Publikationer

Opposing effects of Rho-associated coiled-coil kinase 1 (ROCK1) and ROCK2 on TGF-β-SMAD signaling

Bai, Yu; Ali, Mohamad Moustafa; van Dinther, Maarten; ten Dijke, Peter et al.

Ingår i Cell Communication and Signaling, 2026

• DOI för Opposing effects of Rho-associated coiled-coil kinase 1 (ROCK1) and ROCK2 on TGF-β-SMAD signaling
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TGFβ signaling promotes cell cycle progression and resistance to the CDK4/6 inhibitor palbociclib through SOX4 transcriptional modulation in breast cancer cells

Ali, Mohamad Moustafa; Itoh, Yuka; Badji, Aisha Mariama Pereira; Gallant, Sarah et al.

Ingår i Cell Death and Disease, 2026

• DOI för TGFβ signaling promotes cell cycle progression and resistance to the CDK4/6 inhibitor palbociclib through SOX4 transcriptional modulation in breast cancer cells
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The long noncoding RNA VIM-AS1 and nucleoporin Nup358/RanBP2 regulate SMAD nuclear accumulation during TGF-β signaling

Mendes Rodrigues Junior, Dorival; Ali, Mohamad Moustafa; Itoh, Yuka; Ferreira, Mafalda Sousa et al.

Ingår i Nucleic Acids Research, 2026

• DOI för The long noncoding RNA VIM-AS1 and nucleoporin Nup358/RanBP2 regulate SMAD nuclear accumulation during TGF-β signaling
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Loss of ErbB3 redirects Integrin β1 from early endosomal recycling to secretion in extracellular vesicles

Mendes Rodrigues Junior, Dorival; Saez-Ibañez, Ana Rosa; Terabayashi, Takeshi; Daubel, Nina et al.

Ingår i Journal of Cell Biology, 2025

• DOI för Loss of ErbB3 redirects Integrin β1 from early endosomal recycling to secretion in extracellular vesicles
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TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles

Mendes Rodrigues Junior, Dorival; Tsirigoti, Chrysoula; Psatha, Konstantina; Kletsas, Dimitris et al.

Ingår i Journal of Experimental & Clinical Cancer Research, 2025

• DOI för TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles
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The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma

Ohata, Yae; Ali, Mohamad M.; Tsubakihara, Yutaro; Itoh, Yuka et al.

Ingår i Cell Death and Differentiation, s. 1915-1929, 2025

• DOI för The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma
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Tumoral pSMAD2 as a prognostic biomarker in early-stage breast cancer: insights from the randomized SweBCG91RT trial

Tullberg, Axel Stenmark; Thurfjell, Viktoria; Kovacs, Aniko; Micke, Patrick et al.

Ingår i Breast Cancer Research and Treatment, s. 499-509, 2025

• DOI för Tumoral pSMAD2 as a prognostic biomarker in early-stage breast cancer: insights from the randomized SweBCG91RT trial
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Crosstalk between TGF-β and EGF receptors via direct phosphorylation

Moustakas, Aristidis

Ingår i Journal of Cell Biology, 2024

• DOI för Crosstalk between TGF-β and EGF receptors via direct phosphorylation
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Smad7 palmitoylation by the S-acyltransferase zDHHC17 enhances its inhibitory effect on TGF-β/Smad signaling

Voytyuk, Oleksandr; Ohata, Yae; Moustakas, Aristidis; ten Dijke, Peter et al.

Ingår i Journal of Biological Chemistry, 2024

• DOI för Smad7 palmitoylation by the S-acyltransferase zDHHC17 enhances its inhibitory effect on TGF-β/Smad signaling
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Special issue: TGF-β and epithelial-mesenchymal transition in cancer

ten Dijke, Peter; Miyazono, Kohei; Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Seminars in Cancer Biology, s. 1-3, 2024

• DOI för Special issue: TGF-β and epithelial-mesenchymal transition in cancer

Unboxing the network among long non-coding RNAs and TGF-β signaling in cancer

Mendes Rodrigues Junior, Dorival; Moustakas, Aristidis

Ingår i Upsala Journal of Medical Sciences, 2024

• DOI för Unboxing the network among long non-coding RNAs and TGF-β signaling in cancer
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ΔNp63 bookmarks and creates an accessible epigenetic environment for TGFβ-induced cancer cell stemness and invasiveness

Vasilaki, Eleftheria; Bai, Yu; Ali, Mohamad Moustafa; Sundqvist, Anders et al.

Ingår i Cell Communication and Signaling, 2024

• DOI för ΔNp63 bookmarks and creates an accessible epigenetic environment for TGFβ-induced cancer cell stemness and invasiveness
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Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation

Peleli, Maria; Antoniadou, Ivi; Mendes Rodrigues Junior, Dorival; Savvoulidou, Odysseia et al.

Ingår i Redox Biology, 2023

• DOI för Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation
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The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition

Tzavlaki, Kalliopi; Ohata, Yae; Morén, Anita; Watanabe, Yukihide et al.

Ingår i Journal of Cellular Physiology, s. 790-812, 2023

• DOI för The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition
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The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion

Gélabert, Caroline; Papoutsoglou, Panagiotis; Cancela Golan, Irene; Ahlström, Eric et al.

Ingår i Cell Communication and Signaling, 2023

• DOI för The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion
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Aporphine and isoquinoline derivatives block glioblastoma cell stemness and enhance temozolomide cytotoxicity

Mendes Rodrigues Junior, Dorival; Raminelli, Cristiano; Hassanie, Haifa; Trossini, Gustavo Henrique Goulart et al.

Ingår i Scientific Reports, s. 21113, 2022

• DOI för Aporphine and isoquinoline derivatives block glioblastoma cell stemness and enhance temozolomide cytotoxicity
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Cellular heterogeneity in pancreatic cancer: the different faces of gremlin action

Moustakas, Aristidis; Lohr, J. Matthias; Heuchel, Rainer L.

Ingår i Signal Transduction and Targeted Therapy, 2022

• DOI för Cellular heterogeneity in pancreatic cancer: the different faces of gremlin action
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Dual inhibition of TGF-beta and PD-L1: a novel approach to cancer treatment

Gulley, James L.; Schlom, Jeffrey; Barcellos-Hoff, Mary Helen; Wang, Xiao-Jing et al.

Ingår i Molecular Oncology, s. 2117-2134, 2022

• DOI för Dual inhibition of TGF-beta and PD-L1: a novel approach to cancer treatment
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Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells

Tsirigoti, Chrysoula; Ali, Mohamad Moustafa; Maturi, Varun; Heldin, Carl-Henrik et al.

Ingår i Cell Death and Disease, 2022

• DOI för Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells
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Mast cell chymase has a negative impact on human osteoblasts

Lind, Thomas; Melo, Fabio R.; Gustafson, Ann-Marie; Sundqvist, Anders et al.

Ingår i Matrix Biology, s. 1-19, 2022

• DOI för Mast cell chymase has a negative impact on human osteoblasts
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TGF beta selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition

Tsubakihara, Yutaro; Ohata, Yae; Okita, Yukari; Younis, Shady et al.

Ingår i Molecular Oncology, s. 2330-2354, 2022

• DOI för TGF beta selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition
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The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma

Caja, Laia; Dadras, Mahsa Shahidi; Mezheyeuski, Artur; Mendes Rodrigues-Junior, Dorival et al.

Ingår i Journal of Cellular Physiology, s. 743-762, 2022

• DOI för The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma
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BMP2-induction of FN14 promotes protumorigenic signaling in gynecologic cancer cells

Fukuda, Tomohiko; Fukuda, Risa; Koinuma, Daizo; Moustakas, Aristidis et al.

Ingår i Cellular Signalling, 2021

• DOI för BMP2-induction of FN14 promotes protumorigenic signaling in gynecologic cancer cells

Glucose and Amino Acid Metabolic Dependencies Linked to Stemness and Metastasis in Different Aggressive Cancer Types

Chisari, Andrea; Golan, Irene; Campisano, Sabrina; Gélabert, Caroline et al.

Ingår i Frontiers in Pharmacology, 2021

• DOI för Glucose and Amino Acid Metabolic Dependencies Linked to Stemness and Metastasis in Different Aggressive Cancer Types
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NUAK1 and NUAK2 Fine-Tune TGF-β Signaling

van de Vis, Reinofke A. J.; Moustakas, Aristidis; van der Heide, Lars P.

Ingår i Cancers, 2021

• DOI för NUAK1 and NUAK2 Fine-Tune TGF-β Signaling
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The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor beta signaling

Papoutsoglou, Panagiotis; Rodrigues Junior, Dorival Mendes; Morén, Anita; Bergman, Andrew et al.

Ingår i Oncogene, s. 3748-3765, 2021

• DOI för The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor beta signaling
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The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma

Dadras, Mahsa Shahidi; Caja, Laia; Mezheyeuski, Artur; Liu, Sijia et al.

Ingår i Cell Death and Disease, 2021

• DOI för The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma
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BMP signaling is a therapeutic target in ovarian cancer

Fukuda, Tomohiko; Fukuda, Risa; Tanabe, Ryo; Koinuma, Daizo et al.

Ingår i Cell Death Discovery, 2020

• DOI för BMP signaling is a therapeutic target in ovarian cancer
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Endothelial-Tumor Cell Interaction in Brain and CNS Malignancies

Peleli, Maria; Moustakas, Aristidis; Papapetropoulos, Andreas

Ingår i International Journal of Molecular Sciences, 2020

• DOI för Endothelial-Tumor Cell Interaction in Brain and CNS Malignancies
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Long non-coding RNAs and TGF-beta signaling in cancer

Papoutsoglou, Panagiotis; Moustakas, Aristidis

Ingår i Cancer Science, s. 2672-2681, 2020

• DOI för Long non-coding RNAs and TGF-beta signaling in cancer
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Serglycin activates pro-tumorigenic signaling and controls glioblastoma cell stemness, differentiation and invasive potential

Manou, Dimitra; Bouris, Panagiotis; Kletsas, Dimitris; Götte, Martin et al.

Ingår i Matrix Biology Plus, 2020

• DOI för Serglycin activates pro-tumorigenic signaling and controls glioblastoma cell stemness, differentiation and invasive potential
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TGF beta and EGF signaling orchestrates the AP-1-and p63 transcriptional regulation of breast cancer invasiveness

Sundqvist, Anders; Vasilaki, Eleftheria; Voytyuk, Oleksandr; Bai, Yu et al.

Ingår i Oncogene, s. 4436-4449, 2020

• DOI för TGF beta and EGF signaling orchestrates the AP-1-and p63 transcriptional regulation of breast cancer invasiveness
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TGF-β Signaling

Tzavlaki, Kalliopi; Moustakas, Aristidis

Ingår i Biomolecules, 2020

• DOI för TGF-β Signaling
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Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGFβ-induced EMT in breast cancer

Kolliopoulos, Constantinos; Lin, Chun-Yu; Heldin, Carl-Henrik; Moustakas, Aristidis et al.

Ingår i Matrix Biology, s. 29-45, 2019

• DOI för Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGFβ-induced EMT in breast cancer

JNK-Dependent cJun Phosphorylation Mitigates TGF beta- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses

Sundqvist, Anders; Voytyuk, Olexandr; Hamdi, Mohamed; Popeijus, Herman E. et al.

Ingår i CELLS, 2019

• DOI för JNK-Dependent cJun Phosphorylation Mitigates TGF beta- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses
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LXR alpha limits TGF beta-dependent hepatocellular carcinoma associated fibroblast differentiation

Morén, Anita; Bellomo, Claudia; Tsubakihara, Yutaro; Kardassis, Dimitris et al.

Ingår i Oncogenesis, 2019

• DOI för LXR alpha limits TGF beta-dependent hepatocellular carcinoma associated fibroblast differentiation
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TANK-binding kinase 1 is a mediator of platelet-induced EMT in mammary carcinoma cells

Zhang, Yanyu; Valsala Madhavan Unnithan, Ragaseema; Hamidi, Anahita; Caja, Laia et al.

Ingår i The FASEB Journal, s. 7822-7832, 2019

• DOI för TANK-binding kinase 1 is a mediator of platelet-induced EMT in mammary carcinoma cells

The TGFB2-AS1 lncRNA regulates TGFβ signaling by modulating corepressor activity

Papoutsoglou, Panagiotis; Tsubakihara, Yutaro; Caja, Laia; Pallis, Paris et al.

Ingår i Cell Reports, s. 3182-319800000000000, 2019

• DOI för The TGFB2-AS1 lncRNA regulates TGFβ signaling by modulating corepressor activity
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Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output

Kolliopoulos, Constantinos; Raja, Erna; Razmara, Masoud; Heldin, Paraskevi et al.

Ingår i Journal of Biological Chemistry, s. 4119-4136, 2019

• DOI för Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output
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Upregulated BMP-Smad signaling activity in the glucuronyl C5-epimerase knock out MEF cells

Batool, Tahira; Fang, Jianping; Jansson, Viktor; Zhao, Hongxing et al.

Ingår i Cellular Signalling, s. 122-129, 2019

• DOI för Upregulated BMP-Smad signaling activity in the glucuronyl C5-epimerase knock out MEF cells

Epithelial-Mesenchymal Transition and Metastasis under the Control of Transforming Growth Factor

Tsubakihara, Yutaro; Moustakas, Aristidis

Ingår i International Journal of Molecular Sciences, 2018

• DOI för Epithelial-Mesenchymal Transition and Metastasis under the Control of Transforming Growth Factor
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Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells

Maturi, Varun; Morén, Anita; Enroth, Stefan; Heldin, Carl-Henrik et al.

Ingår i Molecular Oncology, s. 1153-1174, 2018

• DOI för Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells
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Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells

Maturi, Varun; Enroth, Stefan; Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Journal of Cellular Physiology, s. 7113-7127, 2018

• DOI för Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells
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Serglycin promotes breast cancer cell aggressiveness: Induction of epithelial to mesenchymal transition, proteolytic activity and IL-8 signaling

Bouris, Panagiotis; Manou, Dimitra; Sopaki-Valalaki, Anastasia; Kolokotroni, Anthi et al.

Ingår i Matrix Biology, s. 35-51, 2018

• DOI för Serglycin promotes breast cancer cell aggressiveness: Induction of epithelial to mesenchymal transition, proteolytic activity and IL-8 signaling

Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma

Bellomo, Claudia; Caja, Laia; Fabregat, Isabel; Mikulits, Wolfgang et al.

Ingår i Cell Death and Differentiation, s. 885-903, 2018

• DOI för Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma
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Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells

Caja, Laia; Tzavlaki, Kalliopi; Dadras, Mahsa Shahidi; Tan, E-Jean et al.

Ingår i Oncogene, s. 2515-2531, 2018

• DOI för Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells
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Systemic and specific effects of antihypertensive and lipid-lowering medication on plasma protein biomarkers for cardiovascular diseases

Enroth, Stefan; Maturi, Varun; Berggrund, Malin; Bosdotter Enroth, Sofia et al.

Ingår i Scientific Reports, 2018

• DOI för Systemic and specific effects of antihypertensive and lipid-lowering medication on plasma protein biomarkers for cardiovascular diseases
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TGF-beta Family Signaling in Ductal Differentiation and Branching Morphogenesis

Kahata, Kaoru; Maturi, Varun; Moustakas, Aristidis

Ingår i Cold Spring Harbor Perspectives in Biology, 2018

• DOI för TGF-beta Family Signaling in Ductal Differentiation and Branching Morphogenesis

TGF-beta Family Signaling in Epithelial Differentiation and Epithelial-Mesenchymal Transition

Kahata, Kaoru; Dadras, Mahsa Shahidi; Moustakas, Aristidis

Ingår i Cold Spring Harbor Perspectives in Biology, 2018

• DOI för TGF-beta Family Signaling in Epithelial Differentiation and Epithelial-Mesenchymal Transition

TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer

Caja, Laia; Dituri, Francesco; Mancarella, Serena; Caballero-Diaz, Daniel et al.

Ingår i International Journal of Molecular Sciences, 2018

• DOI för TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer
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