Christel Bergström

Optimized Artificial Colonic Mucus Enabling Physiologically Relevant Diffusion Studies of Drugs, Particles, and Delivery Systems

Tjakra, Marco; Chakrapeesirisuk, Nopdanai; Jacobson, Magdalena; Sellin, Mikael E. et al.

Ingår i Molecular Pharmaceutics, 2025

• DOI för Optimized Artificial Colonic Mucus Enabling Physiologically Relevant Diffusion Studies of Drugs, Particles, and Delivery Systems
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Impact of surfactants on solution behavior and membrane transport of amorphous solid dispersions

Alhalaweh, Amjad; El Sayed, Mira; Kovac, Lucia; Bergström, Christel A.S.

Ingår i Journal of Pharmaceutical Sciences, s. 458-467, 2025

• DOI för Impact of surfactants on solution behavior and membrane transport of amorphous solid dispersions
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Liquid crystal nanoparticles for oral combination antibiotic therapies: A strategy towards protecting commensal gut bacteria during treatment

He, Xiguo; Karlsson, Philip; Xiong, Ruisheng; Moodie, Lindon W. K. et al.

Ingår i Journal of Colloid and Interface Science, s. 287-300, 2025

• DOI för Liquid crystal nanoparticles for oral combination antibiotic therapies: A strategy towards protecting commensal gut bacteria during treatment
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Molecular dynamics simulations of lipid composition and its impact on structural and dynamic properties of skin membrane

Altun, Diyar; Larsson, Per; Bergström, Christel; Hossain, Md Shakhawath

Ingår i Chemistry and Physics of Lipids, 2024

• DOI för Molecular dynamics simulations of lipid composition and its impact on structural and dynamic properties of skin membrane
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Drug solubilization in dog intestinal fluids with and without administration of lipid-rich formulations

Parrow, Albin; Kabedev, Aleksei; Larsson, Per; Johansson, Pernilla et al.

Ingår i Journal of Controlled Release, 2024

• DOI för Drug solubilization in dog intestinal fluids with and without administration of lipid-rich formulations
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Optimized Artificial Colonic Mucus Enabling Physiologically Relevant Diffusion Studies of Drugs, Particles, and Delivery Systems

Tjakra, Marco; Chakrapeesirisuk, Nopdanai; Jacobson, Magdalena; Sellin, Mikael E. et al.

Ingår i Molecular Pharmaceutics, 2025

• DOI för Optimized Artificial Colonic Mucus Enabling Physiologically Relevant Diffusion Studies of Drugs, Particles, and Delivery Systems
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Impact of surfactants on solution behavior and membrane transport of amorphous solid dispersions

Alhalaweh, Amjad; El Sayed, Mira; Kovac, Lucia; Bergström, Christel A.S.

Ingår i Journal of Pharmaceutical Sciences, s. 458-467, 2025

• DOI för Impact of surfactants on solution behavior and membrane transport of amorphous solid dispersions
• Ladda ner fulltext (pdf) av Impact of surfactants on solution behavior and membrane transport of amorphous solid dispersions

Liquid crystal nanoparticles for oral combination antibiotic therapies: A strategy towards protecting commensal gut bacteria during treatment

He, Xiguo; Karlsson, Philip; Xiong, Ruisheng; Moodie, Lindon W. K. et al.

Ingår i Journal of Colloid and Interface Science, s. 287-300, 2025

• DOI för Liquid crystal nanoparticles for oral combination antibiotic therapies: A strategy towards protecting commensal gut bacteria during treatment
• Ladda ner fulltext (pdf) av Liquid crystal nanoparticles for oral combination antibiotic therapies: A strategy towards protecting commensal gut bacteria during treatment

Molecular dynamics simulations of lipid composition and its impact on structural and dynamic properties of skin membrane

Altun, Diyar; Larsson, Per; Bergström, Christel; Hossain, Md Shakhawath

Ingår i Chemistry and Physics of Lipids, 2024

• DOI för Molecular dynamics simulations of lipid composition and its impact on structural and dynamic properties of skin membrane
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Drug solubilization in dog intestinal fluids with and without administration of lipid-rich formulations

Parrow, Albin; Kabedev, Aleksei; Larsson, Per; Johansson, Pernilla et al.

Ingår i Journal of Controlled Release, 2024

• DOI för Drug solubilization in dog intestinal fluids with and without administration of lipid-rich formulations
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Estimation of the concentration boundary layer adjacent to a flat surface using computational fluid dynamics

Sinko, Patrick D.; Parker, Louis; Prahl Wittberg, Lisa; Bergström, Christel A. S.

Ingår i International Journal of Pharmaceutics, 2024

• DOI för Estimation of the concentration boundary layer adjacent to a flat surface using computational fluid dynamics
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Excipient effects on supersaturation, particle size dynamics, and thermodynamic activity of multidrug amorphous formulations

El Sayed, Mira; Alhalaweh, Amjad; Kovac, Lucia; Bergström, Christel A.S.

Ingår i International Journal of Pharmaceutics, 2024

• DOI för Excipient effects on supersaturation, particle size dynamics, and thermodynamic activity of multidrug amorphous formulations

Effect of Data Quality and Data Quantity on the Estimation of Intrinsic Solubility: Analysis Based on a Single-Source Data Set

Zhao, Jiaxi; Hermans, Eline; Sepassi, Kia; Tistaert, Christophe et al.

Ingår i Molecular Pharmaceutics, s. 5261-5271, 2024

• DOI för Effect of Data Quality and Data Quantity on the Estimation of Intrinsic Solubility: Analysis Based on a Single-Source Data Set
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Development of a canine artificial colonic mucus model for drug diffusion studies

Barmpatsalou, Vicky; Tjakra, Marco; Li, Lingxiao; Dubbelboer, Ilse R. et al.

Ingår i European Journal of Pharmaceutical Sciences, 2024

• DOI för Development of a canine artificial colonic mucus model for drug diffusion studies
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Benefits of combining supersaturating and solubilizing formulations - Is two better than one?

Alvebratt, Caroline; Karlén, Filip; Åhlén, Michelle; Edueng, Khadijah et al.

Ingår i International Journal of Pharmaceutics, 2024

• DOI för Benefits of combining supersaturating and solubilizing formulations - Is two better than one?

Design, Synthesis, and Evaluation of New 1H-Benzo[d]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections

Soukarieh, Fadi; Mashabi, Alaa; Richardson, William; Oton, Eduard Vico et al.

Ingår i Journal of Medicinal Chemistry, s. 1008-1023, 2024

• DOI för Design, Synthesis, and Evaluation of New 1H-Benzo[d]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections
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Development and characterization of solid lipid-based formulations (sLBFs) of ritonavir utilizing a lipolysis and permeation assay

Schulzen, Arne; Andreadis, Ioannis I.; Bergström, Christel A. S.; Quodbach, Julian

Ingår i European Journal of Pharmaceutical Sciences, 2024

• DOI för Development and characterization of solid lipid-based formulations (sLBFs) of ritonavir utilizing a lipolysis and permeation assay
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Molecular dynamics study on micelle-small molecule interactions: developing a strategy for an extensive comparison

Kabedev, Aleksei; Bergström, Christel A. S.; Larsson, Per

Ingår i Journal of Computer-Aided Molecular Design, 2024

• DOI för Molecular dynamics study on micelle-small molecule interactions: developing a strategy for an extensive comparison
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Analysis of stabilization mechanisms in β-lactoglobulin-based amorphous solid dispersions by experimental and computational approaches

Zhuo, Xuezhi; Foderà, Vito; Larsson, Per; Schaal, Zarah et al.

Ingår i European Journal of Pharmaceutical Sciences, 2024

• DOI för Analysis of stabilization mechanisms in β-lactoglobulin-based amorphous solid dispersions by experimental and computational approaches
• Ladda ner fulltext (pdf) av Analysis of stabilization mechanisms in β-lactoglobulin-based amorphous solid dispersions by experimental and computational approaches

Synergistic stabilization of emulsion gel by nanoparticles and surfactant enables 3D printing of lipid-rich solid oral dosage forms

Johannesson, Jenny; Pathare, Malhar Manik; Johansson, Mathias; Bergström, Christel et al.

Ingår i Journal of Colloid and Interface Science, s. 1253-1264, 2023

• DOI för Synergistic stabilization of emulsion gel by nanoparticles and surfactant enables 3D printing of lipid-rich solid oral dosage forms
• Ladda ner fulltext (pdf) av Synergistic stabilization of emulsion gel by nanoparticles and surfactant enables 3D printing of lipid-rich solid oral dosage forms

Molecular Dynamics Simulations of Self-Assembling Colloids in Fed-State Human Intestinal Fluids and Their Solubilization of Lipophilic Drugs

Parrow, Albin; Larsson, Per; Augustijns, Patrick; Bergström, Christel A. S.

Ingår i Molecular Pharmaceutics, s. 451-460, 2023

• DOI för Molecular Dynamics Simulations of Self-Assembling Colloids in Fed-State Human Intestinal Fluids and Their Solubilization of Lipophilic Drugs
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Exploring the use of modified in vitro digestion assays for the evaluation of ritonavir loaded solid lipid-based formulations

Andreadis, Ioannis I.; Schulzen, Arne; Quodbach, Julian; Bergström, Christel

Ingår i European Journal of Pharmaceutical Sciences, 2023

• DOI för Exploring the use of modified in vitro digestion assays for the evaluation of ritonavir loaded solid lipid-based formulations
• Ladda ner fulltext (pdf) av Exploring the use of modified in vitro digestion assays for the evaluation of ritonavir loaded solid lipid-based formulations

Intrinsic lipolysis rate for systematic design of lipid-based formulations

Jacobsen, Ann-Christin; Kabedev, Aleksei; Sinko, Patrick D.; Palm, Johan E. et al.

Ingår i Drug Delivery and Translational Research, s. 1288-1304, 2023

• DOI för Intrinsic lipolysis rate for systematic design of lipid-based formulations
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Evaluation in pig of an intestinal administration device for oral peptide delivery

Berg, Staffan; Uggla, Teresia; Antonsson, Malin; Nunes, Sandro Filipe et al.

Ingår i Journal of Controlled Release, s. 792-801, 2023

• DOI för Evaluation in pig of an intestinal administration device for oral peptide delivery

Quality attributes for printable emulsion gels and 3D-printed tablets: Towards production of personalized dosage forms

Johannesson, Jenny; Wu, Mingjun; Johansson, Mathias; Bergström, Christel

Ingår i International Journal of Pharmaceutics, 2023

• DOI för Quality attributes for printable emulsion gels and 3D-printed tablets: Towards production of personalized dosage forms

Numerical simulation of peristalsis to study co-localization and intestinal distribution of a macromolecular drug and permeation enhancer

Naranjani, Benyamin; Sinko, Patrick D.; Bergström, Christel; Gogoll, A et al.

Ingår i International Journal of Biological Macromolecules, 2023

• DOI för Numerical simulation of peristalsis to study co-localization and intestinal distribution of a macromolecular drug and permeation enhancer
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Development and validation of a porcine artificial colonic mucus model reflecting the properties of native colonic mucus in pigs

Barmpatsalou, Vicky; Rodler, Agnes; Jacobson, Magdalena; Karlsson, Eva Marie-Louise et al.

Ingår i European Journal of Pharmaceutical Sciences, 2023

• DOI för Development and validation of a porcine artificial colonic mucus model reflecting the properties of native colonic mucus in pigs
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Membrane insertion mechanism of the caveola coat protein Cavin1

Liu, Kang-Cheng; Pace, Hudson; Larsson, Elin; Hossain, Md Shakhawath et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2022

• DOI för Membrane insertion mechanism of the caveola coat protein Cavin1
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Hyperthermia-Induced In Situ Drug Amorphization by Superparamagnetic Nanoparticles in Oral Dosage Forms

Ansari, Shaquib Rahman; Hempel, Nele-Johanna; Asad, Shno; Svedlindh, Peter et al.

Ingår i ACS Applied Materials and Interfaces, s. 21978-21988, 2022

• DOI för Hyperthermia-Induced In Situ Drug Amorphization by Superparamagnetic Nanoparticles in Oral Dosage Forms
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Intestinal Absorption of FITC-Dextrans and Macromolecular Model Drugs in the Rat Intestinal Instillation Model

Berg, Staffan; Suljovic, Denny; Kärrberg, Lillevi; Englund, Maria et al.

Ingår i Molecular Pharmaceutics, s. 2564-2572, 2022

• DOI för Intestinal Absorption of FITC-Dextrans and Macromolecular Model Drugs in the Rat Intestinal Instillation Model
• Ladda ner fulltext (pdf) av Intestinal Absorption of FITC-Dextrans and Macromolecular Model Drugs in the Rat Intestinal Instillation Model

Manipulations and age-appropriateness of oral medications in pediatric oncology patients in Sweden: Need for personalized dosage forms

Johannesson, Jenny; Hansson, Paula; Bergström, Christel; Paulsson, Mattias

Ingår i Biomedicine and Pharmacotherapy, s. 112576-112576, 2022

• DOI för Manipulations and age-appropriateness of oral medications in pediatric oncology patients in Sweden: Need for personalized dosage forms
• Ladda ner fulltext (pdf) av Manipulations and age-appropriateness of oral medications in pediatric oncology patients in Sweden: Need for personalized dosage forms

Gastrointestinal mucus in dog: Physiological characteristics, composition, and structural properties

Dubbelboer, Ilse R; Barmpatsalou, Vicky; Rodler, Agnes; Karlsson, Eva et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 92-102, 2022

• DOI för Gastrointestinal mucus in dog: Physiological characteristics, composition, and structural properties

Impact of Intestinal Concentration and Colloidal Structure on the Permeation-Enhancing Efficiency of Sodium Caprate in the Rat

Berg, Staffan; Karrberg, Lillevi; Suljovic, Denny; Seeliger, Frank et al.

Ingår i Molecular Pharmaceutics, s. 200-212, 2022

• DOI för Impact of Intestinal Concentration and Colloidal Structure on the Permeation-Enhancing Efficiency of Sodium Caprate in the Rat
• Ladda ner fulltext (pdf) av Impact of Intestinal Concentration and Colloidal Structure on the Permeation-Enhancing Efficiency of Sodium Caprate in the Rat

Bioavailability of Celecoxib Formulated with Mesoporous Magnesium Carbonate: An In Vivo Evaluation

Zardán Gómez de la Torre, Teresa; Lindmark, Tuulikki; Cheung, Ocean; Bergström, Christel et al.

Ingår i Molecules, 2022

• DOI för Bioavailability of Celecoxib Formulated with Mesoporous Magnesium Carbonate: An In Vivo Evaluation
• Ladda ner fulltext (pdf) av Bioavailability of Celecoxib Formulated with Mesoporous Magnesium Carbonate: An In Vivo Evaluation

Stabilizing Mechanisms of β-Lactoglobulin in Amorphous Solid Dispersions of Indomethacin

Kabedev, Aleksei; Zhuo, Xuezhi; Leng, Donglei; Foderà, Vito et al.

Ingår i Molecular Pharmaceutics, s. 3922-3933, 2022

• DOI för Stabilizing Mechanisms of β-Lactoglobulin in Amorphous Solid Dispersions of Indomethacin
• Ladda ner fulltext (pdf) av Stabilizing Mechanisms of β-Lactoglobulin in Amorphous Solid Dispersions of Indomethacin

Considerations in the developability of peptides for oral administration when formulated together with transient permeation enhancers

Berg, Staffan; Edlund, Helena; Goundry, William R. F.; Bergström, Christel et al.

Ingår i International Journal of Pharmaceutics, 2022

• DOI för Considerations in the developability of peptides for oral administration when formulated together with transient permeation enhancers

UNGAP best practice for improving solubility data quality of orally administered drugs

Vertzoni, M.; Alsenz, J.; Augustijns, P.; Bauer-Brandl, A. et al.

Ingår i European Journal of Pharmaceutical Sciences, 2022

• DOI för UNGAP best practice for improving solubility data quality of orally administered drugs
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Comparison of cellular monolayers and an artificial membrane as absorptive membranes in the in vitro lipolysis-permeation assay

Keemink, Janneke; Hedge, Oliver; Bianco, Valentina; Hubert, Madlen et al.

Ingår i Journal of Pharmaceutical Sciences, s. 175-184, 2022

• DOI för Comparison of cellular monolayers and an artificial membrane as absorptive membranes in the in vitro lipolysis-permeation assay
• Ladda ner fulltext (pdf) av Comparison of cellular monolayers and an artificial membrane as absorptive membranes in the in vitro lipolysis-permeation assay

Impact of Simulated Intestinal Fluids on Dissolution, Solution Chemistry, and Membrane Transport of Amorphous Multidrug Formulations

El Sayed, Mira; Alhalaweh, Amjad; Bergström, Christel

Ingår i Molecular Pharmaceutics, s. 4079-4089, 2021

• DOI för Impact of Simulated Intestinal Fluids on Dissolution, Solution Chemistry, and Membrane Transport of Amorphous Multidrug Formulations
• Ladda ner fulltext (pdf) av Impact of Simulated Intestinal Fluids on Dissolution, Solution Chemistry, and Membrane Transport of Amorphous Multidrug Formulations

Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease

Asad, Shno; Wegler, Christine; Ahl, David; Bergström, Christel A. S. et al.

Ingår i Journal of Pharmaceutical Sciences, s. 239-250, 2021

• DOI för Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease
• Ladda ner fulltext (pdf) av Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease

3D-printing of solid lipid tablets from emulsion gels

Johannesson, Jenny; Khan, Jamal; Hubert, Madlen; Teleki, Alexandra et al.

Ingår i International Journal of Pharmaceutics, 2021

• DOI för 3D-printing of solid lipid tablets from emulsion gels
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Physiological properties, composition and structural profiling of porcine gastrointestinal mucus

Barmpatsalou, Vicky; Dubbelboer, Ilse R; Rodler, Agnes; Jacobson, Magdalena et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 156-167, 2021

• DOI för Physiological properties, composition and structural profiling of porcine gastrointestinal mucus
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Synergistic Computational Modeling Approaches as Team Players in the Game of Solubility Predictions

Kuentz, Martin; Bergström, Christel A.S.

Ingår i Journal of Pharmaceutical Sciences, s. 22-34, 2021

• DOI för Synergistic Computational Modeling Approaches as Team Players in the Game of Solubility Predictions

Molecular dynamics simulations reveal membrane interactions for poorly water-soluble drugs: impact of bile solubilization and drug aggregation

Kabedev, Aleksei; Hossain, Shakhawath; Hubert, Madlen; Larsson, Per et al.

Ingår i Journal of Pharmaceutical Sciences, s. 176-185, 2021

• DOI för Molecular dynamics simulations reveal membrane interactions for poorly water-soluble drugs: impact of bile solubilization and drug aggregation
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In Vitro and In Vivo Evaluation of 3D Printed Capsules with Pressure Triggered Release Mechanism for Oral Peptide Delivery

Berg, Staffan; Krause, Julius; Björkbom, Anders; Walter, Katrin et al.

Ingår i Journal of Pharmaceutical Sciences, s. 228-238, 2021

• DOI för In Vitro and In Vivo Evaluation of 3D Printed Capsules with Pressure Triggered Release Mechanism for Oral Peptide Delivery

A comparison of chitosan, mesoporous silica and poly(lactic-co-glycolic) acid nanocarriers for optimising intestinal uptake of oral protein therapeutics

Wright, Leah; Joyce, Paul; Barnes, Timothy J.; Lundmark, Richard et al.

Ingår i Journal of Pharmaceutical Sciences, s. 217-227, 2021

• DOI för A comparison of chitosan, mesoporous silica and poly(lactic-co-glycolic) acid nanocarriers for optimising intestinal uptake of oral protein therapeutics

A Tribute to Professor Per Artursson - Scientist, Explorer, Mentor, Innovator, and Giant in Pharmaceutical Research

Matsson, Pär; Baranczewski, Pawel; Giacomini, Kathleen M.; Andersson, Tommy B. et al.

Ingår i Journal of Pharmaceutical Sciences, s. 2-11, 2021

• DOI för A Tribute to Professor Per Artursson - Scientist, Explorer, Mentor, Innovator, and Giant in Pharmaceutical Research

TIRF Microscopy‐Based Monitoring of Drug Permeation Across a Lipid Membrane Supported on Mesoporous Silica

Joyce, Paul; Jõemetsa, Silver; Isaksson, Simon; Hossain, Shakhawath et al.

Ingår i Angewandte Chemie International Edition, s. 2069-2073, 2021

• DOI för TIRF Microscopy‐Based Monitoring of Drug Permeation Across a Lipid Membrane Supported on Mesoporous Silica
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Increasing the Transport of Celecoxib over a Simulated Intestine Cell Membrane Model Using Mesoporous Magnesium Carbonate

Gómez de la Torre, Johan; Bergström, Christel; Zardán Gómez de la Torre, Teresa

Ingår i Molecules, 2021

• DOI för Increasing the Transport of Celecoxib over a Simulated Intestine Cell Membrane Model Using Mesoporous Magnesium Carbonate
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Design and Evaluation of New Quinazolin-4(3H)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in Pseudomonas aeruginosa

Soukarieh, Fadi; Mashabi, Alaa; Richardson, William; Oton, Eduard Vico et al.

Ingår i ACS - Infectious Diseases, s. 2666-2685, 2021

• DOI för Design and Evaluation of New Quinazolin-4(3H)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in Pseudomonas aeruginosa
• Ladda ner fulltext (pdf) av Design and Evaluation of New Quinazolin-4(3H)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in Pseudomonas aeruginosa

Utilizing Laser Activation of Photothermal Plasmonic Nanoparticles to Induce On-Demand Drug Amorphization inside a Tablet

Hempel, Nele-Johanna; Merkl, Padryk; Asad, Shno; Knopp, Matthias Manne et al.

Ingår i Molecular Pharmaceutics, s. 2254-2262, 2021

• DOI för Utilizing Laser Activation of Photothermal Plasmonic Nanoparticles to Induce On-Demand Drug Amorphization inside a Tablet

Investigation of Self-Emulsifying Drug-Delivery System Interaction with a Biomimetic Membrane under Conditions Relevant to the Small Intestine

Hedge, Oliver; Höök, Fredrik; Joyce, Paul; Bergström, Christel

Ingår i Langmuir, s. 10200-10213, 2021

• DOI för Investigation of Self-Emulsifying Drug-Delivery System Interaction with a Biomimetic Membrane under Conditions Relevant to the Small Intestine
• Ladda ner fulltext (pdf) av Investigation of Self-Emulsifying Drug-Delivery System Interaction with a Biomimetic Membrane under Conditions Relevant to the Small Intestine

Pharmaceutical Profiling and Molecular Dynamics Simulations Reveal Crystallization Effects in Amorphous Formulations

Edueng, Khadijah; Kabedev, Aleksei; Ekdahl, Alyssa; Mahlin, Denny et al.

Ingår i International Journal of Pharmaceutics, 2021

• DOI för Pharmaceutical Profiling and Molecular Dynamics Simulations Reveal Crystallization Effects in Amorphous Formulations

Celebrating Women in the Pharmaceutical Sciences

Taylor, Lynne S.; Bergström, Christel; Lavasanifar, Afsaneh; Qian, Feng et al.

Ingår i Molecular Pharmaceutics, s. 1487-1490, 2021

• DOI för Celebrating Women in the Pharmaceutical Sciences

Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa

Soukarieh, Fadi; Liu, Ruiling; Romero, Manuel; Roberston, Shaun N. et al.

Ingår i Frontiers in Chemistry, 2020

• DOI för Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa
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Strategies of solubility enhancement and perspectives in solubility measurements of pharmaceutical compounds

Bergström, Christel; Llinas, Antonio

Ingår i ADMET & DMPK, s. 176-179, 2020

• DOI för Strategies of solubility enhancement and perspectives in solubility measurements of pharmaceutical compounds
• Ladda ner fulltext (pdf) av Strategies of solubility enhancement and perspectives in solubility measurements of pharmaceutical compounds

Insights into Dissolution and Solution Chemistry of Multidrug Formulations of Antihypertensive Drugs

El Sayed, Mira; Alhalaweh, Amjad; Bergström, Christel A. S.

Ingår i Molecular Pharmaceutics, s. 4018-4028, 2020

• DOI för Insights into Dissolution and Solution Chemistry of Multidrug Formulations of Antihypertensive Drugs

Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media

Teleki, Alexandra; Nylander, Olivia; Bergström, Christel

Ingår i Pharmaceutics, 2020

• DOI för Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media
• Ladda ner fulltext (pdf) av Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media

Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions

Antonescu, Irina E.; Karlgren, Maria; Pedersen, Maria L.; Simoff, Ivailo et al.

Ingår i Pharmaceutics, 2020

• DOI för Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions
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In Vitro Performance and Chemical Stability of Lipid-Based Formulations Encapsulated in a Mesoporous Magnesium Carbonate Carrier

Alvebratt, Caroline; Dening, Tahnee J; Åhlén, Michelle; Cheung, Ocean et al.

Ingår i Pharmaceutics, 2020

• DOI för In Vitro Performance and Chemical Stability of Lipid-Based Formulations Encapsulated in a Mesoporous Magnesium Carbonate Carrier
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Selection of In Vivo Predictive Dissolution Media Using Drug Substance and Physiological Properties

Mudie, Deanna M.; Samiei, Nasim; Marshall, Derrick J.; Amidon, Gregory E. et al.

Ingår i AAPS Journal, 2020

• DOI för Selection of In Vivo Predictive Dissolution Media Using Drug Substance and Physiological Properties
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Molecular Dynamics Simulations on Interindividual Variability of Intestinal Fluids: Impact on Drug Solubilization

Parrow, Albin; Larsson, Per; Augustijns, Patrick; Bergström, Christel A. S.

Ingår i Molecular Pharmaceutics, s. 3837-3844, 2020

• DOI för Molecular Dynamics Simulations on Interindividual Variability of Intestinal Fluids: Impact on Drug Solubilization
• Ladda ner fulltext (pdf) av Molecular Dynamics Simulations on Interindividual Variability of Intestinal Fluids: Impact on Drug Solubilization

Suitability of Artificial Membranes in Lipolysis-Permeation Assays of Oral Lipid-Based Formulations

Hedge, Oliver; Bergström, Christel A. S.

Ingår i Pharmaceutical research, 2020

• DOI för Suitability of Artificial Membranes in Lipolysis-Permeation Assays of Oral Lipid-Based Formulations
• Ladda ner fulltext (pdf) av Suitability of Artificial Membranes in Lipolysis-Permeation Assays of Oral Lipid-Based Formulations

Influence of Bile Composition on Membrane Incorporation of Transient Permeability Enhancers

Hossain, Shakhawath; Joyce, Paul; Parrow, Albin; Jõemetsa, Silver et al.

Ingår i Molecular Pharmaceutics, s. 4226-4240, 2020

• DOI för Influence of Bile Composition on Membrane Incorporation of Transient Permeability Enhancers
• Ladda ner fulltext (pdf) av Influence of Bile Composition on Membrane Incorporation of Transient Permeability Enhancers

Model-Informed Drug Discovery and Development in Pulmonary Delivery: Biopharmaceutical Pharmacometric Modeling for Formulation Evaluation of Pulmonary Suspensions

Sou, Tomás; Soukarieh, Fadi; Williams, Paul; Stocks, Michael J. et al.

Ingår i ACS Omega, s. 25733-25746, 2020

• DOI för Model-Informed Drug Discovery and Development in Pulmonary Delivery: Biopharmaceutical Pharmacometric Modeling for Formulation Evaluation of Pulmonary Suspensions
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An in vitro dissolution–digestion–permeation assay for the study of advanced drug delivery systems

Alvebratt, Caroline; Keemink, Janneke; Edueng, Khadijah; Cheung, Ocean et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 21-29, 2020

• DOI för An in vitro dissolution–digestion–permeation assay for the study of advanced drug delivery systems
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Model-Informed Drug Development in Pulmonary Delivery: Semimechanistic Pharmacokinetic-Pharmacodynamic Modeling for Evaluation of Treatments against Chronic Pseudomonas aeruginosa Lung Infections

Sou, Tomás; Kukavica-Ibrulj, Irena; Levesque, Roger C.; Friberg, Lena et al.

Ingår i Molecular Pharmaceutics, s. 1458-1469, 2020

• DOI för Model-Informed Drug Development in Pulmonary Delivery: Semimechanistic Pharmacokinetic-Pharmacodynamic Modeling for Evaluation of Treatments against Chronic Pseudomonas aeruginosa Lung Infections

Long-term physical (in)stability of spray-dried amorphous drugs: relationship with glass-forming ability and physicochemical properties

Edueng, Khadijah; Bergström, Christel; Gråsjö, Johan; Mahlin, Denny

Ingår i Pharmaceutics, 2019

• DOI för Long-term physical (in)stability of spray-dried amorphous drugs: relationship with glass-forming ability and physicochemical properties

Supersaturation Potential of Amorphous Active Pharmaceutical Ingredients after Long-Term Storage

Edueng, Khadijah; Mahlin, Denny; Gråsjö, Johan; Nylander, Olivia et al.

Ingår i Molecules, 2019

• DOI för Supersaturation Potential of Amorphous Active Pharmaceutical Ingredients after Long-Term Storage
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Aggregation Behavior of Medium Chain Fatty Acids Studied by Coarse-Grained Molecular Dynamics Simulation

Hossain, Md Shakhawath; Berg, Staffan; Bergström, Christel; Larsson, Per

Ingår i AAPS PharmSciTech, 2019

• DOI för Aggregation Behavior of Medium Chain Fatty Acids Studied by Coarse-Grained Molecular Dynamics Simulation
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Effect of lipids on absorption of carvedilol in dogs: Is coadministration of lipids as efficient as a lipid-based formulation?

Alskär, Linda C.; Parrow, Albin; Keemink, Janneke; Pernilla, Johansson et al.

Ingår i Journal of Controlled Release, s. 90-100, 2019

• DOI för Effect of lipids on absorption of carvedilol in dogs: Is coadministration of lipids as efficient as a lipid-based formulation?
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The Permeation of Acamprosate Is Predominantly Caused by Paracellular Diffusion across Caco-2 Cell Monolayers: A Paracellular Modeling Approach

Antonescu, Irina E; Rasmussen, Karina F; Neuhoff, Sibylle; Fretté, Xavier et al.

Ingår i Molecular Pharmaceutics, s. 4636-4650, 2019

• DOI för The Permeation of Acamprosate Is Predominantly Caused by Paracellular Diffusion across Caco-2 Cell Monolayers: A Paracellular Modeling Approach

Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems

Boyd, Ben J.; Bergström, Christel; Vinarov, Zahari; Kuentz, Martin et al.

Ingår i European Journal of Pharmaceutical Sciences, 2019

• DOI för Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems
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Does the Intake of Ethanol Affect Oral Absorption of Poorly Soluble Drugs?

Keemink, Janneke; Sjögren, Erik; Holm, Rene; Bergström, Christel A. S.

Ingår i Journal of Pharmaceutical Sciences, s. 1765-1771, 2019

• DOI för Does the Intake of Ethanol Affect Oral Absorption of Poorly Soluble Drugs?
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Lipolysis-Permeation Setup for Simultaneous Study of Digestion and Absorption in Vitro

Keemink, Janneke; Martensson, Elin; Bergström, Christel

Ingår i Molecular Pharmaceutics, s. 921-930, 2019

• DOI för Lipolysis-Permeation Setup for Simultaneous Study of Digestion and Absorption in Vitro
• Ladda ner fulltext (pdf) av Lipolysis-Permeation Setup for Simultaneous Study of Digestion and Absorption in Vitro

Model-Based Drug Development in Pulmonary Delivery: Pharmacokinetic Analysis of Novel Drug Candidates for Treatment of Pseudomonas aeruginosa Lung Infection

Sou, Tomás; Kukavica-Ibrulj, Irena; Soukarieh, Fadi; Halliday, Nigel et al.

Ingår i Journal of Pharmaceutical Sciences, s. 630-640, 2019

• DOI för Model-Based Drug Development in Pulmonary Delivery: Pharmacokinetic Analysis of Novel Drug Candidates for Treatment of Pseudomonas aeruginosa Lung Infection
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Molecular Drivers of Crystallization Kinetics for Drugs in Supersaturated Aqueous Solutions

Alhalaweh, Amjad; Alzghoul, Ahmad; Bergström, Christel A. S.

Ingår i Journal of Pharmaceutical Sciences, s. 252-259, 2019

• DOI för Molecular Drivers of Crystallization Kinetics for Drugs in Supersaturated Aqueous Solutions
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Fifty-Eight Years and Counting: High-Impact Publishing in Computational Pharmaceutical Sciences and Mechanism-Based Modeling

Amidon, Gregory E.; Anderson, Bradley D.; Balthasar, Joseph P.; Bergström, Christel A.S. et al.

Ingår i Journal of Pharmaceutical Sciences, s. 2-7, 2019

• DOI för Fifty-Eight Years and Counting: High-Impact Publishing in Computational Pharmaceutical Sciences and Mechanism-Based Modeling

Automated assays for thermodynamic (equilibrium) solubility determination.

Sou, Tomás; Bergström, Christel

Ingår i Drug Discovery Today, s. 11-19, 2018

• DOI för Automated assays for thermodynamic (equilibrium) solubility determination.

In Vivo Predictive Dissolution and Simulation Workshop Report: Facilitating the Development of Oral Drug Formulation and the Prediction of Oral Bioperformance

Tsume, Yasuhiro; Patel, Sanjaykumar; Fotaki, Nikoletta; Bergström, Christel et al.

Ingår i AAPS Journal, 2018

• DOI för In Vivo Predictive Dissolution and Simulation Workshop Report: Facilitating the Development of Oral Drug Formulation and the Prediction of Oral Bioperformance

A Modified In Situ Method to Determine Release from a Complex Drug Carrier in Particle-Rich Suspensions

Alvebratt, Caroline; Cheung, Ocean; Strömme, Maria; Bergström, Christel A. S.

Ingår i AAPS PharmSciTech, s. 2859-2865, 2018

• DOI för A Modified In Situ Method to Determine Release from a Complex Drug Carrier in Particle-Rich Suspensions
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Impact of Drug Physicochemical Properties on Lipolysis-Triggered Drug Supersaturation and Precipitation from Lipid-Based Formulations

Alskär, Linda C.; Keemink, Janneke; Johannesson, Jenny; Porter, Christopher J H et al.

Ingår i Molecular Pharmaceutics, s. 4733-4744, 2018

• DOI för Impact of Drug Physicochemical Properties on Lipolysis-Triggered Drug Supersaturation and Precipitation from Lipid-Based Formulations
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Caco-2 Cell Conditions Enabling Studies of Drug Absorption from Digestible Lipid-Based Formulations

Keemink, Janneke; Bergström, Christel

Ingår i Pharmaceutical research, 2018

• DOI för Caco-2 Cell Conditions Enabling Studies of Drug Absorption from Digestible Lipid-Based Formulations
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Amorphous Magnesium Carbonate Nanoparticles with Strong Stabilizing Capability for Amorphous Ibuprofen

Yang, Jiaojiao; Alvebratt, Caroline; Lu, Xi; Bergström, Christel et al.

Ingår i International Journal of Pharmaceutics, s. 515-521, 2018

• DOI för Amorphous Magnesium Carbonate Nanoparticles with Strong Stabilizing Capability for Amorphous Ibuprofen

Enhanced release of poorly water-soluble drugs from synergy between mesoporous magnesium carbonate and polymers

Yang, Jiaojiao; Alvebratt, Caroline; Zhang, Peng; Zardán Gómez de la Torre, Teresa et al.

Ingår i International Journal of Pharmaceutics, s. 183-190, 2017

• DOI för Enhanced release of poorly water-soluble drugs from synergy between mesoporous magnesium carbonate and polymers

Characterization of Solubilizing Nanoaggregates Present in Different Versions of Simulated Intestinal Fluid

Clulow, Andrew J.; Parrow, Albin; Hawley, Adrian; Khan, Jamal et al.

Ingår i Journal of Physical Chemistry B, s. 10869-10881, 2017

• DOI för Characterization of Solubilizing Nanoaggregates Present in Different Versions of Simulated Intestinal Fluid
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Substrate and method dependent inhibition of three ABC-transporters (MDR1, BCRP, and MRP2)

Pedersen, Jenny M.; Khan, Elin K.; Bergström, Christel; Palm, Johan et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 70-76, 2017

• DOI för Substrate and method dependent inhibition of three ABC-transporters (MDR1, BCRP, and MRP2)

Controlled Suspensions Enable Rapid Determinations of Intrinsic Dissolution Rate and Apparent Solubility of Poorly Water-Soluble Compounds

Andersson, Sara B. E.; Alvebratt, Caroline; Bergström, Christel

Ingår i Pharmaceutical research, s. 1805-1816, 2017

• DOI för Controlled Suspensions Enable Rapid Determinations of Intrinsic Dissolution Rate and Apparent Solubility of Poorly Water-Soluble Compounds
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Mechanism-based selection of stabilization strategy for amorphous formulations: Insights into crystallization pathways

Edueng, Khadijah; Mahlin, Denny; Larsson, Per; Bergström, Christel

Ingår i Journal of Controlled Release, s. 193-202, 2017

• DOI för Mechanism-based selection of stabilization strategy for amorphous formulations: Insights into crystallization pathways
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Molecular Structuring and Phase Transition of Lipid-Based Formulations upon Water Dispersion: A Coarse-Grained Molecular Dynamics Simulation Approach

Larsson, Per; Alskär, Linda C.; Bergström, Christel

Ingår i Molecular Pharmaceutics, s. 4145-4153, 2017

• DOI för Molecular Structuring and Phase Transition of Lipid-Based Formulations upon Water Dispersion: A Coarse-Grained Molecular Dynamics Simulation Approach
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Investigation of the Intra- and Interlaboratory Reproducibility of a Small Scale Standardized Supersaturation and Precipitation Method

Plum, Jakob; Madsen, Cecilie M.; Teleki, Alexandra; Bevernage, Jan et al.

Ingår i Molecular Pharmaceutics, s. 4161-4169, 2017

• DOI för Investigation of the Intra- and Interlaboratory Reproducibility of a Small Scale Standardized Supersaturation and Precipitation Method

Tools for Early Prediction of Drug Loading in Lipid-Based Formulations

Alskär, Linda C.; Porter, Christopher J. H.; Bergström, Christel A. S.

Ingår i Molecular Pharmaceutics, s. 251-261, 2016

• DOI för Tools for Early Prediction of Drug Loading in Lipid-Based Formulations

Diffusion-Controlled Drug Release from the Mesoporous Magnesium Carbonate Upsalite®

Zhang, Peng; Gómez de La Torre, Teresa Zardán; Forsgren, Johan; Bergström, Christel et al.

Ingår i Journal of Pharmaceutical Sciences, s. 657-663, 2016

• DOI för Diffusion-Controlled Drug Release from the Mesoporous Magnesium Carbonate Upsalite®

Compromised in vitro dissolution and membrane transport of multidrug amorphous formulations.

Alhalaweh, Amjad; Bergström, Christel A. S.; Taylor, Lynne S.

Ingår i Journal of Controlled Release, s. 172-182, 2016

• DOI för Compromised in vitro dissolution and membrane transport of multidrug amorphous formulations.

Interlaboratory Validation of Small-Scale Solubility and Dissolution Measurements of Poorly Water-Soluble Drugs

Andersson, Sara B. E.; Alvebratt, Caroline; Bevernage, Jan; Bonneau, Damien et al.

Ingår i Journal of Pharmaceutical Sciences, s. 2864-2872, 2016

• DOI för Interlaboratory Validation of Small-Scale Solubility and Dissolution Measurements of Poorly Water-Soluble Drugs

Understanding the Challenge of Beyond-Rule-of-5 Compounds Preface

Bergström, Christel A. S.; Porter, Christopher J. H.

Ingår i Advanced Drug Delivery Reviews, s. 1-5, 2016

• DOI för Understanding the Challenge of Beyond-Rule-of-5 Compounds Preface

Rapid determination of drug solubilization versus supersaturation in natural and digested lipids

Gautschi, Nicolas; Bergström, Christel; Kuentz, Martin

Ingår i International Journal of Pharmaceutics, s. 164-174, 2016

• DOI för Rapid determination of drug solubilization versus supersaturation in natural and digested lipids

Lipophilicity in Drug Development: Too Much or Not Enough?

Bergström, Christel A. S.; Yazdanian, Mehran

Ingår i AAPS Journal, s. 1095-1100, 2016

• DOI för Lipophilicity in Drug Development: Too Much or Not Enough?

Partitioning into Colloidal Structures of Fasted State Intestinal Fluid Studied by Molecular Dynamics Simulations

Holmboe, Michael; Larsson, Per; Anwar, Jamshed; Bergström, Christel

Ingår i Langmuir, s. 12732-12740, 2016

• DOI för Partitioning into Colloidal Structures of Fasted State Intestinal Fluid Studied by Molecular Dynamics Simulations
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Supersaturation of poorly soluble drugs induced by mesoporous magnesium carbonate

Zhang, Peng; Gómez de La Torre, Teresa Zardán; Welch, Ken; Bergström, Christel et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 468-474, 2016

• DOI för Supersaturation of poorly soluble drugs induced by mesoporous magnesium carbonate

Concomitant intake of alcohol may increase the absorption of poorly soluble drugs

Fagerberg, Jonas H.; Sjögren, Erik; Bergström, Christel A. S.

Ingår i European Journal of Pharmaceutical Sciences, s. 12-20, 2015

• DOI för Concomitant intake of alcohol may increase the absorption of poorly soluble drugs
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Computational modeling to predict the functions and impact of drug transporters

Matsson, Pär; Bergström, Christel A S

Ingår i In silico pharmacology, 2015

• DOI för Computational modeling to predict the functions and impact of drug transporters
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Models for Predicting Drug Absorption From Oral Lipid-Based Formulations

Persson, Linda C.; Bergström, Christel A S

Ingår i Current molecular biology reports, s. 141-147, 2015

• DOI för Models for Predicting Drug Absorption From Oral Lipid-Based Formulations
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Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability

Alhalaweh, Amjad; Alzghoul, Ahmad; Mahlin, Denny; Bergström, Christel A. S.

Ingår i International Journal of Pharmaceutics, s. 312-317, 2015

• DOI för Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability
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Computational Prediction of Drug Solubility in Fasted Simulated and Aspirated Human Intestinal Fluid

Fagerberg, Jonas H.; Karlsson, Eva; Ulander, Johan; Hanisch, Gunilla et al.

Ingår i Pharmaceutical research, s. 578-589, 2015

• DOI för Computational Prediction of Drug Solubility in Fasted Simulated and Aspirated Human Intestinal Fluid
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Is the full potential of the biopharmaceutics classification system reached?

Bergström, Christel A. S.; Andersson, Sara B. E.; Fagerberg, Jonas H.; Ragnarsson, Gert et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 224-231, 2014

• DOI för Is the full potential of the biopharmaceutics classification system reached?

Experimental and Computational Prediction of Glass Transition Temperature of Drugs

Alzghoul, Ahmad; Alhalaweh, Amjad; Mahlin, Denny; Bergström, Christel A. S.

Ingår i JOURNAL OF CHEMICAL INFORMATION AND MODELING, s. 3396-3403, 2014

• DOI för Experimental and Computational Prediction of Glass Transition Temperature of Drugs

Formulation of the Microbicide INP0341 for In Vivo Protection against a Vaginal Challenge by Chlamydia trachomatis

Pedersen, Christian; Slepenkin, Anatoly; Andersson, Sara B. E.; Fagerberg, Jonas H. et al.

Ingår i PLOS ONE, 2014

• DOI för Formulation of the Microbicide INP0341 for In Vivo Protection against a Vaginal Challenge by Chlamydia trachomatis
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Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid Trypanosoma brucei

Ferrins, Lori; Gazdik, Michelle; Rahmani, Raphael; Varghese, Swapna et al.

Ingår i Journal of Medicinal Chemistry, s. 6393-6402, 2014

• DOI för Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid Trypanosoma brucei

Computational predictions of glass-forming ability and crystallization tendency of drug molecules

Alhalaweh, Amjad; Alzghoul, Ahmad; Kaialy, Waseem; Mahlin, Denny et al.

Ingår i Molecular Pharmaceutics, s. 3123-3132, 2014

• DOI för Computational predictions of glass-forming ability and crystallization tendency of drug molecules

Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs

Bergström, Christel A. S.; Holm, Rene; Jorgensen, Soren Astrup; Andersson, Sara B. E. et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 173-199, 2014

• DOI för Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs

Evaluation of the Structural Determinants of Polymeric Precipitation Inhibitors Using Solvent Shift Methods and Principle Component Analysis

Warren, Dallas B.; Bergström, Christel A. S.; Benameur, Hassan; Porter, Christopher J. H. et al.

Ingår i Molecular Pharmaceutics, s. 2823-2848, 2013

• DOI för Evaluation of the Structural Determinants of Polymeric Precipitation Inhibitors Using Solvent Shift Methods and Principle Component Analysis

Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11)

Pedersen, Jenny M.; Matsson, Pär; Bergström, Christel A. S.; Hoogstraate, Janet et al.

Ingår i Toxicological Sciences, s. 328-343, 2013

• DOI för Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11)
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Early drug development predictions of glass-forming ability and physical stability of drugs

Mahlin, Denny; Bergström, Christel A. S.

Ingår i European Journal of Pharmaceutical Sciences, s. 323-332, 2013

• DOI för Early drug development predictions of glass-forming ability and physical stability of drugs
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Early recognition of absorption challenges of contemporary targets: key molecular properties and in silico tools

Bergström, Christel A S

Ingår i Bulletin Technique Gattefossé, s. 50-57, 2013

Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice

Tehler, Ulrika; Fagerberg, Jonas H.; Svensson, Richard; Larhed, Mats et al.

Ingår i Journal of Medicinal Chemistry, s. 2690-2694, 2013

• DOI för Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice

Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients

Persson, Linda C.; Porter, Christopher J. H.; Charman, William N.; Bergström, Christel A. S.

Ingår i Pharmaceutical research, s. 3225-3237, 2013

• DOI för Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients
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In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug-Drug Interactions

Karlgren, Maria; Ahlin, Gustav; Bergström, Christel A. S; Svensson, Richard et al.

Ingår i Pharmaceutical research, s. 411-426, 2012

• DOI för In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug-Drug Interactions

Computational Prediction of CNS Drug Exposure Based on a Novel In Vivo Dataset

Bergstrom, Christel A. S.; Charman, Susan A.; Nicolazzo, Joseph A.

Ingår i Pharmaceutical research, s. 3131-3142, 2012

• DOI för Computational Prediction of CNS Drug Exposure Based on a Novel In Vivo Dataset

Ethanol Effects on Apparent Solubility of Poorly Soluble Drugs in Simulated Intestinal Fluid

Fagerberg, Jonas H.; Al-Tikriti, Yassir; Ragnarsson, Gert; Bergström, Christel A. S.

Ingår i Molecular Pharmaceutics, s. 1942-1952, 2012

• DOI för Ethanol Effects on Apparent Solubility of Poorly Soluble Drugs in Simulated Intestinal Fluid

Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors

Lazorova, Lucia; Hubatsch, Ina; Ekegren, Jenny K.; Gising, Johan et al.

Ingår i Journal of Pharmaceutical Sciences, s. 3763-3772, 2011

• DOI för Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors

Toward In Silico Prediction of Glass-Forming Ability from Molecular Structure Alone: A Screening Tool in Early Drug Development

Mahlin, Denny; Ponnambalam, Sopana; Hockerfelt, Mina Heidarian; Bergström, Christel A. S.

Ingår i Molecular Pharmaceutics, s. 498-506, 2011

• DOI för Toward In Silico Prediction of Glass-Forming Ability from Molecular Structure Alone: A Screening Tool in Early Drug Development

A Modified Physiological BCS for Prediction of Intestinal Absorption in Drug Discovery

Zaki, Noha M.; Artursson, Per; Bergström, Christel A. S.

Ingår i Molecular pharmaceutics, s. 1478-1487, 2010

• DOI för A Modified Physiological BCS for Prediction of Intestinal Absorption in Drug Discovery

Dissolution Rate and Apparent Solubility of Poorly Soluble Drugs in Biorelevant Dissolution Media

Fagerberg, Jonas H.; Tsinman, Oksana; Sun, Na; Tsinman, Konstantin et al.

Ingår i Molecular pharmaceutics, s. 1419-1430, 2010

• DOI för Dissolution Rate and Apparent Solubility of Poorly Soluble Drugs in Biorelevant Dissolution Media

Interaction of 140 orally administered drugs with the liver-specific organic anion transporter OATP1B1 (SLCO1B1)

Karlgren, Maria; Ahlin, Gustav; Bergström, Christel; Karlsson, Johan et al.

Ingår i Drug metabolism reviews (Softcover ed.), s. 304-305, 2010

Hepatitis C virus NS3 protease inhibitors: large, flexible molecules of peptide origin show satisfactory permeability across Caco-2 cells

Bergström, Christel A S; Bolin, Sara; Artursson, Per; Rönn, Robert et al.

Ingår i European Journal of Pharmaceutical Sciences, s. 556-563, 2009

• DOI för Hepatitis C virus NS3 protease inhibitors: large, flexible molecules of peptide origin show satisfactory permeability across Caco-2 cells

Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs

Matsson, Pär; Pedersen, Jenny M; Norinder, Ulf; Bergström, Christel A S et al.

Ingår i Pharmaceutical research, s. 1816-1831, 2009

• DOI för Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs

Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1

Ahlin, Gustav; Karlsson, Johan; Pedersen, Jenny M; Gustavsson, Lena et al.

Ingår i Journal of Medicinal Chemistry, s. 5932-5942, 2008

• DOI för Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1

Molecular characteristics for solid-state limited solubility

Wassvik, Carola M; Holmén, Anders G; Draheim, Rieke; Artursson, Per et al.

Ingår i Journal of Medicinal Chemistry, s. 3035-3039, 2008

• DOI för Molecular characteristics for solid-state limited solubility

Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2)

Pedersen, Jenny; Matsson, Pär; Norinder, Ulf; Bergström, Christel A. S. et al.

Ingår i Journal of Medicinal Chemistry, s. 3275-3287, 2008

• DOI för Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2)

Poorly soluble marketed drugs display solvation limited solubility

Bergström, Christel; Wassvik, Carola M.; Johansson, Kajsa; Hubatsch, Ina

Ingår i Journal of Medicinal Chemistry, s. 5858-5862, 2007

• DOI för Poorly soluble marketed drugs display solvation limited solubility

A Global Drug Inhibition Pattern for the Human ATP-Binding Cassette Transporter Breast Cancer Resistance Protein (ABCG2)

Matsson, Pär; Englund, Gunilla; Ahlin, Gustav; Bergström, Christel A. S. et al.

Ingår i Journal of Pharmacology and Experimental Therapeutics, s. 19-30, 2007

• DOI för A Global Drug Inhibition Pattern for the Human ATP-Binding Cassette Transporter Breast Cancer Resistance Protein (ABCG2)

Photoinduced Formation of N₂ Molecules in Ammonium Compounds

Aziz, Emad F; Gråsjö, Johan; Forsberg, Johan; Andersson, Egil et al.

Ingår i Journal of Physical Chemistry A, s. 9662-9669, 2007

• DOI för Photoinduced Formation of N₂ Molecules in Ammonium Compounds

Contribution of solid-state properties to the aqueous solubility of drugs.

Wassvik, Carola; Holmén, Anders; Bergström, Christel; Zamora, Ismael et al.

Ingår i Eur J Pharm Sci, s. 294-305, 2006

Prediction of ADMET Properties.

Norinder, U; Bergström, C

Ingår i ChemMedChem, s. 920-937, 2006

X-ray yield and selectively excited X-ray emission spectra of atenolol and nadolol.

Söderström, Johan; Gråsjö, Johan; Kashtanov, S; Bergström, Christel et al.

Ingår i J Electr Spectr, s. 283-285, 2005

Computational models to predict aqueous drug solubility, permeability and intestinal absorption

Bergström, Christel

Ingår i Expert opinion on drug metabolism & toxicology, s. 613-627, 2005

• DOI för Computational models to predict aqueous drug solubility, permeability and intestinal absorption

Theoretical predictions of drug absorption in drug discovery and development 

Stenberg, Patric; Bergström, Christel; Luthman, Kristina; Artursson, Per

Ingår i Clinical Pharmacokinetics, s. 877-899, 2002

Pickering emulsion gel enables 3D printing of lipid-rich solid oral dosage forms

Johannesson, Jenny; Pathare, Malhar Manik; Johansson, Mathias; Bergström, Christel et al.

Contemporary formulation development for inhaled pharmaceuticals

Sou, Tomás; Bergström, Christel A. S.

Ingår i Journal of Pharmaceutical Sciences, s. 66-86, 2021

• DOI för Contemporary formulation development for inhaled pharmaceuticals
• Ladda ner fulltext (pdf) av Contemporary formulation development for inhaled pharmaceuticals

Molecular simulation as a computational pharmaceutics tool to predict drug solubility, solubilization processes and partitioning

Hossain, Md Shakhawath; Kabedev, Aleksei; Parrow, Albin; Bergström, Christel et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 46-55, 2019

• DOI för Molecular simulation as a computational pharmaceutics tool to predict drug solubility, solubilization processes and partitioning
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The Biopharmaceutics Classification System (BCS) and the Biopharmaceutics Drug Disposition Classification System (BDDCS): Beyond guidelines

Charalabidis, Aggelos; Sfouni, Maria; Bergström, Christel; Macheras, Panos

Ingår i International Journal of Pharmaceutics, s. 264-281, 2019

• DOI för The Biopharmaceutics Classification System (BCS) and the Biopharmaceutics Drug Disposition Classification System (BDDCS): Beyond guidelines

Biorelevant intrinsic dissolution profiling in early drug development: Fundamental, methodological, and industrial aspects

Bergström, Christel; Box, Karl; Holm, Rene; Matthews, Wayne et al.

Ingår i European journal of pharmaceutics and biopharmaceutics, s. 101-114, 2019

• DOI för Biorelevant intrinsic dissolution profiling in early drug development: Fundamental, methodological, and industrial aspects

Perspectives in solubility measurement and interpretation

Bergström, Christel A.S.; Avdeef, Alex

Ingår i ADMET AND DMPK, s. 88-105, 2019

• DOI för Perspectives in solubility measurement and interpretation
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Computational prediction of drug solubility in water-based systems: qualitative and quantitative approaches used in the current drug discovery and development setting

Bergström, Christel A S; Larsson, Per

Ingår i International Journal of Pharmaceutics, s. 185-193, 2018

• DOI för Computational prediction of drug solubility in water-based systems: qualitative and quantitative approaches used in the current drug discovery and development setting
• Ladda ner fulltext (pdf) av Computational prediction of drug solubility in water-based systems: qualitative and quantitative approaches used in the current drug discovery and development setting

The Need for Restructuring the Disordered Science of Amorphous Drug Formulations

Edueng, Khadijah; Mahlin, Denny; Bergström, Christel

Ingår i Pharmaceutical Research, s. 1754-1772, 2017

• DOI för The Need for Restructuring the Disordered Science of Amorphous Drug Formulations
• Ladda ner fulltext (pdf) av The Need for Restructuring the Disordered Science of Amorphous Drug Formulations

Computational prediction of formulation strategies for beyond-rule-of-5 compounds

Bergström, Christel A. S.; Charman, William N; Porter, Christopher J H

Ingår i Advanced Drug Delivery Reviews, s. 6-21, 2016

• DOI för Computational prediction of formulation strategies for beyond-rule-of-5 compounds
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50 years of oral lipid-based formulations: Provenance, progress and future perspectives

Feeney, Orlagh M; Crum, Matthew F; McEvoy, Claire L; Trevaskis, Natalie L et al.

Ingår i Advanced Drug Delivery Reviews, s. 167-194, 2016

• DOI för 50 years of oral lipid-based formulations: Provenance, progress and future perspectives

Intestinal solubility and absorption of poorly water soluble compounds: predictions, challenges and solutions

Fagerberg, Jonas H; Bergström, Christel A S

Ingår i Therapeutic delivery, s. 935-959, 2015

• DOI för Intestinal solubility and absorption of poorly water soluble compounds: predictions, challenges and solutions

Prediction of ADMET Properties

Norinder, Ulf; Bergström, Christel

Ingår i ChemMedChem, s. 920-937, 2006

• DOI för Prediction of ADMET Properties

How Physicochemical Properties of Drugs Affect Their Metabolism and Clearance

Karlgren, Maria; Bergström, Christel

Ingår i New Horizons in Predictive Drug Metabolism and Pharmacokinetics, s. 1-26, Royal Society of Chemistry, 2016

• DOI för How Physicochemical Properties of Drugs Affect Their Metabolism and Clearance

Computational absorption prediction

Bergström, Christel; Haeberlein, Markus; Norinder, Ulf

Ingår i Drug bioavailability, s. 409-432, Wiley-VCH, 2008

Prediction of ADMET Properties

Norinder, Ulf; Bergström, Christel

Ingår i Chemical Biology, s. 1003-1044, Wiley-VCH, 2007

Advanced methodologies to study in vitro digestion of a lipid-loaded mesoporous drug carrier

Alvebratt, Caroline; Denning, T.; Prestidge, Cliff; Bergström, Christel et al.

Ingår i Preclinical Form and Formulation for Drug Discovery, Gordon Research Conference 2019, 2019

Synthesis of amorphous magnesium carbonate nanoparticles for biomedical applications

Yang, Jiaojiao; Alvebratt, Caroline; Luo, Jun; Bergström, Christel et al.

Ingår i Bioceramics 29 ISCM 2017, 2017

A new method that enables in situ measurement of drug release from complex carrier-mediated systems

Alvebratt, Caroline; Strömme, Maria; Bergström, Christel

Ingår i 6th FIP Pharmaceutical Sciences World Congress2017., 2017

Dissolution studies of solid formulations - Applicability of µDiss inmonitoring supersaturation, nucleation and crystallization behavior; Casestudy: Carrier-based formulation.

Alvebratt, Caroline; Petersson, E.; Strömme, Maria; Bergström, Christel

Ingår i pION Fiber Optic Advanced Training Course. Uppsala, June 14-15, 2016., 2016

Diffusion controlled drug release from Mesoprous Magnesium Carbonate

Zhang, Peng; Zardán Gómez de La Torre, Teresa; Bergström, Christel; Strømme, Maria

2016

The influence of drug loading and drug-polymer interactions on physical stability and supersaturation of spray-dried solid dispersions

Edueng, Khadijah; Kabedev, Aleksei; Ekdahl, Alyssa; Mahlin, Denny et al.

Classification of promiscuous glass-formers: Limitations of differential scanning calorimetry

Edueng, Khadijah; Bergström, Christel; Mahlin, Denny

Two is better than one: benefits of combining supersaturating and solubilizing effects

Alvebratt, Caroline; Karlén, Filip; Åhlén, Michelle; Edueng, Khadijah et al.

Selective laser sintering 3D printing of personalized dosage forms: Effect of powder formulation and process parameters on the physical properties of the printed tablets

Åhlén, Michelle; Tikhomirov, Evgenii; Lamrabet, Nabil; Di Gallo, Nicole et al.

Influence of lipase products and lipolysis-permeation assay formats on drug absorption from lipid-based formulations

Hedge, Oliver; Zangana, Alaa; Bergström, Christel

Quality attributes of lipid tablets produced by semi-solid extrusion 3D printing: Towards personalized dosage forms in a clinical setting

Johannesson, Jenny; Wu, Mingjun; Johansson, Mathias; Bergström, Christel

In vitro intestinal drug disposition device

Bergström, Christel

2020