Tagawa, Yoshihiko; Eriksson, Jonas et al.

Ingår i Journal of Nuclear Medicine, s. 1974-1983, 2012

• DOI för Altered GABAA Receptor Density and Unaltered Blood-Brain Barrier Transport in a Kainate Model of Epilepsy: An In Vivo Study Using 11C-Flumazenil and PET.

Synthesis and preclinical evaluation of [11C]D617, a metabolite of (R)-[11C]verapamil.

Verbeek, Joost; Syvänen, Stina; Schuit, Robert C; Eriksson, Jonas et al.

Ingår i Nuclear Medicine and Biology, s. 530-9, 2012

• DOI för Synthesis and preclinical evaluation of [11C]D617, a metabolite of (R)-[11C]verapamil.

Simultaneous in vivo measurements of receptor density and affinity using [11C]flumazenil and positron emission tomography: comparison of full saturation and steady state methods.

Syvänen, Stina; de Lange, Elizabeth C; Tagawa, Yoshihiko; Schenke, Maarten et al.

Ingår i NeuroImage, s. 928-37, 2011

• DOI för Simultaneous in vivo measurements of receptor density and affinity using [11C]flumazenil and positron emission tomography: comparison of full saturation and steady state methods.

(R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus.

Syvänen, Stina; Luurtsema, Gert; Molthoff, Carla F M; Windhorst, Albert D et al.

Ingår i BMC medical imaging, s. 1, 2011

• DOI för (R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus.

Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport

Syvänen, Stina; Lindhe, Örjan; Palner, Mikael; Kornum, Birgitte R et al.

Ingår i Drug Metabolism And Disposition, s. 635-643, 2009

• DOI för Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport

A computerized Infusion Pump for control of tissue tracer concentration during Positron Emission Tomography in vivo Pharmacokinetic/Pharmacodynamic measurements

Eriksson, Olof; Wallberg, Andreas; Syvänen, Stina; Josephsson, Raymond et al.

Ingår i BMC Medical Physics, 2008

• DOI för A computerized Infusion Pump for control of tissue tracer concentration during Positron Emission Tomography in vivo Pharmacokinetic/Pharmacodynamic measurements

Pharmacokinetics of P-glycoprotein inhibition in the rat blood-brain barrier

Syvänen, Stina; Hooker, Andrew; Rahman, Obaidur; Wilking, Helena et al.

Ingår i Journal of Pharmaceutical Sciences, s. 5386-5400, 2008

• DOI för Pharmacokinetics of P-glycoprotein inhibition in the rat blood-brain barrier

Synthesis of two potential NK₁-receptor ligands using [1-¹¹C]ethyl iodide and [1-¹¹C]propyl iodide and initial PET-imaging

Syvänen, Stina; Eriksson, Jonas; Genchel, Tove; Lindhe, Örjan et al.

Ingår i BMC Medical Imaging, s. 6, 2007

• DOI för Synthesis of two potential NK₁-receptor ligands using [1-¹¹C]ethyl iodide and [1-¹¹C]propyl iodide and initial PET-imaging

Effect on [11C]DASB binding after tranylcypromine-induced increase in serotonin concentration: positron emission tomography studies in monkeys and rats

Lundquist, Pinelopi; Roman, Magnus; Syvänen, Stina; Hartvig, Per et al.

Ingår i Synapse, s. 440-449, 2007

• DOI för Effect on [11C]DASB binding after tranylcypromine-induced increase in serotonin concentration: positron emission tomography studies in monkeys and rats

PET-evaluated transport of [11C]hydroxyurea across the rat blood-brain barrier -: lack of influence of cyc-losporin and probenecid

Syvänen, Stina; Barletta, Julien; Blomquist, Gunnar; Långström, Bengt et al.

Ingår i Drug Metabolism Letters, s. 189-194, 2007

• DOI för PET-evaluated transport of [11C]hydroxyurea across the rat blood-brain barrier -: lack of influence of cyc-losporin and probenecid

Blood-brain barrier penetration of zolmitriptan--modelling of positron emission tomography data

Bergström, Mats; Yates, Roger; Wall, Anders; Kågedal, Matts et al.

Ingår i Journal of Pharmacokinetics and Pharmacodynamics, s. 75-91, 2006

• DOI för Blood-brain barrier penetration of zolmitriptan--modelling of positron emission tomography data

Pharmacokinetic consequences of active drug efflux at the blood-brain barrier

Syvänen, Stina; Xie, Ruija; Sahin, Selma; Hammarlund-Udenaes, Margareta

Ingår i Pharmaceutical research, s. 705-717, 2006

• DOI för Pharmacokinetic consequences of active drug efflux at the blood-brain barrier

Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood-brain barrier can be studied with PET

Syvänen, Stina; Blomquist, Gunnar; Sprycha, Margareta; Höglund, A. Urban et al.

Ingår i NeuroImage, s. 1134-1141, 2006

• DOI för Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood-brain barrier can be studied with PET

Predicting brain concentrations of drug using positron emission tomography and venous input: modeling of arterial-venous concentration differences

Syvänen, Stina; Blomquist, Gunnar; Appel, Lieuwe; Hammarlund-Udenaes, Margareta et al.

Ingår i European Journal of Clinical Pharmacology, s. 839-848, 2006

• DOI för Predicting brain concentrations of drug using positron emission tomography and venous input: modeling of arterial-venous concentration differences

PET Imaging in Preclinical Anti-Aβ Drug Development

Syvänen, Stina; Meier, Silvio R.; Roshanbin, Sahar; Xiong, Mengfei et al.

Ingår i Pharmaceutical research, s. 1481-1496, 2022

• DOI för PET Imaging in Preclinical Anti-Aβ Drug Development
• Ladda ner fulltext (pdf) av PET Imaging in Preclinical Anti-Aβ Drug Development

Advances in the development of new biomarkers for Alzheimer's disease

Klyucherev, Timofey O.; Olszewski, Pawel K.; Shalimova, Alena; Chubarev, Vladimir N. et al.

Ingår i Translational Neurodegeneration, 2022

• DOI för Advances in the development of new biomarkers for Alzheimer's disease
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Engineered antibodies: new possibilities for brain PET?

Sehlin, Dag; Syvänen, Stina; Ballanger, Benedicte; Barthel, Henryk et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, s. 2848-2858, 2019

• DOI för Engineered antibodies: new possibilities for brain PET?
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Advances in PET Imaging of P-Glycoprotein Function at the Blood-Brain Barrier.

Syvänen, Stina; Eriksson, Jonas

Ingår i ACS Chemical Neuroscience, s. 225-237, 2013

• DOI för Advances in PET Imaging of P-Glycoprotein Function at the Blood-Brain Barrier.

Using PET Studies of P-gp Function to Elucidate Mechanisms Underlying the Disposition of Drugs

Syvänen, Stina; Hammarlund-Udenaes, Margareta

Ingår i Current Topics in Medicinal Chemistry, s. 1799-1809, 2010

• DOI för Using PET Studies of P-gp Function to Elucidate Mechanisms Underlying the Disposition of Drugs

On the rate and extent of drug delivery to the brain

Hammarlund-Udenaes, Margareta; Fridén, Markus; Syvänen, Stina; Gupta, Anubha

Ingår i Pharmaceutical research, s. 1737-1750, 2008

• DOI för On the rate and extent of drug delivery to the brain

Blood-Brain Barrier Transport: Investigation of Active Efflux using Positron Emission Tomography and Modelling Studies

Syvänen, Stina

2008

• Ladda ner fulltext (pdf) av Blood-Brain Barrier Transport: Investigation of Active Efflux using Positron Emission Tomography and Modelling Studies

In Vivo Studies of Drug BBB Transport: Translational Challenges and the Role of Brain Imaging

Syvänen, Stina; Hammarlund-Udenaes, Margareta; Loryan, Irena

Ingår i Handbook of Experimental Pharmacology, s. 223-244, Springer, 2022

• DOI för In Vivo Studies of Drug BBB Transport: Translational Challenges and the Role of Brain Imaging

Brain Distribution of Drugs: Pharmacokinetic Considerations

Loryan, Irena; Hammarlund-Udenaes, Margareta; Syvänen, Stina

Ingår i Handbook of Experimental Pharmacology, s. 121-150, Springer, 2022

• DOI för Brain Distribution of Drugs: Pharmacokinetic Considerations

Journal of Labelled Compounds and Pharmaceuticals: Neurosciences session

Rokka, Johanna; Fang, Xiaotian T.; Hultqvist, Greta; Faresjö, Rebecca et al.

Ingår i ISRS 2019, 2019

• DOI för Journal of Labelled Compounds and Pharmaceuticals: Neurosciences session

Over the BBB and into the cell: Pursuing intracellular targets for immunotherapy of Parkinson’s disease

Stenler, Sofia; Roshanbin, Sahar; Yilmaz Ugur, Canan; Rostami, Jinar et al.

2019

Active transporters in the blood-brain barrier: A simulation study and a Positrion Emmission Tomography study.

Syvänen, Stina

2005

Therapeutic and diagnostic potential of a multivalent antibody against soluble amyloid-beta aggregates

Meier, Silvio R.; Rofo, Fadi; metzendorf, Nicole; Jamie, Morrison et al.

The Uppsala APP mutation promotes wildtype Aβ aggregation and deposition in vivo

Pagnon de la Vega, María; Ge, Junyue; Giedraitis, Vilmantas; Syvänen, Stina et al.

Transgenic mice harboring the Uppsala APP mutation display altered APP processing and accelerated Aβ42 pathology with distinct structural features

Pagnon de la Vega, María; Syvänen, Stina; Hooley, Monique; Giedraitis, Vilmantas et al.

Single domain antibody conjugated to Aβ-binding scFv penetrates BBB via TfR to interact with Aβ

Faresjö, Rebecca; O Sjöström, Elisabet; Berglund, Magnus; Eriksson, Jonas et al.

Synaptic density in aging mice measured by [¹⁸F]SynVesT-1 PET

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