Kenneth Nilsson

The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomain

Alzrigat, Mohammad; Párraga, Alba Atienza; Majumder, Muntasir; Ma, Anqi et al.

Ingår i Oncotarget, s. 103731-103743, 2017

• DOI för The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomain
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EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.

Alzrigat, Mohammad; Párraga, Alba Atienza; Agarwal, Prasoon; Zureigat, Hadil et al.

Ingår i Oncotarget, s. 10213-10224, 2017

• DOI för EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.
• Ladda ner fulltext (pdf) av EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.

The Transcriptomic and Proteomic Landscapes of Bone Marrow and Secondary Lymphoid Tissues

Andersson, Sandra; Nilsson, Kenneth; Fagerberg, Linn; Hallstrom, Bjorn M. et al.

Ingår i PLOS ONE, 2014

• DOI för The Transcriptomic and Proteomic Landscapes of Bone Marrow and Secondary Lymphoid Tissues
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An Epigenomic Map of Multiple Myeloma Reveals the Importance of Polycomb Gene Silencing for the Malignancy

Agarwal, Prasoon; Kalushkova, Antonia; Enroth, Stefan; Alzrigat, Mohammad et al.

Ingår i Blood, 2014

Molecular characterization of neoplastic and normal "sister" lymphoblastoid B-cell lines from chronic lymphocytic leukemia

Myhrinder, Anna Lanemo; Hellqvist, Eva; Bergh, Ann-Charlotte; Jansson, Mattias et al.

Ingår i Leukemia and Lymphoma, s. 1769-1779, 2013

• DOI för Molecular characterization of neoplastic and normal "sister" lymphoblastoid B-cell lines from chronic lymphocytic leukemia

The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomain

Alzrigat, Mohammad; Párraga, Alba Atienza; Majumder, Muntasir; Ma, Anqi et al.

Ingår i Oncotarget, s. 103731-103743, 2017

• DOI för The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomain
• Ladda ner fulltext (pdf) av The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomain

EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.

Alzrigat, Mohammad; Párraga, Alba Atienza; Agarwal, Prasoon; Zureigat, Hadil et al.

Ingår i Oncotarget, s. 10213-10224, 2017

• DOI för EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.
• Ladda ner fulltext (pdf) av EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.

The Transcriptomic and Proteomic Landscapes of Bone Marrow and Secondary Lymphoid Tissues

Andersson, Sandra; Nilsson, Kenneth; Fagerberg, Linn; Hallstrom, Bjorn M. et al.

Ingår i PLOS ONE, 2014

• DOI för The Transcriptomic and Proteomic Landscapes of Bone Marrow and Secondary Lymphoid Tissues
• Ladda ner fulltext (pdf) av The Transcriptomic and Proteomic Landscapes of Bone Marrow and Secondary Lymphoid Tissues

An Epigenomic Map of Multiple Myeloma Reveals the Importance of Polycomb Gene Silencing for the Malignancy

Agarwal, Prasoon; Kalushkova, Antonia; Enroth, Stefan; Alzrigat, Mohammad et al.

Ingår i Blood, 2014

Molecular characterization of neoplastic and normal "sister" lymphoblastoid B-cell lines from chronic lymphocytic leukemia

Myhrinder, Anna Lanemo; Hellqvist, Eva; Bergh, Ann-Charlotte; Jansson, Mattias et al.

Ingår i Leukemia and Lymphoma, s. 1769-1779, 2013

• DOI för Molecular characterization of neoplastic and normal "sister" lymphoblastoid B-cell lines from chronic lymphocytic leukemia

Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma

Dimberg, Lina Y.; Dimberg, Anna; Ivarsson, Karolina; Fryknäs, Mårten et al.

Ingår i BMC Cancer, s. 318, 2012

• DOI för Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma
• Ladda ner fulltext (pdf) av Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma

Tumor-Initiating Cells in Childhood Neuroblastoma: Letter

Mohlin, Sofie; Pietras, Alexander; Wigerup, Caroline; Ora, Ingrid et al.

Ingår i Cancer Research, s. 821-822, 2012

• DOI för Tumor-Initiating Cells in Childhood Neuroblastoma: Letter

The novel NF-kappa B inhibitor IMD-0354 induces apoptosis in chronic lymphocytic leukemia

Kanduri, Meena; Tobin, Gerard; Åleskog, Anna; Nilsson, Kenneth et al.

Ingår i Blood Cancer Journal, 2011

• DOI för The novel NF-kappa B inhibitor IMD-0354 induces apoptosis in chronic lymphocytic leukemia

Large-Scale Protein Profiling in Human Cell Lines Using Antibody-Based Proteomics

Fagerberg, Linn; Strömberg, Sara; El-Obeid, Adila; Gry, Marcus et al.

Ingår i Journal of Proteome Research, s. 4066-4075, 2011

• DOI för Large-Scale Protein Profiling in Human Cell Lines Using Antibody-Based Proteomics

Polycomb target genes are silenced in multiple myeloma

Kalushkova, Antonia; Fryknäs, Mårten; Lemaire, Miguel; Fristedt, Charlotte et al.

Ingår i PLOS ONE, 2010

• DOI för Polycomb target genes are silenced in multiple myeloma
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Epigenetic silencing of the interferon regulatory factor ICSBP/IRF8 in human multiple myeloma

Tshuikina, Marina; Jernberg-Wiklund, Helena; Nilsson, Kenneth; Öberg, Fredrik

Ingår i Experimental Hematology, s. 1673-1681, 2008

• DOI för Epigenetic silencing of the interferon regulatory factor ICSBP/IRF8 in human multiple myeloma

Positive histone marks are associated with active transcription from a methylated ICSBP/IRF8 gene

Tshuikina, Marina; Nilsson, Kenneth; Öberg, Fredrik

Ingår i Gene, s. 259-267, 2008

• DOI för Positive histone marks are associated with active transcription from a methylated ICSBP/IRF8 gene

IFN-gamma-induced upregulation of Fc gamma-receptor-I during activation of monocytic cells requires the PKR and NF kappa B pathways

Kårehed, Karin; Dimberg, Anna; Dahl, Staffan; Nilsson, Kenneth et al.

Ingår i Molecular Immunology, s. 615-624, 2007

• DOI för IFN-gamma-induced upregulation of Fc gamma-receptor-I during activation of monocytic cells requires the PKR and NF kappa B pathways

Targeting the IGF-1R using picropodophyllin in the therapeutical 5T2MM mouse model of multiple myeloma: beneficial effects on tumor growth, angiogenesis, bone disease and survival

Menu, Eline; Jernberg-Wiklund, Helena; De Raeve, Hendrik; De Leenheer, Evy et al.

Ingår i International Journal of Cancer, s. 1857-1861, 2007

• DOI för Targeting the IGF-1R using picropodophyllin in the therapeutical 5T2MM mouse model of multiple myeloma: beneficial effects on tumor growth, angiogenesis, bone disease and survival

Inhibition of monocytic differentiation by phosphorylation-deficient Stat1 is associated with impaired expression of Stat2, ICSBP/IRF8 and C/EBP epsilon

Dimberg, Anna; Kårehed, Karin; Nilsson, Kenneth; Öberg, Fredrik

Ingår i Scandinavian Journal of Immunology, s. 271-279, 2006

• DOI för Inhibition of monocytic differentiation by phosphorylation-deficient Stat1 is associated with impaired expression of Stat2, ICSBP/IRF8 and C/EBP epsilon

IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells.

Strömberg, Thomas; Ekman, Simon; Girnita, Leonard; Dimberg, Lina Y et al.

Ingår i Blood, s. 669-78, 2006

Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model.

Menu, Eline; Jernberg-Wiklund, Helena; Stromberg, Thomas; De Raeve, Hendrik et al.

Ingår i Blood, s. 655-60, 2006

Ectopic and IFN-induced expression of Fas overcomes resistance to Fas-mediated apoptosis in multiple myeloma cells.

Dimberg, Lina; Dimberg, Anna; Ivarsson, Karolina; Strömberg, Thomas et al.

Ingår i Blood, 2005

• DOI för Ectopic and IFN-induced expression of Fas overcomes resistance to Fas-mediated apoptosis in multiple myeloma cells.

Mcl-1 gene promoter insertions do not correlate with disease outcome, stage or V(H) gene mutation status in chronic lymphocytic leukaemia.

Tobin, Gerard; Skogsberg, Åsa; Thunberg, Ulf; Laurell, Anna et al.

Ingår i Leukemia, s. 871-873, 2005

Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone.

Strömberg, Thomas; Dimberg, Anna; Hammarberg, Anna; Carlson, Kristina et al.

Ingår i Blood, s. 3138-47, 2004

Cytotoxic effect in vivo and in vitro of CHS 828 on human myeloma cell lines.

Hovstadius, Peter; Lindhagen, Elin; Hassan, Sadia; Nilsson, Kenneth et al.

Ingår i Anticancer Drugs, s. 63-70, 2004

Elevated levels of soluble CD44 are associated with advanced disease and in vitro proliferation of neoplastic lymphocytes in B-cell chronic lymphocytic leukemia

Eisterer, Wolfgang; Bechter, Oliver; Söderberg, Ola; Nilsson, Kenneth et al.

Ingår i Leukemia Res, s. 1043-1051, 2004

Differentiation-associated redox-regulation in human B cell lines from stemcell/pro-B to plasma cell

Nilssson, Joacim; Söderberg, Ola; Nilsson, Kenneth; Rosén, Anders

Ingår i Immunology Letters, s. 83-89, 2004

VH gene mutation status and cellular drug resistance in chronic lymphocytic leukemia

Åleskog, Anna; Tobin, Gerard; Laurell, Anna; Thunberg, Ulf et al.

Ingår i Eur J Haematol, s. 407-411, 2004

Development and characterization of two human tumor sublines expressing high-grade resistance to the cyanoguadine CHS 828

Gullbo, Joachim; Lövborg, Henrik; Dhar, Sumeer; Lukinius, Agneta et al.

Ingår i Anti-Cancer Drugs, s. 45-54, 2004

PML/RARalpha plays a role for basal activity and retinoid-induced repression of the tissue factor promoter in acute promyelocytic leukemia cells

Tenno, Taavo; Öberg, Fredrik; Mackman, Nigel; Nilsson, Kenneth et al.

Ingår i Thrombosis and Haemostasis, s. 930-9, 2003

Expression of CCL5/RANTES by Hodgkin and Reed-Sternberg cells and its possible role in the recruitment of mast cells into lymphomatous tissue.

Fischer, Marie; Juremalm, Mikael; Olsson, Niclas; Backlin, Carin et al.

Ingår i Int J Cancer, s. 197-201, 2003

Ser727/Tyr701-phosphorylated Stat1 is required for the regulation ofc-Myc, cyclins, and p27Kip1 associated with ATRA-induced G0/G1 arrest ofU-937 cells.

Dimberg, A; Karlberg, I; Nilsson, K; Oberg, F

Ingår i Blood, s. 254, 2003

Expression of the bcl-2 family of pro- and anti-apoptotic genes in multiple myeloma and normal plasma cells: regulation during interleukin-6(IL-6)-induced growth and survival.

Spets, Helena; Strömberg, Thomas; Georgii-Hemming, Patrik; Siljason, Jan et al.

Ingår i Eur J Haematol, s. 76-89, 2002

Retinoic acid-induced cell cycle arrest of human myeloid cell lines is associated with sequential down-regulation of c-Myc and cyclin E andposttranscriptional up-regulation of p27(Kip1).

Dimberg, A; Bahram, F; Karlberg, I; Larsson, LG et al.

Ingår i Blood, s. 2199, 2002

Cytokine-induced restoration of differentiation and cell cycle arrest in v-Myc transformed U-937 monoblasts correlates with reduced Myc activity

Öberg, Fredrik; Wu, S.; Bahram, Fuad; Nilsson, Kenneth et al.

Ingår i Leukemia, s. 217-227, 2001

The role of RAR and RXR activation in retinoid-induced tissue factor suppression

Tenno, Taavo; Botling, Johan; Öberg, Fredrik; Jossan, S. et al.

Ingår i Leukemia, s. 1105-11, 2000

Thioredoxin prolongs survival of B-type chronic lymphocytic leukemia cells

Nilsson, J; Söderberg, Ola; Nilsson, Kenneth; Rosén, A

Ingår i Blood, s. 1420-1426, 2000

Differences in the growth inhibition of cultured K-562 cells by selenium, mercury or cadmium in two tissue culture media (RPMI-1640, Ham's F-10).

Frisk, Peter; Yaqob, Amer; Nilsson, Kenneth; Carlsson, Jörgen et al.

Ingår i Biometals, s. 101-11, 2000

Phosphorylation-deficient Stat1 inhibits retinoic acid-induceddifferentiation and cell cycle arrest in U-937 monoblasts.

Dimberg, A; Nilsson, K; Oberg, F

Ingår i Blood, s. 2870, 2000

Induction of differentiation in U-937 and NB4 cells is associated with inhibition of tissue factor production

Tenno, Taavo; Öberg, Fredrik; Nilsson, Kenneth; Siegbahn, Agneta

Ingår i European Journal of Haematology, s. 112-119, 1999

Staphylococcus aureus Cowan strain 1 activation of B-chronic lymphocytic leukaemia cells augments the response to CD40 stimulation.

Söderberg, O; Thunberg, U; Weigelt, C; Christiansen, I et al.

Ingår i Scand J Immunol, s. 363-70, 1999

The somatostatin analog octreotide inhibits growth of interleukin-6 (IL-dent and IL-6-independent human multiple myeloma cell lines.

Georgii-Hemming, P; Stromberg, T; Tiensuu Janson, E; Stridsberg, M et al.

Ingår i Blood, s. 1724, 1999

Fas/APO-1 (CD95)-mediated apoptosis is activated by interferon-gammanterleukin-6 (IL-6)-dependent and IL-6-independent multiple myeloma cell lines.

Spets, H; Georgii-Hemming, P; Siljason, J; Nilsson, K et al.

Ingår i Blood, s. 2914, 1998

Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation

Botling, Johan; Castro, Diogo S.; Öberg, Fredrik; Nilsson, Kenneth et al.

Ingår i Journal of Biological Chemistry, s. 9443-9, 1997

• DOI för Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation
• Ladda ner fulltext (pdf) av Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation

Tissue and differentiation specific expression of the endogenous retrovirus ERV3 (HERV-R) in normal human tissues and during induced monocytic differentiation in the U-937 cell line

Larsson, Erik; Venables, P.; Andersson, A-C.; Fan, W. et al.

Ingår i Leukemia, s. 142-4, 1997

Myeloperoxidase mediates cell adhesion via the alpha M beta 2 integrin (Mac-1, CD11b/CD18)

Johansson, M; Patarroyo, M; Öberg, Fredrik; Siegbahn, Agneta et al.

Ingår i Journal of Cell Science, s. 1133-1139, 1997

Tissue factor expression in human monocytic cell lines

Tenno, Taavo; Botling, Johan; Öberg, Fredrik; Nilsson, Kenneth et al.

Ingår i Thrombosis Research, s. 215-28, 1997

Interleukin-15 + thioredoxin induce DNA synthesis in B-chronic lymphocytic leukemia cells but not in normal B cells.

Söderberg, O; Christiansen, I; Nilsson, G; Carlsson, M et al.

Ingår i Leukemia, s. 1298-304, 1997

The effects on growth and survival of IL-6 can be dissociated in the U-266-1970/U-266-1984 and HL407E/HL407L human multiple myeloma cell lines.

Spets, H; Jernberg-Wiklund, H; Sambade, C; Söderberg, O et al.

Ingår i Br J Haematol, s. 126-33, 1997

The effects on growth and survival of IL-6 can be dissociated in the U-266-1970/U-266-1984 and HL407E/HL407L human multiple myeloma cell lines.

Spets, H; Jernberg-Wiklund, H; Sambade, C; Soderberg, O et al.

Ingår i Br J Haematol, s. 126, 1997

CD40 ligation inhibits IL-2 and SAC+IL-2 induced proliferation in chronic lymphocytic leukaemia cells.

Söderberg, O; Christiansen, I; Carlsson, M; Nilsson, K

Ingår i Scand J Immunol, s. 706-14, 1997

Vitamin D3 and retinoic acid induced monocytic differentiation: Interactions between the endogenous vitamin D3, retinoic acid and retinoid X receptors in U-937 cells

Botling, Johan; Öberg, Fredrik; Törmä, Hans; Tuohimaa, Pentti et al.

Ingår i Cell growth & differentiation, s. 1239-49, 1996

Characterization of a human basophil-like cell line (LAMA-84)

Blom, T; Nilsson, G; Sundström, C; Nilsson, K et al.

Ingår i Scand. J. Immunol., s. 54-61, 1996

Stem cell factor-dependent human cord blood derived mast cells express alpha- and beta-tryptase, heparin and chondroitin sulphate

Nilsson, G; Blom, T; Harvima, I; Kusche-Gullberg, M et al.

Ingår i Immunology, s. 308-314, 1996

Expression of the endogenous retrovirus ERV3 (HERV-R) during induced monocytic differentiation in the U-937 cell line

Larsson, Erik; Venables, P.J.W.; Andersson, Ann-Catrin; Wansheng, F et al.

Ingår i Int. J. Cancer, s. 451, 1996

Insulin-like growth factor I is a growth- and survival factor in human multiple myeloma cell lines.

Georgii-Hemming, P; Jernberg-Wiklund, H; Ljunggren, Ö; Nilsson, K

Ingår i Blood, s. 2250, 1996

CD49f (alpha 6 integrin) and CD66a (BGP) are specifically induced by retinoids during human monocytic differentiation

Botling, Johan; Öberg, Fredrik; Nilsson, Kenneth

Ingår i Leukemia, s. 2034-41, 1995

Targeting the IGF-1R signaling and mechanisms for epigenetic gene silencing in human multiple myeloma

Jernberg-Wiklund, Helena; Nilsson, Kenneth

Ingår i Upsala Journal of Medical Sciences, s. 166-177, 2012

• DOI för Targeting the IGF-1R signaling and mechanisms for epigenetic gene silencing in human multiple myeloma

Control of Apoptosis in Human Multiple Myeloma by Insulin-like Growth Factor I (IGF-I)

Jernberg-Wiklund, Helena; Nilsson, Kenneth

Ingår i Advances in Cancer Research, s. 139-165, 2007

• DOI för Control of Apoptosis in Human Multiple Myeloma by Insulin-like Growth Factor I (IGF-I)

Plasma Cell and Myeloma Cell Lines

Jernberg Wiklund, Helena; Nilsson, Kenneth

Ingår i Human Cell Culture, Kluwer Academic Publishers, 2000

Stat1 involvement in retinoic acid induced differentiation of myeloid cells

Dimberg, Anna; Nilsson, Kenneth; Oberg, Fredrik

Ingår i Molecular mechanisms of signal transduction, s. 211, IOS press, Amsterdam, The Netherlands, 2000

Monocytes and Macrophages

Öberg, Fredrik; Nilsson, Kenneth

Ingår i Transplantation Biology, s. 241, Lippincott-Raven, 1996

Cytokine induced inhibition of Myc activity in monocytic cells

Larsson, Lars-Gunnar; Bahram, F.; Wu, S.; Öberg, Fredrik et al.

Ingår i C-myc in B-cell neoplasia, s. 191, 1997

The epigenomic map of multiple myeloma reveals the importance of Polycomb gene silencing for the malignancy

Agarwal, Prasoon; Kalushkova, Antonia; Enroth, Stefan; Österborg, Anders et al.

Toward a rational combinaTORial therapy for multiple myeloma

Jernberg Wiklund, Helena; Nilsson, Kenneth

Ingår i Blood, s. 3845-3846, 2004

The control of proliferation, survival and apoptosis in human multiple myeloma cells in vitro

Nilsson, K; Georgii-Hemming, P; Spets, H; Jernberg-Wiklund, H

Ingår i MECHANISMS OF B CELL NEOPLASIA 1998, s. 325-333, 1999