Staffan Svärd
Professor vid Institutionen för cell- och molekylärbiologi; Mikrobiologi och immunologi
- Telefon:
- 018-471 45 58
- Mobiltelefon:
- 070-425 05 94
- E-post:
- Staffan.Svard@icm.uu.se
- Besöksadress:
- Husargatan 3
752 37 Uppsala - Postadress:
- Box 596
751 24 Uppsala
- Akademiska meriter:
- docent

Publikationer
Senaste publikationer
The expanded genome of Hexamita inflata, a free-living diplomonad
Ingår i Scientific Data, 2025
- DOI för The expanded genome of Hexamita inflata, a free-living diplomonad
- Ladda ner fulltext (pdf) av The expanded genome of Hexamita inflata, a free-living diplomonad
Ingår i PLOS ONE, 2024
- DOI för Gene co-expression network analysis reveal core responsive genes in Parascaris univalens tissues following ivermectin exposure
- Ladda ner fulltext (pdf) av Gene co-expression network analysis reveal core responsive genes in Parascaris univalens tissues following ivermectin exposure
Ingår i Transactions of the Royal Society of Tropical Medicine and Hygiene, 2024
Ingår i PLOS ONE, 2023
- DOI för Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain
- Ladda ner fulltext (pdf) av Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain
Adaptation of the late ISC pathway in the anaerobic mitochondrial organelles of Giardia intestinalis
Ingår i PLoS Pathogens, 2023
- DOI för Adaptation of the late ISC pathway in the anaerobic mitochondrial organelles of Giardia intestinalis
- Ladda ner fulltext (pdf) av Adaptation of the late ISC pathway in the anaerobic mitochondrial organelles of Giardia intestinalis
Alla publikationer
Artiklar i tidskrift
The expanded genome of Hexamita inflata, a free-living diplomonad
Ingår i Scientific Data, 2025
- DOI för The expanded genome of Hexamita inflata, a free-living diplomonad
- Ladda ner fulltext (pdf) av The expanded genome of Hexamita inflata, a free-living diplomonad
Ingår i PLOS ONE, 2024
- DOI för Gene co-expression network analysis reveal core responsive genes in Parascaris univalens tissues following ivermectin exposure
- Ladda ner fulltext (pdf) av Gene co-expression network analysis reveal core responsive genes in Parascaris univalens tissues following ivermectin exposure
Ingår i Transactions of the Royal Society of Tropical Medicine and Hygiene, 2024
Ingår i PLOS ONE, 2023
- DOI för Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain
- Ladda ner fulltext (pdf) av Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain
Adaptation of the late ISC pathway in the anaerobic mitochondrial organelles of Giardia intestinalis
Ingår i PLoS Pathogens, 2023
- DOI för Adaptation of the late ISC pathway in the anaerobic mitochondrial organelles of Giardia intestinalis
- Ladda ner fulltext (pdf) av Adaptation of the late ISC pathway in the anaerobic mitochondrial organelles of Giardia intestinalis
Transcriptomic analysis of albendazole resistance in human diarrheal parasite Giardia duodenalis
Ingår i International Journal for Parasitology, s. 9-19, 2023
- DOI för Transcriptomic analysis of albendazole resistance in human diarrheal parasite Giardia duodenalis
- Ladda ner fulltext (pdf) av Transcriptomic analysis of albendazole resistance in human diarrheal parasite Giardia duodenalis
Ingår i Nucleic Acids Research, s. 3436-3451, 2023
- DOI för Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis
- Ladda ner fulltext (pdf) av Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis
Ingår i PLoS Pathogens, 2023
- DOI för Trophozoite fitness dictates the intestinal epithelial cell response to Giardia intestinalis infection
- Ladda ner fulltext (pdf) av Trophozoite fitness dictates the intestinal epithelial cell response to Giardia intestinalis infection
Ingår i Parasites & Vectors, 2022
- DOI för Ivermectin-induced gene expression changes in adult Parascaris univalens and Caenorhabditis elegans: a comparative approach to study anthelminthic metabolism and resistance in vitro
- Ladda ner fulltext (pdf) av Ivermectin-induced gene expression changes in adult Parascaris univalens and Caenorhabditis elegans: a comparative approach to study anthelminthic metabolism and resistance in vitro
A chromosome-scale reference genome for Spironucleus salmonicida
Ingår i Scientific Data, 2022
- DOI för A chromosome-scale reference genome for Spironucleus salmonicida
- Ladda ner fulltext (pdf) av A chromosome-scale reference genome for Spironucleus salmonicida
Ingår i Journal of Biological Chemistry, 2022
- DOI för Giardia intestinalis thymidine kinase is a high-affinity enzyme crucial for DNA synthesis and an exploitable target for drug discovery
- Ladda ner fulltext (pdf) av Giardia intestinalis thymidine kinase is a high-affinity enzyme crucial for DNA synthesis and an exploitable target for drug discovery
Ingår i Frontiers in Microbiology, 2022
- DOI för Characterization of Metronidazole-Resistant Giardia intestinalis Lines by Comparative Transcriptomics and Proteomics
- Ladda ner fulltext (pdf) av Characterization of Metronidazole-Resistant Giardia intestinalis Lines by Comparative Transcriptomics and Proteomics
Ingår i BMC Biology, 2022
- DOI för Combined nanometric and phylogenetic analysis of unique endocytic compartments in Giardia lamblia sheds light on the evolution of endocytosis in Metamonada
- Ladda ner fulltext (pdf) av Combined nanometric and phylogenetic analysis of unique endocytic compartments in Giardia lamblia sheds light on the evolution of endocytosis in Metamonada
Ingår i mBio, 2022
- DOI för High-Definition DIC Imaging Uncovers Transient Stages of Pathogen Infection Cycles on the Surface of Human Adult Stem Cell-Derived Intestinal Epithelium
- Ladda ner fulltext (pdf) av High-Definition DIC Imaging Uncovers Transient Stages of Pathogen Infection Cycles on the Surface of Human Adult Stem Cell-Derived Intestinal Epithelium
Ingår i Trends in Parasitology, s. 605-606, 2022
Ingår i Genomics, 2022
- DOI för Comprehensive characterization of Cysteine-rich protein-coding genes of Giardia lamblia and their role during antigenic variation
- Ladda ner fulltext (pdf) av Comprehensive characterization of Cysteine-rich protein-coding genes of Giardia lamblia and their role during antigenic variation
A Detailed Gene Expression Map of Giardia Encystation
Ingår i Genes, s. 1932, 2021
- DOI för A Detailed Gene Expression Map of Giardia Encystation
- Ladda ner fulltext (pdf) av A Detailed Gene Expression Map of Giardia Encystation
Ingår i Frontiers in Immunology, 2021
- DOI för Serglycin-Deficiency Causes Reduced Weight Gain and Changed Intestinal Cytokine Responses in Mice Infected With Giardia intestinalis
- Ladda ner fulltext (pdf) av Serglycin-Deficiency Causes Reduced Weight Gain and Changed Intestinal Cytokine Responses in Mice Infected With Giardia intestinalis
Ingår i BMC Genomics, 2021
- DOI för Dual RNA-seq transcriptome analysis of caecal tissue during primary Eimeria tenella infection in chickens
- Ladda ner fulltext (pdf) av Dual RNA-seq transcriptome analysis of caecal tissue during primary Eimeria tenella infection in chickens
Ingår i International Journal of Parasitology, s. 225-239, 2021
Ingår i Parasitology, s. 712-725, 2021
- DOI för Dual RNA-Seq transcriptome analysis of chicken macrophage-like cells (HD11) infected in vitro with Eimeria tenella
- Ladda ner fulltext (pdf) av Dual RNA-Seq transcriptome analysis of chicken macrophage-like cells (HD11) infected in vitro with Eimeria tenella
Multimodal regulation of encystation in Giardia duodenalis revealed by deep proteomics
Ingår i International Journal of Parasitology, s. 809-824, 2021
- DOI för Multimodal regulation of encystation in Giardia duodenalis revealed by deep proteomics
- Ladda ner fulltext (pdf) av Multimodal regulation of encystation in Giardia duodenalis revealed by deep proteomics
Eukaryote-Conserved Methylarginine Is Absent in Diplomonads and Functionally Compensated in Giardia
Ingår i Molecular biology and evolution, s. 3525-3549, 2020
- DOI för Eukaryote-Conserved Methylarginine Is Absent in Diplomonads and Functionally Compensated in Giardia
- Ladda ner fulltext (pdf) av Eukaryote-Conserved Methylarginine Is Absent in Diplomonads and Functionally Compensated in Giardia
High Cysteine Membrane Proteins (HCMPs) Are Up-Regulated DuringGiardia-Host Cell Interactions
Ingår i Frontiers in Genetics, 2020
- DOI för High Cysteine Membrane Proteins (HCMPs) Are Up-Regulated DuringGiardia-Host Cell Interactions
- Ladda ner fulltext (pdf) av High Cysteine Membrane Proteins (HCMPs) Are Up-Regulated DuringGiardia-Host Cell Interactions
Ingår i Cells, 2020
- DOI för The Chymase Mouse Mast Cell Protease-4 Regulates Intestinal Cytokine Expression in Mature Adult Mice Infected with Giardia intestinalis
- Ladda ner fulltext (pdf) av The Chymase Mouse Mast Cell Protease-4 Regulates Intestinal Cytokine Expression in Mature Adult Mice Infected with Giardia intestinalis
Ingår i Microbial Genomics, 2020
A chromosome-scale reference genome for Giardia intestinalis WB
Ingår i Scientific Data, 2020
- DOI för A chromosome-scale reference genome for Giardia intestinalis WB
- Ladda ner fulltext (pdf) av A chromosome-scale reference genome for Giardia intestinalis WB
Ingår i BMC Biology, 2019
- DOI för Oxygen induces the expression of invasion and stress response genes in the anaerobic salmon parasite Spironucleus salmonicida
- Ladda ner fulltext (pdf) av Oxygen induces the expression of invasion and stress response genes in the anaerobic salmon parasite Spironucleus salmonicida
Ingår i FEBS Letters, s. 1313-1325, 2019
Ingår i Parasites & Vectors, 2019
- DOI för Further evaluation of recombinant Tsol-p27 by enzyme-linked immunoelectrotransfer blot for the serodiagnosis of cysticercosis in pigs from Mozambique
- Ladda ner fulltext (pdf) av Further evaluation of recombinant Tsol-p27 by enzyme-linked immunoelectrotransfer blot for the serodiagnosis of cysticercosis in pigs from Mozambique
Identification of Conserved Candidate Vaccine Antigens in the Surface Proteome of Giardia lamblia
Ingår i Infection and Immunity, 2019
Proximity Staining using Enzymatic Protein Tagging in Diplomonads
Ingår i mSphere, 2019
- DOI för Proximity Staining using Enzymatic Protein Tagging in Diplomonads
- Ladda ner fulltext (pdf) av Proximity Staining using Enzymatic Protein Tagging in Diplomonads
Ingår i Molecular Immunology, s. 535-544, 2019
Ingår i Molecular and biochemical parasitology (Print), s. 29-38, 2019
Proteomic diversity in a prevalent human-infective Giardia duodenalis sub-species
Ingår i International Journal of Parasitology, s. 817-823, 2018
Ingår i Infection, Genetics and Evolution, s. 7-16, 2018
Ingår i GigaScience, 2018
- DOI för Differential protein expression and post-translational modifications in metronidazole-resistant Giardia duodenalis
- Ladda ner fulltext (pdf) av Differential protein expression and post-translational modifications in metronidazole-resistant Giardia duodenalis
Ingår i Virulence, s. 879-894, 2018
- DOI för Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines
- Ladda ner fulltext (pdf) av Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines
Ingår i Frontiers in Cellular and Infection Microbiology, 2018
- DOI för Responses of the Differentiated Intestinal Epithelial Cell Line Caco-2 to Infection With the Giardia intestinalis GS Isolate
- Ladda ner fulltext (pdf) av Responses of the Differentiated Intestinal Epithelial Cell Line Caco-2 to Infection With the Giardia intestinalis GS Isolate
Recent advances in the genomic and molecular biology of Giardia
Ingår i Acta Tropica, s. 67-72, 2018
Ingår i BMC Biology, 2017
- DOI för Giardia intestinalis mitosomes undergo synchronized fission but not fusion and are constitutively associated with the endoplasmic reticulum
- Ladda ner fulltext (pdf) av Giardia intestinalis mitosomes undergo synchronized fission but not fusion and are constitutively associated with the endoplasmic reticulum
Ingår i Frontiers in Microbiology, 2017
- DOI för Transcriptomics Indicates Active and Passive Metronidazole Resistance Mechanisms in Three Seminal Giardia Lines
- Ladda ner fulltext (pdf) av Transcriptomics Indicates Active and Passive Metronidazole Resistance Mechanisms in Three Seminal Giardia Lines
Giardia-specific cellular immune responses in post-giardiasis chronic fatigue syndrome
Ingår i BMC Immunology, 2017
- DOI för Giardia-specific cellular immune responses in post-giardiasis chronic fatigue syndrome
- Ladda ner fulltext (pdf) av Giardia-specific cellular immune responses in post-giardiasis chronic fatigue syndrome
Ingår i PLoS Neglected Tropical Diseases, 2017
- DOI för Characterization of the Giardia intestinalis secretome during interaction with human intestinal epithelial cells: The impact on host cells
- Ladda ner fulltext (pdf) av Characterization of the Giardia intestinalis secretome during interaction with human intestinal epithelial cells: The impact on host cells
Endoplasmic reticulum is the sorting core facility in the Golgi-lacking protozoan Giardia lamblia
Ingår i Traffic, s. 604-621, 2017
Ingår i BMC Biology, 2016
- DOI för On the reversibility of parasitism: adaptation to a free-living lifestyle via gene acquisitions in the diplomonad Trepomonas sp PC1
- Ladda ner fulltext (pdf) av On the reversibility of parasitism: adaptation to a free-living lifestyle via gene acquisitions in the diplomonad Trepomonas sp PC1
Comparative cell biology and evolution of Annexins in Diplomonads
Ingår i mSphere, 2016
Divergent Transcriptional Responses to Physiological and Xenobiotic Stress in Giardia duodenalis
Ingår i Antimicrobial Agents and Chemotherapy, s. 6034-6045, 2016
Coordinated Changes in Gene Expression Throughout Encystation of Giardia intestinalis
Ingår i PLoS Neglected Tropical Diseases, 2016
- DOI för Coordinated Changes in Gene Expression Throughout Encystation of Giardia intestinalis
- Ladda ner fulltext (pdf) av Coordinated Changes in Gene Expression Throughout Encystation of Giardia intestinalis
Ingår i International Journal of Biochemistry and Cell Biology, s. 32-43, 2016
Human Memory CD4+ T Cell Immune Responses against Giardia lamblia
Ingår i Clinical and Vaccine Immunology, s. 11-18, 2016
Comparative genomic analyses of freshly isolated Giardia intestinalis assemblage A isolates
Ingår i BMC Genomics, 2015
- DOI för Comparative genomic analyses of freshly isolated Giardia intestinalis assemblage A isolates
- Ladda ner fulltext (pdf) av Comparative genomic analyses of freshly isolated Giardia intestinalis assemblage A isolates
UV irradiation responses in Giardia intestinalis
Ingår i Experimental parasitology, s. 25-32, 2015
Ingår i Veterinary parasitology, s. 28-34, 2015
Transcriptional profiling of Giardia intestinalis in response to oxidative stress
Ingår i International Journal of Parasitology, s. 925-938, 2015
Time-Dependent Transcriptional Changes in Axenic Giardia duodenalis Trophozoites
Ingår i PLoS Neglected Tropical Diseases, 2015
- DOI för Time-Dependent Transcriptional Changes in Axenic Giardia duodenalis Trophozoites
- Ladda ner fulltext (pdf) av Time-Dependent Transcriptional Changes in Axenic Giardia duodenalis Trophozoites
Ingår i PLOS Genetics, 2014
- DOI för The genome of Spironucleus salmonicida highlights a fish pathogen adapted to fluctuating environments
- Ladda ner fulltext (pdf) av The genome of Spironucleus salmonicida highlights a fish pathogen adapted to fluctuating environments
Rolf Bernander (1956-2014): pioneer of the archaeal cell cycle Obituary
Ingår i Molecular Microbiology, s. 903-909, 2014
Gene expression changes during Giardia-host cell interactions in serum-free medium
Ingår i Molecular and biochemical parasitology (Print), s. 21-23, 2014
Ingår i BMC Microbiology, s. 256, 2013
Transcriptome Profiling of Giardia intestinalis Using Strand-specific RNAseq
Ingår i PloS Computational Biology, 2013
- DOI för Transcriptome Profiling of Giardia intestinalis Using Strand-specific RNAseq
- Ladda ner fulltext (pdf) av Transcriptome Profiling of Giardia intestinalis Using Strand-specific RNAseq
Hydrogenosomes in the diplomonad Spironucleus salmonicida
Ingår i Nature Communications, s. 2493, 2013
Ingår i PLOS Neglected Tropical Diseases, 2012
- DOI för Common Coinfections of Giardia intestinalis and Helicobacter pylori in Non-Symptomatic Ugandan Children
- Ladda ner fulltext (pdf) av Common Coinfections of Giardia intestinalis and Helicobacter pylori in Non-Symptomatic Ugandan Children
Allelic sequence heterozygosity in single Giardia parasites
Ingår i BMC Microbiology, 2012
Ingår i Eukaryotic Cell, s. 864-873, 2012
Ingår i PLOS ONE, 2012
- DOI för Arginine Consumption by the Intestinal Parasite Giardia intestinalis Reduces Proliferation of Intestinal Epithelial Cells
- Ladda ner fulltext (pdf) av Arginine Consumption by the Intestinal Parasite Giardia intestinalis Reduces Proliferation of Intestinal Epithelial Cells
Stable transfection of the diplomonad parasite Spironucleus salmonicida
Ingår i Eukaryotic Cell, s. 1353-1361, 2012
Laboratory cryo soft X-ray microscopy
Ingår i Journal of Structural Biology, s. 267-272, 2012
Alpha-1 Giardin is an Annexin with Highly Unusual Calcium-Regulated Mechanisms
Ingår i Journal of Molecular Biology, s. 169-181, 2012
Ingår i PLOS Neglected Tropical Diseases, 2012
- DOI för Detection of Giardia duodenalis Assemblages A and B in Human Feces by Simple, Assemblage-Specific PCR Assays
- Ladda ner fulltext (pdf) av Detection of Giardia duodenalis Assemblages A and B in Human Feces by Simple, Assemblage-Specific PCR Assays
Transcriptional changes in Giardia during host-parasite interactions
Ingår i International Journal for Parasitology, s. 277-285, 2011
Ingår i PLoS Neglected Tropical Diseases, 2011
Ingår i Experimental parasitology, s. 804-810, 2011
Ingår i Scandinavian Journal of Infectious Diseases, s. 95-99, 2011
The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology
Ingår i Genome Biology, 2011
- DOI för The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology
- Ladda ner fulltext (pdf) av The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology
Human Cellular Immune Response Against Giardia lamblia 5 Years After Acute Giardiasis
Ingår i Journal of Infectious Diseases, s. 1779-1786, 2011
Ingår i Vaccine, s. 9529-9537, 2011
Ingår i BMC Genomics, 2010
- DOI för Large genomic differences between the morphologically indistinguishable diplomonads Spironucleus barkhanus and Spironucleus salmonicida
- Ladda ner fulltext (pdf) av Large genomic differences between the morphologically indistinguishable diplomonads Spironucleus barkhanus and Spironucleus salmonicida
Ingår i Veterinary parasitology, s. 159-160, 2008
Dominance of Giardia assemblage B in León, Nicaragua.
Ingår i Acta Tropica, s. 44-53, 2008
Eukaryotic RNase P RNA mediates cleavage in the absence of protein
Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 2062-2067, 2007
Protein phosphatase 2A plays a crucial role in Giardia lamblia differentiation
Ingår i Molecular and biochemical parasitology (Print), s. 80-89, 2007
Developmental changes in the adhesive disk during Giardia differentiation.
Ingår i Mol Biochem Parasitol, s. 199-207, 2005
Secretory antibodies against Giardia intestinalis in lactating Nicaraguan women.
Ingår i Parasite Immunol, s. 163-9, 2005
Giardia lamblia-induced changes in gene expression in differentiated Caco-2
Ingår i Infect Immun, s. 8204-8, 2005
Artiklar, forskningsöversikt
Update on Giardia: Highlights from the seventh International Giardia and Cryptosporidium Conference
Ingår i Parasite, 2020
- DOI för Update on Giardia: Highlights from the seventh International Giardia and Cryptosporidium Conference
- Ladda ner fulltext (pdf) av Update on Giardia: Highlights from the seventh International Giardia and Cryptosporidium Conference
Host specificity in the Giardia duodenalis species complex
Ingår i Infection, Genetics and Evolution, s. 335-345, 2018
An up-date on Giardia and giardiasis
Ingår i Current Opinion in Microbiology, s. 47-52, 2016
Drug resistance in Giardia duodenalis
Ingår i Biotechnology Advances, s. 888-901, 2015
Behind the smile: cell biology and disease mechanisms of Giardia species
Ingår i Nature Reviews Microbiology, s. 413-422, 2010
Ingår i BMC Genomics, s. 51, 2007
Kapitel i böcker, delar av antologi
Ingår i Giardia And Giardiasis, Pt B, s. 139-171, Elsevier, 2020
Recent advances in functional research in Giardia intestinalis
Ingår i Giardia And Giardiasis, Pt B, s. 97-137, Elsevier, 2020
The genome of Giardia and other diplomonads
Ingår i Anaerobic Parasitic Protozoa: Genomics and Molecular Biology, s. 23-44, Caister Academic Press, 2010