Maria Karlgren

OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids

Mickols, Evgeniya; Meyer, Alina; Handin, Niklas; Stüwe, Malin et al.

Ingår i Scientific Reports, 2024

• DOI för OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids
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Pharmaceutical Quality by Design Approach to Develop High-Performance Nanoparticles for Magnetic Hyperthermia

Rahman Ansari, Shaquib; Suárez-López, Yael del Carmen; Thersleff, Thomas; Häggström, Lennart et al.

Ingår i ACS Nano, s. 15284-15302, 2024

• DOI för Pharmaceutical Quality by Design Approach to Develop High-Performance Nanoparticles for Magnetic Hyperthermia
• Ladda ner fulltext (pdf) av Pharmaceutical Quality by Design Approach to Develop High-Performance Nanoparticles for Magnetic Hyperthermia

Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1

Wegler, Christine; Gazit, Meryem; Issa, Karolina; Subramaniam, Sujay et al.

Ingår i Journal of Pharmaceutical Sciences, s. 388-396, 2021

• DOI för Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1
• Ladda ner fulltext (pdf) av Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1

Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain

Vallianatou, Theodosia; Shariatgorji, Reza; Nilsson, Anna; Karlgren, Maria et al.

Ingår i ACS Chemical Neuroscience, s. 1811-1823, 2021

• DOI för Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain
• Ladda ner fulltext (pdf) av Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain

Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions

Antonescu, Irina E.; Karlgren, Maria; Pedersen, Maria L.; Simoff, Ivailo et al.

Ingår i Pharmaceutics, 2020

• DOI för Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions
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OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids

Mickols, Evgeniya; Meyer, Alina; Handin, Niklas; Stüwe, Malin et al.

Ingår i Scientific Reports, 2024

• DOI för OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids
• Ladda ner fulltext (pdf) av OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids

Pharmaceutical Quality by Design Approach to Develop High-Performance Nanoparticles for Magnetic Hyperthermia

Rahman Ansari, Shaquib; Suárez-López, Yael del Carmen; Thersleff, Thomas; Häggström, Lennart et al.

Ingår i ACS Nano, s. 15284-15302, 2024

• DOI för Pharmaceutical Quality by Design Approach to Develop High-Performance Nanoparticles for Magnetic Hyperthermia
• Ladda ner fulltext (pdf) av Pharmaceutical Quality by Design Approach to Develop High-Performance Nanoparticles for Magnetic Hyperthermia

Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1

Wegler, Christine; Gazit, Meryem; Issa, Karolina; Subramaniam, Sujay et al.

Ingår i Journal of Pharmaceutical Sciences, s. 388-396, 2021

• DOI för Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1
• Ladda ner fulltext (pdf) av Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1

Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain

Vallianatou, Theodosia; Shariatgorji, Reza; Nilsson, Anna; Karlgren, Maria et al.

Ingår i ACS Chemical Neuroscience, s. 1811-1823, 2021

• DOI för Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain
• Ladda ner fulltext (pdf) av Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain

Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions

Antonescu, Irina E.; Karlgren, Maria; Pedersen, Maria L.; Simoff, Ivailo et al.

Ingår i Pharmaceutics, 2020

• DOI för Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions
• Ladda ner fulltext (pdf) av Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions

The Permeation of Acamprosate Is Predominantly Caused by Paracellular Diffusion across Caco-2 Cell Monolayers: A Paracellular Modeling Approach

Antonescu, Irina E; Rasmussen, Karina F; Neuhoff, Sibylle; Fretté, Xavier et al.

Ingår i Molecular Pharmaceutics, s. 4636-4650, 2019

• DOI för The Permeation of Acamprosate Is Predominantly Caused by Paracellular Diffusion across Caco-2 Cell Monolayers: A Paracellular Modeling Approach

An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice

Skogh, Anna; Lesniak, Anna; Sköld, Christian; Karlgren, Maria et al.

Ingår i Bioorganic & Medicinal Chemistry Letters, s. 2446-2450, 2018

• DOI för An imidazole based H-Phe-Phe-NH2 peptidomimetic with anti-allodynic effect in spared nerve injury mice

A mass spectrometry imaging approach for investigating how drug-drug interactions influence drug blood-brain barrier permeability

Vallianatou, Theodosia; Strittmatter, Nicole; Nilsson, Anna; Shariatgorji, Mohammadreza et al.

Ingår i NeuroImage, s. 808-816, 2018

• DOI för A mass spectrometry imaging approach for investigating how drug-drug interactions influence drug blood-brain barrier permeability

Intracellular drug bioavailability: a new predictor of system dependent drug disposition

Mateus, André; Treyer, Andrea; Wegler, Christine; Karlgren, Maria et al.

Ingår i Scientific Reports, s. 1-12, 2017

• DOI för Intracellular drug bioavailability: a new predictor of system dependent drug disposition
• Ladda ner fulltext (pdf) av Intracellular drug bioavailability: a new predictor of system dependent drug disposition

A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies.

Karlgren, Maria; Simoff, Ivailo; Backlund, Maria; Wegler, Christine et al.

Ingår i Journal of Pharmaceutical Sciences, s. 2909-2913, 2017

• DOI för A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies.

Tumor acidosis enhances cytotoxic effects and autophagy inhibition by salinomycin on cancer cell lines and cancer stem cells

Pellegrini, Paola; Dyczynski, Matheus; Sbrana, Francesca Vittoria; Karlgren, Maria et al.

Ingår i Oncotarget, s. 35703-35723, 2016

• DOI för Tumor acidosis enhances cytotoxic effects and autophagy inhibition by salinomycin on cancer cell lines and cancer stem cells

Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9

Simoff, Ivailo; Karlgren, Maria; Backlund, Maria; Lindström, Anne-Christine et al.

Ingår i Journal of Pharmaceutical Sciences, s. 1017-1021, 2016

• DOI för Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9

Impact of drug transporters on intracellular unbound drug concentrations

Mateus, André; Treyer, Andrea; Matsson, Par; Karlgren, Maria et al.

Ingår i Drug metabolism reviews (Softcover ed.), s. 147-147, 2016

Comparative proteome analysis of human liver tissue and isolated hepatocytes: application to predictions of hepatic pitavastatin uptake clearance

Vildhede, Anna; Wisniewski, Jacek; Norén, Agneta; Karlgren, Maria et al.

Ingår i Drug metabolism reviews (Softcover ed.), s. 96-96, 2016

Mechanistic modeling of hepatic pitavastatin disposition: a proteomics-informed bottom-up approach

Vildhede, Anna; Mateus, André; Khan, Elin K.; Lai, Yurong et al.

Ingår i Drug metabolism reviews (Softcover ed.), s. 56-57, 2016

Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach

Vildhede, Anna; Mateus, André; Khan, Elin K.; Lai, Yurong et al.

Ingår i Drug Metabolism And Disposition, s. 505-516, 2016

• DOI för Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach

Comparative Proteomic Analysis of Human Liver Tissue and Isolated Hepatocytes with a Focus on Proteins Determining Drug Exposure

Vildhede, Anna; Wisniewski, Jacek R.; Noren, Agneta; Karlgren, Maria et al.

Ingår i Journal of Proteome Research, s. 3305-3314, 2015

• DOI för Comparative Proteomic Analysis of Human Liver Tissue and Isolated Hepatocytes with a Focus on Proteins Determining Drug Exposure

Global Membrane Protein Analysis Of The Human Liver: Application In Predictions Of Atorvastatin Uptake Clearance

Karlgren, Maria; Vildhede, Anna; Ölander, Magnus; Wisniewski, Jacek et al.

Ingår i Drug metabolism reviews (Softcover ed.), s. 245-246, 2015

Hepatic Uptake of Atorvastatin: Influence of Variability in Transporter Expression on Uptake Clearance and Drug-Drug Interactions

Vildhede, Anna; Karlgren, Maria; Svedberg, Elin K.; Wisniewski, Jacek R. et al.

Ingår i Drug Metabolism And Disposition, s. 1210-1218, 2014

• DOI för Hepatic Uptake of Atorvastatin: Influence of Variability in Transporter Expression on Uptake Clearance and Drug-Drug Interactions

Combined in Vitro-in Vivo Approach To Assess the Hepatobiliary Disposition of a Novel Oral Thrombin Inhibitor

Matsson, Elin M.; Eriksson, Ulf G.; Palm, Johan E.; Artursson, Per et al.

Ingår i Molecular Pharmaceutics, s. 4252-4262, 2013

• DOI för Combined in Vitro-in Vivo Approach To Assess the Hepatobiliary Disposition of a Novel Oral Thrombin Inhibitor

An Integrated in Vitro Model for Simultaneous Assessment of Drug Uptake, Metabolism, and Efflux

Neve, Etienne P. A.; Artursson, Per; Ingelman-Sundberg, Magnus; Karlgren, Maria

Ingår i Molecular Pharmaceutics, s. 3152-3163, 2013

• DOI för An Integrated in Vitro Model for Simultaneous Assessment of Drug Uptake, Metabolism, and Efflux

In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug-Drug Interactions

Karlgren, Maria; Ahlin, Gustav; Bergström, Christel A. S; Svensson, Richard et al.

Ingår i Pharmaceutical research, s. 411-426, 2012

• DOI för In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug-Drug Interactions

Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug - Drug Interactions

Karlgren, Maria; Vildhede, Anna; Norinder, Ulf; Wisniewski, Jacek R. et al.

Ingår i Journal of Medicinal Chemistry, s. 4740-4763, 2012

• DOI för Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug - Drug Interactions

Integrated cell models for prediction of drug transport and drug metabolism in the human hepatocyte

Karlgren, Maria; Svensson, Richard; Artursson, Per

Ingår i Drug metabolism reviews (Softcover ed.), s. 306-307, 2010

Interaction of 140 orally administered drugs with the liver-specific organic anion transporter OATP1B1 (SLCO1B1)

Karlgren, Maria; Ahlin, Gustav; Bergström, Christel; Karlsson, Johan et al.

Ingår i Drug metabolism reviews (Softcover ed.), s. 304-305, 2010

Specific and general inhibitors of the three hepatic organic anion transporters OATP1B1 (SLCO1B1), OATP1B3 (SLCO1B3) and OATP2B1 (SLCO2B1)

Karlgren, Maria; Ahlin, Gustav; Vildhede, Anna; Artursson, Per

Ingår i Drug metabolism reviews (Softcover ed.), s. 305-306, 2010

Uptake mechanism of ochratoxin A and citrinin through human liver

Gao, Ge; Karlgren, Maria; Artursson, Per

Ingår i Drug metabolism reviews (Softcover ed.), s. 315-315, 2010

The expression of the novel CYP2W1 enzyme is an independent prognostic factor in colorectal cancer: a pilot study.

Edler, David; Stenstedt, Kristina; Ohrling, Katarina; Hallström, Marja et al.

Ingår i European Journal of Cancer, s. 705-712, 2009

• DOI för The expression of the novel CYP2W1 enzyme is an independent prognostic factor in colorectal cancer: a pilot study.

CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box

Karlgren, Maria; Simoff, Ivailo; Keiser, M.; Oswald, S. et al.

Ingår i Drug Metabolism And Disposition, s. 1776-1786, 2018

• DOI för CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box

Molecular genetics and epigenetics of the cytochrome P450 gene family and its relevance for cancer risk and treatment

Rodriguez-Antona, Cristina; Gomez, Alvin; Karlgren, Maria; Sim, Sarah C et al.

Ingår i Human Genetics, s. 1-17, 2010

• DOI för Molecular genetics and epigenetics of the cytochrome P450 gene family and its relevance for cancer risk and treatment

How Physicochemical Properties of Drugs Affect Their Metabolism and Clearance

Karlgren, Maria; Bergström, Christel

Ingår i New Horizons in Predictive Drug Metabolism and Pharmacokinetics, s. 1-26, Royal Society of Chemistry, 2016

• DOI för How Physicochemical Properties of Drugs Affect Their Metabolism and Clearance

In vitro characterization of interactions with drug transporting proteins

Artursson, Per; Matsson, Pär; Karlgren, Maria

Ingår i Transporters in Drug Development , s. 37-65, Springer, 2013

• DOI för In vitro characterization of interactions with drug transporting proteins

Imaging age-induced perturbations of mitochondrial function, neurotransmission and lipid signaling in specific brain regions

Vallianatou, Theodosia; Shariatgorji, Mohammadreza; Nilsson, Anna; Karlgren, Maria et al.

Animal product-free formation and cultivation of 3D primary hepatocyte spheroids

Mickols, Evgeniya; Primpas, Lazaros; Oredsson, Stina; Karlgren, Maria