Joakim Bergström

Reduction of brain stem pathology and transient amelioration of early cognitive symptoms in transgenic mice treated with a monoclonal antibody against α-synuclein oligomers/protofibrils

Ekmark-Lewén, Sara; Aniszewska, Agata; Molisak, Agnieszka; Gumucio, Astrid et al.

Ingår i AGING BRAIN, 2023

• DOI för Reduction of brain stem pathology and transient amelioration of early cognitive symptoms in transgenic mice treated with a monoclonal antibody against α-synuclein oligomers/protofibrils
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Altered Distribution of SNARE Proteins in Primary Neurons Exposed to Different Alpha-Synuclein Proteoforms

Brolin, Emma; Ingelsson, Martin; Bergström, Joakim; Erlandsson, Anna

Ingår i Cellular and molecular neurobiology, s. 3023-3035, 2023

• DOI för Altered Distribution of SNARE Proteins in Primary Neurons Exposed to Different Alpha-Synuclein Proteoforms
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Studies on alpha-synuclein and islet amyloid polypeptide interaction

Wang, Ye; Bergström, Joakim; Ingelsson, Martin; Westermark, Gunilla

Ingår i Frontiers in Molecular Biosciences, 2023

• DOI för Studies on alpha-synuclein and islet amyloid polypeptide interaction
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Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

Roshanbin, Sahar; Julku, Ulrika; Xiong, Mengfei; Eriksson, Jonas et al.

Ingår i Pharmaceutics, 2022

• DOI för Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody
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Modeling Parkinson's disease-related symptoms in alpha-synuclein overexpressing mice

Aniszewska, Agata; Bergström, Joakim; Ingelsson, Martin; Ekmark-Lewén, Sara

Ingår i Brain and Behavior, 2022

• DOI för Modeling Parkinson's disease-related symptoms in alpha-synuclein overexpressing mice
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Reduction of brain stem pathology and transient amelioration of early cognitive symptoms in transgenic mice treated with a monoclonal antibody against α-synuclein oligomers/protofibrils

Ekmark-Lewén, Sara; Aniszewska, Agata; Molisak, Agnieszka; Gumucio, Astrid et al.

Ingår i AGING BRAIN, 2023

• DOI för Reduction of brain stem pathology and transient amelioration of early cognitive symptoms in transgenic mice treated with a monoclonal antibody against α-synuclein oligomers/protofibrils
• Ladda ner fulltext (pdf) av Reduction of brain stem pathology and transient amelioration of early cognitive symptoms in transgenic mice treated with a monoclonal antibody against α-synuclein oligomers/protofibrils

Altered Distribution of SNARE Proteins in Primary Neurons Exposed to Different Alpha-Synuclein Proteoforms

Brolin, Emma; Ingelsson, Martin; Bergström, Joakim; Erlandsson, Anna

Ingår i Cellular and molecular neurobiology, s. 3023-3035, 2023

• DOI för Altered Distribution of SNARE Proteins in Primary Neurons Exposed to Different Alpha-Synuclein Proteoforms
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Studies on alpha-synuclein and islet amyloid polypeptide interaction

Wang, Ye; Bergström, Joakim; Ingelsson, Martin; Westermark, Gunilla

Ingår i Frontiers in Molecular Biosciences, 2023

• DOI för Studies on alpha-synuclein and islet amyloid polypeptide interaction
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Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

Roshanbin, Sahar; Julku, Ulrika; Xiong, Mengfei; Eriksson, Jonas et al.

Ingår i Pharmaceutics, 2022

• DOI för Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody
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In vivo imaging of alpha-synuclein with antibody-based PET

Roshanbin, Sahar; Xiong, Mengfei; Hultqvist, Greta; Soderberg, Linda et al.

Ingår i Neuropharmacology, 2022

• DOI för In vivo imaging of alpha-synuclein with antibody-based PET
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Visualization of early oligomeric α‐synuclein pathology and its impact on the dopaminergic system in the (Thy‐1)‐h[A30P]α‐syn transgenic mouse model

Behere, Anish; Thörnqvist, Per-Ove; Winberg, Svante; Ingelsson, Martin et al.

Ingår i Journal of Neuroscience Research, s. 2525-2539, 2021

• DOI för Visualization of early oligomeric α‐synuclein pathology and its impact on the dopaminergic system in the (Thy‐1)‐h[A30P]α‐syn transgenic mouse model
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Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates

Rostami, Jinar; Mothes, Tobias; Kolahdouzan, Mahshad; Eriksson, Olle et al.

Ingår i Journal of Neuroinflammation, 2021

• DOI för Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates
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Age-related increase of alpha-synuclein oligomers is associated with motor disturbances in L61 transgenic mice

Roshanbin, Sahar; Aniszewska, Agata; Gumucio, Astrid; Masliah, Eliezer et al.

Ingår i Neurobiology of Aging, s. 207-220, 2021

• DOI för Age-related increase of alpha-synuclein oligomers is associated with motor disturbances in L61 transgenic mice
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ABBV-0805, a novel antibody selective for soluble aggregated alpha-synuclein, prolongs lifespan and prevents buildup of alpha-synuclein pathology in mouse models of Parkinson's disease

Nordström, Eva; Eriksson, Fredrik; Sigvardson, Jessica; Johannesson, Malin et al.

Ingår i Neurobiology of Disease, 2021

• DOI för ABBV-0805, a novel antibody selective for soluble aggregated alpha-synuclein, prolongs lifespan and prevents buildup of alpha-synuclein pathology in mouse models of Parkinson's disease
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Astrocytes have the capacity to act as antigen-presenting cells in the Parkinson's disease brain

Rostami, Jinar; Fotaki, Grammatiki; Sirois, Julien; Mzezewa, Ropafadzo et al.

Ingår i Journal of Neuroinflammation, 2020

• DOI för Astrocytes have the capacity to act as antigen-presenting cells in the Parkinson's disease brain
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Inhibition of nSMase2 Reduces the Transfer of Oligomeric alpha-Synuclein Irrespective of Hypoxia

Sackmann, Valerie; Sinha, Maitrayee Sardar; Sackmann, Christopher; Civitelli, Livia et al.

Ingår i Frontiers in Molecular Neuroscience, 2019

• DOI för Inhibition of nSMase2 Reduces the Transfer of Oligomeric alpha-Synuclein Irrespective of Hypoxia
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Early fine motor impairment and behavioral dysfunction in (Thy-1)-h[A30P] alpha-synuclein mice

Ekmark-Lewén, Sara; Lindstrom, Veronica; Gumucio, Astrid; Ihse, Elisabet et al.

Ingår i Brain and Behavior, 2018

• DOI för Early fine motor impairment and behavioral dysfunction in (Thy-1)-h[A30P] alpha-synuclein mice
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In situ proximity ligation assay reveals co-localization of alpha-synuclein and SNARE proteins in murine primary neurons

Almandoz-Gil, Leire; Persson, Emma; Lindström, Veronica; Ingelsson, Martin et al.

Ingår i Frontiers in Neurology, 2018

• DOI för In situ proximity ligation assay reveals co-localization of alpha-synuclein and SNARE proteins in murine primary neurons
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Secretion and uptake of α-synuclein via extracellular vesicles in cultured cells

Gustafsson, Gabriel; Lööv, Camilla; Persson, Emma; Lázaro, Diana F. et al.

Ingår i Cellular and molecular neurobiology, s. 1539-1550, 2018

• DOI för Secretion and uptake of α-synuclein via extracellular vesicles in cultured cells
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Low molar excess of 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote oligomerization of alpha-synuclein through different pathways

Almandoz-Gil, Leire; Welander, Hedvig; Ihse, Elisabet; Khoonsari, Payam Emami et al.

Ingår i Free Radical Biology & Medicine, s. 421-431, 2017

• DOI för Low molar excess of 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote oligomerization of alpha-synuclein through different pathways
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Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes

Gustafsson, Gabriel; Lindström, Veronica; Rostami, Jinar; Nordström, Eva et al.

Ingår i Journal of Neuroinflammation, 2017

• DOI för Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes
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Mice Immunized With IgG Anti-Sheep Red Blood Cells (SRBC) Together With SRBC Have a Suppressed Anti-SRBC Antibody Response but Generate Germinal Centers and Anti-IgG Antibodies in Response to the Passively Administered IgG

Bergström, Joakim J. E.; Heyman, Birgitta

Ingår i Frontiers in Immunology, 2017

• DOI för Mice Immunized With IgG Anti-Sheep Red Blood Cells (SRBC) Together With SRBC Have a Suppressed Anti-SRBC Antibody Response but Generate Germinal Centers and Anti-IgG Antibodies in Response to the Passively Administered IgG
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Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes

Rostami, Jinar; Holmqvist, Staffan; Lindström, Veronica; Sigvardson, Jessica et al.

Ingår i Journal of Neuroscience, s. 11835-11853, 2017

• DOI för Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes
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Mapping of Surface-Exposed Epitopes of In Vitro and In Vivo Aggregated Species of Alpha-Synuclein

Almandoz-Gil, Leire; Lindström, Veronica; Sigvardson, Jessica; Kahle, Philipp J. et al.

Ingår i Cellular and molecular neurobiology, s. 1217-1226, 2017

• DOI för Mapping of Surface-Exposed Epitopes of In Vitro and In Vivo Aggregated Species of Alpha-Synuclein
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Cellular Uptake of alpha-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of alpha-Synuclein and Mediated via Fc gamma Receptors

Gustafsson, Gabriel; Eriksson, Fredrik; Möller, Christer; da Fonseca, Tomas Lopes et al.

Ingår i Cellular and molecular neurobiology, s. 121-131, 2017

• DOI för Cellular Uptake of alpha-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of alpha-Synuclein and Mediated via Fc gamma Receptors

Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage

Lindström, Veronica; Gustafsson, Gabriel; Sanders, Laurie H; Howlett, Evan H et al.

Ingår i Molecular and Cellular Neuroscience, s. 143-156, 2017

• DOI för Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage

Aggregated Alpha-Synuclein Transfer Efficiently between Cultured Human Neuron-Like Cells and Localize to Lysosomes

Domert, Jakob; Sackmann, Christopher; Severinsson, Emelie; Agholme, Lotta et al.

Ingår i PLOS ONE, 2016

• DOI för Aggregated Alpha-Synuclein Transfer Efficiently between Cultured Human Neuron-Like Cells and Localize to Lysosomes
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An Overview of Mechanical Properties and Material Modeling of Polylactide (PLA) for Medical Applications

Bergström, Joakim; Hayman, Danika

Ingår i Annals of Biomedical Engineering, s. 330-340, 2016

• DOI för An Overview of Mechanical Properties and Material Modeling of Polylactide (PLA) for Medical Applications

Changes in secondary structure of α-synuclein during oligomerization induced by reactive aldehydes.

Cai, Yixiao; Lendel, Christofer; Österlund, Lars; Kasrayan, Alex et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 336-341, 2015

• DOI för Changes in secondary structure of α-synuclein during oligomerization induced by reactive aldehydes.

IgG Suppresses Antibody Responses in Mice Lacking C1q, C3, Complement Receptors 1 and 2, or IgG Fc-Receptors.

Bergström, Joakim J E; Heyman, Birgitta

Ingår i PLOS ONE, 2015

• DOI för IgG Suppresses Antibody Responses in Mice Lacking C1q, C3, Complement Receptors 1 and 2, or IgG Fc-Receptors.
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Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice

Lindström, Veronica; Fagerqvist, Therese; Eva, Nordström; Eriksson, Fredrik et al.

Ingår i Neurobiology of Disease, s. 134-143, 2014

• DOI för Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice

Size separation of large proteins and protein complexes under native conditions.

Graner, T.; Salomonsson, I.; Wang, L.; Bergström, Joakim

Ingår i Molecular Biology of the Cell, 2014

Off-pathway alpha-synuclein oligomers seem to alter alpha-synuclein turnover in a cell model but lack seeding capability in vivo

Fagerqvist, Therese; Näsström, Thomas; Ihse, Elisabet; Lindström, Veronica et al.

Ingår i Amyloid, s. 233-244, 2013

• DOI för Off-pathway alpha-synuclein oligomers seem to alter alpha-synuclein turnover in a cell model but lack seeding capability in vivo

Monoclonal antibodies selective for α-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α-synuclein transgenic mice with the disease-causing A30P mutation

Fagerqvist, Therese; Lindström, Veronica; Nordstrom, Eva; Lord, Anna et al.

Ingår i Journal of Neurochemistry, s. 131-144, 2013

• DOI för Monoclonal antibodies selective for α-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α-synuclein transgenic mice with the disease-causing A30P mutation

Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

Diogenes, Maria Jose; Dias, Raquel B.; Rombo, Diogo M.; Miranda, Hugo Vicente et al.

Ingår i Journal of Neuroscience, s. 11750-11762, 2012

• DOI för Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

Antibodies against alpha-synuclein reduce oligomerization in living cells

Näsström, Thomas; Goncalves, Susana; Sahlin, Charlotte; Nordström, Eva et al.

Ingår i PLOS ONE, 2011

• DOI för Antibodies against alpha-synuclein reduce oligomerization in living cells
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The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties

Näsström, Thomas; Fagerqvist, Therese; Barbu, Mikael; Karlsson, Mikael et al.

Ingår i Free Radical Biology & Medicine, s. 428-437, 2011

• DOI för The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties

Gelsolin co-occurs with Lewy bodies in vivo and accelerates alpha-synuclein aggregation in vitro

Welander, Hedvig; Bontha, Sai Vineela; Näsström, Tomas; Karlsson, Mikael et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 32-38, 2011

• DOI för Gelsolin co-occurs with Lewy bodies in vivo and accelerates alpha-synuclein aggregation in vitro

The lipid peroxidation metabolite 4-oxo-2-nonenal cross-links alpha-synuclein causing rapid formation of stable oligomers

Näsström, Thomas; Wahlberg, Therese; Karlsson, Mikael; Nikolajeff, Fredrik et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 872-876, 2009

• DOI för The lipid peroxidation metabolite 4-oxo-2-nonenal cross-links alpha-synuclein causing rapid formation of stable oligomers

Amyloid deposits in transthyretin derived amyloidosis: Cleaved transthyretin is associated with distinct amyloid morphology

Bergström, Joakim; Gustavsson, Åsa; Hellman, Ulf; Sletten, Knut et al.

Ingår i The Internet Journal of Pathology, s. 224-232, 2005

• DOI för Amyloid deposits in transthyretin derived amyloidosis: Cleaved transthyretin is associated with distinct amyloid morphology

Two different types of amyloid deposits - apolipoprotein A-IV and transthyretin - in a patient with systemic amyloidosis

Bergström, Joakim; Murphy, Charles L.; Weiss, Deborah T.; Solomon, Alan et al.

Ingår i Lab. Invest., s. 981-988, 2004

Modeling Parkinson's disease-related symptoms in alpha-synuclein overexpressing mice

Aniszewska, Agata; Bergström, Joakim; Ingelsson, Martin; Ekmark-Lewén, Sara

Ingår i Brain and Behavior, 2022

• DOI för Modeling Parkinson's disease-related symptoms in alpha-synuclein overexpressing mice
• Ladda ner fulltext (pdf) av Modeling Parkinson's disease-related symptoms in alpha-synuclein overexpressing mice

Immunotherapy targeting alpha-synuclein, with relevance for future treatment of Parkinson's disease and other Lewy body disorders

Lindström, Veronica; Ihse, Elisabet; Fagerqvist, Therese; Bergström, Joakim et al.

Ingår i Immunotherapy, s. 141-153, 2014

• DOI för Immunotherapy targeting alpha-synuclein, with relevance for future treatment of Parkinson's disease and other Lewy body disorders

Development of a diamond waveguide sensor for sensitive protein analysis using IR quantum cascade lasers

Piron, Pierre; Vargas Catalan, Ernesto; Haas, Julian; Österlund, Lars et al.

Ingår i SPIE Proceedings Volume 10539, 2018

• DOI för Development of a diamond waveguide sensor for sensitive protein analysis using IR quantum cascade lasers

Protein analysis by label free evanescent mid-IR diamond waveguide spectroscopy

Karlsson, Mikael; Nikolajeff, Fredrik; Österlund, Lars; Andersson, Per Ola et al.

2017

ATR- FTIR spectroscopy study of oxidative modification of the a-synuclein secondary structure

Cai, Yixao; Almandoz-Gil, Leire; Karlsson, Mikael; Nikolajeff, Fredrik et al.

2013

Seeding of cross linked alpha-synuclein oligomers in vitro and in vivo

Wahlberg, Therese; Näsström, Thomas; Sahlin, Charlotte; Ingvast, Sofie et al.

2010

• DOI för Seeding of cross linked alpha-synuclein oligomers in vitro and in vivo

Seeding of cross linked alpha-synuclein oligomers in vitro and in vivo

Ingelsson, Martin; Wahlberg, Therese; Näsström, Thomas; Sahlin, Charlotte et al.

2010

Morphological and functional differences of aldehyde-induced alpha-synuclein oligomers

Näsström, Thomas; Wahlberg, Therese; Barbu, Mikael; Silva, V. et al.

Ingår i Amyloid - Journal of Protein Folding Disorders, s. 93-94, 2010

Effects of lipid peroxidation metabolites on alpha-synuclein aggregation

Bergström, Joakim; Näsström, Thomas; Wahlberg, Therese; Karlsson, Mikael et al.

2009

Studies on Alpha-synuclein and Islet Amyloid Polypeptide Interaction in Islets

Wang, Ye; Gucek, Alenka; Bergström, Joakim; Ingelsson, Martin et al.

Alpha-synuclein aggregates affect the distribution of SNARE complex proteins in synapses of A30P alpha-synuclein transgenic mice and Parkinson´s disease brain

Brolin, Emma; Almandoz-Gil, Leire; Rofo, Fadi; Ekmark-Lewén, Sara et al.

Altered distribution of SNARE proteins in primary neurons exposed to different alpha-synuclein species

Brolin, Emma; Erlandsson, Anna; Bergström, Joakim

Novel visualization of phosphorylated tau and alpha-synuclein aggregates in the Alzheimer’s disease and Parkinson’s disease brain

Behere, Anish; Ingelsson, Martin; Erlandsson, Anna; Bergström, Joakim

Alpha synuclein pre-formed fibrils trigger astrocytic activation prior to intra-neuronal deposition in a seeding mouse model of Parkinson’s disease

Behere, Anish; Hårrskog, Emma; Södergren, Moa; Ingelsson, Martin et al.

A proximity ligation assay recognizing phosphorylated α-syn reveals previously undetected α-syn pathology in the brains of synucleinopathy patients and mouse model.

Behere, Anish; Ingelsson, Martin; Ekmark-Lewén, Sara; Bergström, Joakim