Publikationer

Integrated conjugative elements drive the formation of pandemic clones of Escherichia coli with hybrid chromosomes

Berruga Fernández, Talia; Huseby, Douglas L.; Koshla, Oksana; Shaukat, Anum et al.

Ingår i Molecular biology and evolution, 2026

• DOI för Integrated conjugative elements drive the formation of pandemic clones of Escherichia coli with hybrid chromosomes
• Ladda ner fulltext (pdf) av Integrated conjugative elements drive the formation of pandemic clones of Escherichia coli with hybrid chromosomes

The COMBINE pneumonia model: a multicenter study to standardize a mouse pneumonia model with Pseudomonas aeruginosa and Klebsiella pneumoniae for antibiotic development

Hansen, Jon U.; Arrazuria, Rakel; Hoover, Jennifer L.; Kerscher, Bernhard et al.

Ingår i Microbiology Spectrum, 2026

• DOI för The COMBINE pneumonia model: a multicenter study to standardize a mouse pneumonia model with Pseudomonas aeruginosa and Klebsiella pneumoniae for antibiotic development
• Ladda ner fulltext (pdf) av The COMBINE pneumonia model: a multicenter study to standardize a mouse pneumonia model with Pseudomonas aeruginosa and Klebsiella pneumoniae for antibiotic development

Impact of early-life human microbiota on the murine host metabolome: insights from a two-generation HMA mouse model and implications for allergic disease

de Jong, Ymke A.; Seren, Rana M.; Ramsak Marceta, Vida; Checa, Antonio et al.

Ingår i BMC Microbiology, 2025

• DOI för Impact of early-life human microbiota on the murine host metabolome: insights from a two-generation HMA mouse model and implications for allergic disease
• Ladda ner fulltext (pdf) av Impact of early-life human microbiota on the murine host metabolome: insights from a two-generation HMA mouse model and implications for allergic disease

Model-informed drug development for antimicrobials: translational pharmacokinetic-pharmacodynamic modelling of apramycin to facilitate prediction of efficacious dose in complicated urinary tract infections

Hernández-Lozano, Irene; Aranzana-Climent, Vincent; Cao, Sha; Matias, Carina et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 301-310, 2025

• DOI för Model-informed drug development for antimicrobials: translational pharmacokinetic-pharmacodynamic modelling of apramycin to facilitate prediction of efficacious dose in complicated urinary tract infections
• Ladda ner fulltext (pdf) av Model-informed drug development for antimicrobials: translational pharmacokinetic-pharmacodynamic modelling of apramycin to facilitate prediction of efficacious dose in complicated urinary tract infections

Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria

Huseby, Douglas L.; Cao, Sha; Zamaratski, Edouard; Sooriyaarachchi, Sanjeewani et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2024

• DOI för Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria
• Ladda ner fulltext (pdf) av Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria

Apramycin efficacy against carbapenem- and aminoglycoside-resistant Escherichia coli and Klebsiella pneumoniae in murine bloodstream infection models

Frimodt-Møller, Niels; Hansen, Jon U.; Plattner, Michel; Huseby, Douglas L. et al.

Ingår i International Journal of Antimicrobial Agents, 2024

• DOI för Apramycin efficacy against carbapenem- and aminoglycoside-resistant Escherichia coli and Klebsiella pneumoniae in murine bloodstream infection models
• Ladda ner fulltext (pdf) av Apramycin efficacy against carbapenem- and aminoglycoside-resistant Escherichia coli and Klebsiella pneumoniae in murine bloodstream infection models

Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors

Benediktsdottir, Andrea; Sooriyaarachchi, Sanjeewani; Cao, Sha; Ottosson, Nina E. et al.

Ingår i European Journal of Medicinal Chemistry, 2024

• DOI för Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors
• Ladda ner fulltext (pdf) av Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors

Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model

Zhao, Chenyan; Kristoffersson, Anders N.; Khan, David D.; Lagerbäck, Pernilla et al.

Ingår i Scientific Reports, 2024

• DOI för Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model
• Ladda ner fulltext (pdf) av Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model

Repurposing zidovudine and 5-fluoro-2′-deoxyuridine as antibiotic drugs made possible by synergy with both trimethoprim and the mitochondrial toxicity–reducing agent uridine

Levenfors, Jolanta J.; Bjerketorp, Joakim; Guss, Bengt; Nord, Christina et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 509-517, 2024

• DOI för Repurposing zidovudine and 5-fluoro-2′-deoxyuridine as antibiotic drugs made possible by synergy with both trimethoprim and the mitochondrial toxicity–reducing agent uridine
• Ladda ner fulltext (pdf) av Repurposing zidovudine and 5-fluoro-2′-deoxyuridine as antibiotic drugs made possible by synergy with both trimethoprim and the mitochondrial toxicity–reducing agent uridine

Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa

Cotman, Andrej Emanuel; Durcik, Martina; Tiz, Davide Benedetto; Fulgheri, Federica et al.

Ingår i Journal of Medicinal Chemistry, s. 1380-1425, 2023

• DOI för Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa
• Ladda ner fulltext (pdf) av Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa

New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus

Durcik, Martina; Cotman, Andrej Emanuel; Toplak, Zan; Mozina, Stefan et al.

Ingår i Journal of Medicinal Chemistry, s. 3968-3994, 2023

• DOI för New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus
• Ladda ner fulltext (pdf) av New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus

Evolution of Bacterial Interspecies Hybrids with Enlarged Chromosomes

Bartke, Katrin; Huseby, Douglas L; Brandis, Gerrit; Hughes, Diarmaid

Ingår i Genome Biology and Evolution, 2022

• DOI för Evolution of Bacterial Interspecies Hybrids with Enlarged Chromosomes
• Ladda ner fulltext (pdf) av Evolution of Bacterial Interspecies Hybrids with Enlarged Chromosomes

Expert workshop summary: Advancing toward a standardized murine model to evaluate treatments for antimicrobial resistance lung infections

Arrazuria, Rakel; Kerscher, Bernhard; Huber, Karen E.; Hoover, Jennifer L. et al.

Ingår i Frontiers in Microbiology, 2022

• DOI för Expert workshop summary: Advancing toward a standardized murine model to evaluate treatments for antimicrobial resistance lung infections
• Ladda ner fulltext (pdf) av Expert workshop summary: Advancing toward a standardized murine model to evaluate treatments for antimicrobial resistance lung infections

Positive Selection during Niche Adaptation Results in Large-Scale and Irreversible Rearrangement of Chromosomal Gene Order in Bacteria

Cao, Sha; Brandis, Gerrit; Huseby, Douglas L; Hughes, Diarmaid

Ingår i Molecular biology and evolution, 2022

• DOI för Positive Selection during Niche Adaptation Results in Large-Scale and Irreversible Rearrangement of Chromosomal Gene Order in Bacteria
• Ladda ner fulltext (pdf) av Positive Selection during Niche Adaptation Results in Large-Scale and Irreversible Rearrangement of Chromosomal Gene Order in Bacteria

Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)

Lu, Lu; Åkerbladh, Linda; Ahmad, Shabbir; Konda, Vivek et al.

Ingår i ACS - Infectious Diseases, s. 482-498, 2022

• DOI för Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)
• Ladda ner fulltext (pdf) av Synthesis and in vitro biological evaluation of quinolinyl pyrimidines targeting type II NADH-dehydrogenase (NDH-2)

Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia

Aranzana-Climent, Vincent; Hughes, Diarmaid; Cao, Sha; Tomczak, Magdalena et al.

Ingår i Clinical Microbiology and Infection, s. 1367-1374, 2022

• DOI för Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia
• Ladda ner fulltext (pdf) av Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia

Variability of murine bacterial pneumonia models used to evaluate antimicrobial agents

Arrazuria, Rakel; Kerscher, Bernhard; Huber, Karen E.; Hoover, Jennifer L. et al.

Ingår i Frontiers in Microbiology, 2022

• DOI för Variability of murine bacterial pneumonia models used to evaluate antimicrobial agents
• Ladda ner fulltext (pdf) av Variability of murine bacterial pneumonia models used to evaluate antimicrobial agents

Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis

Becker, Katja; Cao, Sha; Nilsson, Anna; Erlandsson, Maria et al.

Ingår i EBioMedicine, 2021

• DOI för Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis
• Ladda ner fulltext (pdf) av Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis

Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation

Benediktsdottir, Andrea; Lu, Lu; Cao, Sha; Zamaratski, Edouard et al.

Ingår i European Journal of Medicinal Chemistry, 2021

• DOI för Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation
• Ladda ner fulltext (pdf) av Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation

Chromosomal Location Determines the Rate of Intrachromosomal Homologous Recombination in Salmonella

Garmendia, Eva; Brandis, Gerrit; Guy, Lionel; Cao, Sha et al.

Ingår i mBio, 2021

• DOI för Chromosomal Location Determines the Rate of Intrachromosomal Homologous Recombination in Salmonella
• Ladda ner fulltext (pdf) av Chromosomal Location Determines the Rate of Intrachromosomal Homologous Recombination in Salmonella

Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice

Becker, Katja; Aranzana-Climent, Vincent; Cao, Sha; Nilsson, Anna et al.

Ingår i Clinical Microbiology and Infection, s. 1315-1321, 2021

• DOI för Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice
• Ladda ner fulltext (pdf) av Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice

ENABLE: an engine for European antibacterial drug discovery and development

Olliver, Marie; Griestop, Laura; Hughes, Diarmaid; Belfrage, Anna Karin et al.

Ingår i Nature reviews. Drug discovery, s. 407-408, 2021

• DOI för ENABLE: an engine for European antibacterial drug discovery and development

Evaluating the potential efficacy and limitations of a phage for joint antibiotic and phage therapy of Staphylococcus aureus infections

Berryhill, Brandon A.; Huseby, Douglas L; McCall, Ingrid C.; Hughes, Diarmaid et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2021

• DOI för Evaluating the potential efficacy and limitations of a phage for joint antibiotic and phage therapy of Staphylococcus aureus infections
• Ladda ner fulltext (pdf) av Evaluating the potential efficacy and limitations of a phage for joint antibiotic and phage therapy of Staphylococcus aureus infections

Expression of the qepA1 gene is induced under antibiotic exposure

Brandis, Gerrit; Gockel, Jonas; Garoff, Linnéa; Guy, Lionel et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 1433-1440, 2021

• DOI för Expression of the qepA1 gene is induced under antibiotic exposure
• Ladda ner fulltext (pdf) av Expression of the qepA1 gene is induced under antibiotic exposure

Genetic Architecture and Fitness of Bacterial Interspecies Hybrids

Bartke, Katrin; Garoff, Linnéa; Huseby, Douglas L; Brandis, Gerrit et al.

Ingår i Molecular biology and evolution, s. 1472-1481, 2021

• DOI för Genetic Architecture and Fitness of Bacterial Interspecies Hybrids
• Ladda ner fulltext (pdf) av Genetic Architecture and Fitness of Bacterial Interspecies Hybrids

Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin

Sou, Tomás; Hansen, Jon; Liepinsh, Edgars; Backlund, Maria et al.

Ingår i Clinical Pharmacology and Therapeutics, s. 1063-1073, 2021

• DOI för Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin
• Ladda ner fulltext (pdf) av Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin

Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response

Brandis, Gerrit; Granström, Susanna; Leber, Anna T.; Bartke, Katrin et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 606-615, 2021

• DOI för Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response
• Ladda ner fulltext (pdf) av Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response

Phenotypic and genetic barriers to establishment of horizontally transferred genes encoding ribosomal protection proteins

Yadav, Kavita; Garoff, Linnea; Huseby, Douglas L; Hughes, Diarmaid

Ingår i Journal of Antimicrobial Chemotherapy, s. 1441-1447, 2021

• DOI för Phenotypic and genetic barriers to establishment of horizontally transferred genes encoding ribosomal protection proteins

Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli

Praski Alzrigat, Lisa; Huseby, Douglas L.; Brandis, Gerrit; Hughes, Diarmaid

Ingår i Journal of Antimicrobial Chemotherapy, s. 77-83, 2021

• DOI för Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli
• Ladda ner fulltext (pdf) av Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli

Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene

Huseby, Douglas L; Brandis, Gerrit; Praski Alzrigat, Lisa; Hughes, Diarmaid

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 3185-3191, 2020

• DOI för Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene
• Ladda ner fulltext (pdf) av Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene

Isopedopeptins A-H: Cationic Cyclic Lipodepsipeptides from Pedobacter cryoconitis UP508 Targeting WHO Top-Priority Carbapenem-Resistant Bacteria

Nord, Christina; Bjerketorp, Joakim; Levenfors, Jolanta J.; Cao, Sha et al.

Ingår i ACS Chemical Biology, s. 2937-2944, 2020

• DOI för Isopedopeptins A-H: Cationic Cyclic Lipodepsipeptides from Pedobacter cryoconitis UP508 Targeting WHO Top-Priority Carbapenem-Resistant Bacteria
• Ladda ner fulltext (pdf) av Isopedopeptins A-H: Cationic Cyclic Lipodepsipeptides from Pedobacter cryoconitis UP508 Targeting WHO Top-Priority Carbapenem-Resistant Bacteria

Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli

Garoff, Linnéa; Pietsch, Franziska; Huseby, Douglas L; Lilja, Tua et al.

Ingår i Molecular biology and evolution, s. 1637-1646, 2020

• DOI för Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli
• Ladda ner fulltext (pdf) av Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli

Structure-activity relationship studies on the inhibition of the bacterial translation of novel Odilorhabdins analogues

Loza, Einars; Sarciaux, Matthieu; Ikaunieks, Martins; Katkevics, Martins et al.

Ingår i Bioorganic & Medicinal Chemistry, 2020

• DOI för Structure-activity relationship studies on the inhibition of the bacterial translation of novel Odilorhabdins analogues

Synthesis of New N-Acyl-1,2,3-triazole Chalcones and Determination of Their Antibacterial Activity

Odin, I. S.; Cao, Sha; Hughes, Diarmaid; Zamaratskii, E. V. et al.

Ingår i Doklady. Chemistry, s. 89-92, 2020

• DOI för Synthesis of New N-Acyl-1,2,3-triazole Chalcones and Determination of Their Antibacterial Activity

The SNAP hypothesis: Chromosomal rearrangements could emerge from positive Selection during Niche Adaptation

Brandis, Gerrit; Hughes, Diarmaid

Ingår i PLOS Genetics, 2020

• DOI för The SNAP hypothesis: Chromosomal rearrangements could emerge from positive Selection during Niche Adaptation
• Ladda ner fulltext (pdf) av The SNAP hypothesis: Chromosomal rearrangements could emerge from positive Selection during Niche Adaptation

In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii

Juhas, Mario; Widlake, Emma; Teo, Jeanette; Huseby, Douglas L et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 944-952, 2019

• DOI för In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii
• Ladda ner fulltext (pdf) av In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii

Measuring Homologous Recombination Rates between Chromosomal Locations in Salmonella

Brandis, Gerrit; Cao, Sha; Hughes, Diarmaid

Ingår i Bio-protocol, 2019

• DOI för Measuring Homologous Recombination Rates between Chromosomal Locations in Salmonella

Operon Concatenation Is an Ancient Feature That Restricts the Potential to Rearrange Bacterial Chromosomes

Brandis, Gerrit; Cao, Sha; Hughes, Diarmaid

Ingår i Molecular biology and evolution, s. 1990-2000, 2019

• DOI för Operon Concatenation Is an Ancient Feature That Restricts the Potential to Rearrange Bacterial Chromosomes
• Ladda ner fulltext (pdf) av Operon Concatenation Is an Ancient Feature That Restricts the Potential to Rearrange Bacterial Chromosomes

Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase

Szałaj, Natalia; Lu, Lu; Benediktsdottir, Andrea; Zamaratski, Edouard et al.

Ingår i European Journal of Medicinal Chemistry, s. 1346-1360, 2018

• DOI för Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase

Co-evolution with recombination affects the stability of mobile genetic element insertions within gene families of Salmonella

Brandis, Gerrit; Cao, Sha; Hughes, Diarmaid

Ingår i Molecular Microbiology, s. 697-710, 2018

• DOI för Co-evolution with recombination affects the stability of mobile genetic element insertions within gene families of Salmonella
• Ladda ner fulltext (pdf) av Co-evolution with recombination affects the stability of mobile genetic element insertions within gene families of Salmonella

Effect of aminoacyl-tRNA synthetase mutations on susceptibility to ciprofloxacin in Escherichia coli

Garoff, Linnéa; Huseby, Douglas L; Praski Alzrigat, Lisa; Hughes, Diarmaid

Ingår i Journal of Antimicrobial Chemotherapy, s. 3285-3292, 2018

• DOI för Effect of aminoacyl-tRNA synthetase mutations on susceptibility to ciprofloxacin in Escherichia coli
• Ladda ner fulltext (pdf) av Effect of aminoacyl-tRNA synthetase mutations on susceptibility to ciprofloxacin in Escherichia coli

Imidazopyrazinones (IPYs): Non-Quinolone Bacterial Topoisomerase Inhibitors Showing Partial Cross-Resistance with Quinolones

Jeannot, Frédéric; Taillier, Thomas; Despeyroux, Pierre; Renard, Stéphane et al.

Ingår i Journal of Medicinal Chemistry, s. 3565-3581, 2018

• DOI för Imidazopyrazinones (IPYs): Non-Quinolone Bacterial Topoisomerase Inhibitors Showing Partial Cross-Resistance with Quinolones

Increased expression of Qnr is sufficient to confer clinical resistance to ciprofloxacin in Escherichia coli

Garoff, Linnéa; Yadav, Kavita; Hughes, Diarmaid

Ingår i Journal of Antimicrobial Chemotherapy, s. 348-352, 2018

• DOI för Increased expression of Qnr is sufficient to confer clinical resistance to ciprofloxacin in Escherichia coli
• Ladda ner fulltext (pdf) av Increased expression of Qnr is sufficient to confer clinical resistance to ciprofloxacin in Escherichia coli

Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB.

Brandis, Gerrit; Hughes, Diarmaid

Ingår i Scientific Reports, 2018

• DOI för Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB.
• Ladda ner fulltext (pdf) av Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB.

Methods to determine mutational trajectories after experimental evolution of antibiotic resistance.

Huseby, Douglas L; Hughes, Diarmaid

Ingår i Methods in Molecular Biology, s. 95-103, 2018

• DOI för Methods to determine mutational trajectories after experimental evolution of antibiotic resistance.

Muramyl Endopeptidase Spr Contributes to Intrinsic Vancomycin Resistance in Salmonella enterica Serovar Typhimurium

Vestö, Kim; Huseby, Douglas L; Snygg, Lina; Wang, Helen et al.

Ingår i Frontiers in Microbiology, 2018

• DOI för Muramyl Endopeptidase Spr Contributes to Intrinsic Vancomycin Resistance in Salmonella enterica Serovar Typhimurium
• Ladda ner fulltext (pdf) av Muramyl Endopeptidase Spr Contributes to Intrinsic Vancomycin Resistance in Salmonella enterica Serovar Typhimurium

Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site

Pantel, Lucile; Florin, Tanja; Dobosz-Bartoszek, Malgorzata; Racine, Emilie et al.

Ingår i Molecular Cell, s. 83-94, 2018

• DOI för Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site

Predicting mutant selection in competition experiments with ciprofloxacin-exposed Escherichia coli

Khan, David; Lagerbäck, Pernilla; Malmberg, Christer; Kristoffersson, Anders et al.

Ingår i International Journal of Antimicrobial Agents, s. 399-406, 2018

• DOI för Predicting mutant selection in competition experiments with ciprofloxacin-exposed Escherichia coli

Transcriptional Regulation Buffers Gene Dosage Effects on a Highly Expressed Operon in Salmonella

Garmendia, Eva; Brandis, Gerrit; Hughes, Diarmaid

Ingår i mBio, 2018

• DOI för Transcriptional Regulation Buffers Gene Dosage Effects on a Highly Expressed Operon in Salmonella
• Ladda ner fulltext (pdf) av Transcriptional Regulation Buffers Gene Dosage Effects on a Highly Expressed Operon in Salmonella

Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureus

Cao, Sha; Huseby, Douglas L; Brandis, Gerrit; Hughes, Diarmaid

Ingår i mBio, 2017

• DOI för Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureus
• Ladda ner fulltext (pdf) av Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureus