Gustaf Christoffersson
Universitetslektor vid Institutionen för medicinsk cellbiologi; Forskargrupp Gustaf Christoffersson
- Telefon:
- 018-471 43 25, 070-223 15 99
- Mobiltelefon:
- 018-471 43 25
- E-post:
- gustaf.christoffersson@mcb.uu.se
- Besöksadress:
- BMC
Husargatan 3
751 23 Uppsala - Postadress:
- Box 571
751 23 UPPSALA
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Kort presentation
Denna text finns inte på svenska, därför visas den engelska versionen.
Overall, the lab strives to connect imaging-based preclinical models of type 1 diabetes to human clinical data and vice versa. We have the ability to explore hypotheses in organoid systems and in vivo models, and relate these to human pathophysiological findings in tissue samples, genomic data, and relevant patient characteristics in registries through clinical collaborations.
Publikationer
Senaste publikationer
- Macrophages upregulate mural cell-like markers and support healing of ischemic injury by adopting functions important for vascular support (2024)
- Footprints of immune cells in the type 1 diabetic pancreas, volume II (2024)
- GABA-mediated inhibition of human CD4+ T cell functions is enhanced by insulin but impaired by high glucose levels (2024)
- Boundary cap neural crest stem cells promote angiogenesis after transplantation to avulsed dorsal roots in mice and induce migration of endothelial cells in 3D printed scaffolds (2024)
- Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes (2024)
Alla publikationer
Artiklar
- Macrophages upregulate mural cell-like markers and support healing of ischemic injury by adopting functions important for vascular support (2024)
- Footprints of immune cells in the type 1 diabetic pancreas, volume II (2024)
- GABA-mediated inhibition of human CD4+ T cell functions is enhanced by insulin but impaired by high glucose levels (2024)
- Boundary cap neural crest stem cells promote angiogenesis after transplantation to avulsed dorsal roots in mice and induce migration of endothelial cells in 3D printed scaffolds (2024)
- Non-invasive imaging of sympathetic innervation of the pancreas in individuals with type 2 diabetes (2024)
- Microgravity Effect on Pancreatic Islets (2024)
- Three-dimensional Co-culture Model for Live Imaging of Pancreatic Islets, Immune Cells, and Neurons in Agarose Gel (2023)
- Long-term SARS-CoV-2-specific and cross-reactive cellular immune responses correlate with humoral responses, disease severity, and symptomatology (2022)
- Putative regulation of macrophage-mediated inflammation by catestatin (2022)
- The anti-inflammatory peptide Catestatin blocks chemotaxis (2022)
- The effect of Toll-like receptor stimulation on the motility of regulatory T cells (2021)
- An evaluation of a FluoroSpot assay as a diagnostic tool to determine SARS-CoV-2 specific T cell responses (2021)
- Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides (2021)
- Phagocytosis and Efferocytosis by Resident Macrophages in the Mouse Pancreas (2021)
- Means, Motive, and Opportunity (2021)
- Perivascular macrophages regulate blood flow following tissue damage (2021)
- Interference with pancreatic sympathetic signaling halts the onset of diabetes in mice (2020)
- Turning Up the Heat (2019)
- Regulatory Immune Mechanisms beyond Regulatory T Cells (2019)
- Case Reports of Pre-clinical Replication Studies in Metabolism and Diabetes (2019)
- The neutrophil (2018)
- Bioengineering with Endothelial Progenitor Cells Improves the Vascular Engraftment of Transplanted Human Islets (2018)
- Elucidating the dynamics and role of peri-vascular macrophages (2018)
- Perivascular macrophages regulate blood flow following tissue damage (2018)
- Vascular sprouts induce local attraction of proangiogenic neutrophils (2017)
- Rapid Restoration of Vascularity and Oxygenation in Mouse and Human Islets Transplanted to Omentum May Contribute to Their Superior Function Compared to Intraportally Transplanted Islets (2016)
- Matrix Metalloproteinase-9 Is Essential for Physiological Beta Cell Function and Islet Vascularization in Adult Mice (2015)
- Identification and characterization of VEGF-A-responsive neutrophils expressing CD49d, VEGFR1, and CXCR4 in mice and humans (2015)
- Immunological shielding by induced recruitment of regulatory T lymphocytes delays rejection of islets transplanted to muscle (2015)
- Immunological Shielding by Induced Recruitment of Regulatory T-Lymphocytes Delays Rejection of Islets Transplanted in Muscle (2015)
- Acute sleep deprivation increases serum levels of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in healthy young men (2014)
- Acute sleep deprivation in healthy young men (2014)
- Strategical steering of the immune system (2014)
- A distinct subset of proangiogenic CD11b(+)/Gr-1(+)/CXCR4(+)/MMP-9(hi) neutrophils are recruited by VEGF-A to transplanted hypoxic tissue (2013)
- Restored Vascular Density and Blood Fow in Mouse and Human Islets Experimentally Transplanted to The Greater Omentum (2013)
- The mechanisms of VEGF-A-induced recruitment of pro-angiogenic neutrophils (2013)
- Strategic recruitment of proangiogenic leukocytes to the ischemic hindlimb increases functional tissue perfusion (2013)
- Aberrant association between vascular endothelial growth factor receptor-2 and VE-cadherin in response to vascular endothelial growth factor-a in Shb-deficient lung endothelial cells (2013)
- VEGF-A recruits a proangiogenic MMP-9-delivering neutrophil subset that induces angiogenesis in transplanted hypoxic tissue (2012)
- Vascular adaptation to a dysfunctional endothelium as a consequence of Shb deficiency (2012)
- Sustained Beta-Cell Dysfunction but Normalized Islet Mass in Aged Thrombospondin-1 Deficient Mice (2012)
- Intramuscular islet transplantation promotes restored islet vascularity (2011)
- Increased Recruitment but Impaired Function of Leukocytes during Inflammation in Mouse Models of Type 1 and Type 2 Diabetes (2011)
- Clinical and Experimental Pancreatic Islet Transplantation to Striated Muscle (2010)
- A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils (2010)
- Altered leukocyte recruitment during inflammation in type 1 and type 2 diabetes models (2010)
- Gastroprotective and blood pressure lowering effects of dietary nitrate are abolished by an antiseptic mouthwash (2009)
- Pro-angiogenic neutrophils are potentiated by hypoxia
- Characterization of pro-angiogenic neutrophils
- Uncovering a new role for immune cells
Böcker
