Paul O'Callaghan
Forskare vid Institutionen för medicinsk cellbiologi; Forskargrupp Paul O'Callaghan
- E-post:
- Paul.Ocallaghan@mcb.uu.se
- Besöksadress:
- BMC
Husargatan 3
751 23 Uppsala - Postadress:
- Box 571
751 23 UPPSALA
- ORCID:
- 0000-0003-3117-5367
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Kort presentation
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Biografi
Denna text finns inte på svenska, därför visas den engelska versionen.
Academic qualifications:
2023 Docent (Assoc. Prof.) in Medical Cell Biology, Uppsala University
2011 PhD. in Medical Science. Dept. of Public Health & Caring Sciences (IFV), Rudbeck Laboratory, Uppsala University
2004 BSc. in Biochemistry. Dept. of Biochemistry, University College Cork, Ireland
Current positions:
2024 - ongoing: Researcher, Dept. of Medical Cell Biology, Uppsala University
2023 - ongoing: Director of U-Print, 3D printing facility, Uppsala University
2019 - ongoing: Director of Studies, Dept. of Medical Cell Biology, Uppsala University
Media
Publikationer
Urval av publikationer
- Fe and C additions decrease the dissolution rate of silicon nitride coatings and are compatible with microglial viability in 3D collagen hydrogels (2023)
- The β-cell primary cilium is an autonomous Ca2+ compartment for paracrine GABA signaling (2023)
- Piezo1 activation attenuates thrombin-induced blebbing in breast cancer cells (2022)
- An open source extrusion bioprinter based on the E3D motion system and tool changer to enable FRESH and multimaterial bioprinting (2021)
- Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates (2021)
- Formation of precisely composed cancer cell clusters using a cell assembly generator (CAGE) for studying paracrine signaling at single-cell resolution (2019)
- Modular microfluidic systems cast from 3D-printed molds for imaging leukocyte adherence to differentially treated endothelial cultures (2019)
- Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response (2015)
- Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein (2011)
- Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells (2008)
Senaste publikationer
- Towards a bioprinted spinal cord model for monitoring cell responses to particles and ions released from spinal implants (2023)
- In vitro 3D model for monitoring glial cell responses to particles and ions released from spinal implants (2023)
- Fe and C additions decrease the dissolution rate of silicon nitride coatings and are compatible with microglial viability in 3D collagen hydrogels (2023)
- The β-cell primary cilium is an autonomous Ca2+ compartment for paracrine GABA signaling (2023)
- Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3 (2022)
Alla publikationer
Artiklar
- Fe and C additions decrease the dissolution rate of silicon nitride coatings and are compatible with microglial viability in 3D collagen hydrogels (2023)
- The β-cell primary cilium is an autonomous Ca2+ compartment for paracrine GABA signaling (2023)
- Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3 (2022)
- Piezo1 activation attenuates thrombin-induced blebbing in breast cancer cells (2022)
- An open source extrusion bioprinter based on the E3D motion system and tool changer to enable FRESH and multimaterial bioprinting (2021)
- Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates (2021)
- Heparanase overexpression impedes perivascular clearance of amyloid-beta from murine brain (2021)
- SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-beta antibody in a mouse model of Alzheimer's disease (2020)
- Formation of precisely composed cancer cell clusters using a cell assembly generator (CAGE) for studying paracrine signaling at single-cell resolution (2019)
- Modular microfluidic systems cast from 3D-printed molds for imaging leukocyte adherence to differentially treated endothelial cultures (2019)
- Modeling the structural implications of an alternatively spliced Exoc3l2, a paralog of the tunneling nanotube-forming M-Sec (2018)
- Heparan Sulfate Proteoglycans as Relays of Neuroinflammation (2018)
- Vascular sprouts induce local attraction of proangiogenic neutrophils (2017)
- FGD5 sustains vascular endothelial growth factor A (VEGFA) signaling through inhibition of proteasome-mediated VEGF receptor 2 degradation (2017)
- Failure to Genotype (2016)
- Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response (2015)
- Apolipoprotein E increases cell association of amyloid-β 40 through heparan sulfate and LRP1 dependent pathways (2014)
- MicroRNA-24 Suppression of N-Deacetylase/N-Sulfotransferase-1 (NDST1) Reduces Endothelial Cell Responsiveness to Vascular Endothelial Growth Factor A (VEGFA) (2013)
- Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-beta in murine brain (2012)
- Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein (2011)
- Animal models of amyloid-β-related pathologies in Alzheimer’s disease (2010)
- Heparan sulfate mediates amyloid-beta internalization and cytotoxicity (2010)
- Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells (2008)
- Quantitative imaging of doxorubicin diffusion and cellular uptake in biomimetic gels with human liver tumor cells
- Impact of particles derived from spinal implant materials on glial survival and activation