Fredrik Öberg

PVT1 interacts with the polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma

Nylund, Patrick; Garrido-Zabala, Berta; Atienza Párraga, Alba; Vasquez, Louella et al.

Ingår i Haematologica, s. 567-577, 2024

• DOI för PVT1 interacts with the polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma
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A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma

Nylund, Patrick; Atienza Párraga, Alba; Haglöf, Jakob; De Bruyne, Elke et al.

Ingår i Cell Death and Disease, 2021

• DOI för A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma
• Ladda ner fulltext (pdf) av A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma

The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomain

Alzrigat, Mohammad; Párraga, Alba Atienza; Majumder, Muntasir; Ma, Anqi et al.

Ingår i Oncotarget, s. 103731-103743, 2017

• DOI för The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomain
• Ladda ner fulltext (pdf) av The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomain

EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.

Alzrigat, Mohammad; Párraga, Alba Atienza; Agarwal, Prasoon; Zureigat, Hadil et al.

Ingår i Oncotarget, s. 10213-10224, 2017

• DOI för EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.
• Ladda ner fulltext (pdf) av EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.

Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target.

Agarwal, Prasoon; Alzrigat, Mohammad; Párraga, Alba Atienza; Enroth, Stefan et al.

Ingår i Oncotarget, s. 6809-6923, 2016

• DOI för Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target.

PVT1 interacts with the polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma

Nylund, Patrick; Garrido-Zabala, Berta; Atienza Párraga, Alba; Vasquez, Louella et al.

Ingår i Haematologica, s. 567-577, 2024

• DOI för PVT1 interacts with the polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma
• Ladda ner fulltext (pdf) av PVT1 interacts with the polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma

A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma

Nylund, Patrick; Atienza Párraga, Alba; Haglöf, Jakob; De Bruyne, Elke et al.

Ingår i Cell Death and Disease, 2021

• DOI för A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma
• Ladda ner fulltext (pdf) av A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma

The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomain

Alzrigat, Mohammad; Párraga, Alba Atienza; Majumder, Muntasir; Ma, Anqi et al.

Ingår i Oncotarget, s. 103731-103743, 2017

• DOI för The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomain
• Ladda ner fulltext (pdf) av The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomain

EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.

Alzrigat, Mohammad; Párraga, Alba Atienza; Agarwal, Prasoon; Zureigat, Hadil et al.

Ingår i Oncotarget, s. 10213-10224, 2017

• DOI för EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.
• Ladda ner fulltext (pdf) av EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.

Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target.

Agarwal, Prasoon; Alzrigat, Mohammad; Párraga, Alba Atienza; Enroth, Stefan et al.

Ingår i Oncotarget, s. 6809-6923, 2016

• DOI för Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target.

AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and a dose dependent reduction of kinase activity in acute myeloid leukemia

Eriksson, Anna; Kalushkova, Antonia; Jarvius, Malin; Hilhorst, Riet et al.

Ingår i Biochemical Pharmacology, s. 284-291, 2014

• DOI för AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and a dose dependent reduction of kinase activity in acute myeloid leukemia
• Ladda ner fulltext (pdf) av AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and a dose dependent reduction of kinase activity in acute myeloid leukemia

An Epigenomic Map of Multiple Myeloma Reveals the Importance of Polycomb Gene Silencing for the Malignancy

Agarwal, Prasoon; Kalushkova, Antonia; Enroth, Stefan; Alzrigat, Mohammad et al.

Ingår i Blood, 2014

Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma

Dimberg, Lina Y.; Dimberg, Anna; Ivarsson, Karolina; Fryknäs, Mårten et al.

Ingår i BMC Cancer, s. 318, 2012

• DOI för Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma
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Polycomb target genes are silenced in multiple myeloma

Kalushkova, Antonia; Fryknäs, Mårten; Lemaire, Miguel; Fristedt, Charlotte et al.

Ingår i PLOS ONE, 2010

• DOI för Polycomb target genes are silenced in multiple myeloma
• Ladda ner fulltext (pdf) av Polycomb target genes are silenced in multiple myeloma

Herbal melanin activates TLR4/NF-kappaB signaling pathway

Öberg, Fredrik; Haseeb, Adil; Ahnfelt, Matilda; Pontén, Fredrik et al.

Ingår i Phytomedicine, s. 477-84, 2009

• DOI för Herbal melanin activates TLR4/NF-kappaB signaling pathway

TGF-beta enforces senescence in Myc-transformed hematopoietic tumor cells through induction of Mad1 and repression of Myc activity

Wu, Siqin; Hultquist, Anne; Hydbring, Per; Cetinkaya, Cihan et al.

Ingår i Experimental Cell Research, s. 3099-3111, 2009

• DOI för TGF-beta enforces senescence in Myc-transformed hematopoietic tumor cells through induction of Mad1 and repression of Myc activity

Positive histone marks are associated with active transcription from a methylated ICSBP/IRF8 gene

Tshuikina, Marina; Nilsson, Kenneth; Öberg, Fredrik

Ingår i Gene, s. 259-267, 2008

• DOI för Positive histone marks are associated with active transcription from a methylated ICSBP/IRF8 gene

Epigenetic silencing of the interferon regulatory factor ICSBP/IRF8 in human multiple myeloma

Tshuikina, Marina; Jernberg-Wiklund, Helena; Nilsson, Kenneth; Öberg, Fredrik

Ingår i Experimental Hematology, s. 1673-1681, 2008

• DOI för Epigenetic silencing of the interferon regulatory factor ICSBP/IRF8 in human multiple myeloma

STAT1 signaling is associated with acquired crossresistance to doxorubicin and radiation in myeloma cell lines

Fryknäs, Mårten; Dhar, Sumeer; Öberg, Fredrik; Rickardson, Linda et al.

Ingår i International Journal of Cancer, s. 189-195, 2007

• DOI för STAT1 signaling is associated with acquired crossresistance to doxorubicin and radiation in myeloma cell lines

IFN-gamma-induced upregulation of Fc gamma-receptor-I during activation of monocytic cells requires the PKR and NF kappa B pathways

Kårehed, Karin; Dimberg, Anna; Dahl, Staffan; Nilsson, Kenneth et al.

Ingår i Molecular Immunology, s. 615-624, 2007

• DOI för IFN-gamma-induced upregulation of Fc gamma-receptor-I during activation of monocytic cells requires the PKR and NF kappa B pathways

Inhibition of proteasome activity, nuclear factor-KB translocation and cell survival by the antialcoholism drug disulfiram

Lövborg, Henrik; Öberg, Fredrik; Rickardson, Linda; Gullbo, Joachim et al.

Ingår i Int J Cancer, s. 1577-1580, 2006

• DOI för Inhibition of proteasome activity, nuclear factor-KB translocation and cell survival by the antialcoholism drug disulfiram

Ectopic and IFN-induced expression of Fas overcomes resistance to Fas-mediated apoptosis in multiple myeloma cells.

Dimberg, Lina; Dimberg, Anna; Ivarsson, Karolina; Strömberg, Thomas et al.

Ingår i Blood, 2005

• DOI för Ectopic and IFN-induced expression of Fas overcomes resistance to Fas-mediated apoptosis in multiple myeloma cells.

Development and characterization of two human tumor sublines expressing high-grade resistance to the cyanoguadine CHS 828

Gullbo, Joachim; Lövborg, Henrik; Dhar, Sumeer; Lukinius, Agneta et al.

Ingår i Anti-Cancer Drugs, s. 45-54, 2004

PML/RARalpha plays a role for basal activity and retinoid-induced repression of the tissue factor promoter in acute promyelocytic leukemia cells

Tenno, Taavo; Öberg, Fredrik; Mackman, Nigel; Nilsson, Kenneth et al.

Ingår i Thrombosis and Haemostasis, s. 930-9, 2003

Ser727/Tyr701-phosphorylated Stat1 is required for the regulation ofc-Myc, cyclins, and p27Kip1 associated with ATRA-induced G0/G1 arrest ofU-937 cells.

Dimberg, A; Karlberg, I; Nilsson, K; Oberg, F

Ingår i Blood, s. 254, 2003

Retinoic acid-induced cell cycle arrest of human myeloid cell lines.

Dimberg, A; Oberg, F

Ingår i Leuk Lymphoma, s. 1641, 2003

Retinoic acid-induced cell cycle arrest of human myeloid cell lines is associated with sequential down-regulation of c-Myc and cyclin E andposttranscriptional up-regulation of p27(Kip1).

Dimberg, A; Bahram, F; Karlberg, I; Larsson, LG et al.

Ingår i Blood, s. 2199, 2002

Cytokine-induced restoration of differentiation and cell cycle arrest in v-Myc transformed U-937 monoblasts correlates with reduced Myc activity

Öberg, Fredrik; Wu, S.; Bahram, Fuad; Nilsson, Kenneth et al.

Ingår i Leukemia, s. 217-227, 2001

The role of RAR and RXR activation in retinoid-induced tissue factor suppression

Tenno, Taavo; Botling, Johan; Öberg, Fredrik; Jossan, S. et al.

Ingår i Leukemia, s. 1105-11, 2000

Phosphorylation-deficient Stat1 inhibits retinoic acid-induceddifferentiation and cell cycle arrest in U-937 monoblasts.

Dimberg, A; Nilsson, K; Oberg, F

Ingår i Blood, s. 2870, 2000

Induction of differentiation in U-937 and NB4 cells is associated with inhibition of tissue factor production

Tenno, Taavo; Öberg, Fredrik; Nilsson, Kenneth; Siegbahn, Agneta

Ingår i European Journal of Haematology, s. 112-119, 1999

Posttranslational regulation of Myc function in response to phorbol ester/interferon-gamma-induced differentiation of v-Myc-transformed U-937 monoblasts

Bahram, Fuad; Wu, Siqin; Öberg, Fredrik; Luscher, Bernhard et al.

Ingår i Blood, s. 3900-3912, 1999

Serglycin expression during differentiation of U937-1 cells

Kulseth, Mari Ann; Mustorp, Stina Lund; Uhlin-Hansen, Lars; Öberg, Fredrik et al.

Ingår i Glycobiology, s. 747-753, 1998

Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation

Botling, Johan; Castro, Diogo S.; Öberg, Fredrik; Nilsson, Kenneth et al.

Ingår i Journal of Biological Chemistry, s. 9443-9, 1997

• DOI för Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation
• Ladda ner fulltext (pdf) av Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation

Myeloperoxidase mediates cell adhesion via the alpha M beta 2 integrin (Mac-1, CD11b/CD18)

Johansson, M; Patarroyo, M; Öberg, Fredrik; Siegbahn, Agneta et al.

Ingår i Journal of Cell Science, s. 1133-1139, 1997

Tissue and differentiation specific expression of the endogenous retrovirus ERV3 (HERV-R) in normal human tissues and during induced monocytic differentiation in the U-937 cell line

Larsson, Erik; Venables, P.; Andersson, A-C.; Fan, W. et al.

Ingår i Leukemia, s. 142-4, 1997

Tissue factor expression in human monocytic cell lines

Tenno, Taavo; Botling, Johan; Öberg, Fredrik; Nilsson, Kenneth et al.

Ingår i Thrombosis Research, s. 215-28, 1997

Vitamin D3 and retinoic acid induced monocytic differentiation: Interactions between the endogenous vitamin D3, retinoic acid and retinoid X receptors in U-937 cells

Botling, Johan; Öberg, Fredrik; Törmä, Hans; Tuohimaa, Pentti et al.

Ingår i Cell growth & differentiation, s. 1239-49, 1996

Expression of the endogenous retrovirus ERV3 (HERV-R) during induced monocytic differentiation in the U-937 cell line

Larsson, Erik; Venables, P.J.W.; Andersson, Ann-Catrin; Wansheng, F et al.

Ingår i Int. J. Cancer, s. 451, 1996

CD49f (alpha 6 integrin) and CD66a (BGP) are specifically induced by retinoids during human monocytic differentiation

Botling, Johan; Öberg, Fredrik; Nilsson, Kenneth

Ingår i Leukemia, s. 2034-41, 1995

Stat1 involvement in retinoic acid induced differentiation of myeloid cells

Dimberg, Anna; Nilsson, Kenneth; Oberg, Fredrik

Ingår i Molecular mechanisms of signal transduction, s. 211, IOS press, Amsterdam, The Netherlands, 2000

Monocytes and Macrophages

Öberg, Fredrik; Nilsson, Kenneth

Ingår i Transplantation Biology, s. 241, Lippincott-Raven, 1996

Cytokine induced inhibition of Myc activity in monocytic cells

Larsson, Lars-Gunnar; Bahram, F.; Wu, S.; Öberg, Fredrik et al.

Ingår i C-myc in B-cell neoplasia, s. 191, 1997

The epigenomic map of multiple myeloma reveals the importance of Polycomb gene silencing for the malignancy

Agarwal, Prasoon; Kalushkova, Antonia; Enroth, Stefan; Österborg, Anders et al.

A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans

Prokunina, Ludmila; Castillejo-Lopez, Casimiro; Öberg, Fredrik; Gunnarsson, Iva et al.

Ingår i Nature Genetics, s. 666-669, 2002

• DOI för A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans